Sugar-modified conjugated diene analogues of adenosine and uridine: Synthesis, interaction with S-adenosyl-L-homocysteine hydrolase, and antiviral and cytostatic effects

Journal of Medicinal Chemistry

Volumn 45, Issue 12, 2002, Pages 2651-2658

  Wnuk, Stanislaw F ^a   De Clercq, Erik ^e   Ro, Bong Oh ^a,b   Valdez, Carlos A ^a   Lewandowska, Elzbieta ^a,c   Valdez, Neida X ^a   Sacasa, Pablo R ^a   Yin, Dan ^d   Zhang, Jinsong ^d   Borchardt, Ronald T ^d  

^a FLORIDA INTERNATIONAL UNIVERSITY   (United States)

^b Chosun University   (South Korea)

^c POZNA UNIVERSITY OF LIFE SCIENCES   (Poland)

^d UNIVERSITY OF KANSAS   (United States)

^e REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

9 (8,8 DIBROMO 5,6,7,8 TETRADEOXY BETA DEXTRO RIBO OCT 5,7 DIENOFURANOSYL)ADENINE; ADENOSINE DERIVATIVE; ADENOSYLHOMOCYSTEINASE; ANTIVIRUS AGENT; CYTOSTATIC AGENT; ETHYL 1 (ADENIN 9 YL) 1,5,6,7,8 PENTADEOXY BETA DEXTRO RIBO NON 5,7 DIENOFURANURONATE; ETHYL 1,5,6,7,8 PENTADEOXY 1 (URACIL 1 YL) BETA DEXTRO RIBO NON 5,7 DIENOFURANURONATE; UNCLASSIFIED DRUG; URIDINE DERIVATIVE;

ANTIVIRAL ACTIVITY; ARTICLE; CATALYSIS; CONCENTRATION RESPONSE; CYTOMEGALOVIRUS; CYTOSTASIS; DRUG SYNTHESIS; ENZYME INACTIVATION; NONHUMAN; OXIDATION; POLYMERIZATION; REACTION ANALYSIS; VARICELLA ZOSTER VIRUS;

ADENOSINE; ADENOSYLHOMOCYSTEINASE; ALKADIENES; ANTINEOPLASTIC AGENTS; ANTIVIRAL AGENTS; CARBOHYDRATES; CELL LINE; CYTOMEGALOVIRUS; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; HERPESVIRUS 3, HUMAN; HIV-1; HIV-2; HUMANS; HYDROLASES; URIDINE;

EID: 0037030638     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020064f     Document Type: Article

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