메뉴 건너뛰기




Volumn 20, Issue 4, 2002, Pages 167-176

Hypermethylation of gene promoters in hematological neoplasia

Author keywords

CpG island; Hematologic malignancy; Hypermethylation; Tumour suppressor gene

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; AZACITIDINE; CALCITONIN; DNA METHYLTRANSFERASE; ESTROGEN RECEPTOR; GENE PRODUCT; HISTONE DEACETYLASE; PROTEIN HIC 1; PROTEIN P15; PROTEIN P16; PROTEIN P73; UNCLASSIFIED DRUG; UVOMORULIN;

EID: 0036941943     PISSN: 02780232     EISSN: None     Source Type: Journal    
DOI: 10.1002/hon.694     Document Type: Review
Times cited : (101)

References (50)
  • 1
    • 0034305821 scopus 로고    scopus 로고
    • DNA methylation in health and disease
    • Robertson KD, Wolffe AP. DNA methylation in health and disease. Nature Rev 2000; 1: 11-19.
    • (2000) Nature Rev , vol.1 , pp. 11-19
    • Robertson, K.D.1    Wolffe, A.P.2
  • 2
    • 0034176798 scopus 로고    scopus 로고
    • DNA hypermethylation in tumorigenesis: Epigenetics joins genetics
    • Baylin SB, Herman JG. DNA hypermethylation in tumorigenesis: epigenetics joins genetics. Trends Genet 2000; 16: 168-174.
    • (2000) Trends Genet , vol.16 , pp. 168-174
    • Baylin, S.B.1    Herman, J.G.2
  • 3
    • 0033564902 scopus 로고    scopus 로고
    • DNA methylation
    • Singal R, Ginder GD. DNA methylation. Blood 1999; 93: 4059-4070.
    • (1999) Blood , vol.93 , pp. 4059-4070
    • Singal, R.1    Ginder, G.D.2
  • 4
    • 0035283201 scopus 로고    scopus 로고
    • Expression of DNA methyltransferases DNMTI, 3A, and 3B in normal hematopoiesis and in acute and chronic myelogenous leukemia
    • Mizuno S, Chijiwa T, Okamura T, et al. Expression of DNA methyltransferases DNMTI, 3A, and 3B in normal hematopoiesis and in acute and chronic myelogenous leukemia. Blood 2001; 97: 1172-1179.
    • (2001) Blood , vol.97 , pp. 1172-1179
    • Mizuno, S.1    Chijiwa, T.2    Okamura, T.3
  • 5
    • 0026337295 scopus 로고
    • Tumor suppressor genes
    • Weinberg RA. Tumor suppressor genes. Science 1991; 254: 1138-1146.
    • (1991) Science , vol.254 , pp. 1138-1146
    • Weinberg, R.A.1
  • 6
    • 0029011539 scopus 로고
    • 5′CpG island methylation is associated with transcriptional silencing of the tumor suppressor p16/CDKN2/MTSI in human cancers
    • Merlo A, Herman JG, Mao L, et al. 5′CpG island methylation is associated with transcriptional silencing of the tumor suppressor p16/CDKN2/MTSI in human cancers. Nature Med 1995; 1: 686-692.
    • (1995) Nature Med , vol.1 , pp. 686-692
    • Merlo, A.1    Herman, J.G.2    Mao, L.3
  • 7
    • 0026546877 scopus 로고
    • A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands
    • Frommer M, McDonald LE, Millar DS, et al. A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands. Proc Natl A cad Sci U S A 1992; 89: 1827-1831.
    • (1992) Proc Natl A Cad Sci U S A , vol.89 , pp. 1827-1831
    • Frommer, M.1    McDonald, L.E.2    Millar, D.S.3
  • 10
    • 0025900902 scopus 로고
    • Acceleration of chronic myeloid leukemia correlates with calcitonin gene hypermethylation
    • Malinen T, Palotie A, Pakkala S, Peltonen L, Ruutu T, Jansson SE. Acceleration of chronic myeloid leukemia correlates with calcitonin gene hypermethylation. Blood 1991; 77: 2435-2440.
