Metabolic regulation of fermentation processes

Enzyme and Microbial Technology

Volumn 31, Issue 7, 2002, Pages 895-906

  Sanchez, Sergio ^a   Demain, Arnold L ^b  

^a UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^b DREW UNIVERSITY   (United States)

Author keywords

Fermentation; Industrial microbiology; Production of metabolites; Regulation

Indexed keywords

BIOTECHNOLOGY; ENZYMES; METABOLISM; METABOLITES; MICROORGANISMS; NUTRITION;

METABOLIC REGULATION;

FERMENTATION;

BACITRACIN; BENZODIAZEPINE DERIVATIVE; CEPHALOSPORIN DERIVATIVE; CHLORAMPHENICOL; CHLORTETRACYCLINE; CLORTETRACYCLINE; CYCLOSERINE; DACTINOMYCIN; ENNIATIN; ENZYME INHIBITOR; ERGOT ALKALOID; ERYTHROMYCIN; GENTAMICIN; GRAMICIDIN S; INDOLMYCIN; KANAMYCIN; MILBEMYCIN; MYCOPHENOLIC ACID; NISIN; NITROGEN; OLEANDOMYCIN; OXYTETRACYCLINE; PENICILLIN G; PHOSPHORUS; PUROMYCIN; REBECCAMYCIN; STREPTOMYCIN; TETRACYCLINE; TYLOSIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

BACTERIAL STRAIN; BIOTECHNOLOGY; CARBON SOURCE; CATABOLITE REPRESSION; DRUG EFFECT; DRUG MECHANISM; ENZYME INHIBITION; ENZYME REPRESSION; FEEDBACK SYSTEM; FERMENTATION; METABOLIC REGULATION; NONHUMAN; NUTRITION; PROTEIN TARGETING; REVIEW; SPECIES DIFFERENCE; SYNTHESIS;

EID: 0037010892     PISSN: 01410229     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0141-0229(02)00172-2     Document Type: Review

References (140)

