Neurobiology of lysophosphatidic acid signaling

Neuroscientist

Volumn 8, Issue 6, 2002, Pages 540-550

  Fukushima, Nobuyuki ^a   Ye, Xiaoqin ^b   Chun, Jerold ^c  

^a HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b San Diego   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Developments; Glia; LPA; Neuroblast; Neuron

Indexed keywords

GENE PRODUCT; GROWTH FACTOR; LYSOPHOSPHATIDIC ACID; LYSOPHOSPHATIDIC ACID RECEPTOR; LYSOPHOSPHOLIPID; UNCLASSIFIED DRUG;

BRAIN CORTEX; BRAIN REGION; CELL FUNCTION; CELL GROWTH; CELL MATURATION; CELL PROLIFERATION; CENTRAL NERVOUS SYSTEM; EMBRYO DEVELOPMENT; GLIA CELL; NERVE CELL; NEUROBIOLOGY; NEUROBLAST; PRIORITY JOURNAL; RECEPTOR GENE; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; HUMANS; LYSOPHOSPHOLIPIDS; NERVOUS SYSTEM; NEUROGLIA; NEURONS; RECEPTORS, CELL SURFACE; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, LYSOPHOSPHATIDIC ACID; SIGNAL TRANSDUCTION;

EID: 0036892749     PISSN: 10738584     EISSN: None     Source Type: Journal    
DOI: 10.1177/1073858402238513     Document Type: Review

References (81)

