Vascular effects following homozygous disruption of p47(phox): An essential component of NADPH oxidase

Circulation

Volumn 101, Issue 11, 2000, Pages 1234-1236

  Hsich, Eileen ^a   Segal, Brahm H ^b   Pagano, Patrick J ^d   Rey, Federico E ^d   Paigen, Beverly ^c   Deleonardis, John ^a   Hoyt, Robert F ^a   Holland, Steven M ^b   Finkel, Toren ^a,e  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c JACKSON LABORATORY   (United States)

^d HENRY FORD HOSPITAL   (United States)

^e NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Apolipoproteins; Atherosclerosis; Blood pressure

Indexed keywords

APOLIPOPROTEIN E; NITRIC OXIDE SYNTHASE; OXIDOREDUCTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; BLOOD PRESSURE REGULATION; BLOOD VESSEL WALL; CONTROLLED STUDY; DISEASE COURSE; ENZYME INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN TARGETING; VASCULAR RING;

EID: 0034696590     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.101.11.1234     Document Type: Article

References (23)

1. DeLeo FR, Quinn MT. Assembly of the phagocyte NADPH oxidase: molecular interaction of oxidase proteins. J Leukoc Biol. 1996;60: 677-691.
2. Mohazzabh KM, Wolin MS. Properties of a superoxide anion-generating microsomal NADH oxidoreductase, a potential pulmonary-artery P-O2 sensor. Am J Physiol. 1994;11:L823-L831.
3. Rajagopalan S, Kurz S, Munzel T, Tarpey M, Freeman BA. Griendling KK, Harrison DG. Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation: contribution to alterations of vasomotor tone. J Clin Invest. 1996;97:1916-1923.
4. Pagano PJ, Ito Y, Tornheim K, Gallop PM, Tauber AI, Cohen RA. An NADPH oxidase superoxide-generating system in the rabbit aorta. Am J Physiol. 1995;37:H2274-H2280.
5. Griendling KK, UshioFakai M. NADPH/NADPH oxidase and vascular function. Trends Cardiovasc Med. 1997;7:301-307.
6. Griendling KK, Minien CA, Ollerenshaw JD, Alexander RW. Angiotensin-II stimulates NADH and NADPH oxidase activity in cultured vascular smooth-muscle cells. Circ Res. 1994;74:1141-1148.
7. Pagano PJ, Clark JK, Cifuentes-Pagano ME, Clark SM, Callis GM, Quinn MT. Localization of constitutively active, phagocyte-like NADPH oxidase in rabbit aortic adventitia: enhancement by angiotensin II. Proc Natl Acad Sci U S A. 1997;94:14483-14488.
8. UshioFukai M, Zafari AM, Fukui T, Ishizaka N, Griendling KK. P22(phox) is a critical component of the superoxide-generating NADH/NADPH oxidase system and regulates angiotensin II-induced hypertrophy in vascular smooth muscle cells. J Biol Chem. 1996;271: 23317-23321.
9. Sundaresan M, Yu ZX, Ferrans VJ, Sulciner DJ, Gutkind JS, Irani K, Godlschmidt-Clermont PJ, Finkel T. Regulation of reactive-oxygen-species generation in fibroblasts by Rac1. Biochem J. 1996;318:379-382.
10. Patterson C, Ruef J, Madamanchi NR, Barry-Lane P, Hu ZY, Horaist C, Ballinger CA, Grasier AR, Bode C, Runge MS. Stimulation of a vascular smooth muscle cell NAD(P)H oxidase by thrombin: evidence that p47(phox) may participate in forming this oxidase in vitro and in vivo. J Biol Chem. 1999;274:19814-19822.
11. phox in human coronary arteries. Circulation. 1999;100:1494-1498.
12. DeKeulenaer GW, Alexander RW, Ushio-Fukai M, Ishizaka N, Griendling KK. Tumor necrosis factor alpha activities a p22(phox)-based NADH oxidase in vascular smooth muscle. Biochem J. 1998;329: 653-657.
13. Pagano PJ, Chanock SJ, Siwik DA, Colucci WS, Clark JK. Angiotensin II induces p67(phox) mRNA expression and NADPH oxidase superoxide generation in rabbit aortic adventitial fibroblasts. Hypertension. 1998;32: 331-337.
14. Fukui T, Ishizaka N, Rajagopalan S, Lauren JB, Capers Q, Taylor WR, Harrison DG, deLeon H, Wilcox JN, Griendling KK. p22phox mRNA expression and NADPH oxidase activity are increased in aortas from hypertensive rats. Circ Res. 1997;80:45-51.
15. Jackson SH, Gallin JI, Holland SM. The P47(phox) mouse knock-out model of chronic granulomatous-disease. J Exp Med. 1995;182:751-758.
16. Paigen B, Morrow A, Holmes PA, Mitchell D, Williams RA. Quantitative assessment of atherosclerotic lesions in mice. Atherosclerosis. 1987;68: 231-240.
17. Kurihara N, Alfie ME, Sigmon DH, Rhaleb NE, Shesely EG, Carretero OA. Role of nNOS in blood pressure regulation in eNOS null mutant mice. Hypertension. 1998;32:856-861.
18. Archer SL, Reeve HL, Michelakis E, Puttagunta L, Waite R, Nelson DP, Dinauer MC, Weir EK. O-2 sensing is preserved in mice lacking the gp91 phox subunit of NADPH oxidase. Proc Natl Acad Sci USA. 1999;96: 7944-7949.
19. Harrison DG, Ohara Y. Physiological consequences of increased vascular oxidant stresses in hypercholesterolemia and atherosclerosis: implications for impaired vasomotion. Am J Cardiol. 1995;75:B75-B81.
20. Miller FJ, Gutterman DD, Rios CD, Heistad DD, Davidson BL. Superoxide production in vascular smooth muscle contributes to oxidative stress and impaired relaxation in atherosclerosis. Circ Res. 1998; 82:1298-1305.
21. Warnholtz A, Nickenig G, Schulz E, Macharzina R, Brasen JH, Skatchkov M, Heitzer T, Stasch JP, Griendling KK, Harrison DG, Bohm M, Meinertz T, Munzel T. Increased NADH-oxidase-mediated superoxide production in the early stages of atherosclerosis: evidence for involvement of the renin-angiotensin system. Circulation. 1999;99: 2027-2033.
22. Kerr S, Brosnan MJ, McIntyre M, Reid JL, Dominiczak AF, Hamilton CA. Superoxide anion production is increased in a model of genetic hypertension: role of the endothelium. Hypertension. 1999;33: 1353-1358.
23. Suh YA, Arnold RS, Lassegue B, Shi J, Xu XX, Sorescu D, Chung AB, Griendling KK, Lambeth JD. Cell transformation by the superoxide-generating oxidase Mox1. Nature. 1999;401:79-82.