Cytogenetic monitoring of hospital workers occupationally exposed to ionizing radiation using the micronucleus centromere assay

Mutagenesis

Volumn 15, Issue 3, 2000, Pages 245-249

  Thierens, H ^a,b   Vral, A ^a   Morthier, R ^b   Aousalah, B ^a   De Ridder, L ^a  

^a GHENT UNIVERSITY   (Belgium)

^b GHENT UNIVERSITY HOSPITAL   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

CLASTOGEN;

ADULT; ARTICLE; BIOLOGICAL MONITORING; CENTROMERE; CHROMOSOME LOSS; CONTROLLED STUDY; CYTOGENETICS; FEMALE; GAMMA RADIATION; HOSPITAL PERSONNEL; HUMAN; HUMAN CELL; IN SITU HYBRIDIZATION; IONIZING RADIATION; LONG TERM EXPOSURE; LYMPHOCYTE; MAJOR CLINICAL STUDY; MALE; MICRONUCLEUS TEST; OCCUPATIONAL EXPOSURE; PERSONNEL RADIATION MONITORING; PRIORITY JOURNAL; RADIATION EXPOSURE; SMOKING; X CHROMOSOME; X RAY;

EID: 0034069125     PISSN: 02678357     EISSN: None     Source Type: Journal    
DOI: 10.1093/mutage/15.3.245     Document Type: Article

References (36)

