Optical non-invasive approaches to diagnosis of skin diseases

Journal of Investigative Dermatology Symposium Proceedings

Volumn 7, Issue 1, 2002, Pages 64-75

  Kollias, Nikiforos ^a,b   Stamatas, Georgios N ^a  

^a JOHNSON AND JOHNSON   (United States)

^b NONE   (United States)

Author keywords

Confocal; Fluorescence; Imaging; Microscopy; Oct; Raman; Reflectance; Spectroscopy

Indexed keywords

ACNE; CONFERENCE PAPER; CONFOCAL LASER MICROSCOPY; DIAGNOSTIC IMAGING; DIAGNOSTIC TEST; DIFFUSE REFLECTANCE SPECTROSCOPY; FLUORESCENCE MICROSCOPY; INFRARED SPECTROSCOPY; LASER; MELANOMA; MICROSCOPY; OPTICAL COHERENCE TOMOGRAPHY; OPTICAL INSTRUMENTATION; PSORIASIS; RAMAN SPECTROMETRY; REFLECTOMETRY; SKIN BIOPSY; SKIN CANCER; SKIN DISEASE; SPECTROSCOPY; THREE DIMENSIONAL IMAGING;

EID: 0036967628     PISSN: 10870024     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.2002.19635.x     Document Type: Conference Paper

References (90)

