Novel β2-adrenergic receptor signaling pathways

Journal of Allergy and Clinical Immunology

Volumn 110, Issue 6 SUPPL., 2002, Pages

  Benovic, Jeffrey L ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

G protein coupled receptors; Signaling; Trafficking; 2 adrenergic receptor

Indexed keywords

ADAPTOR PROTEIN; ADENYLATE CYCLASE; BETA 2 ADRENERGIC RECEPTOR; CYCLIC AMP DEPENDENT PROTEIN KINASE; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR KINASE; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; PROTEIN KINASE; PROTEIN KINASE C; PROTEIN TYROSINE KINASE; REGULATOR PROTEIN; RETINA S ANTIGEN; SODIUM PROTON EXCHANGE PROTEIN; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN;

CONFERENCE PAPER; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; PHYSIOLOGY; PROTEIN CONFORMATION; REVIEW;

ARRESTINS; GTP-BINDING PROTEINS; HUMANS; PROTEIN CONFORMATION; PROTEIN KINASES; RECEPTORS, ADRENERGIC, BETA-2; SIGNAL TRANSDUCTION;

EID: 0036907442     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1067/mai.2002.129370     Document Type: Conference Paper

References (60)

1. Marinissen MJ, Gutkind JS. G-protein-coupled receptors and signaling networks: Emerging paradigms. Trends Pharmacol Sci 2001;22:368-76.
2. Hall RA, Premont RT, Lefkowitz RJ. Heptahelical receptor signaling: Beyond the G protein paradigm. J Cell Biol 1999;145:927-32.
3. Brady AE, Limbird, LE. G protein-coupled receptor interacting proteins: Emerging roles in localization and signal transduction. Cell Signal 2002;14:297-309.
4. Penn RB, Benovic JL. Regulation of G protein-coupled receptors. In: Corm PM, editor. Handbook of Physiology, Oxford: Oxford University Press; 1998. p. 125-64.
5. Krupnick JG, Benovic JL. The role of receptor kinases and arrestins in G protein-coupled receptor regulation. Annu Rev Pharmacol Toxicol 1998;38:289-319.
6. Ferguson SSG. Evolving concepts in G protein-coupled receptor endocytosis: The role in receptor desensitization and signaling. Pharmacol Rev 2001;53:1-24.
7. Stadel JM, Nambi P, Lavin TN, Heald SL, Caron MG, Lefkowitz RJ. Catecholamine-induced desensitization of turkey erythrocyte adenylate cyclase. J Biol Chem 1982:257:9242-5.
8. Stadel JM, Nambi P, Shorr RGL, Sawyer DF, Caron MG, Lefkowitz RJ. Catecholamine-induced desensitization of turkey erythrocyte adenylate cyclase is associated with phosphorylation of the β-adrenergic receptor. Proc Natl Acad Sci U S A 1983;80:3173-7.
9. Benovic JL, Pike LJ, Cerione RA, Staniszewski C, Yoshimasa T, Codina J, et al. Phosphorylation of the mammalian β-adrenergic receptor by cyclic AMP-dependent protein kinase: Regulation of the rate of receptor phosphorylation and dephosphorylation by agonist occupancy and effects on coupling of the receptor to the stimulatory guanine nucleotide regulatory protein. J Biol Chem 1985;260:7094-101.
10. 2-adrenergic receptor that is autoregulated via protein kinase A-dependent phosphorylation. Cell 1991:67:723-30.
11. 2-adrenergic receptor to different G proteins by protein kinase A. Nature 1997:390:88-91.
12. Michel JJC, Scott JD. AKAP mediated signal transduction. Annu Rev Pharmacol Toxicol 2002;42:235-57.
13. 2-adrenergic receptors with protein kinases and phosphatases and the role of gravin. J Biol Chem 1999;274:1588-195.
