Doubly homologated dihalovinyl and acetylene analogues of adenosine: Synthesis, interaction with S-adenosyl-L-homocysteine hydrolase, and antiviral and cytostatic effects

Journal of Medicinal Chemistry

Volumn 43, Issue 6, 2000, Pages 1180-1186

  Wnuk, Stanislaw F ^a   Valdez, Carlos A ^a   Khan, Jahanzeb ^a   Moutinho, Priscilla ^a   Robins, Morris J ^b   Yang, Xiaoda ^c   Borchardt, Ronald T ^c   Balzarini, Jan ^d   De Clercq, Erik ^d  

^a FLORIDA INTERNATIONAL UNIVERSITY   (United States)

^b Brigham Young University   (United States)

^c UNIVERSITY OF KANSAS   (United States)

^d REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

9 (5,6,7 TRIDEOXY BETA DEXTRO RIBO HEPT 6 YNFURANOSYL)ADENINE; 9 (7 BROMO 5,6,7 TRIDEOXY 7 FLUORO BETA DEXTRO RIBO HEPT 6 ENOFURANOSYL)ADENINE; 9 (7,7 DIBROMO 5,6,7 TRIDEOXY BETA DEXTRO RIBO HEPT 6 ENOFURANOSYL)ADENINE; ADENOSINE DERIVATIVE; ANTIVIRUS AGENT; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CYTOSTASIS; DRUG SYNTHESIS; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HYDROLYSIS; IC 50; REDUCTION; TIME; VACCINIA VIRUS; VESICULAR STOMATITIS VIRUS;

ADENOSYLHOMOCYSTEINASE; ALKYNES; ANTINEOPLASTIC AGENTS; ANTIVIRAL AGENTS; DIDEOXYADENOSINE; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; HUMANS; HYDROLASES; PLACENTA; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0034704823     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm990486y     Document Type: Article

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