1. Andersen PH, Bjerring P: Noninvasive computerized analysis of skin chromophores in vivo by reflectance spectroscopy. Photodermatol Photoimmunol Photomed 7:249-257. 1990
2. Anderson RR: Polarized light examination and photography of the skin. Arch Dermatol 127:1000-1005, 1991
3. Anderson RR, Parrish JA: The optics of human skin. J Invest Dermatol 77:13-19, 1981
4. Bissonnette R, Zeng H, McLean DI, Schreiber WE, Roscoe DL, Lui H: Psoriatic plaques exhibit red autofluorescence that is due to protoporphyrin IX. J Invest Dermatol 111:586-591, 1998
5. Bommannan D, Potts RO, Guy RH: Examination of stratuni corneum barrier function in vivo by infrared spectroscopy. J Invest Dermatol 95:403-408, 1990
6. Brancaleon L, Lin G, Kollias N: The in vivo fluorescence of tryptophan moieties in human skin increases with UV exposure and is a marker for epidermal proliferation. J Invest Dermatol 113:977-982, 1999
7. Brancaleon L, Bamberg MP, Kollias N: Spectral differences between stratum corneum and sebaceous molecular components in the mid-IR. Appl Spectroscopy 54:1175-1182, 2000
8. Brancaleon L, Bamberg MP, Sakamaki T, Kollias N: Attenuated total reflection-Fourier transform infrared spectroscopy as a possible method to investigate biophysical parameters of stratum corneum in vivo. J Invest Dermatol 116:380-386, 2001a
9. Brancaleon L, Durkin AJ, Tu JH, Menaker G, Fallon JD, Kollias N: In vivo fluorescence spectroscopy of nonmelanoma skin cancer. Photochem Photobiol 73:178-183, 2001b
10. Busam KJ, Hester K, Charles C, et al: Detection of clinically amelanotic malignant melanoma and assessment of its margins by in vivo confocal scanning laser microscopy. Arch Dermatol 137:923-929, 2001
11. Bussau LJ, Vo LT, Delaney PM, Papworth GD, Barkla DH, King RG: Fibre optic confocal imaging (FOCI) of keratinocytes, blood vessels and nerves in hairless mouse skin in vivo. J Anat 192:187-194, 1998
12. Caspers PJ, Lucassen GW, Wolthuis R. Bruining HA, Puppels GJ: In vitro and in vivo Raman spectroscopy of human skin. Biospectroscopy 4 (Suppl.): S31-S39, 1998
13. Caspers PJ, Lucassen GW, Carter EA, Bruining HA, Puppels GJ: In vivo confocal Raman microspectroscopy of the skin: noninvasive determination of molecular concentration profiles. J Invest Dermatol 116:434-442, 2001
14. Corcuff P, Bertrand C, Leveque JL: Morphometry of human epidermis in vivo by real-time confocal microscopy. Arch Dermatol Res 285:475-481, 1993
15. Corcuff P, Chaussepied C, Madry G, Hadjur C: Skin optics revisited by in vivo confocal microscopy: melanin and sun exposure. J Cosmet Sci 52:91-102, 2001
16. Doukas AG, Soukos NS, Babusis S, Appa Y, Kollias N: Fluorescence excitation spectroscopy for the measurement of epidermal proliferation. Photochem Photobiol 74:96-102, 2001
17. Edwards EA, Duntley SQ: The pigments and color of living human skin. Am J Anat 65:1-33, 1939
18. Eun HC: Evaluation of skin blood flow by laser Doppler flowmetry. Clin Dermatol 13:337-347, 1995
19. Farkas DL, Becker D: Applications of spectral imaging: detection and analysis of human melanoma and its precursors. Pigment Cell Res 14:2-8, 2001
20. Farrell TJ, Patterson MS, Wilson B: A diffusion theory model of spatially resolved, steady-state diffuse reflectance for the noninvasive determination of tissue optical properties in vivo. Med Phys 19:879-888, 1992
21. Frushour BG, Koenig JL: Raman scattering of collagen, gelatin, and elastin. Biopolymers 14:379-391, 1975
22. Fulton JE: Utilizing the ultraviolet (UV detect) camera to enhance the appearance of photodamage and other skin conditions. Dermatol Surg 23:163-169, 1997
23. van Gemert MJ, Jacques SL, Sterenborg HJ, Star WM: Skin optics. IEEE Trans Biomed Eng 36:1146-1154, 1989
24. van Gemert MJ, Nelson JS, Milner TE, et al: Non-invasive determination of port wine stain anatomy and physiology for optimal laser treatment strategies. Phys Med Biol 42:937-950, 1997
