Anticancer and antiviral effects and inactivation of S-adenosyl-L- homocysteine hydrolase with 5'-carboxaldehydes and oximes synthesized from adenosine and sugar-modified analogues

Journal of Medicinal Chemistry

Volumn 40, Issue 11, 1997, Pages 1608-1618

  Wnuk, Stanislaw F ^a   Yuan, Chong Sheng ^b   Borchardt, Ronald T ^b   Balzarini, Jan ^c   De Clercq, Erik ^c   Robins, Morris J ^a  

^a BRIGHAM YOUNG UNIVERSITY   (United States)

^b UNIVERSITY OF KANSAS   (United States)

^c REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSYLHOMOCYSTEINASE; ADENOSYLHOMOCYSTEINASE INHIBITOR; ALDEHYDE DERIVATIVE; OXIME DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; CANCER CELL; CONTROLLED STUDY; CYTOMEGALOVIRUS; CYTOTOXICITY; DRUG MECHANISM; DRUG SYNTHESIS; ENZYME ACTIVE SITE; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; VACCINIA VIRUS; VIRUS INFECTION;

ADENOSINE; ADENOSYLHOMOCYSTEINASE; ALDEHYDES; ANIMALS; ANTINEOPLASTIC AGENTS; ANTIVIRAL AGENTS; CARBOHYDRATES; CELL LINE; CYTOMEGALOVIRUS; DOGS; ENZYME INHIBITORS; HUMANS; HYDROLASES; LEUKEMIA L1210; MAMMARY NEOPLASMS, EXPERIMENTAL; OXIMES; TUMOR CELLS, CULTURED; VACCINIA VIRUS;

EID: 0031006943     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960828p     Document Type: Article

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