NK cell receptors: Emerging roles in host defense against infectious agents

Microbes and Infection

Volumn 4, Issue 15, 2002, Pages 1523-1530

  Robbins, Scott H ^a   Brossay, Laurent ^a  

^a BROWN UNIVERSITY   (United States)

Author keywords

Activating receptors; Infection; Inhibitory receptors; NK cells

Indexed keywords

CELL RECEPTOR CD94; CELL RECEPTOR DAP10; CELL RECEPTOR GP49B; CELL RECEPTOR KLRG1; CELL RECEPTOR LY 49H; CELL RECEPTOR NKG2A; CELL RECEPTOR NKG2C; CELL RECEPTOR NKG2D; CELL RECEPTOR NKG2E; CELL SURFACE RECEPTOR; UNCLASSIFIED DRUG;

CELL ACTIVATION; CYTOKINE PRODUCTION; CYTOTOXICITY; HOST RESISTANCE; IMMUNOPATHOLOGY; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW;

ANIMALS; COMMUNICABLE DISEASES; HUMANS; KILLER CELLS, NATURAL; LYMPHOCYTE ACTIVATION; RECEPTORS, IMMUNOLOGIC;

EID: 0036927970     PISSN: 12864579     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1286-4579(02)00035-7     Document Type: Review

References (48)