25. Gillies R, Tian WD, Anderson RR, Drake LA, Kollias N: Noninvasive monitoring of treatment related changes in psoriatic plaques using fluorescence excitation and diffuse reflectance spectroscopy. In: Sevick-Muraca EM, Izatt JA Edinger MN. eds. Trends in Optics and Photonics: Biomedical Optical Spectroscopy and Diagnosis. Washington, DC: Optical Society of America, 1998: pp 113-115
26. Gillies R, Zonios G, Anderson RR, Kollias N: Fluorescence excitation spectroscopy provides information about human skin in vivo. J Invest Dermatol 115:704-707, 2000
27. Gniadecka M, Wulf HC, Nielsen OF, Christensen DH, Hercogova J: Distinctive molecular abnormalities in benign and malignant skin lesions: studies by Raman spectroscopy. Photochem Photobiol 66:418-423, 1997
28. Gniadecka M, Faurskov Nielsen O, Christensen DH, Wulf HC: Structure of water, proteins, and lipids in intact human skin, hair, and nail. J Invest Dermatol 110:393-398, 1998
29. Gonzalez S, Hegyi V, Baqer A, Sadiq I, Kollias N: Development of cutaneous tolerance to ultraviolet B during ultraviolet B phototherapy for psoriasis. Photodermatol Photoimmunol Photomed 12:73-78, 1996
30. Gonzalez S, Rajadhyaksha M, Anderson RR: Non-invasive (real-time) imaging of histologic margin of a proliferative skin lesion in vivo. J Invest Dermatol 111:538-539, 1998
31. Gonzalez S, Rajadhyaksha M, Rubinstein G, Anderson RR: Characterization of psoriasis in vivo by reflectance confocal microscopy. J Med 30:337-356, 1999
32. Gonzalez S, Zonios G, Nguyen BC, Gillies R, Kollias N: Endogenous skin fluorescence is a good marker for objective evaluation of comedolysis. J Invest Dermatol 115:100-105, 2000
33. Hata TR, Scholz TA, Ermakov IV, et al: Non-invasive Raman spectroscopic detection of carotenoids in human skin. J Invest Dermatol 115:441-448, 2000
34. Hecht E, Zajac A: Optics, 4th edn. Reading, MA: Addison-Wesley Co, 1979
35. Hee MR, Izatt JA, Swanson EA, et al: Optical coherence tomography of the human retina. Arch Ophthalmol 113:325-332, 1995
36. Huzaira M, Rius F, Rajadhyaksha M, Anderson RR, Gonzalez S: Topographic variations in normal skin, as viewed by in vivo reflectance confocal microscopy. J Invest Dermatol 116:846-852, 2001
37. Jemec GB, Gniadecka M, Ulrich J: Ultrasound in dermatology. Part I. High frequency ultrasound. Eur J Dermatol 10:492-497, 2000
38. Knuttel A, Boehlau-Godau M: Spatially confined and temporally resolved refractive index and scattering evaluation in human skin performed with optical coherence tomography. J Biomed Opt 5:83-92, 2000
39. Kollias N: UVA melanogenesis - spectral observations. In Urbach F, ed. Biological Responses to UVA Radiation. Overland Park, KS: Valdenmar Publishers Co, 1992
40. Kollias N, Baqer A: An experimental study of the changes in pigmentation in human skin in vivo with visible and near infrared light. Photochem Photobiol 39:651-659, 1984
41. Kollias N, Baqer A: On the assessment of melanin in human skin in vivo. Photochem Photobiol 43:49-54, 1986
42. Kollias N, Baqer AH: Absorption mechanisms of human melanin in the visible, 400-720 nm. J Invest Dermatol 89:384-388, 1987
43. Kollias N, Baqer AH: Quantitative assessment of UV-induced pigmentation and erythema. Photodermatol 5:53-60, 1988
44. Kollias N, Baqer A, Sadiq I: Minimum erythema dose determination in individuals of skin type V and VI with diffuse reflectance spectroscopy. Photodermatol Photoimmunol Photomed 10:249-254, 1994
45. Kollias N, Gillies R, Muccini JA, Uyeyama RK, Phillips SB, Drake LA: A single parameter, oxygenated hemoglobin, can be used to quantify experimental irritant-induced inflammation. J Invest Dermatol 104:421-424, 1995
46. Kollias N, Gillies R, Cohen-Goihman C, et al: Fluorescence photography in the evaluation of hyperpigmentation in photodamaged skin. J Am Acad Dermatol 36(Part 1): 226-230, 1997
47. Kollias N, Gillies R, Moran M, Kochevar IE, Anderson RR: Endogenous skin fluorescence includes bands that may serve as quantitative markers of aging and photoaging. J Invest Dermatol 111:776-780, 1998