    • (1991) Blood , vol.77 , pp. 2435-2440
    • Malinen, T.1    Palotie, A.2    Pakkala, S.3    Peltonen, L.4    Ruutu, T.5    Jansson, S.E.6
  • 11
    • 0025874367 scopus 로고
    • Abnormal methylation of the calcitonin gene marks progression of chronic myelogenous leukemia
    • Nelkin BD, Przepiorka D, Burke PJ, Thomas ED, Baylin SB. Abnormal methylation of the calcitonin gene marks progression of chronic myelogenous leukemia. Blood 1991; 77: 2431-2434.
    • (1991) Blood , vol.77 , pp. 2431-2434
    • Nelkin, B.D.1    Przepiorka, D.2    Burke, P.J.3    Thomas, E.D.4    Baylin, S.B.5
  • 12
    • 0023270085 scopus 로고
    • Hypermethylation of the 5′ region of the calcitonin gene is a property of human lymphoid and acute myeloid malignancies
    • Baylin SB, Fearon ER, Vogelstein B, et al. Hypermethylation of the 5' region of the calcitonin gene is a property of human lymphoid and acute myeloid malignancies. Blood 1987; 70: 412-417.
    • (1987) Blood , vol.70 , pp. 412-417
    • Baylin, S.B.1    Fearon, E.R.2    Vogelstein, B.3
  • 14
    • 0030831310 scopus 로고    scopus 로고
    • DNA methylation patterns in the calcitonin gene region at first diagnosis and at relapse of acute lymphoblastic leukemia (ALL)
    • Leegwater PA, Lambooy LH, De Abreu RA, Bokkerink JP, van den Heuvel LP. DNA methylation patterns in the calcitonin gene region at first diagnosis and at relapse of acute lymphoblastic leukemia (ALL). Leukemia 1997; 11: 971-978.
    • (1997) Leukemia , vol.11 , pp. 971-978
    • Leegwater, P.A.1    Lambooy, L.H.2    De Abreu, R.A.3    Bokkerink, J.P.4    Van den Heuvel, L.P.5
  • 15
    • 0030909701 scopus 로고    scopus 로고
    • DNA methylation changes in hematologic malignancies: Biologic and clinical implications
    • Issa JP, Baylin SB, Herman JG. DNA methylation changes in hematologic malignancies: biologic and clinical implications. Leukemia 1997; 11 (Suppl. 1): S7-S11.
    • (1997) Leukemia , vol.11 , pp. S7-S11
    • Issa, J.P.1    Baylin, S.B.2    Herman, J.G.3
  • 16
    • 0033179375 scopus 로고    scopus 로고
    • Concurrent DNA hypermethylation of multiple genes in acute myeloid leukemia
    • Melki JR, Vincent PC, Clark SJ. Concurrent DNA hypermethylation of multiple genes in acute myeloid leukemia. Cancer Res 1999; 59: 3730-3740.
    • (1999) Cancer Res , vol.59 , pp. 3730-3740
    • Melki, J.R.1    Vincent, P.C.2    Clark, S.J.3
  • 17
    • 0030063853 scopus 로고    scopus 로고
    • The estrogen receptor CpG island is methylated in most hematopoietic neoplasms
    • Issa JP, Zehnbauer BA, Civin CI, et al. The estrogen receptor CpG island is methylated in most hematopoietic neoplasms. Cancer Res 1996; 56: 973-977.
    • (1996) Cancer Res , vol.56 , pp. 973-977
    • Issa, J.P.1    Zehnbauer, B.A.2    Civin, C.I.3
  • 18
    • 0031025368 scopus 로고    scopus 로고
    • Distinct patterns of inactivation of p15INK4B and p16INK4A characterize the major types of hematological malignancies
    • Herman JG, Civin CI, Issa JP, Collector MI, Sharkis SJ, Baylin SB. Distinct patterns of inactivation of p15INK4B and p16INK4A characterize the major types of hematological malignancies. Cancer Res 1997; 57: 837-841.
