메뉴 건너뛰기




Volumn 163, Issue 3, 1999, Pages 1327-1333

Thymus-derived glucocorticoids set the threshold for thymocyte selection by inhibiting TCR-mediated thymocyte activation

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD5 ANTIGEN; CD8 ANTIGEN; CORTICOSTERONE; GLUCOCORTICOID; METYRAPONE; T LYMPHOCYTE RECEPTOR;

EID: 0033179257     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (97)

References (39)
  • 2
    • 0024372111 scopus 로고
    • Acquisition of immunologic self-tolerance
    • Schwartz, R. H. 1989. Acquisition of immunologic self-tolerance. Cell 57:1073.
    • (1989) Cell , vol.57 , pp. 1073
    • Schwartz, R.H.1
  • 3
    • 0028806218 scopus 로고
    • A targeted glucocorticoid receptor antisense transgene increases thymocyte apoptosis and alters thymocyte development
    • King, L. B., M. S. Vacchio, K. Dixon, R. Hunziker, D. H. Margulies, and J. D. Ashwell. 1995. A targeted glucocorticoid receptor antisense transgene increases thymocyte apoptosis and alters thymocyte development. Immunity 3:647.
    • (1995) Immunity , vol.3 , pp. 647
    • King, L.B.1    Vacchio, M.S.2    Dixon, K.3    Hunziker, R.4    Margulies, D.H.5    Ashwell, J.D.6
  • 4
    • 0002820657 scopus 로고
    • Adrenocorticotropic hormone; adrenocortical steroids and their synthetic analogs; inhibitors of the synthesis and actions of adrenocortical hormones
    • A. G. Gilman, T. W. Rall, A. S. Nies, and P. Taylor, eds. Pergamon Press, New York
    • Haynes, Jr., R. C. 1990. Adrenocorticotropic hormone; adrenocortical steroids and their synthetic analogs; inhibitors of the synthesis and actions of adrenocortical hormones. In The Pharmacological Basis of Therapeutics. A. G. Gilman, T. W. Rall, A. S. Nies, and P. Taylor, eds. Pergamon Press, New York, p. 1431.
    • (1990) The Pharmacological Basis of Therapeutics , pp. 1431
    • Haynes R.C., Jr.1
  • 5
    • 0028233225 scopus 로고
    • Steroid production in the thymus: Implications for thymocyte selection
    • Vacchio, M. S., V. Papadopoulos, and J. D. Ashwell. 1994. Steroid production in the thymus: implications for thymocyte selection. J. Exp. Med. 179:1835.
    • (1994) J. Exp. Med. , vol.179 , pp. 1835
    • Vacchio, M.S.1    Papadopoulos, V.2    Ashwell, J.D.3
  • 6
    • 0031011063 scopus 로고    scopus 로고
    • Thymus-derived glucocorticoids regulate antigen-specific positive selection
    • Vacchio, M. S., and J. D. Ashwell. 1997. Thymus-derived glucocorticoids regulate antigen-specific positive selection. J. Exp. Med. 185:2033.
    • (1997) J. Exp. Med. , vol.185 , pp. 2033
    • Vacchio, M.S.1    Ashwell, J.D.2
  • 9
    • 0021338681 scopus 로고
    • Monoclonal antibodies specific for Ia glycoproteins raised by immunization with activated T cells: Possible role of T cell bound Ia antigen as targets of immunoregulatory T cells
    • Janeway, Jr., C. A., P. J. Conrad, E. A. Lerner, J. Babich, P. Wettstein, and D. B. Murphy. 1984. Monoclonal antibodies specific for Ia glycoproteins raised by immunization with activated T cells: possible role of T cell bound Ia antigen as targets of immunoregulatory T cells. J. Immunol. 132:662.