1. Aoyama, T. (1989) Radiation risk of Japanese and Chinese low dose repeatedly irradiated population. J. Univ. Occup. Environ. Health, 11, 432-442.
2. Au, W., Walker, D., Ward, J.B., Whorton, E., Lagator, M.S. and Singh, V. (1991) Factors contributing to chromosome damage in lymphocytes of cigarettes smokers. Mutat. Res., 260, 137-144.
3. Ban, S., Cologne, J.B., Fujita, S. and Awa, A.A. (1993) Radiosensitivity of atomic bomb survivors as determined with a micronucleus assay. Radiat. Res., 134, 170-178.
4. Barquinero, J.F., Barrios, L., Caballin, M.R., Miro, R., Ribas, M., Subias, A. and Egozcue, J. (1993) Cytogenetic analysis of lymphocytes from hospital workers occuputionally exposed to low levels of ionizing radiation. Mutat. Res., 286, 275-279.
5. Bigatti, P., Lamberti, L., Ardito, G. and Armellino, F. (1988) Cytogenetic monitoring of hospital workers exposed to low-level ionizing radiation. Mutat. Res., 204, 343-347.
6. Boei, J.J.W.A. and Natarajan, A.T. (1495) Detection of chromosome malsegregation to the daughter nuclei in cytokinesis-blocked transgenic mouse splenocytes. Chromosome Res., 3, 45-53.
7. Carere, A., Antoccia, A., Cimini, D., Crebelli, R., Degrassi, F., Leopardi, P., Marcon, F., Sgura, A., Tanzarella, C. and Zijno, A. (1999) Analysis of chromosome loss and non-disjunction in cytokinesis-blocked lymphocytes of 24 male subjects. Mutagenesis, 14, 491-496.
8. Catalán, J., Autio, K., Kuosma, E. and Norppa, H. (1998) Age-dependent inclusion of sex chromosomes in lymphocyte micronuclei in man. Am. J. Hum. Genet., 63, 1464-1472.
9. Da Cruz, A.D., McArthur, A.G., Silva, C.C., Curado, M.P. and Glickman, B.W. (1994) Human micronucleus counts are correlated with age, smoking and cesium-137 dose in the Goiana (Brazil) radiological accident. Mutat. Res., 313, 57-68.
10. Duffaud, F., Orsière, T., Villani, R. Pelissier, A.L., Volot, F., Favre, R. and Botta, A. (1997) Comparison between micronucleated lymphocyte rates observed in healthy subjects and cancer patients. Mutagenesis, 12, 227-231.
11. Fenech, M. (1993) The cytokinesis-block micronucleus technique: a detailed description of the method and its application to genotoxicity studies in human populations. Mutat. Res., 285, 35-44.
12. Fenech, M. (1998) Important variables that influence base-line micronucleus frequency in cytokinesis-blocked lymphocytes - a biomarker for DNA damage in human populations. Mutat. Res., 404, 155-165.
13. Fenech, M. and Morley, A.A. (1985) Measurement of micronuclei in human lymphocytes. Mutat. Res., 147, 29-36.
14. Hande, M.R, Boei, J.J., Granath, F. and Natarajan, A.T. (1996a) Induction and persistence of cytogenetic damage in mouse splenoeytes following whole-body X-irradiation analysed by fluorescence in situ hybridization. I. Dicentrics and translocations. Int. J. Radiat. Biol., 69, 437-446.
15. Hande, M.P., Boei, J.J. and Natarajan, A.T. (1996b) Induction and persistence of cytogenetic damage in mouse splenocytes following whole-body X-irradiation analysed by fluorescence in situ hybridization. II. Micronuclei. Int. J. Radiat. Biol., 70, 375-383.
16. Hando, J.C., Nath, J. and Tucker, J.D. (1994) Sex chromosomes, micronuclei and aging in women. Chromosoma, 103, 186-192.
17. Holmen, A., Karlsson, A., Bratt, I. and Hogstedt, B. (1995) Increased frequencies of micronuclei in T lymphocytes of smokers. Mutat. Res., 334, 205-208.
18. Jha, A.N. and Sharma, T. (1991) Enhanced frequency of chromosome aberrations in workers occupationally exposed to diagnostic X-rays. Mutat. Res., 260, 343-348.
19. Kirsch-Volders, M., Elhajouji, A., Cundari, E. and Van Hummelen, P. (1997) The in vitro micronucleus lest: a multi-endpoint assay to detect simultaneously mitotic delay, apoptosis, chromosome breakage, chromosome loss and non-disjunction. Mutat. Res., 392, 19-30.
20. Migliore, L., Parrini, M., Sbrana, I., Biagini, C., Battaglia, A. and Loprieno, N. (1991) Micronucleated lymphocytes in people occupationally exposed to potential environmental contaminants: the age effect. Mutat. Res., 256, 13-19.
21. Mitchell, A.R., Gosden, J.R. and Miller, D.A. (1985) A cloned sequence p82H of the alphoid repeated DNA family found at the centromeres of all human chromosomes. Chromosoma, 92, 369-377.
22. Natarajan, A.T., Vyas, R.C., Wiegant, K. and Curado, M.P. (1991) A cytogenetic follow-up study of the victims of a radiation accident in Goiania (Brazil). Mutat. Res., 247, 103-111.
23. Nederlof, P.M., Van der Flier, S., Viegant J., Raap, A.K., Tanke, H.J., Ploem, J.S. and Van der Ploeg, M. (1990) Multiple fluorescence in situ hybridization. Cytometry, 11, 126-131.
24. Ramirez, M.J., Surrales, J., Galofré, P., Creus, A. and Marcos, R. (1997) Radioactive iodine induces clastogenic and age-dependent aneugenic effects in lymphocytes of thyroid cancer patients as revealed by interphase FISH. Mutagenesis, 12, 449-455.
25. Richard, F., Muleris, M. and Dutrillaux, B. (1994) The frequency of micronuclei with X-chromosome increases with age in human females. Mutat. Res., 316, 1-7.
26. Smith, P.G. and Doll, R. (1981) Mortality from cancer and other causes among British radiologists. Br. J. Radiol., 54, 187-194.
27. Streffer, C., Muller, W.U., Kryscio, A. and Bökker, W. (1998) Micronuclei -biological indicator for retrospective dosimetry after exposure to ionizing radiation. Mutat. Res., 404, 101-105.
28. Surrallés, J., Jeppesen, R, Morrison, H. and Natarajan, A.T. (1996) Analysis of loss of inactive X-chromosomes in interphase cells. Am. J. Hum. Genet., 59, 151-154.
29. Thierens, H., Vral, A., Van Eijkeren, M., Speleman, F. and De Ridder, L. (1995) Micronucleus induction in peripheral blood lymphocytes of patients under radiotherapy treatment for cervical cancer or Hodgkin's disease. Int. J. Radiat. Biol., 67, 529-539.
30. Thierens, H., Vral, A., De Ridder, L., Touil, N., Kirsch-Volders, M., Lambert, V. and Laurent, C. (1999) Interlaboratory comparison of cytogenetic endpoints for the biomonitoring of radiological workers. Int. J. Radiat. Biol., 75, 23-34.
31. Tomanin, K., Ballarin, C., Nardini, B., Mastrangelo, G. and Sarto, F. (1991) Influence of smoking habits on the frequency of micronuclei in human lymphocytes by the cytokinesis block method. Mutagenesis, 6, 123-126.
32. Vrai, A., Verhaegen. F., Thierens, H. and De Ridder, L. (1994) The in vitro micronucleus assay: a detailed description of an improved slide preparation technique for the automated detection of micronuclei in human lymphocytes. Mutagenesis, 9. 439-443.
33. Vrai, A.,Thierens, H. and De Ridder, L. (1997) In vitro micronucleus-centromere assay to detect radiation-damage induced by low doses in human lymphocytes. Int. J. Radiat. Biol., 71, 61-68.
34. Wang, J., Boice, J.D. and Li, B. (1988) Cancer among medical diagnostic workers in China. J. Natl Cancer. Inst., 80, 344-350.
35. Zijno, A., Leopardi, P., Marcon, F. and Crebelli, R. (1996a) Sex chromosome loss and non-disjunction in women: analysis of chromosomal segregation in binucleated lymphocytes. Chromosoma, 104, 461-467.
36. Zijno, A., Leopardi, P., Marcon, F. and Crebelli, R. (1996b) Analysis of chromosome segregation by means of fluorescence in situ hybridization: application to cytokinesis-blocked human lymphocytes. Mutat. Res., 372, 211-219.