48. Kollias N, Stamatas GN, Youn JI: Suppression of UVB-induced cutaneous erythema by a previous UVB exposure. Photochem Photobiol 74:471-476, 2001
49. Kopf AW, Salopek TG, Slade J, Marghoob AA, Bart RS: Techniques of cutaneous examination for the detection of skin cancer. Cancer 75(Suppl.): 684-690, 1995
50. Leffell DJ, Stetz ML, Milstone LM, Deckelbaum LI: In vivo fluorescence of human skin. A potential marker of photoaging. Arch Dermatol 124:1514-1518, 1988
51. Lohmann W, Paul E: In situ detection of melanomas by fluorescence measurements. Naturwissenschaften 75:201-202, 1988
52. Lohmann W, Schill WB, Bucher D, et al: Elastosis and cancer. Z Naturforsch [C] 49:223-229, 1994
53. Lucassen GW, van Veen GNA, Jansen, JAJ: Band analysis of hydrated human skin stratum corneum attenuated total reflectance Fourier transform infrared spectra in vivo. J Biomed Opt 3:267-280, 1998
54. Lucchina LC, Kollias N, Gillies R, et al: Fluorescence photography in the evaluation of acne. J Am Acad Dermatol 35:58-63, 1996
55. Mak VH, Potts RO, Guy RH: Percutaneous penetration enhancement in vivo measured by attenuated total reflectance infrared spectroscopy. Pharm Res 7:835-841, 1990
56. Marchesini R, Tomatis S, Bartoli C, et al: In vivo spectrophotometric evaluation of neoplastic and non-neoplastic skin pigmented lesions. III. CCD camera-based reflectance imaging. Photochem Photobiol 62:151-154, 1995
57. Masters BR, Gonnord G, Corcuff P: Three-dimensional microscopic biopsy of in vivo human skin: a new technique based on a flexible confocal microscope. J Microsc 185(Part 3): 329-338, 1997a
58. Masters BR, So PT, Gratton E: Multiphoton excitation fluorescence microscopy and spectroscopy of in vivo human skin. Biophys J 72:2405-2412, 1997b
59. Masters BR, So PT, Gratton E: Multiphoton excitation microscopy of in vivo human skin. Functional and morphological optical biopsy based on three-dimensional imaging, lifetime measurements and fluorescence spectroscopy. Ann N Y Acad Sci 838:58-67, 1998
60. Masters BR, So PT, Kim KH, Buehler C, Gratton E: Multiphoton excitation microscopy, confocal microscopy, and spectroscopy of living cells and tissues; functional metabolic imaging of human skin in vivo. Methods Enzymol 307:513-536, 1999
61. McIntosh LM, Jackson M, Mantsch HH, Stranc MF, Pilavdzic D, Crowson AN: Infrared spectra of basal cell carcinomas are distinct from non-tumor-bearing skin components. J Invest Dermatol 112:951-956, 1999
62. McIntosh LM, Summers R, Jackson M, et al: Towards non-invasive screening of skin lesions by near-infrared spectroscopy. J Invest Dermatol 116:175-181, 2001
63. Muccini JA, Kollias N, Phillips SB, et al: Polarized light photography in the evaluation of photoaging. J Am Acad Dermatol 33(Part 1): 765-769, 1995
64. Mustakallio KK, Korhonen P: Monochromatic ultraviolet-photography in dermatology. J Invest Dermatol 47:351-356, 1966
65. Na R, Stender IM, Henriksen M, Wulf HC: Autofluorescence of human skin is age-related after correction for skin pigmentation and redness. J Invest Dermatol 116:536-540, 2001
66. Oberg PA: Laser-Doppler flowmetry. Crit Rev Biomed Eng 18:125-163, 1990
67. Pagnoni A, Kligman AM, Kollias N, Goldberg S, Stoudemayer T: Digital fluorescence photography can assess the suppressive effect of benzoyl peroxide on Propionibacterium acnes. J Am Acad Dermatol 41 (Part 1): 710-716, 1999
68. Phillips SB, Kollias N, Gillies R, Muccini JA, Drake LA: Polarized light photography enhances visualization of inflammatory lesions of acne vulgaris. J Am Acad Dermatol 37:948-952, 1997
69. Pouliot R, Germain L, Auger FA, Tremblay N, Juhasz J: Physical characterization of the stratum corneum of an in vitro human skin equivalent produced by tissue engineering and its comparison with normal human skin by ATR-FTIR spectroscopy and thermal analysis (DSC). Biochim Biophys Acta 1439:341-352, 1999
