Rejoining and misrejoining of radiation-induced chromatin breaks. II. Biophysical model

Radiation Research

Volumn 145, Issue 3, 1996, Pages 281-288

  Wu, H ^a,b   Durante, M ^a,d   George, K ^a,b   Goodwin, E H ^c   Yang, T C ^a  

^a NASA JOHNSON SPACE CENTER   (United States)

^b KRUG Life Sciences Inc   (United States)

^c LOS ALAMOS NATIONAL LABORATORY   (United States)

^d UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED DNA;

ARTICLE; CELL CYCLE PHASE; CHROMATIN; CHROMOSOME ABERRATION; CHROMOSOME BREAKAGE; DNA REPAIR; DNA STRAND BREAKAGE; FIBROBLAST; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN; HUMAN CELL; IRRADIATION; KINETICS; LYMPHOCYTE; MATHEMATICAL MODEL; PREMATURE CHROMOSOME CONDENSATION; PRIORITY JOURNAL;

NASA CENTER JSC; NASA DISCIPLINE RADIATION HEALTH;

CELL LINE; CHROMATIN; CHROMOSOME ABERRATIONS; CHROMOSOMES, HUMAN, PAIR 4; DNA; DNA DAMAGE; DNA REPAIR; FIBROBLASTS; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; KINETICS; LYMPHOCYTES; MATHEMATICS; MODELS, GENETIC; MODELS, THEORETICAL; TIME FACTORS;

EID: 0029886402     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.2307/3578983     Document Type: Article

References (39)

