[3H]RX821002 [2-methoxyidazoxan) binds to α2-adrenoceptor subtypes and a non-adrenoceptor imidazoline binding site in rat kidney

European Journal of Pharmacology

Volumn 316, Issue 2-3, 1996, Pages 359-368

  Callado, Luis F ^a   Gabilondo, Ane M ^a   Meana, J Javier ^a  

^a UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

Author keywords

2 Adrenoceptors; Imidazoline binding sites; Kidney, rat; RX821002

Indexed keywords

2 (1 METHYL 2 ISOINDOLINYLMETHYL) 2 IMIDAZOLINE; 2 (2 IMIDAZOLIN 2 YL)QUINOLINE; 2 (2 METHOXY 1,4 BENZODIOXAN 2 YL) 2 IMIDAZOLINE; 2 [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] 4,4 DIMETHYL 1,3(2H,4H) ISOQUINOLINEDIONE; 4 IMIDAZOLEACETIC ACID; ADENOSINE A2 RECEPTOR; ADRENALIN; AMILORIDE; CIMETIDINE; CLONIDINE; EFAROXAN; GUANABENZ; ISAGLIDOLE MALEATE; MOXONIDINE; NORADRENALIN; OXYMETAZOLINE; PRAZOSIN; RECEPTOR SUBTYPE; RILMENIDINE; SEROTONIN; 2-METHOXYIDAZOXAN; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; DRUG DERIVATIVE; IDAZOXAN;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; KIDNEY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; ANIMAL; DOSE RESPONSE; DRUG EFFECT; SPRAGUE DAWLEY RAT;

ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; IDAZOXAN; KIDNEY; MALE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, ALPHA-2;

EID: 0030571306     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(96)00692-9     Document Type: Article

References (54)