1. Allard J, Barraon S, Diaz J, Lubetzki C, Zalc B, Schwartz JC, and others. 1998. A rat G protein-coupled receptor selectively expressed in myelin-forming cells. Eur J Neurosci 10:1045-53.
2. An S, Bleu T, Hallmark OG, Goetzl EJ. 1998. Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid. J Biol Chem 273:7906-10.
3. Bandoh K, Aoki J, Hosono H, Kobayashi S, Kobayashi T, Murakami-Murofushi K, and others. 1999. Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid. J Biol Chem 274:27776-85.
4. Boulder Committee. 1970. Embryonic vertebrate central nervous system: Revised terminology. Anat Rec 166:257-61.
5. Cameron HA, Hazel TG, McKay RDG. 1998. Regulation of neurogenesis by growth factors and neurotransmitters. J Neurobiol 36:287-306.
6. Chrzanowska-Wodnicka M, Burridge K. 1996. Rho-stimulated contractility drives the formation of stress fibers and focal adhesions. J Cell Biol 133:1403-15.
7. Chun J. 1999. Lysophospholipid receptors: Implications for neural signaling. Crit Rev Neurobiol 13:151-68.
8. Chun J, Contos JJA, Munroe D. 1999. A growing family of receptor genes for lysophosphatidic acid (LPA) and other lyso-phospholipids (LPs). Cell Biochem Biophys 30:213-42.
9. Chun J, Jaenisch R. 1996. Clonal cell lines produced by infection of neocortical neuroblasts using multiple oncogenes transduced by retroviruses. Mol Cell Neurosci 7:304-21.
10. A/vzg-1/Gpcr26. Genomics 51:364-78.
11. A/Edg4, and identification of a frameshift mutation in a previously characterized cDNA. Genomics 64:155-69.
12. A3/Edg7 lysophosphatidic acid receptor gene: Genomic structure, chromosomal localization, and expression pattern. Gene, in press.
13. Contos JJA, Fukushima N, Weiner JA, Kaushal D, Chun J. 2000. Requirement for the lpA1 lysophosphatidic acid receptor gene in normal suckling behavior. Proc Natl Acad Sci U S A 97:13384-9.
14. Contos JJA, Ishii I, Chun J. 2000. Lysophosphatidic acid receptors. Mol Pharmacol 58:1188-96.
15. Das AK, Hajra AK. 1989. Quantification, characterization and fatty acid composition of lysophosphatidic acid in different rat tissues. Lipids 24:329-33.
16. Daub H, Weiss FU, Wallasch C, Ullrich A. 1996. Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors. Nature 379:557-60.
17. Dubin A, Bahnson T, Weiner JA, Fukushima N, Chun J. 1999. Lysophosphatidic acid (LPA) stimulates neurotransmitter-like conductance changes that precede GABA and L-glutamate in early, presumptive cortical neuroblasts. J Neurosci 19:1371-81.
18. Eichholtz T, Jalink K, Fahrenfort I, Moolenaar WH. 1993. The bioactive phospholipid lysophosphatidic acid is released from activated platelets. Biochem J 291:677-80.
19. Erickson JR, Wu JJ, Goddard JG, Tigyi G, Kawanishi K, Tomei LD, and others. 1998. Edg-2/Vzg-1 couples to the yeast pheromone response pathway selectively in response to lysophosphatidic acid. J Biol Chem 273:1506-10.
20. Fukushima N, Chun J. 2001. The LPA Receptors. Prostaglandins and Other Lipid Mediators 64:21-32.
21. Fukushima N, Ishii I, Contos JA, Weiner JA, Chun J. 2001. Lysophospholipid receptors. Annu Rev Pharmacol Toxicol 41:507-34.
22. A/edg-2 couples to G proteins and mediates multiple cellular responses to lysophosphatidic acid. Proc Natl Acad Sci U S A 95:6151-6.
23. Fukushima N, Weiner JA, Chun J. 2000. Lysophosphatidic acid (LPA) is a novel extracellular regulator of cortical neuroblast morphology. Dev Biol 228:6-18.
24. Fukushima N, Weiner JA, Kaushal D, Contos JJA, Rehen SK, Kingsbury MA, and others. 2002. Lysophosphatidic acid influences the morphology and motility of young, postmitotic cortical neurons. Mol Cell Neurosci, in press.
25. Gaits F, Fourcade O, Le Balle F, Gueguen G, Gaig B, Gassama-Diagne A, and others. 1997. Lysophosphatidic acid as a phospholipid mediator: Pathways of synthesis. FEBS Lett 410:54-8.
26. Guo Z, Liliom K, Fischer DJ, Bathurst IC, Tomei LD, Kiefer MC, and others. 1996. Molecular cloning of a high-affinity receptor for the growth factor-like lipid mediator lysophosphatidic acid from Xenopus oocytes. Proc Natl Acad Sci U S A 93:14367-72.
27. Hecht JH, Weiner JA, Post SR, Chun J. 1996. Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex. J Cell Biol 135:1071-83.
28. Higgs HN, Han MH, Johnson GE, Glomset JA. 1998. Cloning of a phosphatidic acid-preferring phospholipase A1 from bovine testis. J Biol Chem 273:5468-77.