1. Agrawal P., Koshy G., Ramseier M. An algorithm for operating a fed-batch fermentor at optimum specific growth rate. Biotechnol. Bioeng. 33:1989;115-125.
2. Aleksieva P., Micheva-Viteva S. Regulation of extracellular acid phosphatase biosynthesis by phosphates in proteinase producing fungus Humicola lutea. Enzyme Microb. Technol. 27:2000;570-575.
3. Angell S., Schwartz E., Bibb M.J. The glucose kinase gene of Streptomyces coelicolor A3(2): its nucleotide sequence, transcriptional analysis and role in glucose repression. Mol. Microbiol. 6:1992;2833-2844.
4. Angell S., Lewis C.G., Buttner M.J., Bibb M.J. Glucose repression in Streptomyces coelicolor A3(2): a likely regulatory role for glucose kinase. Mol. Gen. Genet. 244:1994;135-143.
5. Aristidou A., Penttilä M. Metabolic engineering applications to renewable resource utilization. Curr. Opin. Biotechnol. 11:2000;187-198.
6. Barbesgaard P., Heldt-Hansen H.P., Diderichsen B. On the safety of Aspergillus oryzae. Appl. Microbiol. Biotechnol. 36:1992;569-572.
7. Barker SA, Shirley JA. Glucose oxidase, glucose dehydrogenase, glucose isomerase, β-galactosidase and invertase. In: Rose AH, editor. Microbial Enzymes and Bioconversions. New York: Academic Press, 1980. p. 173-226.
8. Behal V., Neuzil J., Hostalek Z. Effect of tetracycline derivatives and some cations on the activity of anhydrotetracycline oxygenase. Biotechnol. Lett. 5:1983;537-542.
9. Botsford J.L. Metabolism of cyclic adenosine 3′,5′-monophosphate and induction of tryptophanase in Escherichia coli. J. Bacteriol. 124:1975;380-390.
10. Brown S.B., Sonenshein A.L. Autogenous regulation of the Bacillus subtilis glnRA operon. J. Bacteriol. 178:1996;2450-2454.
11. Carlsen M., Nielsen J. Influence of carbon source on α-amylase production by Aspergillus oryzae. Appl. Microbiol. Biotechnol. 57:2001;346-349.
12. Casqueiro J., Gutiérrez S., Bañuelos O., Hijarrubia M.J., Martín J.F. Gene targeting in Penicillium chrysogenum: disruption of the lys2 gene leads to penicillin overproduction. J. Bacteriol. 181:1999;1181-1188.
13. Cha C., Gao P., Chen Y.C., Shaw P.D., Farrand S.K. Production of acyl-homoserine lactone quorum-sensing signals by Gram-negative plant-associated bacteria. Mol. Plant Microbe. Interact. 11:1998;1119-1129.
14. Chaterjee S., Vining L.C. Catabolite repression in Streptomyces venezuelae. Induction of β-galactosidase, chloramphenicol production, and intracellular cyclic adenosine 3′, 5′-monophosphate concentrations. Can. J. Microbiol. 28:1982;311-317.
15. Cheng C.W., Yang S.-S. Amylase production of Streptomyces rimosus TM-55 and their 2-deoxyglucose mutants. Chin. J. Microbiol. Immunol. 28:1995;109-116.
16. Colón G.E., Nguyen T.T., Jetten M.S.M., Sinskey A., Stephanopoulos G. Production of isoleucine by overexpression of ilvA in Corynebacterium lactofermentum threonine producer. Appl. Microbiol. Biotechnol. 43:1995;482-488.
17. Delic I., Robbins P., Westpheling J. Direct repeat sequences are implicated in the regulation of two Streptomyces chitinase promoters that are subject to carbon catabolite control. Proc. Natl. Acad. Sci. U.S.A. 89:1992;1885-1889.
18. Demain A.L. Overproduction of microbial metabolites and enzymes due to alteration of regulation. Adv. Biochem. Eng. Biotechnol. 1:1971;113-142.
19. Demain A.L. Contributions of genetics to the production and discovery of microbial pharmaceuticals. Pure Appl. Chem. 60:1988;833-836.
20. Demain AL. Carbon source regulation of idiolite biosynthesis in actinomycetes. In: Shapiro S, editor. Regulation of Secondary Metabolism in Actinomycetes. Boca Raton, FL: CRC Press, 1989. p. 127-34.
