KNI-577, a potent small-sized HIV protease inhibitor based on the dipeptide containing the hydroxymethylcarbonyl isostere as an ideal transition-state mimic

Archiv der Pharmazie

Volumn 331, Issue 3, 1998, Pages 87-89

  Kiso, Yoshiaki ^a   Yamaguchi, Satoshi ^a   Matsumoto, Hikaru ^a   Mimoto, Tsutomu ^b   Kato, Ryohei ^b   Nojima, Satoshi ^b   Takaku, Haruo ^b   Fukazawa, Tominaga ^b   Kimura, Tooru ^a   Akaji, Kenichi ^a  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

^b JAPAN ENERGY CORPORATION   (Japan)

Author keywords

Allophenylnorstatine; Anti HIV drug; HIV protease inhibitors; Transition state mimic

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; DIPEPTIDE; KNI 577; KYNOSTATIN 272; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANTIVIRAL ACTIVITY; ARTICLE; DRUG POTENCY; DRUG SYNTHESIS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; PRIORITY JOURNAL;

DIPEPTIDES; HIV PROTEASE INHIBITORS; HIV-1; MOLECULAR WEIGHT;

EID: 0031947532     PISSN: 03656233     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4184(199803)331:3<87::AID-ARDP87>3.0.CO;2-H     Document Type: Article

References (13)

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2. This paper was preliminarily presented at the 15th American Peptide Symposium in Nashville, Tennessee (June 14-19, 1997), Abstracts, L023; the 33rd Symposium on Peptide Chemistry in Sapporo, Japan (October 4-6, 1995), Peptide Chemistry 1995, pp. 373-376; the 34th Symposium on Peptide Chemistry in Tsukuba, Japan (October 16-18, 1996), Peptide Chemistry 1996, pp. 297-300.
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