A pyrroloquinazoline derivative with anti-inflammatory and analgesic activity by dual inhibition of cyclo-oxygenase-2 and 5-lipoxygenase

European Journal of Pharmacology

Volumn 434, Issue 3, 2002, Pages 177-185

  Rioja, Inmaculada ^a   Terencio, M Carmen ^a   Ubeda, Amalia ^a   Molina, Pedro ^b   Tárraga, Alberto ^b   Gonzalez Tejero, Antonia ^b   Alcaraz, M Jose ^a  

^a UNIVERSITY OF VALENCIA   (Spain)

^b UNIVERSITY OF MURCIA   (Spain)

Author keywords

Air pouch, mouse; Analgesia; Carrageenan paw oedema; Cyclo oxygenase 2; Eicosanoid; Pyrroloquinazoline

Indexed keywords

1 ETHYL 6 [[3 FLUORO 5 (3,4,5,6 TETRAHYDRO 4 METHOXY 2H PYRAN 4 YL)]PHENOXYMETHYL] 2 QUINOLONE; 3 (4' ACETOXY 3',5' DIMETHOXY)BENZYLIDENE 1,2 DIHYDROPYRROLO[2,1 B]QUINAZOLIN 9 ONE; ARACHIDONATE 5 LIPOXYGENASE; CARRAGEENAN; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; DEXAMETHASONE; INDOMETACIN; ISOENZYME; LEUKOTRIENE B4; PHENYLQUINONE; PROSTAGLANDIN E2; QUINAZOLINE DERIVATIVE; UNCLASSIFIED DRUG; ZYMOSAN;

ANALGESIC ACTIVITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL ASSAY; CELL MIGRATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; EXPERIMENTAL MODEL; FEMALE; HUMAN; HUMAN CELL; LEUKOCYTE; MOUSE; NONHUMAN; PAW EDEMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; WRITHING TEST;

ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARACHIDONATE 5-LIPOXYGENASE; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; EDEMA; ENZYME INHIBITORS; FEMALE; HUMANS; ISOENZYMES; MEMBRANE PROTEINS; MICE; MONOCYTES; PAIN MEASUREMENT; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PYRROLES; QUINAZOLINES; QUINOLINES; SHEEP;

EID: 0037059429     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(01)01539-4     Document Type: Article

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