Astrocyte spreading in response to thrombin and lysophosphatidic acid is dependent on the Rho GTPase

GLIA

Volumn 21, Issue 2, 1997, Pages 244-252

  Suidan, Hana S ^a   Nobes, Catherine D ^b   Hall, Alan ^b   Monard, Denis ^a  

^a FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH   (Switzerland)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Actin; Astrocyte morphology; Plasticity; Rac; Thrombin receptor

Indexed keywords

GUANOSINE TRIPHOSPHATASE; LYSOPHOSPHOLIPID; PHALLOIDIN; THROMBIN; VINCULIN;

ARTICLE; ASTROCYTE; CELL ADHESION; CELL CULTURE; CELL DIVISION; DRUG EFFECT; ENZYMOLOGY; HUMAN; METABOLISM; MICROINJECTION; MICROSCOPY; PHYSIOLOGY;

ASTROCYTES; CELL ADHESION; CELL DIVISION; CELLS, CULTURED; GTP PHOSPHOHYDROLASES; HUMANS; LYSOPHOSPHOLIPIDS; MICROINJECTIONS; MICROSCOPY, VIDEO; PHALLOIDINE; THROMBIN; VINCULIN;

EID: 0031260271     PISSN: 08941491     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-1136(199710)21:2<244::AID-GLIA7>3.0.CO;2-6     Document Type: Article

References (55)