    • (1984) J. Immunol. , vol.132 , pp. 662
    • Janeway C.A., Jr.1    Conrad, P.J.2    Lerner, E.A.3    Babich, J.4    Wettstein, P.5    Murphy, D.B.6
  • 10
    • 0019458092 scopus 로고
    • Antigen-inducible, H-2 restricted, interleukin-2-producing T cell hybridomas: Lack of independent antigen and H-2 recognition
    • Kappler, J. W., B. Skidmore, J. White, and P. Marrack. 1981. Antigen-inducible, H-2 restricted, interleukin-2-producing T cell hybridomas: lack of independent antigen and H-2 recognition. J. Exp. Med. 153:1198.
    • (1981) J. Exp. Med. , vol.153 , pp. 1198
    • Kappler, J.W.1    Skidmore, B.2    White, J.3    Marrack, P.4
  • 11
    • 0026648674 scopus 로고
    • Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
    • Gavrieli, Y., Y. Sherman, and S. A. Ben-Sasson. 1992. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol. 119:493.
    • (1992) J. Cell Biol. , vol.119 , pp. 493
    • Gavrieli, Y.1    Sherman, Y.2    Ben-Sasson, S.A.3
  • 12
    • 0023683669 scopus 로고
    • Positive selection of antigen-specific T cells in thymus by restricting MHC molecules
    • Kisielow, P., H. S. Teh, H. Blüthmann, and H. von Boehmer. 1988. Positive selection of antigen-specific T cells in thymus by restricting MHC molecules. Nature 335:730.
    • (1988) Nature , vol.335 , pp. 730
    • Kisielow, P.1    Teh, H.S.2    Blüthmann, H.3    Von Boehmer, H.4
  • 13
    • 0025327432 scopus 로고
    • The effects of MHC gene dosage and allelic variation on T cell receptor selection
    • Berg, L. J., G. D. Frank, and M. M. Davis. 1990. The effects of MHC gene dosage and allelic variation on T cell receptor selection. Cell 60:1043.
    • (1990) Cell , vol.60 , pp. 1043
    • Berg, L.J.1    Frank, G.D.2    Davis, M.M.3
  • 14
    • 0028142707 scopus 로고
    • Quantitative analysis of the efficiency of clonal deletion in the thymus
    • Spain, L. M., and L. J. Berg. 1994. Quantitative analysis of the efficiency of clonal deletion in the thymus. Dev. Immunol. 4:43.
    • (1994) Dev. Immunol. , vol.4 , pp. 43
    • Spain, L.M.1    Berg, L.J.2
  • 15
    • 0029038585 scopus 로고
    • Selective expression of major histocompatibility complex (MHC) antigens and modulation of T-cell differentiation in chickens with increased MHC-chromosome dosages
    • Hemendinger, R. A., M. M. Miller, and S. E. Bloom. 1995. Selective expression of major histocompatibility complex (MHC) antigens and modulation of T-cell differentiation in chickens with increased MHC-chromosome dosages. Vet. Immunol. Immunopathol. 46:303.
    • (1995) Vet. Immunol. Immunopathol. , vol.46 , pp. 303
    • Hemendinger, R.A.1    Miller, M.M.2    Bloom, S.E.3
  • 16
    • 0016161205 scopus 로고
    • Genetic nomenclature for new lymphocyte antigens controlled by the Ir region of the H-2 complex
    • Shreffler, D., C. David, D. Gotze, J. Klein, H. McDevitt, and D. Sachs. 1974. Genetic nomenclature for new lymphocyte antigens controlled by the Ir region of the H-2 complex. Immunogenetics 1:189.
    • (1974) Immunogenetics , vol.1 , pp. 189
    • Shreffler, D.1    David, C.2    Gotze, D.3    Klein, J.4    McDevitt, H.5    Sachs, D.6
  • 18
  • 21
    • 0028930772 scopus 로고
    • + thymocyte development defined by the lack of coreceptor binding in positive selection
    • + thymocyte development defined by the lack of coreceptor binding in positive selection. J. Immunol. 154:2588.