21. Distler J., Ebert A., Mansouri K., Pissowitski K., Stockmann M., Piepersberg W. Gene cluster for streptomycin biosynthesis in Streptomyces griseus: nucleotide sequence of three genes and analysis of transcriptional activity. Nucleic Acids Res. 15:1987;8041-8056.
22. Distler Eggeling L, Sahm H. Amino acid production: Principles of metabolic engineering. In: Lee SY, Papoutsakis ET, editors. Metabolic Engineering. New York: Marcel Dekker, 1999. p. 153-76.
23. Fierro-Monti I.P., Reid S.J., Woods D.R. Differential expression of a Clostridium acetobutylicum antisense RNA: implications for regulation of glutamine synthetase. J. Bacteriol. 174:1992;7642-7647.
24. Fisher S.H., Wray L.V. Jr. Regulation of glutamine synthetase in Streptomyces coelicolor. J. Bacteriol. 171:1989;2378-2383.
25. Fisher S.H., Sonenshein A.L. Control of carbon and nitrogen metabolism in Bacillus subtilis. Annu. Rev. Microbiol. 45:1991;107-135.
26. Flores M.E., Ponce E., Rubio M., Huitron C. Glucose and glycerol repression of amylase in Streptomyces kanamyceticus and isolation of deregulated mutants. Biotechnol. Lett. 15:1993;595-600.
27. Flores M.E., Perea M., Rodriguez O., Malvaes A., Huitron C. Physiological studies on induction and catabolite repression of β-xylosidase and endoxylanase in Streptomyces sp. J. Biotechnol. 49:1996;179-187.
28. Freudl R. Protein secretion in Gram-positive bacteria. J. Biotechnol. 23:1992;231-240.
29. Froyshov O., Mathiesen A., Haavik H.I. Regulation of bacitracin synthetase by divalent metal ions in Bacillus licheniformis. J. Gen. Microbiol. 117:1980;163-167.
30. Gersch D., Romero W., Bocker H., Thrum H. Variations in cyclic adenosine 3′, 5′-monophosphate and cyclic guanosine 3′,5′-monophosphate in antibiotic-producing strains of Streptomyces hygroscopicus. FEMS Microbiol. Lett. 3:1979;39-41.
31. Gesheva V. Isolation of spontaneous Streptomyces hygroscopicus 111-81 phosphate-deregulated mutants hyperproducing its antibiotic complex. Biotechnol. Lett. 16:1994;443-448.
32. Ghosh A., Chatterjee B., Das A. Production of glucoamylase by 2-deoxy-D-glucose resistant mutant of Aspergillus terreus. Biotechnol. Lett. 13:1991;515-520.
33. Gonzalez R., Islas L., Obregon A.M., Escalante L., Sanchez S. Gentamicin formation in Micromonospora purpurea: stimulatory effect of ammonium. J. Antibiot. 48:1995;715-719.
34. Gupta R., Saxena R.K., Chaturvedi P., Virdi J.S. Chitinase production by Streptomyces viridificans: its potential on fungal cell wall lysis. J. Appl. Bacteriol. 78:1995;378-383.
35. Gustafson J., Strassle A., Hachler H., Kayser F.H., Berger-Bachi B. The femC locus of Staphylococcus aureus required for methicillin resistance includes the glutamine synthetase operon. J. Bacteriol. 176:1994;1460-1467.
36. Haavik HI, Froyshov O. On the role of L-leucine in the control of bacitracin formation by Bacillus licheniformis. In: Kleinkauf H, von Döhren H, editors. Peptide Antibiotics: Biosynthesis and Functions. Berlin: Walter de Gruyter, 1982. p. 155-9.
37. Harmsen H.J.M., Kubicek-Pranz E.M., Röhr M., Visser J., Kubicek C.P. Regulation of 6-phosphofructo-2-kinase from the citric-acid-accumulating fungus Aspergillus niger. Appl. Microbiol. Biotechnol. 37:1992;784-788.
38. Hartley C.J., Manford F., Burton S.G., Dorrington R.A. Over-production of hydantoinase and N-carbamoylamino acid amidohydrolase enzymes by regulatory mutants of Agrobacterium tumefaciens. Appl. Microbiol. Biotechnol. 57:2001;43-49.
39. Havarstein L.S., Coomaraswamy G., Morrison D.A. An unmodified heptadecapeptide pheromone induces competence for genetic transformation in Streptococcus pneumoniae. Proc. Natl. Acad. Sci. U.S.A. 92:1995;11140-11144.
40. Hawker K.L., Montague P., Kinghorn J.R. Nitrate reductase and nitrite reductase transcript levels in various mutants of Aspergillus nidulans: confirmation of autogenous regulation. Mol. Gen. Genet. 231:1992;485-488.
