Somatic mutation screening: Identification of individuals harboring K- ras mutations with the use of plasma DNA

Journal of the National Cancer Institute

Volumn 92, Issue 11, 2000, Pages 918-923

  Kopreski, Michael S ^a   Benko, Floyd A ^c   Borys, David J ^c   Khan, Amin ^c   McGarrity, Thomas J ^c   Gocke, Christopher D ^b  

^a OncoMEDx Inc   (United States)

^b Penn State Geisinger al Hershey   (United States)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

DNA;

ADULT; AGED; ARTICLE; BLOOD LEVEL; CODON; COLONOSCOPY; COLORECTAL CANCER; CONTROLLED STUDY; FEMALE; GENE AMPLIFICATION; GENETIC SCREENING; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MASS SCREENING; ONCOGENE K RAS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RECTUM BIOPSY; RISK FACTOR; SOMATIC MUTATION;

EID: 0034616665     PISSN: 00278874     EISSN: None     Source Type: Journal    
DOI: 10.1093/jnci/92.11.918     Document Type: Article

References (33)

1. Warmuth MA, Sutton LM, Winer EP. A review of hereditary breast cancer: from screening to risk factor modification. Am J Med 1997;102:407-15.
2. Lynch HT, Lemon SJ, Karr B, Franklin B, Lynch JF, Watson P, et al. Etiology, natural history, management and molecular genetics of hereditary nonpolyposis colorectal cancer (Lynch syndromes): genetic counseling implications. Cancer Epidemiol Biomarkers Prev 1997;6:987-91.
3. Vogelstein B, Fearon ER, Hamilton SR, Kern SE, Preisinger AC, Leppert M, et al. Genetic alterations during colorectal-tumor development. N Engl J Med 1988;319:525-32.
4. Powell SM, Zilz N, Beazer-Barclay Y, Bryan TM, Hamilton SR, Thibodeau SN, et al. APC mutations occur early during colorectal tumorigenesis. Nature 1992;359:235-7.
5. Sorenson GD, Pribish DM, Valone FH, Memoli VA, Bzik DJ, Yao SL. Soluble normal and mutated DNA sequences from single-copy genes in human blood. Cancer Epidemiol Biomarkers Prev 1994;3:67-71.
6. Mulcahy HE, Lyautey J, Lederrey C, qiChen X, Anker P, Alstead EM, et al. A prospective study of K-ras mutations in the plasma of pancreatic cancer patients. Clin Cancer Res 1998;4:271-5.
7. Kopreski MS, Benko FA, Kwee C, Leitzel KE, Eskander E, Lipton A, et al. Detection of mutant K-ras DNA in plasma or serum of patients with colorectal cancer. Br J Cancer 1997;76:1293-9.
8. Anker P, Lefort F, Vasioukhin V, Lyautey J, Lederrey C, Chen XQ, et al. K-ras mutations are found in DNA extracted from the plasma of patients with colorectal cancer. Gastroenterology 1997;112:1114-20.
9. Hibi K, Robinson CR, Booker S, Wu L, Hamilton SR, Sidransky D, et al. Molecular detection of genetic alterations in the serum of colorectal cancer patients. Cancer Res 1998;58:1405-7.
10. de Kok JB, van Solinge WW, Ruers TJ, Roelofs RW, van Muijen GN, Willems JL, et al. Detection of tumour DNA in serum of colorectal cancer patients. Scand J Clin Lab Invest 1997;57:601-4.
11. Vasioukhin V, Anker P, Maurice P, Lyautey J, Lederrey C, Stroun M. Point mutations of the N-ras gene in the blood plasma DNA of patients with myelodysplastic syndrome or acute myelogenous leukaemia. Br J Haematol 1994;86:774-9.
12. Frickhofen N, Muller E, Sandherr M, Binder T, Bangerter M, Wiest C, et al. Rearranged Ig heavy chain DNA is detectable in cell-free blood samples of patients with B-cell neoplasia. Blood 1997;90:4953-60.
13. Chen XQ, Stroun M, Magnenat JL, Nicod LP, Kurt AM, Lyautey J, et al. Microsatellite alterations in plasma DNA of small cell lung cancer patients. Nat Med 1996;2:1033-5.
14. Nawroz H, Koch W, Anker P, Stroun M, Sidransky D. Microsatellite alterations in serum DNA of head and neck cancer patients. Nat Med 1996;2:1035-7.