29. Hla T, Maciag T. 1990. An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors. J Biol Chem 265:9308-13.
30. Holtsberg FW, Steiner MR, Furukawa K, Keller JN, Mattson MP, Steiner SM. 1997. Lysophosphatidic acid induces a sustained elevation of neuronal intracellular calcium. J Neurochem 69:68-75.
31. Holtsberg FW, Steiner MR, Keller JN, Mark RJ, Mattson MP, Steiner SM. 1998. Lysophosphatidic acid induces necrosis and apoptosis in hippocampal neurons. J Neurochem 70:66-76.
32. Huang R, Sochocka E, Hertz L. 1997. Cell culture studies of the role of elevated extracellular glutamate and K+ in neuronal cell death during and after anoxia/ischemia. Neurosci Biobehav Rev 21:129-34.
33. Im DS, Heise CE, Harding MA, George SR, O'Dowd BF, Theodorescu D, and others. 2000. Molecular cloning and characterization of a lysophosphatidic acid receptor, Edg-7, expressed in prostate. Mol Pharmacol 57:753-9.
34. A3/EDG-7 in neuronal cell lines using a retrovirus expression system. Mol Pharmacol 58:895-902.
35. Jalink K, Eichholtz T, Postma FR, van Corven EJ, Moolenaar WH. 1993. Lysophosphatidic acid induces neuronal shape changes via a novel, receptor-mediated signaling pathway: Similarity to thrombin action. Cell Growth Differ 4:247-55.
36. Jin Z, Strittmatter SM. 1997. Rac1 mediates collapsin-1-induced growth cone collapse. J Neurosci 17:6256-63.
37. Kawasawa Y, Kume K, Izumi T, Shimizu T. 2000. Mammalian PSP24s (alpha and beta isoforms) are not responsive to lysophosphatidic acid in mammalian expression systems. Biochem Biophys Res Commun 276:957-64.
38. Keller JN, Steiner MR, Holtsberg FW, Mattson MP, Steiner SM. 1997. Lysophosphatidic acid-induced proliferation-related signals in astrocytes. J Neurochem 69:1073-84.
39. Keller JN, Steiner MR, Mattson MP, Steiner SM. 1996. Lysophosphatidic acid decreases glutamate and glucose uptake by astrocytes. J Neurochem 67:2300-5.
40. A1/EDG-2 function as lysophosphatidic acid receptors in Xenopus oocytes and mammalian cells. J Biol Chem 276:15208-15.
41. Lee MJ, Van Brocklyn JR, Thangada S, Liu CH, Hand AR, Menzeleev R, and others. 1998. Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1. Science 279:1552-5.
42. LoTurco JJ, Owens DF, Heath MJ, Davis MB, Kriegstein AR. 1995. GABA and glutamate depolarize cortical progenitor cells and inhibit DNA synthesis. Neuron 15:1287-98.
43. Lu Q, Sun EE, Klein RS, Flanagan JG. 2001. Ephrin-B reverse signaling is mediated by a novel PDZ-RGS protein and selectively inhibits G protein-coupled chemoattraction. Cell 105:69-79.
44. Lu WY, Xiong ZG, Lei S, Orser BA, Dudek E, Browning MD, and others. 1999. G-protein-coupled receptors act via protein kinase C and Src to regulate NMDA receptors. Nat Neurosci 2:331-8.
45. Macrae AD, Premont RT, Jaber M, Peterson AS, Lefkowitz RJ. 1996. Cloning, characterization, and chromosomal localization of rec1.3, a member of the G-protein-coupled receptor family highly expressed in brain. Brain Res Mol Brain Res 42:245-54.
46. Manning TJ Jr, Rosenfeld SS, Sontheimer H. 1998. Lysophosphatidic acid stimulates actomyosin contraction in astrocytes. J Neurosci Res 53:343-52.
47. Manning TJ Jr, Sontheimer H. 1997. Bovine serum albumin and lysophosphatidic acid stimulate calcium mobilization and reversal of cAMP-induced stellation in rat spinal cord astrocytes. Glia 20:163-72.
48. McConnell SK. 1995. Constructing the cerebral cortex: Neurogenesis and fate determination. Neuron 15:761-8.
49. Moller T, Contos JJ, Musante DB, Chun J, Ransom BR. 2001. Expression and function of lysophosphatidic acid receptors in cultured rodent microglial cells. J Biol Chem 276:25946-52.
50. Moller T, Musante DB, Ransom BR. 1999. Lysophosphatidic acid-induced calcium signals in cultured rat oligodendrocytes. Neuroreport 10:2929-32.
51. Moolenaar WH. 1995. Lysophosphatidic acid signalling. Curr Opin Cell Biol 7:203-10.
52. Moolenaar WH, Kranenburg O, Postma FR, Zondag GC. 1997. Lysophosphatidic acid: G-protein signalling and cellular responses. Curr Opin Cell Biol 9:168-73.
53. Pages C, Simon MF, Valet P, Saulnier-Blache JS. 2001. Lysophosphatidic acid synthesis and release. Prostaglandins Other Lipid Mediat 64:1-10.
54. Pebay A, Torrens Y, Toutant M, Cordier J, Glowinski J, Tence M. 1999. Pleiotropic effects of lysophosphatidic acid on striatal astrocytes. Glia 28:25-33.