    • (1997) Cancer Res , vol.57 , pp. 837-841
    • Herman, J.G.1    Civin, C.I.2    Issa, J.P.3    Collector, M.I.4    Sharkis, S.J.5    Baylin, S.B.6
  • 19
    • 0035300727 scopus 로고    scopus 로고
    • Methylation of p15 and p16 genes in Acute Promyelocytic Leukemia: Diagnostic and prognostic significance
    • Chim CS, Liang R, Tam CYY, Kwong YL. Methylation of p15 and p16 genes in Acute Promyelocytic Leukemia: diagnostic and prognostic significance. J Clin Oncol 2001; 19: 2033-2040.
    • (2001) J Clin Oncol , vol.19 , pp. 2033-2040
    • Chim, C.S.1    Liang, R.2    Tam, C.Y.Y.3    Kwong, Y.L.4
  • 20
    • 0035876192 scopus 로고    scopus 로고
    • Methylation of p15 and p16 genes in Adult Acute Leukemia: Lack of prognostic significance
    • Chim CS, Tam CYY, Liang R, Kwong YL. Methylation of p15 and p16 genes in Adult Acute Leukemia: lack of prognostic significance. Cancer 2001; 91: 2222-2229.
    • (2001) Cancer , vol.91 , pp. 2222-2229
    • Chim, C.S.1    Tam, C.Y.Y.2    Liang, R.3    Kwong, Y.L.4
  • 21
    • 0034654269 scopus 로고    scopus 로고
    • Aberrant p15 promoter methylation in adult and childhood acute leukemias of nearly all morphologic subtypes: Potential prognostic implications
    • Wong IHN, Ng MHL, Huang DP, Lee JCK. Aberrant p15 promoter methylation in adult and childhood acute leukemias of nearly all morphologic subtypes: potential prognostic implications. Blood 2000; 95: 1942-1949.
    • (2000) Blood , vol.95 , pp. 1942-1949
    • Wong, I.H.N.1    Ng, M.H.L.2    Huang, D.P.3    Lee, J.C.K.4
  • 22
    • 0032523011 scopus 로고    scopus 로고
    • Methylation of the p15(INK4b) gene in myelodysplastic syndromes is frequent and acquired during disease progression
    • Quesnel B, Guillerm G, Vereecque R, et al. Methylation of the p15(INK4b) gene in myelodysplastic syndromes is frequent and acquired during disease progression. Blood. 1998; 91: 2985-2990.
    • (1998) Blood , vol.91 , pp. 2985-2990
    • Quesnel, B.1    Guillerm, G.2    Vereecque, R.3
  • 23
    • 0033556427 scopus 로고    scopus 로고
    • Extensive intra- and interindividual heterogeneity of p15INK4B methylation in acute myeloid leukemia
    • Aggerholm A, Guldberg P, Hokland M, Hokland P. Extensive intra- and interindividual heterogeneity of p15INK4B methylation in acute myeloid leukemia. Cancer Res 1999; 59: 436-441.
    • (1999) Cancer Res , vol.59 , pp. 436-441
    • Aggerholm, A.1    Guldberg, P.2    Hokland, M.3    Hokland, P.4
  • 24
    • 0031035406 scopus 로고    scopus 로고
    • Frequent and selective methylation of p15 and deletion of both p15 and p16 in T-cell acute lymphoblastic leukemia
    • Batova A, Diccianni MB, Yu JC, et al. Frequent and selective methylation of p15 and deletion of both p15 and p16 in T-cell acute lymphoblastic leukemia. Cancer Res 1997; 57: 832-839.
    • (1997) Cancer Res , vol.57 , pp. 832-839
    • Batova, A.1    Diccianni, M.B.2    Yu, J.C.3
  • 25
    • 0030940091 scopus 로고    scopus 로고
    • Frequent hypermethylation of p16 and p15 genes in multiple myeloma
    • Ng MH, Chung YF, Lo KW, Wickham NW, Lee JC, Huang DP. Frequent hypermethylation of p16 and p15 genes in multiple myeloma. Blood 1997; 89: 2500-2506.