15. Goessl C, Heicappell R, Munker R, Anker P, Stroun M, Krause H, et al. Microsatellite analysis of plasma DNA from patients with clear cell renal carcinoma. Cancer Res 1998;58:4728-32.
16. Rodenhuis S, van de Watering ML, Mooi WJ, Evers SG, van Zandwijk N, Bos JL. Mutational activation of the K-ras oncogene. A possible pathogenetic factor in adenocarcinoma of the lung. N Engl J Med 1987;317: 929-35.
17. Almoguera C, Shibata D, Forrester K, Martin J, Arnheim N, Perucho M. Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes. Cell 1988;53:549-54.
18. Forrester K, Almoguera C, Han K, Grizzle WE, Perucho M. Detection of high incidence of K-ras oncogenes during human colon tumorigenesis. Nature 1987;327:298-303.
19. Smith AJ, Stern HS, Penner M, Hay K, Mitri A, Bapat BV, et al. Somatic APC and K-ras codon 12 mutations in aberrant crypt foci from human colons. Cancer Res 1994;54:5527-30.
20. Pretlow TP, Brasitus TA, Fulton NC, Cheyer C, Kaplan EL. K-ras mutations in putative preneoplastic lesions in human colon. J Natl Cancer Inst 1993;85:2004-7.
21. McLellan EA, Owen RA, Stepniewska KA, Sheffield JP, Lemoine NR. High frequency of K-ras mutations in sporadic colorectal adenomas. Gut 1993;34:392-6.
22. Ward R, Hawkins N, O'Grady R, Sheehan C, O'Connor T, Impey H, et al. Restriction endonuclease-mediated selective polymerase chain reaction: a novel assay for the detection of K-ras mutations in clinical samples. Am J Pathol 1998;153:373-9.
23. Kwok S, Higuchi R. Avoiding false positives with PCR. Nature 1989;339: 237-8.
24. Saraga E, Bautista D, Dorta G, Chaubert P, Martin P, Sordat B, et al. Genetic heterogeneity in sporadic colorectal adenomas. J Pathol 1997;181: 281-6.
25. Zhu D, Keohavong P, Finkelstein SD, Swalsky P, Bakker A, Weissfeld J, et al. K-ras gene mutations in normal colorectal tissues from K-ras mutation-positive colorectal cancer patients. Cancer Res 1997;57:2485-92.
26. Gocke C, Benko FA, Kopreski MS, McGarrity TJ. p53 and APC mutations are detectable in the plasma and serum of patients with colorectal cancer (CRC) or adenomas. Ann N Y Acad Sci 2000;906:44-51.
27. Hixson LJ, Fennerty MB, Sampliner RE, McGee D, Garewal H. Prospective study of the frequency and size distribution of polyps missed by colonoscopy. J Natl Cancer Inst 1990;82:1769-72.
28. Rex DK, Rahmani EY, Haseman JH, Lemmel GT, Kaster S, Buckley JS. Relative sensitivity of colonoscopy and barium enema for detection of colorectal cancer in clinical practice. Gastroenterology 1997;112:17-23.
29. Minamoto T, Yamashita N, Ochiai A, Mai M, Sugimura T, Ronai Z, et al. Mutant K-ras in apparently normal mucosa of colorectal cancer patients. Its potential as a biomarker of colorectal tumorigenesis. Cancer 1995;75(6 Suppl):1520-6.
30. Ronai Z, Minamoto T, Butler R, Tobi M, Luo FQ, Zang E, et al. Sampling method as a key factor in identifying K-ras oncogene mutations in preneoplastic colorectal lesions. Cancer Detect Prev 1995;19:512-7.
31. Takayama T, Katsuki S, Takahashi Y, Ohi M, Nojiri S. Sakamaki S, et al. Aberrant crypt foci of the colon as precursors of adenoma and cancer. N Engl J Med 1998;339:1277-84.
32. Tobi M, Luo FC, Ronai Z. Detection of K-ras mutation in colonie effluent samples from patients without evidence of colorectal carcinoma. J Natl Cancer Inst 1994;86:1007-10.
33. Villa E, Dugani A, Rebecchi AM, Vignoli A, Grottola A, Buttafoco P, et al. Identification of subjects at risk for colorectal carcinoma through a test based on K-ras determination in the stool. Gastroenterology 1996;110: 1346-53.