41. Hobbs G., Frazer C.M., Gardener J., Flett F., Oliver S.G. Pigmented antibiotic production by Streptomyces coelicolor A3(2): kinetics and the influence of nutrients. J. Gen. Microbiol. 136:1990;2291-2296.
42. Hobbs G., Obanye A.I.C., Petty J., Mason C., Barratt E., Gardner D.C.J.et al. An integrated approach to studying regulation of production of the antibiotic methylenomycin by Streptomyces coelicolor A3(2). J. Bacteriol. 174:1992;1487-1494.
43. Hodgson D.A. Glucose repression of carbon source uptake and metabolism in Streptomyces coelicolor A3(2) and its perturbation in mutants resistant to 2-deoxyglucose. J. Gen. Microbiol. 128:1982;2417-2430.
44. Hönlinger C., Kubicek C.P. Regulation of δ-(L-α-aminoadipyl)-L-cysteinyl-D-valine and isopenicillin N biosynthesis in Penicillium chrysogenum by the α-aminoadipate pool size. FEMS Microbiol. Lett. 65:1989;71-76.
45. Horikoshi K. Alkaliphiles: some applications of their products for biotechnology. Microbiol. Mol. Biol. Rev. 63:1999;735-750.
46. Horinouchi S., Beppu T. Autoregulatory factors and communication in actinomycetes. Annu. Rev. Microbiol. 46:1992;377-398.
47. Ikeda H., Seno E.T., Bruton C.J., Chater K.F. Genetic mapping, cloning and physiological aspects of the glucose kinase gene of Streptomyces coelicolor. Mol. Gen. Genet. 196:1984;501-507.
48. Ikeda M., Katsumata R. Metabolic engineering to produce tyrosine or phenylalanine in a tryptophan-producing Corynebacterium glutamicum strain. Appl. Environ. Microbiol. 58:1992;781-785.
49. Imriskova I., Langley E., Arreguin-Espinosa R., Aguilar G., Sanchez S. Rapid purification and characterization of glucose kinase from Streptomyces peucetius var. caesius. Arch. Biochem. Biophys. 394:2001;137-144.
50. Inoue S., Nishizawa Y., Nagai S. Stimulatory effect of ammonium on streptomycin formation by Streptomyces griseus growing on a glucose minimal medium. J. Ferment. Technol. 61:1983;7-12.
51. Jaklitsh W.M., Hampel W., Rhör M., Kubicek C.P., Gamerith G. α-Aminoadipate pool concentration and penicillin biosynthesis in strains of Penicillium chrysogenum. Can. J. Microbiol. 32:1986;473-480.
52. Jekosch K., Kück U. Loss of glucose repression in an Acremonium chrysogenum β-lactam producer strain and its restoration by multiple copies of the cre1 gene. Appl. Microbiol. Biotechnol. 54:2000;556-563.
53. Kaempfer R.O., Magasanik B. Mechanism of β-galactosidase induction in Escherichia coli. J. Mol. Biol. 27:1967;475-494.
54. Kylä-Nikkilä K., Hujanen M., Leisola M., Palva A. Metabolic engineering of Lactobacillus helveticus CNRZ32 for production of pure L-(+)-lactic acid. Appl. Environ. Microbiol. 66:2000;3835-3841.
55. Kawaguchi T., Azuma M., Horinouchi S., Beppu T. Effect of B-factor and its analogues on rifamycin biosynthesis in Nocardia sp. J. Antibiot. 41:1988;360-365.
56. Khetan A, Hu W-S. Metabolic engineering of antibiotic biosynthesis for process improvement. In: Lee SY, Papoutsakis ET, editors. Metabolic Engineering. New York: Marcel Dekker, 1999. p. 177-202.
57. Khokhlov A.S., Tovarova I.I., Borisova L.N., Pilner S.A., Shevchenko L.N., Kornitskaya E.Y.et al. A-factor securing the biosynthesis of streptomycin by a mutant strain of Actinomyces streptomycini. Dokl. Akad. Nauk. SSSR. 177:1967;231-235. [in Russian].
58. Kikuchi Y., Kojima H., Tanaka T. Mutational analysis of the feedback sites of lysine-sensitive aspartokinase of Escherichia coli. FEMS Microbiol. Lett. 173:1999;211-215.
59. Kirimura K., Saragbin S., Rugsaseel S., Usami S. Citric acid production by 2-deoxyglucose-resistant mutant strains of Aspergillus niger. Appl. Microbiol. Biotechnol. 36:1992;573-577.