    • (1997) Blood , vol.89 , pp. 2500-2506
    • Ng, M.H.1    Chung, Y.F.2    Lo, K.W.3    Wickham, N.W.4    Lee, J.C.5    Huang, D.P.6
  • 26
    • 0032523043 scopus 로고    scopus 로고
    • p16(INK4a) gene inactivation by deletions, mutations, and hypermethylation is associated with transformed and aggressive variants of non-Hodgkin's lymphomas
    • Pinyol M, Cobo F, Bea S, et al. p16(INK4a) gene inactivation by deletions, mutations, and hypermethylation is associated with transformed and aggressive variants of non-Hodgkin's lymphomas. Blood 1998; 91: 2977-2984.
    • (1998) Blood , vol.91 , pp. 2977-2984
    • Pinyol, M.1    Cobo, F.2    Bea, S.3
  • 27
    • 0033199104 scopus 로고    scopus 로고
    • Frequent methylation silencing of p15(INK4b) (MTS2) and p16(INK4a) (MTSI) in B-cell and T-cell lymphomas
    • Baur AS, Shaw P, Burri N, Delacretaz F, Bosman FT, Chaubert P. Frequent methylation silencing of p15(INK4b) (MTS2) and p16(INK4a) (MTSI) in B-cell and T-cell lymphomas. Blood 1999; 94: 1773-1781.
    • (1999) Blood , vol.94 , pp. 1773-1781
    • Baur, A.S.1    Shaw, P.2    Burri, N.3    Delacretaz, F.4    Bosman, F.T.5    Chaubert, P.6
  • 28
    • 0031860559 scopus 로고    scopus 로고
    • Review of alterations of the cyclin-dependent kinase inhibitor INK4 family genes p15, p16, p18 and p19 in human leukemia-lymphoma cells
    • Drexler HG. Review of alterations of the cyclin-dependent kinase inhibitor INK4 family genes p15, p16, p18 and p19 in human leukemia-lymphoma cells. Leukemia 1998; 12: 845-859.
    • (1998) Leukemia , vol.12 , pp. 845-859
    • Drexler, H.G.1
  • 30
    • 0033565514 scopus 로고    scopus 로고
    • Transcriptional silencing of the p73 gene in acute lymphoblastic leukemia and Burkitt's lymphoma is associated with 5′ CpG island methylation
    • Corn PG, Kuerbitz SJ, van-Noesel MM, et al. Transcriptional silencing of the p73 gene in acute lymphoblastic leukemia and Burkitt's lymphoma is associated with 5′ CpG island methylation. Cancer Res 1999; 59: 3352-3356.
    • (1999) Cancer Res , vol.59 , pp. 3352-3356
    • Corn, P.G.1    Kuerbitz, S.J.2    Van-Noesel, M.M.3
  • 31
    • 0033179665 scopus 로고    scopus 로고
    • Loss of p73 gene expression in leukemias/lymphomas due to hypermethylation
    • Kawano S, Miller CW, Gombart AF, et al. Loss of p73 gene expression in leukemias/lymphomas due to hypermethylation. Blood 1999; 94: 1113-1120.
    • (1999) Blood , vol.94 , pp. 1113-1120
    • Kawano, S.1    Miller, C.W.2    Gombart, A.F.3
  • 33
    • 0033559955 scopus 로고    scopus 로고
    • Methylation of the ABLI promoter in chronic myelogenous leukemia: Lack of prognostic significance
    • Issa JP, Kantarjian H, Mohan A, et al. Methylation of the ABLI promoter in chronic myelogenous leukemia: lack of prognostic significance. Blood 1999; 93: 2075-2080.
    • (1999) Blood , vol.93 , pp. 2075-2080
    • Issa, J.P.1    Kantarjian, H.2    Mohan, A.3
  • 34
    • 0028275733 scopus 로고
    • Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers
    • Nobori T, Miura K, Wu DJ, Lois A, Takabayashi K, Carson DA. Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers. Nature 1994; 368: 753-756.