    • (1995) J. Immunol. , vol.154 , pp. 2588
    • Dutz, J.P.1    Ong, C.J.2    Marth, J.3    Teh, H.S.4
  • 23
    • 84958685199 scopus 로고
    • Effect of hormones on lymphatic tissue
    • Dougherty, T. F. 1952. Effect of hormones on lymphatic tissue. Physiol. Rev. 32:379.
    • (1952) Physiol. Rev. , vol.32 , pp. 379
    • Dougherty, T.F.1
  • 24
    • 0026030196 scopus 로고
    • +) thymocytes as post-selection intermediates leading to mature T cells
    • +) thymocytes as post-selection intermediates leading to mature T cells. J. Exp. Med. 173:323.
    • (1991) J. Exp. Med. , vol.173 , pp. 323
    • Shortman, K.1    Vremec, D.2    Egerton, M.3
  • 25
    • 0028054017 scopus 로고
    • T-cell apoptosis detected in situ during positive and negative selection in the thymus
    • Surh, C. D., and J. Sprent. 1994. T-cell apoptosis detected in situ during positive and negative selection in the thymus. Nature 372:100.
    • (1994) Nature , vol.372 , pp. 100
    • Surh, C.D.1    Sprent, J.2
  • 27
    • 0027478380 scopus 로고
    • + T cells induced by major histocompatibility complex binding peptides in fetal thymic organ culture
    • + T cells induced by major histocompatibility complex binding peptides in fetal thymic organ culture. J. Exp. Med. 177:1469.
    • (1993) J. Exp. Med. , vol.177 , pp. 1469
    • Hogquist, K.A.1    Gavin, M.A.2    Bevan, M.J.3
  • 28
    • 0030058657 scopus 로고    scopus 로고
    • The repertoire of T cells shaped by a single MHC/peptide ligand
    • Ignatowicz, L., J. Kappler, and P. Marrack. 1996. The repertoire of T cells shaped by a single MHC/peptide ligand. Cell 84:521.
    • (1996) Cell , vol.84 , pp. 521
    • Ignatowicz, L.1    Kappler, J.2    Marrack, P.3
  • 29
    • 0031047189 scopus 로고    scopus 로고
    • The helper T-cell repertoire of mice expressing class II major histocompatibility complex β chains in the absence of α chains
    • Vidovic, D., N. Boulanger, O. Kuye, J. Toral, K. Ito, J. Guenot, H. Bluethmann, and Z. A. Nagy. 1997. The helper T-cell repertoire of mice expressing class II major histocompatibility complex β chains in the absence of α chains. Immunogenetics 45:325.
    • (1997) Immunogenetics , vol.45 , pp. 325
    • Vidovic, D.1    Boulanger, N.2    Kuye, O.3    Toral, J.4    Ito, K.5    Guenot, J.6    Bluethmann, H.7    Nagy, Z.A.8
  • 30
    • 0030935007 scopus 로고    scopus 로고
    • The MHC reactivity of the T cell repertoire prior to positive and negative selection
    • Zerrahn, J., W. Held, and D. H. Raulet. 1997. The MHC reactivity of the T cell repertoire prior to positive and negative selection. Cell 88:627.
    • (1997) Cell , vol.88 , pp. 627
    • Zerrahn, J.1    Held, W.2    Raulet, D.H.3
  • 31
    • 0029801742 scopus 로고    scopus 로고
    • Regulation of cytokine and cytokine receptor expression by glucocorticoids
    • Almawi, W. Y., H. N. Beyhum, A. A. Rahme, and M. J. Rieder. 1996. Regulation of cytokine and cytokine receptor expression by glucocorticoids. J. Leukocyte Biol. 60:563.