60. Kole M.M., Draper I., Gerson D.F. Protease production by Bacillus subtilis in oxygen-controlled, glucose fed-batch fermentations. Appl. Microbiol. Biotechnol. 28:1988;404-408.
61. Kondo K., Higuchi Y., Sakuda S., Nihira T., Yamada Y. New virginiae butanolide from Streptomyces virginiae. J. Antibiot. 42:1989;1873-1876.
62. Krebs E.G., Beavo J.A. Phosphorylation-dephosphorylation of enzymes. Annu. Rev. Biochem. 48:1979;923-959.
63. Krupinski V.M., Robbers J.E., Floss H.G. Physiological study of ergot: induction of alkaloid synthesis by tryptophan at the enzymatic level. J. Bacteriol. 125:1976;158-165.
64. Kwakman J.H.J.M., Postma P.W. Glucose kinase has a regulatory role in carbon catabolite repression in Streptomyces coelicolor. J. Bacteriol. 176:1994;2694-2698.
65. Lara F., Mateos R.C., Vázquez G., Sanchez S. Induction of penicillin biosynthesis by L-glutamate in Penicillium chrysogenum. Biochem. Biophys. Res. Commun. 105:1982;172-178.
66. Leichtling B.H., Majerfeld I.H., Spitz E., Schaller K.L., Woffendin C., Kakinuma S.et al. A cytosolic cyclic AMP-dependent protein kinase in Dictyostelium discoideum. J. Biol. Chem. 259:1984;662-668.
67. Levander F., Svensson M., Rådström P. Enhanced exopolysaccharide production by metabolic engineering of Streptococcus thermophilus. Appl. Environ. Microbiol. 68:2002;784-790.
68. Lin T.F., Demain A.L. Resting cell studies on formation of water-soluble red pigments by Monascus sp. J. Indust. Microbiol. 12:1993;361-367.
69. Loera O., Aguirre J., Viniegra-Gonzalez G. Pectinase production by a diploid construct from two Aspergillus niger overproducing mutants. Enzyme Microb. Technol. 25:1999;103-108.
70. Luckner M, Nover L, Böhm H. Secondary Metabolism and Cell Differentiation. Berlin: Springer, 1977.
71. Mansouri K, Pissowotzki K, Distler J, Mayer G, Heinzel P, Braun C, et al. Genetics of streptomycin production. In: Hershberger CL, Queener SW, Hegeman G, editors. Genetics and Molecular Biology of Industrial Microorganisms. Washington, DC: American Society of Microbiology, 1989. p. 61-7.
72. Martín JF. Molecular mechanisms for the control by phosphate of the biosynthesis of antibiotics and other secondary metabolites. In: Shapiro S, editor. Regulation of Secondary Metabolism in Actinomycetes. Boca Raton, FL: CRC Press, 1988. p. 213-37.
73. Marzluf G, Fu Y-H. Genetic and metabolic regulation of nitrogen metabolism in Neurospora crassa. In: Sanchez S, editor. Nitrogen Source Control of Microbial Processes. Boca Raton, FL: CRC Press, 1988. p. 83-98.
74. Merrick M.J., Edwards R.A. Nitrogen control in bacteria. Microbiol. Rev. 59:1995;604-622.
75. Miura Y., Kondo K., Saito T., Shimada H., Fraser P.D., Misawa N. Production of the carotenoids lycopene, β-carotene, and astaxanthin in the food yeast Candida utilis. Appl. Environ. Microbiol. 64:1998;1226-1229.
76. Miyake K., Horinouchi S., Yoshida M., Chiba N., Mori K., Nogawa N.et al. Detection and properties of A-factor-binding protein from Streptomyces griseus. J. Bacteriol. 171:1989;4298-4302.
77. Miyata R, Yonehara T. Fermentative manufacture of pyruvic acid with Torulopsis species, JP Patent No. 2308795 (1990).
78. Mori K. Revision of the absolute configuration of A-factor. J. Antibiot. 35:1983;349-358.
79. Mukherjee J., Majumdar S., Scheper T. Studies on nutritional and oxygen requirements for production of L-asparaginase by Enterobacter aerogenes. Appl. Microbiol. Biotechnol. 53:2000;180-184.
80. Muller J.P., Harwood C.R. Protein secretion in phosphate-limited cultures of Bacillus subtilis 168. Appl. Microbiol. Biotechnol. 49:1998;321-327.
81. Nakano Y., Kimura K. Purification and characterization of a repressor for the Bacillus cereus glnRA operon. J. Biochem. 109:1991;223-228.
82. Nakayama K. The production of amino acids. Process Biochem. 11:1976;4-9.