70. Rajadhyaksha M, Grossman M, Esterowitz D, Webb RH, Anderson RR: In vivo confocal scanning laser microscopy of human skin: melanin provides strong contrast. J Invest Dermatol 104:946-952, 1995
71. Rajadhyaksha M, Gonzalez S, Zavislan JM, Anderson RR, Webb RH: In vivo confocal scanning laser microscopy of human skin II. Advances in instrumentation and comparison with histology. J Invest Dermatol 113:293-303, 1999
72. Rajadhyaksha M, Menaker G, Flotte T, Dwyer PJ, Gonzalez S: Confocal examination of nonmelanoma cancers in thick skin excisions to potentially guide Mohs micrographic surgery without frozen histopathology. J Invest Dermatol 117:1137-1143, 2001
73. Richards-Kortum R, Sevick-Muraca E: Quantitative optical spectroscopy for tissue diagnosis. Annu Rev Phys Chem 47:555-606, 1996
74. Savolainen L, Kontinen J, Roning J, Oikarinen A: Application of machine vision to assess involved surface in patients with psoriasis. Br J Dermatol 137:395-400, 1997
75. 2) accumulation in the epidermis of patients with vitiligo and its successful removal by a UVB-activated pseudocatalase. J Invest Dermatol Symp Proc The 4:91-96, 1999
76. Tanaka M, Gaskell S, Edwards C, Marks R: Simple horizontal averaging programme enables shade correction for image analysis in psoriasis. Clin Exp Dermatol 25:323-326, 2000
77. Tian WD, Gillies R, Brancaleon L, Kollias N: Aging and effects of ultraviolet A exposure may be quantified by fluorescence excitation spectroscopy in vivo. J Invest Dermatol 116:840-845, 2001
78. Ulrich J, Voit C: Ultrasound in dermatology Part II. Ultrasound of regional lymph node basins and subcutaneous tumours. Eur J Dermatol 11:73-79, 2001
79. Unholzer A, Korting HC: High-frequency ultrasound in the evaluation of pharmacological effects on the skin. Skin Pharmacol Appl Skin Physiol 15:71-84, 2002
80. Vitkin IA, Woolsey J, Wilson BC, Anderson RR: Optical and thermal characterization of natural (Sepia officinalis) melanin. Photochem Photobiol 59:455-462, 1994
81. Vo LT, Papworth GD, Delaney PM, Barkla DH, King RG: A study of vascular response to thermal injury on hairless mice by fibre optic confocal imaging, laser doppler flowmetry and conventional histology. Burns 24:319-324, 1998
82. Vo LT, Anikijenko P, McLaren WJ, Delaney PM, Barkla DH, King RG: Autofluorescence of skin burns detected by fiber-optic confocal imaging: evidence that cool water treatment limits progressive thermal damage in anesthetized hairless mice. J Trauma 51:98-104, 2001
83. Wan S, Anderson RR, Parrish JA: Analytical modeling for the optical properties of the skin with in vitro and in vivo applications. Photochem Photobiol 34:493-499, 1981
84. Welzel J, Lankenau E, Birngruber R, Engelhardt R: Optical coherence tomography of the human skin. J Am Acad Dermatol 37:958-963, 1997
85. White PJ, Fogarty RD, Liepe IJ, Delaney PM, Werther GA, Wraight CJ: Live confocal microscopy of oligonucleotide uptake by keratinocytes in human skin grafts on nude mice. J Invest Dermatol 112:887-892, 1999
86. Wohlrab J, Vollmann A, Wartewig S, Marsch WC, Neubert R: Noninvasive characterization of human stratum corneum of undiseased skin of patients with atopic dermatitis and psoriasis as studied by Fourier transform Raman spectroscopy. Biopolymers 62:141-146, 2001
87. Young AR: Chromophores in human skin. Phys Med Biol 42:789-802, 1997
88. Zeng H, MacAulay C, McLean DI, Palcic B: Spectroscopic and microscopic characteristics of human skin autofluorescence emission. Photochem Photobiol 61:639-645, 1995
89. Zeng H, MacAulay C, McLean DI, Palcic B, Lui H: The dynamics of laser-induced changes in human skin autofluorescence-experimental measurements and theoretical modeling. Photochem Photobiol 68:227-236, 1998
90. Zonios G, Bykowski J, Kollias N: Skin melanin, hemoglobin, and light scattering properties can be quantitatively assessed in vivo using diffuse reflectance spectroscopy. J Invest Dermatol Press 117:1452-1457, 2001