2,3-Dihydro-1H,7H-pyrimido[5,6,1-de]acridine-1,3,7-trione derivatives, a class of cytotoxic agents active on multidrug-resistant cell lines: Synthesis, biological evaluation, and structure-activity relationships

Journal of Medicinal Chemistry

Volumn 42, Issue 14, 1999, Pages 2535-2541

  Antonini, Ippolito ^a   Polucci, Paolo ^a   Kelland, Lloyd R ^b   Menta, Ernesto ^c   Pescalli, Nicoletta ^c   Martelli, Sante ^a  

^a UNIVERSITY OF CAMERINO   (Italy)

^b INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^c Boehringer Ingelheim Italia SpA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

6 [(2 AMINOETHYL)AMINO] 2 [2 (DIMETHYLAMINO)ETHYL] 2,3 DIHYDRO 1H,7H PYRIMIDO[5,6,1]ACRIDINE 1,3,7 TRIONE; 9 AMINO 2 [2 (DIMETHYLAMINO)ETHYL] 6 [2 (DIMETHYLAMINO)ETHYL]AMINO 2,3 DIHYDRO 1H,7H PYRIMIDO[5,6,1]ACRIDINE 1,3,7 TRIONE; ACRIDINE DERIVATIVE; CISPLATIN; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; COLON CARCINOMA; CYTOTOXICITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; INTERCALATION COMPLEX; OVARY CARCINOMA; STRUCTURE ACTIVITY RELATION;

ACRIDINES; ANIMALS; ANTINEOPLASTIC AGENTS; CATTLE; DNA; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; FLUORESCENCE; HUMANS; PYRIMIDINONES; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0033566075     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9805586     Document Type: Article

References (14)

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