14. 2-adrenergic receptor desensitization and resensitization. J Biol Chem 2000;275:19025-34.
15. 2-adrenergic receptor via the receptor cytoplasmic Arg-329 to Leu-413 domain and provides a mobile scaffold during desensitization. J Biol Chem 2001:276:24005-14.
16. 2-adrenergic receptor complex facilitates receptor phosphorylation and signaling. Curr Biol 2000:10:409-12.
17. Cong M, Perry SJ, Lin F-T, Fraser ID, Hu LA, Chen W, et al. Regulation of membrane targeting of the G protein-coupled receptor kinase 2 by protein kinase A and its anchoring protein AKAP79. J Biol Chem 2001;276:15192-9.
18. 2-adrenergic receptors in response to insulin. J Biol Chem 1992;267:26017-22.
19. Karoor V, Baltensperger K, Paul H, Czech MP, Malbon CC. Phosphorylation of tyrosyl residues 350/354 of the β-adrenergic receptor is obligatory for counterregulatory effects of insulin. J Biol Chem 1995;270:25305-8.
20. 2-adrenergic receptor. EMBO J 1995;14:5542-9.
21. Baltensperger K, Karoor V, Paul H, Ruoho A, Czech MP, Malbon CC. The β-adrenergic receptor is a substrate for the insulin receptor tyrosine kinase. J Biol Chem 1996;271:1061-4.
22. 2-adrenergic receptor in vivo on sites distinct from those phosphorylated in response to insulin. J Biol Chem 1996;271:29347-52.
23. Karoor V, Wang L, Wang H-Y, Malbon CC. Insulin stimulates sequestration of β-adrenergic receptors and enhanced association of β-adrenergic receptors with Grb2 via tyrosine 350. J Biol Chem 1998;273:33035-41.
24. 2-adrenergic receptor via phospho-Tyr-350, phosphorylates G-protein-linked receptor kinase 2, and mediates agonist-induced receptor desensitization. J Biol Chem 2001;276:13240-7.
25. Sarnago S, Elorza A, Mayor F Jr. Agonist-dependent phosphorylation of the G protein-coupled receptor kinase 2 (GRK2) by Src tyrosine kinase. J Biol Chem 1999:274:34411-6.
26. 350 of the receptor. J Biol Chem 2000;275:36086-93.
27. 2-adrenergic receptor by the insulin receptor, creating a potent feedback inhibitor of its tyrosine kinase. J Biol Chem 2002:277:10698-703.
28. 2-adrenergic receptor mediates extracellular signal-regulated kinase activation via assembly of a multi-receptor complex with the epidermal growth factor receptor, J Biol Chem 2000;275:9572-80.
29. Benovic JL, Strasser RH, Caron MG, Lefkowitz RJ. β-adrenergic receptor kinase: Identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor. Proc Natl Acad Sci U S A 1986;83:2797-801.
30. Benovic JL, DeBlasi A, Stone WC, Caron MG, Lefkowitz RJ. β-adrenergic receptor kinase: Primary structure delineates a multigene family. Science 1989:246:235-9.
31. Pitcher JA, Freedman NJ, Lefkowitz RJ. G protein-coupled receptor kinases. Annu Rev Biochem 1998;67:653-92.
32. 2-adrenergic receptor. J Biol Chem. 1996;271:13795-803.
33. 2-adrenergic receptor. Nature 1999;401:286-90.
34. Koch WJ, Rockman HA, Samama P, Hamilton RA, Bond RA, Milano CA, et al. Cardiac function in mice overexpressing the β-adrenergic receptor kinase or a βARK inhibitor. Science 1995;268:1350-3.
35. Iaccarino G, Rockman HA, Shotwell KF, Tomhave ED, Koch WJ. Myocardial overexpression of GRK3 in transgenic mice: Evidence for in vivo selectivity of GRKs. Am J Physiol 1998;275:H1298-306.
36. Rockman HA, Choi DJ, Rahman NU, Akhter SA, Lefkowitz RJ, Koch WJ. Receptor-specific in vivo desensitization by the G protein-coupled receptor kinase-5 in transgenic mice. Proc Natl Acad Sci U S A 1996;93:9954-9.
