Synthesis, mechanism of action, and antiviral activity of a new series of covalent mechanism-based inhibitors of S-adenosyl-L-homocysteine hydrolase

Journal of Medicinal Chemistry

Volumn 44, Issue 17, 2001, Pages 2743-2752

  Guillerm, G ^a   Guillerm, D ^a   Vandenplas Witkowki, C ^a   Rogniaux, H ^b   Carte, N ^b   Leize, E ^b   Van Dorsselaer, A ^b   De Clercq, E ^c   Lambert, C ^d  

^a UNIVERSITÉ DE REIMS CHAMPAGNE ARDENNE   (France)

^b UNIVERSITÉ DE STRASBOURG   (France)

^c REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^d ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

5' S ALLENYL 5' THIOADENOSINE; 5' S PROPARGYL 5' THIOADENOSINE; 5' S PROPYNYL 5' THIOADENOSINE; ADENOSINE DERIVATIVE; ADENOSYLHOMOCYSTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CATALYSIS; COVALENT BOND; DRUG EFFECT; DRUG MECHANISM; ENZYME INACTIVATION; METHYLATION; NEGATIVE FEEDBACK; NONHUMAN; PROTEIN DEGRADATION; SYNTHESIS; VIRUS REPLICATION;

ADENOSYLHOMOCYSTEINASE; AMINO ACID SEQUENCE; ANTIVIRAL AGENTS; CELL LINE; CHROMATOGRAPHY, LIQUID; ENZYME INHIBITORS; HUMANS; HYDROLASES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NAD; PLACENTA; RECOMBINANT PROTEINS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; STRUCTURE-ACTIVITY RELATIONSHIP; THIONUCLEOSIDES;

EID: 0035899173     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0108350     Document Type: Article

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