55. Ramakers GJ, Moolenaar WH. 1998. Regulation of astrocyte morphology by RhoA and lysophosphatidic acid. Exp Cell Res 245:252-62.
56. Renback K, Inoue M, Ueda H. 1999. Lysophosphatidic acid-induced, pertussis toxin-sensitive nociception through a substance P release from peripheral nerve endings in mice. Neurosci Lett 270:59-61.
57. Renback K, Inoue M, Yoshida A, Nyberg F, Ueda H. 2000. Vzg-1/lysophosphatidic acid-receptor involved in peripheral pain transmission. Brain Res Mol Brain Res 75:350-4.
58. Ridley AJ, Hall A. 1992. The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell 70:389-99.
59. Saito S. 1997. Effects of lysophosphatidic acid on primary cultured chick neurons. Neurosci Lett 229:73-6.
60. Scheetz AJ, Constantine-Paton M. 1994. Modulation of NMDA receptor function: Implications for vertebrate neural development. FASEB J 8:745-52.
61. Schmidt A, Wolde M, Thiele C, Fest W, Kratzin H, Podtelejnikov AV, and others. 1999. Endophilin I mediates synaptic vesicle formation by transfer of arachidonate to lysophosphatidic acid. Nature 401:133-41.
62. Sirlin JL. 1956. Vacillans, a neurological mutant in the house mouse linked to brown. J Genet 54:42-8.
63. Smith JL, Schoenwolf GC, Quan J. 1994. Quantitative analyses of neuroepithelial cell shapes during bending of the mouse neural plate. J Comp Neurol 342:144-51.
64. Sugiura T, Nakane S, Kishimoto S, Waku K, Yoshioka Y, Tokumura A, and others. 1999. Occurrence of lysophosphatidic acid and its alkyl ether-linked analog in rat brain and comparison of their biological activities toward cultured neural cells. Biochim Biophys Acta 1440:194-204.
65. Suidan H, Nobes C, Hall A, Monard D. 1997. Astrocyte spreading in response to thrombin and lysophosphatidic acid is dependent on the Rho GTPase. Glia 21:244-52.
66. Tabuchi S, Kume K, Aihara M, Shimizu T. 2000. Expression of lysophosphatidic acid receptor in rat astrocytes: Mitogenic effect and expression of neurotrophic genes. Neurochem Res 25:573-82.
67. Thomson FJ, Clark MA. 1995. Purification of a phosphatidic-acid-hydrolysing phospholipase A2 from rat brain. Biochem J 306:305-9.
68. Thoreson WB, Chacko DM. 1997. Lysophosphatidic acid stimulates two ion currents in cultured human retinal pigment epithelial cells. Exp Eye Res 65:7-14.
69. Thoreson WB, Khandalavala BN, Manahan RG, Polyak IA, Liu JL, Chacko DM. 1997. Lysophosphatidic acid stimulates proliferation of human retinal pigment epithelial cells. Curr Eye Res 16:698-702.
70. Tigyi G, Hong L, Yakubu M, Parfenova H, Shibata M, Leffler CW. 1995. Lysophosphatidic acid alters cerebrovascular reactivity in piglets. Am J Physiol 268:H2048-55.
71. Tigyi G, Miledi R. 1992. Lysophosphatidates bound to serum albumin activate membrane currents in Xenopus oocytes and neurite retraction in PC12 pheochromocytoma cells. J Biol Chem 267:21360-7.
72. 2-adrenergic receptor-mediated release of lysophosphatidic acid by adipocytes. A paracrine signal for preadipocyte growth. J Clin Invest 101:1431-8.
73. van Corven EJ, Groenink A, Jalink K, Eichholtz T, Moolenaar WH. 1989. Lysophosphatidate-induced cell proliferation: Identification and dissection of signaling pathways mediated by G proteins. Cell 59:45-54.
74. Vemuri GS, McMorris FA. 1996. Oligodendrocytes and their precursors require phosphatidylinositol 3-kinase signaling for survival. Development 122:2529-37.
75. Vogt W. 1963. Pharmacologically active acidic phospholipids and glycolipids. Biochem Pharmacol 12:415-20.
76. Wang YT, Salter MW. 1994. Regulation of NMDA receptors by tyrosine kinases and phosphatases. Nature 369:233-5.
77. Weiner JA, Chun J. 1999. Schwann cell survival mediated by the signaling phospholipid lysophosphatidic acid. Proc Natl Acad Sci U S A 96:5233-8.
78. Weiner JA, Fukushima N, Contos JJA, Scherer SS, Chun J. 2001. Regulation of Schwann cell morphology and adhesion by receptor-mediated lysophosphatidic acid signaling. J Neurosci 21:7069-78.
79. A/edg-2 is expressed by mature oligodendrocytes during myelination in the postnatal murine brain. J Comp Neurol 398:587-98.
80. Ye X, Ishii I, Kingsbury MA, Chun J. Lysophosphatidic acid as a novel cell survival factor. Biochem Biophys Acta, in press.
81. 2+ mobilization in the neural retina of chick embryo. J Neurobiol 41:495-504.