1. Biron C.A., Nguyen K.B., Pien G.C., Cousens L.P., Salazar-Mather T.P. Natural killer cells in antiviral defense: function and regulation by innate cytokines. Annu. Rev. Immunol. 17:1999;189-220.
2. Biron C.A., Brossay L. NK cells and NKT cells in innate defense against viral infections. Curr. Opin. Immunol. 13:2001;458-464.
3. Lanier L.L. On guard - Activating NK cell receptors. Nature Immunol. 2:2001;23-27.
4. Long E.O. Regulation of immune responses through inhibitory receptors. Annu. Rev. Immunol. 17:1999;875-904.
5. Vivier E., Daeron M. Immunoreceptor tyrosine-based inhibition motifs. Immunol. Today. 18:1997;286-291.
6. Nakamura M.C., Seaman W.E. Ligand interactions by activating and inhibitory Ly-49 receptors. Immunol. Rev. 181:2001;138-148.
7. Ljunggren H.G., Kärre K. In search of the 'missing self': MHC molecules and NK cell recognition. Immunol. Today. 11:1990;237-244.
8. Raulet D.H., Vance R.E., McMahon C.W. Regulation of the natural killer cell receptor repertoire. Annu. Rev. Immunol. 19:2001;291-330.
9. Anfossi N., Pascal V., Vivier E., Ugolini S. Biology of T memory type 1 cells. Immunol. Rev. 181:2001;269-278.
10. Wang L.L., Chu D.T., Dokun A.O., Yokoyama W.M. Inducible expression of the gp49B inhibitory receptor on NK cells. J. Immunol. 164:2000;5215-5220.
11. Robbins S.H., Nguyen K.B., Takahashi N., Mikayama T., Biron C.A., Brossay L. Cutting edge: inhibitory functions of the killer cell lectin-like receptor G1 molecule during the activation of mouse NK cells. J. Immunol. 168:2002;2585-2589.
12. Anderson S.K., Ortaldo J.R., McVicar D.W. The ever-expanding Ly49 gene family: repertoire and signaling. Immunol. Rev. 181:2001;79-89.
13. Tay C.H., Yu L.Y., Kumar V., Mason L., Ortaldo J.R., Welsh R.M. The role of LY49NK cell subsets in the regulation of murine cytomegalovirus infections. J. Immunol. 162:1999;718-726.
14. Daniels K.A., Devora G., Lai W.C., O'Donnell C.L., Bennett M., Welsh R.M. Murine cytomegalovirus is regulated by a discrete subset of natural killer cells reactive with monoclonal antibody to Ly49H. J. Exp. M. 194:2001;29-44.
15. Braud V.M., Allan D.S., O'Callaghan C.A., Soderstrom K., D'Andrea A., Ogg G.S., Lazetic S., Young N.T., Bell J.I., Phillips J.H., Lanier L.L., McMichael A.J. HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C. Nature. 391:1998;795-799.
16. Vance R.E., Kraft J.R., Altman J.D., Jensen P.E., Raulet D.H. Mouse CD94/NKG2A is a natural killer cell receptor for the nonclassical major histocompatibility complex (MHC) class I molecule Qa-1(b). J. Exp. M. 188:1998;1841-1848.
17. Vance R.E., Jamieson A.M., Cado D., Raulet D.H. Implications of CD94 deficiency and monoallelic NKG2A expression for natural killer cell development and repertoire formation. Proc. Natl. Acad. Sci. USA. 99:2002;868-873.
18. Takei F., McQueen K.L., Maeda M., Wilhelm B.T., Lohwasser S., Lian R.H., Mager D.L., Ly C.D. NKG2: developmentally regulated expression and evolution. Immunol. Rev. 181:2001;90-103.
19. Salcedo M., Bousso P., Ljunggren H.G., Kourilsky P., Abastado J.P. The Qa-1b molecule binds to a large subpopulation of murine NK cells. Eur. J. Immunol. 28:1998;4356-4361.
20. Kurepa Z., Hasemann C.A., Forman J. Qa-1b binds conserved class I leader peptides derived from several mammalian species. J. Exp. M. 188:1998;973-978.
21. Rojo S., Burshtyn D.N., Long E.O., Wagtmann N. Type I transmembrane receptor with inhibitory function in mouse mast cells and NK cells. J. Immunol. 158:1997;9-12.
22. Hanke T., Corral L., Vance R.E., Raulet D.H. 2F1 antigen, the mouse homolog of the rat "mast cell function-associated antigen", is a lectin-like type II transmembrane receptor expressed by natural killer cells. Eur. J. Immunol. 28:1998;4409-4417.
23. Voehringer D., Kaufmann M., Pircher H. Genomic structure, alternative splicing, and physical mapping of the killer cell lectin-like receptor G1 gene (KLRG1), the mouse homologue of MAFA. Immunogenetics. 52:2001;206-211.
24. Corral L., Hanke T., Vance R.E., Cado D., Raulet D.H. NK cell expression of the killer cell lectin-like receptor G1 (KLRG1), the mouse homolog of MAFA, is modulated by MHC class I molecules. Eur. J. Immunol. 30:2000;920-930.
25. Natarajan K., Dimasi N., Wang J., Mariuzza R.A., Margulies D.H. Stucture and function of natural killer cell receptors: multiple molecular solutions to self, nonself discrimination. Annu. Rev. Immunol. 20:2002;853-885.
26. Tormo J., Natarajan K., Margulies D.H., Mariuzza R.A. Crystal structure of a lectin-like natural killer cell receptor bound to its MHC class I ligand. Nature. 402:1999;623-631.