1. M. N. Cornforth and J. S. Bedford, Ionizing radiation damage and its early development in chromosomes. In Advances in Radiation Biology. Vol. 17 (J. T. Lett and W. K. Sinclair, Eds.), pp. 423-489. Academic Press. San Diego, 1993.
2. B. D. Loucas and C. R. Geard, Kinetics of chromosome rejoining in normal human fibroblasts after exposure to low- and high-LET radiations. Radiat. Res. 138, 352-360 (1994).
3. J. M. Brown, J. W. Evans and M. S. Kovacs, Mechanism of chromosome exchange formation in human fibroblasts: Insights from "chromosome painting." Environ. Mol. Mutagen. 22, 218-224 (1993).
4. M. Durante, K. George, H. Wu and T. C. Yang, Rejoining and misrejoining of radiation-induced chromatin breaks. I. Experiments in human lymphocytes. Radiai. Res. 145, 274-280 (1996).
5. C. A. Tobias, E. A. Blakely, F. O. H. Ngo and T. C. H. Yang, The repair-misrepair model of cell survival. In Radiation Biology and Cancer Research (R. E. Meyn and H. R. Withers, Eds.), pp. 195-230. Raven Press, New York. 1980.
6. S. B. Curtis, Lethal and potentially lethal lesions induced by radiation - A unified repair model. Radiat. Res. 106, 252-270 (1986).
7. D. Brenner, Track structure, lesion development, and cell survival. Radiat Res. 124, S29-S37 (1990).
8. L. Hlatky, R. Sachs and P. Hahnfeldt. Reaction kinetics for the development of radiation-induced chromosome aberrations. Int. J. Radiat. Biol. 59, 1147-1172 (1991).
9. P. Hahnfeldt and L. R. Hlatky. A Monte Carlo/Markov chain model for the association of data for chromosome aberrations and formation of micronuclei. Radiat. Res. 138, 239-245 (1994).
10. R. K. Sachs and D. J. Brenner, Effect of LET on chromosomal aberration yield. I. Do long-lived, exchange-prone double strand breaks play a role? Int. J. Radiat. Biol. 64, 677-688 (1993).
11. R. K. Sachs, P. Chen. P. Hahnfeldt, D. Lai and L. R. Hlatky, DNA damage in non-proliferating cells subjected to ionizing irradiation at high and low dose rates. J. Math. Biol. 31, 291-315 (1993).
12. L. J. Stadler, The experimental modification of heredity in crop plants I. Induced chromosomal irregularities. Sci. Agr. 11, 557-572 (1931).
13. K. Sax, The behavior of x-ray-induced chromosomal aberrations in Allium root tip cells. Genetics 26, 418-425 (1941).
14. D. E. Lea, Actions of Radiations on Living Cells. Cambridge University Press, Cambridge, 1955.
15. S. H. Revell, The breakage-and-reumon theory and the exchange theory for chromosomal aberrations induced by ionizing radiations: a short history. In Advances in Radiation Biology, Vol. 4 (J. T. Lett and H. Adler, Eds.), pp. 367-416. Academic Press, New York, 1974.
16. J. M. Brown and M. S. Kovacs, Visualization of nonreciprocal chromosome exchanges in irradiated human fibroblasts by fluorescence in situ hybridization. Radiat. Res. 136, 71-78 (1993).
17. J. N. Lucas and R. K. Sachs, Using three-color chromosome painting to test chromosome aberration models. Proc. Natl Acad Sci. USA 90, 1484-1487 (1993).
18. A. M. Kellerer and H. H. Rossi, A generalized formulation of dual radiation action. Radiat. Res. 75, 471-488 (1978).
19. A. A. Edwards, V V. Moiseenko and H Nikjoo, Modeling of DNA breaks and the formation of chromosome aberrations. Int. J. Radiat. Biol. 66, 633-637 (1994).
20. L. R. Hlatky, R. K. Sachs and P. Hahnfeldt, The ratio of dicentrics to centric rings produced in human lymphocytes by acute low-LET radiation. Radiat. Res. 129, 304-308 (1992).
21. J. N. Lucas, A. Awa, T. Straume, M. Poagensee, Y. Kodama, M. Nakano, K. Ohtaki, H. U. Weier, D. Pinkel, J. Gray and G. Little-field. Rapid translocation frequency analysis in human decades after exposure to ionizing radiation. Int. J. Radiat. Biol. 62, 53-63 (1992).
22. P. Hahnfeldt, L. R. Hlatky, D. J. Brenner and R. K, Sachs, Chromosome aberrations produced by radiation: the relationship between excess acentric fragments and dicentrics. Radiat. Res. 141, 136-152 (1995).
23. M. N. Cornforth and J. S. Bedford, A quantitative comparison of potentially lethal damage repair and the rejoining of interphase chromosome breaks in low-passage normal human fibroblasts. Radiat. Res. 111, 385-405 (1987).
24. J. R. K. Savage. Classification and relationship of induced chromosomal structural changes. J. Med Genet. 12, 103-122 (1975).
25. J. R. K. Savage and P. J. Simpson. FISH "painting" patterns resulting from complex exchanges. Mutat Res. 312, 51-60 (1994).
26. S. Knehr. H. Zitzelsberger, H. Braselmann and M. Bauchinger. Analysis for DNA-proportional distribution of radiation-induced chromosome aberrations in various triple combinations of human chromosomes using fluorescence in situ hybridization. Int. J. Radiat. Biol. 65, 683-690 (1994).
27. T. Straume and J. N. Lucas, A comparison of the yields of translocations and dicentrics measured using fluorescence in situ hybridization. Int. J. Radiat. Biol. 64, 185-187 (1993).
28. M. Nakano. E. Nakashima, D. J. Pawel, Y. Kodama and A. Awa, Frequency of reciprocal translocations and dicentrics induced in human blood lymphocytes by X-irradiation as determined by fluorescence in situ hybridization. Int. J. Radiat. Biol. 64, 565-569 (1993).
29. M. S. Kovacs, J. W. Evans, I. M. Johnstone and J. M. Brown. Radiation-induced damage, repair and exchange formation in different chromosomes of human fibroblasts determined by fluorescence in situ hybridization. Radiat. Res. 137, 34-43 (1994).
30. J. R. Savage and D. G. Papworth, Frequency and distribution studies of asymmetrical versus symmetrical chromosome aberrations. Mutat. Res. 95, 7-18 (1982).
31. R. C. Vyas, F. Darroudi and A. T. Natarajan. Radiation-induced chromosomal breakage and rejoining in interphase-metaphase chromosomes of human lymphocytes. Mutat. Res 249, 29-35 (1991).
32. R. Greinert, E. Detzler. B. Volkmer and D. Harder, Kinetics of the formation of chromosome aberrations in X-irradiated human lymphocytes: Analysis by premature chromosome condensation with delayed fusion. Radiat. Res. 144, 190-197 (1995).
33. M. G. Kendall and P. A. P. Moran, Geometrical Probability, pp. 53-54. Charles Griffin, London, 1963.
34. M. Durante, G. F. Grossi, M. Napolitano, M. Pugliese and G. Gialanella. Chromosome damage induced by high-LET α-particles in plateau-phase C3H 10T1/2 cells Int. J. Radiat. Bioi 62, 571-580 (1992).
35. D. J. Brenner and R. K. Sachs. Chromosome "fingerprints" of prior exposure to densely ionizing radiation. Radiat. Res. 140, 134-142 (1994). [Commentary]
36. T. K. Pandita, V. Gregoire, K. Dhingra and W. N. Hittelman, Effect of chromosome size on aberration levels caused by gamma radiation as detected bv fluorescence in situ hybridization. Cytogenet. Cell Genet. 67, 94-101 (1994).
37. G. E. Iliakis, D. Blocher, L. Metzger and G. Pantelias. Comparison of DNA double strand-break rejoining as measured by pulse field gel electrophoresis, neutral sucrose gradient centrifugation and non-unwinding filter elution in irradiated plateau-phase CHO cells. Int. J. Radiat. Biol. 59, 927-939 (1991).
38. 1-phase Chinese hamster ovary cells exposed to charged-particle beams. Radiat. Res. 138, 343-351 (1995).
39. E. H. Goodwin, S. M. Bailey, D. J. Chen and M. N. Cornforth, The effect of track structure on cell inactivation and chromosome damage at a constant LET of 120 keV/μm. Adv. Space Res. 18, (1/2)93-(1/2)98 (1996).