    • (1996) J. Leukocyte Biol. , vol.60 , pp. 563
    • Almawi, W.Y.1    Beyhum, H.N.2    Rahme, A.A.3    Rieder, M.J.4
  • 32
    • 0010575601 scopus 로고
    • Fruitful outcomes of intracellular cross-talk
    • Zacharchuk, C. M., and J. D. Ashwell. 1992. Fruitful outcomes of intracellular cross-talk. Curr. Biol. 2:246.
    • (1992) Curr. Biol. , vol.2 , pp. 246
    • Zacharchuk, C.M.1    Ashwell, J.D.2
  • 33
    • 0028879819 scopus 로고
    • Role of transcriptional activation of IκBα in mediation of immunosuppression by glucocorticoids
    • Scheinman, R. I., P. C. Cogswell, A. K. Lofquist, and A. S. Baldwin, Jr. 1995. Role of transcriptional activation of IκBα in mediation of immunosuppression by glucocorticoids. Science 270:283.
    • (1995) Science , vol.270 , pp. 283
    • Scheinman, R.I.1    Cogswell, P.C.2    Lofquist, A.K.3    Baldwin A.S., Jr.4
  • 34
    • 0028867899 scopus 로고
    • Immunosuppression by glucocorticoids: Inhibition of NF-κB activity through induction of IκB synthesis
    • Auphan, N., J. A. Didonata, C. Rosette, A. Hemberg, and M. Karin. 1995. Immunosuppression by glucocorticoids: inhibition of NF-κB activity through induction of IκB synthesis. Science 270:286.
    • (1995) Science , vol.270 , pp. 286
    • Auphan, N.1    Didonata, J.A.2    Rosette, C.3    Hemberg, A.4    Karin, M.5
  • 35
    • 0028107237 scopus 로고
    • Physical association and functional antagonism between the p65 subunit of transcription factor NF-κB and the glucocorticoid receptor
    • Ray, A., and K. E. Prefontaine. 1994. Physical association and functional antagonism between the p65 subunit of transcription factor NF-κB and the glucocorticoid receptor. Proc. Natl. Acad. Sci. USA 91:752.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 752
    • Ray, A.1    Prefontaine, K.E.2
  • 36
    • 0031459881 scopus 로고    scopus 로고
    • Glucocorticoid-mediated repression of nuclear factor-κB-dependent transcription involves direct interference with transactivation
    • De Bosscher, K., M. L. Schmitz, W. Vanden Berghe, S. Plaisance, W. Fiers, and G. Haegeman. 1997. Glucocorticoid-mediated repression of nuclear factor-κB-dependent transcription involves direct interference with transactivation. Proc. Natl. Acad. Sci. USA 94:13504.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 13504
    • De Bosscher, K.1    Schmitz, M.L.2    Berghe, W.V.3    Plaisance, S.4    Fiers, W.5    Haegeman, G.6
  • 38
    • 0029971886 scopus 로고    scopus 로고
    • Dexamethasone inhibits the early steps of antigen receptor signaling in activated T lymphocytes
    • Baus, E., F. Andris, P. M. Dubois, J. Urbain, and O. Leo. 1996. Dexamethasone inhibits the early steps of antigen receptor signaling in activated T lymphocytes. J. Immunol. 156:4555.
    • (1996) J. Immunol. , vol.156 , pp. 4555
    • Baus, E.1    Andris, F.2    Dubois, P.M.3    Urbain, J.4    Leo, O.5
  • 39
    • 0031907999 scopus 로고    scopus 로고
    • Thymocyte glucocorticoid resistance alters positive selection and inhibits autoimmunity and lymphoproliferative disease in MRL-lpr/lpr mice
    • Tolosa, E., L. B. King, and J. D. Ashwell. 1998. Thymocyte glucocorticoid resistance alters positive selection and inhibits autoimmunity and lymphoproliferative disease in MRL-lpr/lpr mice. Immunity 8:67.
    • (1998) Immunity , vol.8 , pp. 67
    • Tolosa, E.1    King, L.B.2    Ashwell, J.D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.