    • (1994) Nature , vol.368 , pp. 753-756
    • Nobori, T.1    Miura, K.2    Wu, D.J.3    Lois, A.4    Takabayashi, K.5    Carson, D.A.6
  • 35
    • 0028121279 scopus 로고
    • A cell cycle regulator potentially involved in genesis of many tumor types
    • Kamb A, Gruis NA, Weaver-Feldhaus J, et al. A cell cycle regulator potentially involved in genesis of many tumor types. Science 1994; 264: 436-440.
    • (1994) Science , vol.264 , pp. 436-440
    • Kamb, A.1    Gruis, N.A.2    Weaver-Feldhaus, J.3
  • 36
    • 0029134016 scopus 로고
    • Role of the cyclin-dependent kinase inhibitors in the development of cancer
    • Hirama T, Koeffler HP. Role of the cyclin-dependent kinase inhibitors in the development of cancer. Blood 1995; 86: 841-854.
    • (1995) Blood , vol.86 , pp. 841-854
    • Hirama, T.1    Koeffler, H.P.2
  • 38
    • 0033215453 scopus 로고    scopus 로고
    • p15(INK4B) CpG island methylation in primary acute leukemia is heterogeneous and suggests density as a critical factor for transcriptional silencing
    • Cameron EE, Baylin SB, Herman JG. p15(INK4B) CpG island methylation in primary acute leukemia is heterogeneous and suggests density as a critical factor for transcriptional silencing. Blood 1999; 94: 2445-2451.
    • (1999) Blood , vol.94 , pp. 2445-2451
    • Cameron, E.E.1    Baylin, S.B.2    Herman, J.G.3
  • 39
    • 0031000207 scopus 로고    scopus 로고
    • Acute leukemia with promyelocytic features in PML/RARalpha transgenic mice
    • He LZ, Tribioli C, Rivi R, et al. Acute leukemia with promyelocytic features in PML/RARalpha transgenic mice. Proc Natl Acad Sci U S A 1997; 94: 5302-5307.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 5302-5307
    • He, L.Z.1    Tribioli, C.2    Rivi, R.3
  • 40
    • 0030615230 scopus 로고    scopus 로고
    • A PMLRARalpha transgene initiates murine acute promyelocytic leukemia
    • Brown D, Kogan S, Lagasse E, et al. A PMLRARalpha transgene initiates murine acute promyelocytic leukemia. Proc Natl Acad Sci U S A 1997; 94: 2551-2556.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 2551-2556
    • Brown, D.1    Kogan, S.2    Lagasse, E.3
  • 41
    • 0030040436 scopus 로고    scopus 로고
    • Investigation of minimal residual disease by the use of a semi quantitative multi-step test combination in ALL
    • Chim JC, Coyle LA, Yaxley JC, et al. Investigation of minimal residual disease by the use of a semi quantitative multi-step test combination in ALL. Br J Haematol 1996; 92: 104-115.
    • (1996) Br J Haematol , vol.92 , pp. 104-115
    • Chim, J.C.1    Coyle, L.A.2    Yaxley, J.C.3
  • 42
    • 16944366700 scopus 로고    scopus 로고
    • Molecular detection of minimal residual disease in adult and childhood ALL reveals differences in treatment responses
    • Foroni L, Coyle LA, Papioannou M, et al. Molecular detection of minimal residual disease in adult and childhood ALL reveals differences in treatment responses. Leukemia 1997; 11: 1732-1741.
    • (1997) Leukemia , vol.11 , pp. 1732-1741
    • Foroni, L.1    Coyle, L.A.2    Papioannou, M.3
  • 43
    • 0028905531 scopus 로고
    • Detection of minimal residual disease in acute leukemia: Methodological advances and clinical significance
    • Campana D, Pui CH. Detection of minimal residual disease in acute leukemia: methodological advances and clinical significance. Blood 1995; 85: 1416-1434.