83. Neway JO. Fermentation Process Development of Industrial Organisms. New York: Marcel Dekker, 1989.
84. Nguyen K.T., Nguyen L.T., Behal V. The induction of valine dehydrogenase activity from Streptomyces by L-valine is not repressed by ammonium. Biotechnol. Lett. 17:1995;31-34.
85. Nielsen J. Metabolic engineering. Appl. Microbiol. Biotechnol. 55:2001;263-283.
86. Nielsen J., Jørgensen H.S. Metabolic control analysis of the penicillin biosynthetic pathway in a high yielding strain of Penicillium chrysogenum. Biotechnol. Prog. 11:1995;299-305.
87. Obregon A.M., Escalante L., González R., Rodríguez R., Sánchez S. Physiological studies on gentamicin: phosphate repression of antibiotic formation. J. Antibiot. 47:1994;1442-1446.
88. Oestreicher N., Scazzocchio C. Sequence, regulation, and mutational analysis of the gene encoding urate oxidase in Aspergillus nidulans. J. Biol. Chem. 268:1993;23382-23389.
89. Ohnishi Y., Kameyama S., Onaka H., Horinouchi S. The A-factor regulatory cascade leading to streptomycin biosynthesis in Streptomyces griseus: identification of a target gene of the A-factor receptor. Mol. Microbiol. 34:1999;102-112.
90. Okazaki H., Ono H., Yamada K., Beppu T., Arima K. Relationship among cellular fatty acid composition, amino acid uptake and neomycin formation in a mutant strain of Streptomyces fradiae. Agric. Biol. Chem. 37:1973;2319-2323.
91. Ômura S, Tanaka Y. Control of ammonium ion level in antibiotic fermentation. In: Ortiz-Ortiz L, Bojalil LF, Yakoleff V, editors. Biological, Biochemical, and Biomedical Aspects of Actinomycetes. Orlando, FL: Academic Press, 1984. p. 367-79.
92. Onaka H., Ando N., Nihira T., Yamada Y., Beppu T., Horinouchi S. Cloning and characterization of the A-factor receptor gene from Streptomyces griseus. J. Bacteriol. 177:1995;6083-6092.
93. Ozcengiz G., Alaeddinoglu N.G., Demain A.L. Regulation of biosynthesis of bacilysin by Bacillus subtilis. J. Indust. Microbiol. 6:1990;91-100.
94. Pan F.L., Coote J.G. Glutamine synthetase and glutamate synthase activities during growth and sporulation of Bacillus subtilis. J. Gen. Microbiol. 112:1979;373-377.
95. Papoutsakis ET, Bennett GN. Molecular regulation and metabolic engineering of solvent production by Clostridium acetobutylicum. In: Lee SY, Papoutsakis ET, editors. Metabolic Engineering. New York: Marcel Dekker, 1999. p. 253-79.
96. Parekh S., Vinci V.A., Strobel R.J. Improvement of microbial strains and fermentation processes. Appl. Microbiol. Biotechnol. 54:2000;287-301.
97. Park Y.S., Dohijima T., Okabe M. Enhanced α-amylase production in recombinant Bacillus brevis by fed-batch culture with amino acid control. Biotechnol. Bioeng. 49:1995;36-44.
98. Parro V., Mellado R.P., Harwood C.R. Effects of phosphate limitation on agarase production by Streptomyces lividans TK21. FEMS Microbiol. Lett. 158:1998;107-113.
99. Piepersberg W. Streptomycin and related aminoglycosides. In: Vining LC, Stuttard C, editors. Biochemistry and Genetics of Antibiotic Biosynthesis. Boston, MA: Butterworths-Heinemann, 1995. p. 531-70.
100. Piepersberg W, Distler J. Aminoglycosides and sugar components in other secondary metabolites. In: Rehm H-J, Reed G, editors. Biotechnology. 2nd Ed. Kleinkauf H, von Döhren H, editors. Products of secondary metabolism, vol. 7. Weinheim: VCH, 1997. p. 397-488.
101. Piepersberg W. Streptomycin and related aminoglycosides, In: Vining LC, Stuttard C, editors. Biochemistry and Genetics of Antibiotic Biosynthesis. Boston: Butterworths-Heinemann, 1995. p. 531-70.
102. Reinscheid D.J., Kronemeyer W., Eggeling L., Eikmanns B.J., Sahm H. Stable expression of hom-1-thrB in Corynebacterium glutamicum and its effect on the carbon flux to threonine and related amino acids. Appl. Environ. Microbiol. 60:1994;126-132.
