The mechanism of inactivation of human placental S-adenosylhomocysteine hydrolase by (E)-4',5'-didehydro-5'-methoxyadenosine and adenosine 5'- carboxaldehyde oxime

Archives of Biochemistry and Biophysics

Volumn 343, Issue 1, 1997, Pages 109-117

  Huang, He ^a   Yuan, Chong Sheng ^a   Wnuk, Stanislaw F ^b   Robins, Morris J ^b   Borchardt, Ronald T ^a  

^a UNIVERSITY OF KANSAS   (United States)

^b Brigham Young University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4',5' DIDEHYDRO 5' METHOXYADENOSINE; ADENOSINE 5' CARBOXALDEHYDE OXIME; ADENOSYLHOMOCYSTEINASE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; ENZYME ACTIVITY; ENZYME INACTIVATION; OXIDATION; PRIORITY JOURNAL; REACTION ANALYSIS;

EID: 0031195042     PISSN: 00039861     EISSN: None     Source Type: Journal    
DOI: 10.1006/abbi.1997.0159     Document Type: Article

References (19)

1. 1. De Clercq, E. (1987) Biochem. Pharmacol. 36, 2567-2575.
2. 2. Liu, S., Wolfe, M. S., and Borchardt, R. T. (1992) Antiviral Res. 19, 247-265.
3. 3. Chiang, P. K., and Cantoni, G. L. (1979) Biochem Pharmacol. 28, 1897-1902.
4. 4. Keller, B. T., and Borchardt, R. T. (1986) in Biological Methylation and Drug Design (Borchardt, R. T., Creveling, C. R., and Ueland, P. M., Eds,) pp. 385-396, Humana Press, Clifton, NJ.
5. 5. De La Haba, G., and Cantoni, G. L. (1959) J. Biol. Chem. 234, 603-608.
6. 6. Hasobe, M., McKee, J. G., and Borchardt, R. T. (1989) Antimicrob. Agents Chemother. 33, 828-834.
7. 7. Pugh, C. S. G., Borchardt, R. T., and Stone, H. O. (1978) J. Biol. Chem. 253, 4075-4077.
8. 8. Palmer, J. L., and Abeles, R. H. (1979) J. Biol. Chem. 254, 1217-1226.
9. 9. Yuan, C-S., Yeh, J., Liu, S., and Borchardt, R. T. (1993) J. Biol. Chem. 268, 17030-17037.
10. 10. Mehdi, S., Jarvi, E. T., Koehl, J. R., McCarthy, J. R., and Bey, P. J. (1990) J. Enzyme Inhib. 4, 1-13.
11. 11. McCarthy, J. R., Jarvi, E. T., Mathews, D. P., Edwards, M. L., Prakash, N. J., Bowlin, T. L., Mehdi, S., Sunkara, P. S., and Bey, P. (1989) J. Am. Chem. Soc. 111, 1127-1128.
12. 12. Liu, S., Wnuk, S. F., Yuan, C-S., Robins, M. J., and Borchardt, R. T. (1993) J. Med. Chem. 36, 883-887.
13. 13. Robins, M. J., Wnuk, S. F., Mullah, K., Dalley, N. K., Yuan, C-S., Lee, Y., and Borchardt, R. T. (1994) J. Org. Chem. 59, 544-555.
14. 14. Wnuk, S. F., Yuan, C. S., Borchardt, R. T., Balzarini, J., Declercq, E., and Robins, M. J. (1997) Submitted.
15. 15. Bradford, M. M. (1976) Anal. Biochem. 72, 248-252.
16. 16. Kitz, R., and Wilson, I. B. (1962) J. Biol. Chem. 237, 3245-3249.
17. 17. Yuan, C-S., and Borchardt, R. T. (1995) J. Biol. Chem. 270, 16140-16146.
18. 18. Yuan, C-S., Yeh, J., Squier, T. C., Rawitch, A., and Borchardt, R. T. (1993) Biochemistry 32, 10414-10422.
19. 19. Abeles, R. H., Fish, S., and Lapinskas, B. (1982) Biochemistry 21, 5557-5562.