1. Allan, D.R., S.B. Penner and D.D. Smyth, 1993, Renal imidazoline preferring sites and solute excretion in the rat, Br. J. Pharmacol. 108, 870.
2. Berdeu, D., R. Gross, G. Ribes, M.M. Loubatières-Mariani and G. Bertrand, 1994, Effects of imidazolines and derivatives on insulin secretion and vascular resistance in perfused rat pancreas. Eur. J. Pharmacol. 254, 119.
3. + transport and intracellular pH in renal proximal tubule cells, Biochim. Biophys. Acta 1024, 173.
4. 2D-Adrenoccptors modulate renal noradrenaline release in normotensive and spontaneously hypertensive rats, Eur. J. Pharmacol. 271, 283.
5. Bricca, G., M. Dontenwill, A. Molines, J. Feldman, A. Belcourt and P. Bousquet, 1989. The imidazoline preferring receptor: Binding studies in bovine, rat and human brainstem, Eur. J. Pharmacol. 162, 1.
6. Brown, C.A., A.C. Loweth, S.A. Smith and N.G. Morgan, 1993, Stimulation of insulin secretion by imidazoline compounds is not due to interaction with non-adrenoceptor idazoxan binding sites, Br. J. Pharmacol. 108, 312.
7. 2-adrenergic receptors, FASEB J. 6, 832.
8. 2-adrenergic receptors: Comparison of pharmacologically defined subtypes with subtypes identified by molecular cloning, Mol. Pharmacol. 42, 1.
9. 2-adrenoceptors and imidazoline-binding sites in the control of insulin secretion, Clin. Sci. 85, 671.
10. + ATP channels in insulin-secreting cells, Eur. J. Pharmacol. 204, 41.
11. 2-sites, Br. J. Pharmacol. 112, 1065.
12. 2-adrenoceptors in paniculate and soluble preparations of human platelet and rat and rabbit kidney, Biochern. Pharmacol. 35, 3767.
13. 2-adrenoceptors, Br. J. Pharmacol. 101, 285.
14. Coupry, I., D. Atlas, R.A. Podevin, I. Uzielli and A. Parini, 1989, Imidazoline-guanidinium receptive site in renal proximal tubule: Asymetric distribution, regulation by cations and interaction with an endogenous clonidine displacing substance, J. Pharmacol. Exp. Ther. 252, 293.
15. De Lean, A, P.J. Munson and D. Rodbard, 1978, Simultaneous analysis of families of sigmoidal curves: Application to bioassay, radioligand assay, and physiological dose-response curves, Am. J. Physiol. 235, E97.
16. 2-adrenoceptors in the human central nervous system, Neuroscience 59, 589.
17. 3H]rauwolscine? A comparison of nine tissues and cell lines, J. Pharmacol. Exp. Ther. 273, 1287.
18. 2-adrenoceptors in the ventrolateral medulla, Eur. J. Pharmacol. 134, 1.
19. Ernsberger, P., G. Feinland, M.P. Meely and D.J. Reis, 1990, Characterization and visualization of clonidine-sensitive imidazole sites in rat kidney which recognize clonidine-displacing substance, Am. J. Hypertens. 3, 90.
20. 1-imidazoline receptors, J. Cardiovasc. Pharmacol. 20 (Suppl. 4). S1.
21. 1-imidazoline sites, J. Pharmacol. Exp. Ther. 264, 172.
22. 2-adrenoceptors after manipulation of noradrenergic transmission in the rat, Eur. J. Pharmacol. 164, 455.
23. Hamilton, C.A., 1992, The role of imidazoline receptors in blood pressure regulation, Pharmacol. Ther. 54, 231.
24. 2D subtype, Eur. J. Pharmacol. 277, 215.
25. 2-adrenoceptors in the rat brain, Mol. Neuropharmacol. 1, 219.
26. 2-sites), Br. J. Pharmacol. 112, 320P.
27. 2-sites), Br. J. Pharmacol. 114, 411P.
28. + channels in pancreatic β-cells, Br. J. Pharmacol. 107, 8.
29. + channels in pancreatic B-cells, Eur. J. Pharmacol. 264, 81.
30. 3H]imidazoline binding sites in rat kidney, Eur. J. Pharmacol. 281, 341.
31. 2-adrenergic binding sites, Mol. Pharmacol. 37, 876.
32. 2-receptor classification, Mol. Pharmacol. 38, 599.
33. Lowry, O.H., N.J. Rosebrough, A.L. Farr and R.J. Randall, 1951, Protein measurement with the Folin phenol reagent, J. Biol. Chem. 193, 265.
34. 3H]idazoxan label different populations of imidazoline sites on rat kidney, Eur. J. Pharmacol. 232, 79.
35. McPherson, G.A., 1985, Analysis of radioligand binding experiments, A collection of computer programs for the IBM PC, J. Pharmacol. Methods 14, 213.
36. 2-adrenergic drugs also bind with high affinity to a nonadrenergic site, Mol. Pharmacol. 35, 324.
37. Michel, M.C. and P. Ernsberger, 1992, Keeping an eye in the I site: Imidazoline-preferring receptors, Trends Pharmacol. Sci. 13, 369.
38. 2B-adrenoceptor subtypes, Br. J. Pharmacol. 98, 890.
39. 2H]RX821002 (2-methoxy idazoxan) in the human and rat brains, J. Pharmacol. Exp. Ther. 264, 1187.
40. Motulsky, H.J., and L.A. Ransnas, 1987, Fitting curves to data using nonlinear regression: A practical and nonmathematical review, FASEB J. 1, 365.
41. Munson, P.J. and D. Rodbard, 1980, LIGAND: A versatile computerized approach for characterization of ligand-binding systems, Anal. Biochem. 107, 220.
42. 2 receptors, Eur. J. Pharmacol. 262, 41.
43. O'Rourke, M.F., L.J. Iversen, J.W. Lomasney and D.E. Bylund, 1994, Species orthologs of the alpha-2A adrenergic receptor: The pharmacological properties of the bovine and rat receptors differ from the human and porcine receptors, J. PharmacoL Exp. Ther. 271, 735.
44. Piletz, J.E. and K. Sletten, 1993, Nonadrenergic imidazoline binding sites on human platelets, J. Pharmacol. Exp. Ther. 267, 1493.
45. 2-adrenoceptors are blocked, Naunyn-Schmiedeberg's Arch. Pharmacol. 340, 712.
46. Schwartz, D.D. and K.U. Malik, 1992, Characterization of prejunctional alpha-2 adrenergic receptors involved in modulation of adrenergic transmitter release in the isolated perfused rat kidney, J. Pharmacol. Exp. Ther. 261, 1050.
47. 2A-selective compound, Eur. J. Pharmacol. 202, 235.
48. 2-adrenoceptor in the rat kidney, Br. J. Pharmacol. 104, 657.
49. 2A-adrenoceptors in the rat, Naunyn-Schmiedeberg's Arch. Pharmacol. 347, 280.
50. 3H]idazoxan, Neurochem. Int. 17, 537.
51. Vigne, P., M. Lazdunski and C. Frelin, 1989, Guanabenz, guanochlor, guanoxan and idazoxan bind with high affinity to non-adrenergic sites in pig kidney membranes, Eur. J. Pharmacol. 160, 295.
52. 2-adrenoceptors in rat cerebral cortical membranes, Eur. J. Pharmacol. 258, 67.
53. Wikberg, J.E.S., S. Uhlén and V. Chhajlani, 1991, Medetomidine stereoisomers delineate two closely related subtypes of idazoxan (imidazoline) I-receptors in the guinea pig, Eur. J. Pharmacol. 193, 335.
54. 2C-adrenoceptors in the pig cerebellum and kidney cortex, Eur. J. Pharmacol. 284, 271.