Genomic organization and functional expression of differentially regulated cysteine protease genes of Leishmania donovani complex

Gene

Volumn 282, Issue 1-2, 2002, Pages 257-265

  Mundodi, Vasanthakrishna ^a   Somanna, Ashwini ^a   Farrell, Patrick J ^b   Gedamu, Lashitew ^a  

^a UNIVERSITY OF CALGARY   (Canada)

^b UNIVERSITY OF CALGARY   (Canada)

Author keywords

3 untranslated region; Gene cluster; Insect expression system; Partial library

Indexed keywords

AMINO ACID; CYSTEINE PROTEINASE; GELATIN; HISTIDINE; NUCLEOTIDE;

3' UNTRANSLATED REGION; ARTICLE; BIOASSAY; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; GENE AMPLIFICATION; GENE CLUSTER; GENE CONTROL; GENE DELETION; GENE EXPRESSION; GENE LOCATION; GENETIC ORGANIZATION; GENETIC VARIABILITY; HUMAN; HUMAN CELL; LEISHMANIA DONOVANI; NONHUMAN; PARASITE; PRIORITY JOURNAL; PROMASTIGOTE; PROTEIN ANALYSIS; PROTEIN DOMAIN;

5' FLANKING REGION; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BLOTTING, WESTERN; CYSTEINE ENDOPEPTIDASES; DNA, PROTOZOAN; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENES, PROTOZOAN; LEISHMANIA; LEISHMANIA DONOVANI; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; RECOMBINANT FUSION PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS, DNA; SEQUENCE HOMOLOGY, AMINO ACID; SEQUENCE HOMOLOGY, NUCLEIC ACID;

INSECTA; LEISHMANIA DONOVANI; LEISHMANIA DONOVANI CHAGASI;

EID: 0037045399     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1119(01)00851-4     Document Type: Article

References (28)

1. Leishmania mexicana cysteine proteinase deficient mutants have attenuated virulence for mice and potentiate a Th1 response
2. Regulation of Trichophyton rubrum proteolytic activity
3. The C-terminal extension of the major cysteine protease (cruzipain) from Trypanosoma cruzi
4. A prospective study of visceral leishmaniasis in an endemic area of Brazil
5. Viral cysteine proteases are homologous to the trypsin - Like family of serine proteases: Structural and functional amplification
6. Genes encoding the major surface glycoprotein in Leishmania are tandemly linked at a single chromosomal locus and are constitutively transcribed
7. The developmental expression of Leishmania donovani A2 amastigote-specific genes is post-transcriptionally mediated and involves elements located in the 3′-untranslated region
8. Single-step method of RNA isolation by acid-guanidinium thiocyanate-phenol-chloroform extraction
9. Parasite proteinases and amino acid metabolism: Possibilities for chemotherapeutic exploitation
10. The sequence, organization, and expression of the major cysteine protease (cruzain) from Trypanosoma cruzi
11. Epidemiology of visceral leishmaniasis Northeast Brazil
12. High-level expression of secreted glycoproteins in transformed lepidopteron insect cells using a novel expression vector
13. Secretion of cytoplasmic and nuclear proteins from animal cells using novel secretion modules
14. Stage-specific expression in Leishmania conferred by 3′ untranslated regions of L. major leishmanolysin genes (GP63)
15. Comparative specificity of microbial proteinases
16. The multiple cpb cysteine proteinase genes of Leishmania mexicana encode isoenzymes that differ in their stage regulation and substrate preferences
17. Molecular cloning, characterization and over expression of two distinct cysteine protease cDNA from Leishmania donovani chagasi
18. Analysis of post-transcriptional regulation operating on transcription products of the tandemly linked Leishmania infantum hsp70 genes
19. Identification of putative regulatory elements in the 3′-untranslated region that controls expression of HSP70 in Leishmania infantum
20. Sequence diversity and organization of the msp gene family encoding gp63 of Leishmania chagasi
21. Multiple high activity cysteine proteases of L. mexicana are encoded by the lmcpb gene array
22. Protease of protozoan parasites
23. Cysteine protease inhibitors as chemotherapy: Lessons from a parasite target
24. Role of the Entamoeba histolytica cysteine protease in amoebic liver abscess formation in severe combined immunodeficient mice
25. Developmental changes in the expression of Leishmania chagasi gp63 and heat shock protein in a human macrophage cell line
26. Kala-azar in Athens basin
27. A new developmentally regulated gene family in Leishmania amastigotes encoding a homolog of amastin surface proteins