27. Chung D.H., Natarajan K., Boyd L.F., Tormo J., Mariuzza R.A., Yokoyama W.M., Margulies D.H. Mapping the ligand of the NK inhibitory receptor Ly49A on living cells. J. Immunol. 165:2000;6922-6932.
28. Hanke T., Takizawa H., McMahon C.W., Busch D.H., Pamer E.G., Miller J.D., Altman J.D., Liu Y., Cado D., Lemonnier F.A., Bjorkman P.J., Raulet D.H. Direct assessment of MHC class I binding by seven Ly49 inhibitory NK cell receptors. Immunity. 11:1999;67-77.
29. Nakamura M.C., Niemi E.C., Fisher M.J., Shultz L.D., Seaman W.E., Ryan J.C. Mouse Ly-49A interrupts early signaling events in natural killer cell cytotoxicity and functionally associates with the SHP-1 tyrosine phosphatase. J. Exp. M. 185:1997;673-684.
30. Wallach D., Varfolomeev E.E., Malinin N.L., Goltsev Y.V., Kovalenko A.V., Boldin M.P. Tumor necrosis factor receptor and Fas signaling mechanisms. Annu. Rev. Immunol. 17:1999;331-367.
31. Brown M.G., Dokun A.O., Heusel J.W., Smith H.R., Beckman D.L., Blattenberger E.A., Dubbelde C.E., Stone L.R., Scalzo A.A., Yokoyama W.M. Vital involvement of a natural killer cell activation receptor in resistance to viral infection. Science. 292:2001;934-937.
32. Lee S.H., Girard S., Macina D., Busa M., Zafer A., Belouchi A., Gros P., Vidal S.M. Susceptibility to mouse cytomegalovirus is associated with deletion of an activating natural killer cell receptor of the C-type lectin superfamily. Nature Genet. 28:2001;42-45.
33. Dokun A.O., Kim S., Smith H.R., Kang H.S., Chu D.T., Yokoyama W.M. Specific and nonspecific NK cell activation during virus infection. Nature Immunol. 2:2001;951-956.
34. Arase H., Mocarski E.S., Campbell A.E., Hill A.B., Lanier L.L. Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptors. Science. 296:2002;1226-1323.
35. Sjolin H., Tomasello E., Mousavi-Jazi M., Bartolazzi A., Karre K., Vivier E., Cerboni C. Pivotal role of KARAP/DAP12 adaptor molecule in the natural killer cell-mediated resistance to murine cytomegalovirus infection. J. Exp. M. 195:2002;825-834.
36. Vivier E., Tomasello E., Paul P. Lymphocyte activation via NKG2D: towards a new paradigm in immune recognition? Curr. Opin. Immunol. 14:2002;306-311.
37. Wu J., Song Y., Bakker A.B., Bauer S., Spies T., Lanier L.L., Phillips J.H. An activating immunoreceptor complex formed by NKG2D and DAP10. Science. 285:1999;730-732.
38. Cosman D., Mullberg J., Sutherland C.L., Chin W., Armitage R., Fanslow W., Kubin M., Chalupny N.J. ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor. Immunity. 14:2001;123-133.
39. Cerwenka A., Bakker A.B., McClanahan T., Wagner J., Wu J., Phillips J.H., Lanier L.L. Retinoic acid early inducible genes define a ligand family for the activating NKG2D receptor in mice. Immunity. 12:2000;721-727.
40. Diefenbach A., Jamieson A.M., Liu S.D., Shastri N., Raulet D.H. Ligands for the murine NKG2D receptor: expression by tumor cells and activation of NK cells and macrophages. Nature Immunol. 1:2000;119-126.
41. Sutherland C.L., Chalupny N.J., Cosman D. The UL16-binding proteins, a novel family of MHC class I-related ligands for NKG2D, activate natural killer cell functions. Immunol. Rev. 181:2001;185-192.
42. Kubin M., Cassiano L., Chalupny J., Chin W., Cosman D., Fanslow W., Mullberg J., Rousseau A.M., Ulrich D., Armitage R. ULBP1, 2, 3: novel MHC class I-related molecules that bind to human cytomegalovirus glycoprotein UL16, activate NK cells. Eur. J. Immunol. 31:2001;1428-1437.
43. Ploegh H.L. Viral strategies of immune evasion. Science. 280:1998;248-253.
44. Cosman D., Fanger N., Borges L., Kubin M., Chin W., Peterson L., Hsu M.L. A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules. Immunity. 7:1997;273-282.
45. Cretney E., Degli-Esposti M.A., Densley E.H., Farrell H.E., Davis-Poynter N.J., Smyth M.J. m144, a murine cytomegalovirus (MCMV)-encoded major histocompatibility complex class I homologue, confers tumor resistance to natural killer cell-mediated rejection. J. Exp. M. 190:1999;435-444.
46. Tomasec P., Braud V.M., Rickards C., Powell M.B., McSharry B.P., Gadola S., Cerundolo V., Borysiewicz L.K., McMichael A.J., Wilkinson G.W. Surface expression of HLA-E, an inhibitor of natural killer cells, enhanced by human cytomegalovirus gpUL40. Science. 287:2000;1031-1033.
47. Kavanagh D.G., Gold M.C., Wagner M., Koszinowski U.H., Hill A.B. The multiple immune-evasion genes of murine cytomegalovirus are not redundant: m4 and m152 inhibit antigen presentation in a complementary and cooperative fashion. J. Exp. M. 194:2001;967-978.
48. +T-cells and NK cells in vivo. Nature Immunol. 3:2002;529-535.