    • (1995) Blood , vol.85 , pp. 1416-1434
    • Campana, D.1    Pui, C.H.2
  • 44
    • 0033566692 scopus 로고    scopus 로고
    • Quantitative analysis of aberrant p16 methylation using real-time quantitative methylation-specific polymerase chain reaction
    • Lo YM, Wong IH, Zhang J, Tein MS, Ng MH, Hjelm NM. Quantitative analysis of aberrant p16 methylation using real-time quantitative methylation-specific polymerase chain reaction. Cancer Res 1999; 59: 3899-3903.
    • (1999) Cancer Res , vol.59 , pp. 3899-3903
    • Lo, Y.M.1    Wong, I.H.2    Zhang, J.3    Tein, M.S.4    Ng, M.H.5    Hjelm, N.M.6
  • 45
    • 0028981085 scopus 로고
    • Loss of expression of the p16/cyclin-dependent kinase inhibitor 2 tumor suppressor gene in melanocytic lesions correlates with invasive stage of tumor progression
    • Reed JA, Loganzo F, Shea CR, et al. Loss of expression of the p16/cyclin-dependent kinase inhibitor 2 tumor suppressor gene in melanocytic lesions correlates with invasive stage of tumor progression. Cancer Res 1995; 55: 2713-2718.
    • (1995) Cancer Res , vol.55 , pp. 2713-2718
    • Reed, J.A.1    Loganzo, F.2    Shea, C.R.3
  • 46
    • 0033528084 scopus 로고    scopus 로고
    • Alterations of INK4A and INK4B genes in adult soft tissue sarcomas: Effect on survival
    • Orlow I, Drobnjak M, Zhang ZF, et al. Alterations of INK4A and INK4B genes in adult soft tissue sarcomas: effect on survival. J Natl Cancer Inst 1999; 91: 73-79.
    • (1999) J Natl Cancer Inst , vol.91 , pp. 73-79
    • Orlow, I.1    Drobnjak, M.2    Zhang, Z.F.3
  • 47
    • 0032949084 scopus 로고    scopus 로고
    • Estrogen receptor methylation is associated with improved survival in adult acute myeloid leukemia
    • Li Q, Kopecky KJ, Mohan A, et al. Estrogen receptor methylation is associated with improved survival in adult acute myeloid leukemia. Clin Cancer Res 1999; 5: 1077-1084.
    • (1999) Clin Cancer Res , vol.5 , pp. 1077-1084
    • Li, Q.1    Kopecky, K.J.2    Mohan, A.3
  • 48
    • 0031961755 scopus 로고    scopus 로고
    • Analysis of prognostic factors in newly diagnosed acute promyelocytic leukemia treated with all-trans retinoic acid and chemotherapy
    • Japan Adult Leukemia Study Group
    • Asou N, Adachi K, Tamura J, et al. Analysis of prognostic factors in newly diagnosed acute promyelocytic leukemia treated with all-trans retinoic acid and chemotherapy. Japan Adult Leukemia Study Group. J Clin Oncol 1998; 16: 78-85.
    • (1998) J Clin Oncol , vol.16 , pp. 78-85
    • Asou, N.1    Adachi, K.2    Tamura, J.3
  • 49
    • 0035799382 scopus 로고    scopus 로고
    • Changes in DNA methylation in neoplasia: Pathophysiology and therapeutic implications
    • Santini V, Kantarjian HM, Issa JP. Changes in DNA methylation in neoplasia: pathophysiology and therapeutic implications. Ann Intern Med 2001; 134: 573-586.
    • (2001) Ann Intern Med , vol.134 , pp. 573-586
    • Santini, V.1    Kantarjian, H.M.2    Issa, J.P.3
  • 50
    • 0343621494 scopus 로고    scopus 로고
    • Aberrant CpG-island methylation has non-random and tumour-type-specific patterns
    • Costello JF, Fruhwald MC, Smiraglia DJ, et al. Aberrant CpG-island methylation has non-random and tumour-type-specific patterns. Nature Genet 2000; 24: 132-138.
    • (2000) Nature Genet , vol.24 , pp. 132-138
    • Costello, J.F.1    Fruhwald, M.C.2    Smiraglia, D.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.