103. Retzlaff L., Distler J. The regulator of streptomycin gene expression, StrR, of Streptomyces griseus is a DNA-binding activator protein with multiple recognition sites. Mol. Microbiol. 18:1995;151-162.
104. Rius N., Maeda K., Demain A.L. Induction of L-lysine ε-aminotransferase by L-lysine in Streptomyces clavuligerus, producer of cephalosporins. FEMS Microbiol. Lett. 144:1996;207-211.
105. Saier M.H. Jr. Cyclic AMP-independent catabolite repression in bacteria. FEMS Microbiol. Lett. 138:1996;97-103.
106. Saier M.H. Jr. Multiple mechanisms controlling carbon metabolism in bacteria. Biotechnol. Bioeng. 58:1998;170-174.
107. Saier M.H. Jr., Chauvaux S., Deutscher J., Reizer J., Ye J.-J. Protein phosphorylation and the regulation of carbon metabolism: comparisons in Gram-negative versus Gram-positive bacteria. Trends Biochem. Sci. 20:1995;267-271.
108. Saito A., Fugii T., Yoneyama T., Miyashita K. The glkA is involved in glucose repression of chitinase production in Streptomyces lividans. J. Bacteriol. 180:1998;2911-2914.
109. Sanchez S., Quinto M.C. D-Glucose isomerase: constitutive and catabolite repression resistant mutants of Streptomyces phaeochromogenes. Appl. Microbiol. 30:1975;750-754.
110. Sanchez S., Smiley K.L. Properties of D-xylose isomerase from Streptomyces albus. Appl. Microbiol. 29:1975;745-750.
111. Sauer U., Hatzimanikatis V., Hohmann H.P., Manneberg M., van Loon A.P., Bailey J.E. Physiology and metabolic fluxes of wild-type and riboflavin-producing Bacillus subtilis. Appl. Environ. Microbiol. 62:1996;3687-3696.
112. Schreier H.J., Brown S.W., Hirschi K.D., Nomellini J.F., Sonenshein A.L. Regulation of Bacillus subtilis glutamine synthetase gene expression by the product of the glnR gene. J. Mol. Biol. 210:1989;51-63.
113. Segura D., Gonzalez R., Rodriguez R., Sandoval T., Escalante L., Sanchez S. Streptomyces mutants insensitive to glucose repression showed deregulation of primary and secondary metabolism. Asia Pac. J. Mol. Biol. Biotechnol. 4:1996;30-36.
114. Segura D., Santana C., Ghosh R., Escalante L., Sanchez S. Anthracyclines: isolation of overproducing strains by the selection and genetic recombination of putative regulatory mutants of Streptomyces peucetius var. caesius. Appl. Microbiol. Biotechnol. 48:1997;615-620.
115. Seno E.T., Baltz R.H. Properties of S-adenosyl-L-methionine:macrocin O-methyltransferase in extracts of Streptomyces fradiae strains which produce normal or elevated levels of tylosin and in mutants blocked in specific O-methylations. Antimicrob. Agents Chemother. 20:1981;370-377.
116. Seno E.T., Chater K.F. Glycerol catabolic enzymes and their regulation in wild-type and mutant strains of Streptomyces coelicolor A3(2). J. Gen. Microbiol. 129:1983;1403-1413.
117. Servin-Gonzalez L., Jensen M.R., White J., Bibb M.J. Transcriptional regulation of the four promoters of the agarase gene (dagA) of Streptomyces coelicolor A3(2). Microbiology. 140:1994;2555-2565.
118. Shapiro S. Nitrogen assimilation in actinomycetes and the influence of nitrogen nutrition on actinomycete secondary metabolism. In: Shapiro S, editor. Regulation of Secondary Metabolism in Actinomycetes. Boca Raton, FL: CRC Press, 1989. p. 135-211.
119. Shene C., Bravo S. Zymomonas mobilis CP4 fed-batch fermentations of glucose-fructose mixtures to ethanol and sorbitol. Appl. Microbiol. Biotechnol. 57:2001;323-328.
120. Shimada H., Kondo K., Fraser P.D., Miura Y., Saito T., Misawa N. Increased carotenoid production by the food yeast Candida utilis through metabolic engineering of the isoprenoid pathway. Appl. Environ. Microbiol. 64:1998;2676-2680.
