Structure-activity relationship of orally potent tripeptide-based HIV protease inhibitors containing hydroxymethylcarbonyl isostere

Chemical and Pharmaceutical Bulletin

Volumn 48, Issue 9, 2000, Pages 1310-1326

  Mimoto, Tsutomu ^a   Hattori, Naoko ^b   Takaku, Haruo ^b   Kisanuki, Sumitsugu ^a   Fukazawa, Tominaga ^b   Terashima, Keisuke ^b   Kato, Ryohei ^b   Nojima, Satoshi ^b   Misawa, Satoru ^b   Ueno, Takamasa ^b   Imai, Junya ^a   Enomoto, Hiroshi ^a   Tanaka, Shigeki ^a   Sakikawa, Hiroshi ^a   Shintani, Makoto ^b   Hayashi, Hideya ^b   Kiso, Yoshiaki ^a  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

^b JAPAN ENERGY CORPORATION   (Japan)

Author keywords

AIDS; Allophenylnorstatine; HIV protease; Inhibitor; KNI 272

Indexed keywords

ALLOPHENYLNORSTATINE; AMINO ACID; ANTIRETROVIRUS AGENT; ANTIVIRUS AGENT; JE 2178; JE 2179; KNI 227; KYNOSTATIN 272; N TERT BUTYL 3 [2 HYDROXY 3 [2 (3 DIMETHYLAMINOPHENOXYACETYL)AMINO 3 METHYLBUTANOYL]AMINO 4 PHENYLBUTANOYL] 5,5 DIMETHYL 1,3 THIAZOLIDINE 4 CARBOXAMIDE; N TERT BUTYL 3 [2 HYDROXY 3 [2 (3 DIMETHYLAMINOPHENOXYACETYL)AMINOBUTANOYL]AMINO 4 PHENYLBUTANOYL] 5,5 DIMETHYL 1,3 THIAZOLIDINE 4 CARBOXAMIDE; N TERT BUTYL 3 [3 [2 (5 ISOQUINOLINYLOXYACETYL)AMINO 3 METHYLTHIOPROPIONYL]AMINO 2 HYDROXY 4 PHENYLBUTANOYL] 5,5 DIMETHYL 1,3 THIAZOLIDINE 4 CARBOXAMIDE; PROTEINASE INHIBITOR; RITONAVIR; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL MODEL; ANTIVIRAL ACTIVITY; ARTICLE; CLINICAL TRIAL; DRUG BIOAVALABILITY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MALE; NONHUMAN; PROTEINASE INHIBITION; RAT; STRUCTURE ACTIVITY RELATION; VIRUS INHIBITION;

EID: 0033780533     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.48.1310     Document Type: Article

References (40)