1. Aktories, K., Braun, U., Rosener, S., Just, I., and Hall, A. (1989) The rho gene product expressed in E. coli is a substrate of botulinum ADP-ribosyltransferase C3. Biochem. Biophys. Res. Commun., 158: 209-213.
2. Aldskogius, H. and Svensson, M. (1993) Neuronal and glial cell responses to axon injury. Adv. Struct. Biol., 2:191-223.
3. Beecher, K.L., Andersen, T.T., Fenton II, J.W., and Festoff, B.W. (1994) Thrombin receptor peptides induce shape change in neonatal murine astrocytes in culture. J. Neurosci. Res., 37:108-115.
4. Cavanaugh, K.P., Gurwitz, D., Cunningham, D.D., and Bradshaw, R.A. (1990) Reciprocal modulation of astrocyte stellation by thrombin and protease nexin-1. J. Neurochem., 54:1735-1743.
5. Crago, A.M., Wu, K.F., Hoffman, M., and Church, F.C. (1995) Monocyte chemoattractant activity of Ser(195)-Ala active site mutant recombinant α-thrombin. Exp. Cell Res., 219:650-656.
6. Dawes, K.E., Gray, A.J., and Laurent, G.J. (1993) Thrombin stimulates fibroblast chemotaxis and replication. Eur. J Cell Biol., 61:126-130.
7. Feig, L.A. and Cooper, G.M. (1988) Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP. Mol. Cell. Biol., 8:3235-3243.
8. Garrett, M.D., Self, A.J., van Oers, C., and Hall, A. (1989) Identification of distinct cytoplasmic targets for ras/R-ras and rho regulatory proteins. J. Biol. Chem., 264:10-13.
9. Garrett, M.D., Major, G.N., Totty, N., and Hall, A. (1991) Purification and N-terminal sequence of the p21rho GTPase-activating protein rho GAP. Biochem. J., 276:833-836.
10. Grabham, P. and Cunningham, D.D. (1995) Thrombin receptor activation stimulates astrocyte proliferation and reversal of stellation by distinct pathways: Involvement of tyrosine phosphorylation. J. Neurochem., 64:583-591.
11. Hall, A. (1994) Small GTP-binding proteins and the regulation of the actin cytoskeleton. Annu Rev. Cell Biol., 10:31-54.
12. Hatton, G.I., Perlmutter, L.S., Salm, A.K., and Tweedle, C.D. (1984) Dynamic neuronal-glial interactions in hypothalamus and pituitary: implications for control of hormone synthesis and release. Peptides, 5:121-138.
13. Hecht, J.H., Weiner, J.A., Post, S.R., and Chun, J. (1996) Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex. J. Cell. Biol., 135:1071-1083.
14. Jalink, K. and Moolenaar, W.H. (1992) Thrombin receptor activation causes rapid neural cell rounding and neurite retraction independent of classic second messengers. J. Cell Biol., 118:411-419.
15. Jalink, K., Eichholtz,T., Postma, F.R., van Corven, E.J., and Moolenaar, W.H. (1993a) Lysophosphatidic acid induces neuronal shape changes via a novel receptor-mediated signaling pathway: Similarity to thrombin action. Cell Growth Differ., 4:247-255.
16. Jalink, K., Moolenaar, W.H., and van Duijn, B. (1993b) Lysophosphatidic acid is a chemoattractant for Dictyostelium discoideum amoebae. Proc. Natl. Acad. Sci. (U.S.A.), 90:1857-1861.
17. Jalink, K., van Corven, E.J., Hengeveld, T., Morii, N., Narumiya. S., and Moolenaar, W.H. (1994) Inhibition of lysophosphatidate- and thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein Rho. J. Cell Biol., 126:801-810.
18. Jenkins, A.L., Howells, G.L., Scott, E., Lebonniec, B.F., Curtis, M.A., and Stone, S.R. (1995) The response to thrombin of human neutrophils: Evidence for two novel receptors. J. Cell Sci., 108:3059-3066.
19. Jockusch, B.M., Bubeck, P., Giehl, K., Kroemker, M., Moschner, J., Rothkegel, M., Rudiger, M., Schluter, K., Stanke, G., and Winkler, J. (1995) The molecular architecture of focal adhesions. Annu. Rev. Cell Dev. Biol., 11:379-416.
20. Koschel, K. and Tas, P.W.L. (1993) Lysophosphatidic acid reverts the β-adrenergic agonist-induced morphological response in C6 rat glioma cells. Exp. Cell Res., 206:162-166.
21. Lazar, P., Reddington, M., Streit, W., Raivich, G., and Kreutzberg, G.W. (1991) The action of calcitonin gene-related peptide on astrocyte morphology and cyclic AMP accumulation in astrocyte cultures from neonatal rat brain. Neurosci. Lett., 130:99-102.
22. Lim, R., Mitsunobu, K., and Li, W.K.P. (1973) Maturation-stimulating effect of brain extract and dibutyryl cyclic AMP on dissociated embryonic brain cells in culture. Exp. Eye Res., 79:243-246.
23. Luo, L., Hensch, T.K., Ackerman, L., Barbel, S., Jan, L.Y., and Jan, Y.N. (1996) Differential effects of the Rac GTPase on Purkinje cell axons and dendritic trunks and spines. Nature, 379:837-840.
24. Mackay, D.J., Nobes, C.D., and Hall, A. (1995) The Rho's progress: A potential role during neuritogenesis for the Rho family of GTPases. Trends Neurosci., 18:496-501.
25. Mazzoni, I.E. and Kenigsberg, R.L. (1991) Thrombin indirectly affects cholinergic cell expression in primary septal cell cultures in a manner distinct from nerve growth factor. Neuroscience, 45:195-204.
26. Moonen, G., Cam, Y., Sensenbrenner, M., and Mandel, P. (1975) Variability of the effects of serum-free medium, dibutyryl-cyclic AMP or theophylline on the morphology of cultured new-born rat astroblasts. Cell Tissue Res., 163:365-372.
27. Mucke, L. and Eddleston, M. (1993) Astrocytes in infectious and immune-mediated diseases of the central nervous system. FASEB J., 7:1226-1232.
28. Nedergaard, M. (1994) Direct signaling from astrocytes to neurons in cultures of mammalian brain cells. Science, 263:1768-1771.
29. Nelson, R.B. and Siman, R. (1990) Thrombin and its inhibitors regulate morphological and biochemical differentiation of astrocytes in vitro. Brain Res. Dev. Brain Res., 54:93-104.
30. Neveu, I., Jehan, F., Jandrot-Perrus, M., Wion, D., and Brachet, P. (1993) Enhancement of the synthesis and secretion of nerve growth factor in primary cultures of glial cells by proteases: a possible involvement of thrombin. J. Neurochem., 60:858-867.
31. Niclou, S., Suidan, H.S., Brown-Luedi, M., and Monard, D. (1994) Expression of the thrombin receptor mRNA in rat brain. Cell. Mol. Biol., 40:421-428.
32. Nishiki, T., Narumiya, S., Morii, N., Yamamoto, M., Fujiwara, M., Kamata, Y., Sakaguchi, G., and Kozaki, S. (1990) ADP-ribosylation of the rho/rac proteins induces growth inhibition, neurite outgrowth and acetylcholine esterase in cultured PC-12 cells. Biochem. Biophys. Res. Commun., 167:265-272.
33. Nobes, C.D. and Hall, A. (1995) Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell, 81:53-62.
34. Noda-Heiny, H. and Sobel, B.E. (1995) