C-terminal cyclization of an SDF-1 small peptide analogue dramatically increases receptor affinity and activation of the CXCR4 receptor

Journal of Medicinal Chemistry

Volumn 45, Issue 10, 2002, Pages 2024-2031

  Tudan, Christopher ^a,b   Willick, Gordon E ^c   Chahal, Sarabjit ^b   Arab, Lakhdar ^b   Law, Ping ^b   Salari, Hassan ^b   Merzouk, Ahmed ^b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b Chemokine Therapeutics Corporation   (Canada)

^c NATIONAL RESEARCH COUNCIL CANADA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; LACTAM DERIVATIVE; PEPTIDE DERIVATIVE; STROMAL CELL DERIVED FACTOR 1; STROMAL CELL DERIVED FACTOR 1 DERIVATIVE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CIRCULAR DICHROISM; CYCLIZATION; DRUG RECEPTOR BINDING; HUMAN; HUMAN CELL; RECEPTOR AFFINITY;

AMINO ACID SEQUENCE; BINDING, COMPETITIVE; CELL LINE; CHEMOKINES, CXC; CIRCULAR DICHROISM; HUMANS; LACTAMS; MOLECULAR SEQUENCE DATA; PEPTIDES, CYCLIC; PROTEIN STRUCTURE, SECONDARY; RADIOLIGAND ASSAY; RECEPTORS, CXCR4;

EID: 0037046515     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0104015     Document Type: Article

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