121. Shirafuji H., Nogami I., Kida M., Yoneda M. Two alkaline phosphatases from a butirosin A producer, Bacillus vitellinus. Agric. Biol. Chem. 46:1982;2465-2476.
122. Stanbury PF, Whitaker A, Hall SJ. Principles of Fermentation Technology. 2nd Ed. Oxford: Pergamon Press, 1995.
123. Stowe D.J., Atkinson T., Mann N.H. Protein kinase activities in cell-free extracts of Streptomyces coelicolor A3(2). Biochimie. 71:1989;1101-1105.
124. Stramondo JG, Avgerinos GC, Costa JM, Colton CK, Wang DIC. Enzymatic synthesis of the antibiotic gramicidin S: Kinetics of inhibition and enzyme destabilization. In: Vezina C, Singh K, editors. Advances in Biotechnology. Fermentation Products, vol. 3. Ontario: Pergamon Press Canada Ltd., 1981. p. 101-6.
125. Stülke J., Hillen W. Regulation of carbon catabolism in Bacillus species. Annu. Rev. Microbiol. 54:2000;849-880.
126. Szabo G., Vitalis S. Sporulation without aerial mycelium formation on agar medium by Streptomyces bikinienis HH1, an A-factor-deficient mutant. J. Gen. Microbiol. 138:1992;1887-1892.
127. Takano E., Nihira T., Hara Y., Jones J.J., Gershater C.J.L., Yamada Y.et al. Purification and structural determination of SCB1, a γ-butyrolactone that elicits antibiotic production in Streptomyces coelicolor A3(2). J. Biol. Chem. 275:2000;11010-11016.
128. Titgemeyer F., Walkenhorst J., Reizer J., Stiver M.H., Cui X., Saier M.H. Jr. Identification and characterization of phosphoenolpyruvate:fructose phosphotransferase systems in three Streptomyces species. Microbiology. 141:1995;51-58.
129. Varmenen P., Savijoki K., Avall S., Palva A., Tynkkynen S. X-prolyl dipeptidyl aminopeptidase gene (pepx) is part of the glnRA operon in Lactobacillus rhamnosus. J. Bacteriol. 182:2000;146-154.
130. Virolle M.J., Long C.M., Chang S., Bibb M.J. Cloning, characterization and regulation of an α-amylase gene from Streptomyces venezuelae. Gene. 74:1988;321-334.
131. Vrljic M., Sahm H., Eggeling L. A new type of transporter with a new type of cellular function: L-lysine export in Corynebacterium glutamicum. Mol. Microbiol. 22:1996;815-826.
132. Vujaklija D., Ueda K., Hong S.-K., Beppu T., Horinouchi S. Identification of an A-factor-dependent promoter in the streptomycin biosynthetic gene cluster of Streptomyces griseus. Mol. Gen. Genet. 229:1991;119-128.
133. Vujaklija D., Horinouchi S., Beppu T. Detection of an A-factor-responsive protein that binds to the upstream activation sequence of strR, a regulatory gene for streptomycin biosynthesis in Streptomyces griseus. J. Bacteriol. 175:1993;2652-2661.
134. Walter S., Schrempf H. The synthesis of the Streptomyces reticuli cellulase (avicelase) is regulated by both activation and repression mechanisms. Mol. Gen. Genet. 251:1996;186-195.
135. Xu J., Nogawa M., Okada H., Morikawa Y. Regulation of xyn3 gene expression in Trichoderma reesei PC-3-7. Appl. Microbiol. Biotechnol. 54:2000;370-375.
136. Yang S.-S., Wang J.-Y. Protease and amylase production of Streptomyces rimosus in submerged and solid state cultivations. Bot. Bull. Acad. Sin. 40:1999;265-269.
137. + permease of Lactobacillus brevis. Proc. Natl. Acad. Sci. U.S.A. 92:1995;417-421.
138. Zahner H, Kurth R. Over-production of microbial metabolites-the supply of precursors for the intermediary metabolism. In: Krumphanzl V, Sikyta B, Vanek Z, editors. Overproduction of Microbial Products. London: Academic Press, 1982. p. 167-79.
139. Zhang J., Banko G., Wolfe S., Demain A.L. Methionine induction of ACV synthetase in Cephalosporium acremonium. J. Indust. Microbiol. 2:1987;251-255.
140. Zhu Y., Rinzema A., Tramper A., de Bruin E., Bol J. Fed-batch fermentation dealing with nitrogen limitation in microbial transglutaminase production by Streptoverticillium mobaraense. Appl. Microbiol. Biotechnol. 49:1998;251-257.