37. Miller WE, Lefkowitz RJ. Expanding roles for β-arrestins as scaffolds and adapters in GPCR signaling and trafficking. Curr Opin Cell Biol 2001;13:139-45.
38. Ferguson SSG, Downey WE III, Colapietro A-M, Barak LS, Ménard L. Caron MG. Role of β-arrestin in mediating agonist-promoted G protein-coupled receptor internalization. Science 1996;271:363-6.
39. 2-adrenergic receptor. Nature 1996;383:447-50.
40. Kohout TA, Lin F-T, Perry SJ, Conner DA, Lefkowitz RJ. β-arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking. Proc Natl Acad Sci U S A 2001;98:1601-6.
41. 2-adrenergic receptor. J Biol Chem 1998;273:6976-81.
42. 2-adrenergic receptor and β-arrestin. Science 2001;294:1307-13.
43. 2 adrenergic receptor-Src protein kinase complexes. Science 1999:283:655-61.
44. 2-adrenergic receptor internalization and mitogen-activated protein kinase signaling. J Biol Chem 1999;274:1185-8.
45. DeFea KA, Zalevsky J, Thoma MS, Déry O, Mullins RD, Bunnett NW. β-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2. J Cell Biol 2000:148:1267-81.
46. DeFea KA, Vaughn ZD, O'Bryan EM, Nishijima D, Déry O, Bunnett NW. The proliferative and antiapoptotic effects of substance P are facilitated by formation of a β-arrestin-dependent scaffolding complex. Proc Natl Acad Sci U S A 2000;97:11086-91.
47. Luttrell LM, Roudabush FL, Choy EW, Miller WE, Field ME, Pierce KL, et al. Activation and targeting of extracellular signal-regulated kinases by β-arrestin scaffolds. Proc Natl Acad Sci U S A 2001;98:2449-54.
48. McDonald PH, Chow C-W, Miller WE, Laporte SA, Field ME, Lin F-T. et al. β-arrestin 2: A receptor-regulated MAPK scaffold for the activation of JNK3. Science 2000:290:1574-7.
49. Fanning AS, Anderson JM. PDZ domains: Fundamental building blocks in the organization of protein complexes at the plasma membrane. J Clin Invest 1999;103:767-72.
50. Songyang Z, Fanning AS, Fu C, Xu J, Marfatia SM, Chishti AH, et al. Recognition of unique carboxyl-terminal motifs by distinct PDZ domains. Science 1997:275:73-7.
51. 2+ channel by INAD in Drosophila photoreceptors. Neuron 1996:16:991-8.
52. + exchange. Nature 1998;392:626-30.
53. + exchanger. J Clin Invest 1995:95:2143-9.
54. Weiss A, Schlessinger J. Switching signals on or off by receptor dimerization. Cell 1998;94:277-80.
55. 2-adrenergic receptor transmembrane domain inhibits both receptor dimerization and activation. J Biol Chem 1996;271:16384-92.
56. Angers S, Salahpour A, Bouvier M. Dimerization: An emerging concept for G protein-coupled receptor ontogeny and function. Annu Rev Pharmacol Toxicol 2002;42:409-35.
57. 2-adrenergic receptor dimerization in living ceils using bioluminescence resonance energy transfer (BRET). Proc Natl Acad Sci U S A 2000;97:3684-9.
58. 2 adrenergic receptor to N-ethylmaleimide-sensitive factor regulates receptor recycling. J Biol Chem 2001;276:45145-52.
59. Klein U, Ramirez MT, Kobilka BK, von Zastrow M. A novel interaction between adrenergic receptors and the α-subunit of eukaryotic initiation factor 2B. J Biol Chem 1997;272:19099-102.
60. Chruscinski AJ, Rohrer DK, Schauble E, Desai KH, Bernstein D, Kobilka BK. Targeted disruption of the β2 adrenergic receptor gene. J Biol Chem 1999;274:16694-700.