Discovery of type II (Covalent) inactivation of S-adenosyl-L- homocysteine hydrolase involving its 'hydrolytic activity': Synthesis and evaluation of dihalohomovinyl nucleoside analogues derived from adenosine

Journal of Medicinal Chemistry

Volumn 41, Issue 16, 1998, Pages 3078-3083

  Wnuk, Stanislaw F ^a,d   Mao, Yue ^a,e   Yuan, Chong Sheng ^b,f   Borchardt, Ronald T ^b   Andrei, Graciela ^c   Balzarini, Jan ^c   De Clercq, Erik ^c   Robins, Morris J ^a  

^a Brigham Young University   (United States)

^b UNIVERSITY OF KANSAS   (United States)

^c REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^d FLORIDA INTERNATIONAL UNIVERSITY   (United States)

^e ABBOTT LABORATORIES   (United States)

^f Tanabe Research Laboratories   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

9 (5,6 DIBROMO 5,6 DIDEOXY BETA DEXTRO RIBO HEX 5 ENOFURANOSYL)ADENINE; 9 (6 BROMO 5,6 DIDEOXY 6 FLUORO BETA DEXTRO RIBO HEX 5 ENOFURANOSYL)ADENINE; 9 (6,6 DIBROMO 5,6 DIDEOXY BETA DEXTRO RIBO HEX 5 ENOFURANOSYL)ADENINE; ADENINE DERIVATIVE; ADENOSYLHOMOCYSTEINASE; NUCLEOSIDE ANALOG; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CELL CULTURE; DRUG CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INACTIVATION; NONHUMAN; STRUCTURE ACTIVITY RELATION; VERO CELL;

ADENOSYLHOMOCYSTEINASE; ANTIVIRAL AGENTS; CELL LINE, TRANSFORMED; DIDEOXYADENOSINE; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; HYDROLASES; HYDROLYSIS; MICROBIAL SENSITIVITY TESTS; PLACENTA; RECOMBINANT PROTEINS;

EID: 0032581608     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9801410     Document Type: Article

References (25)

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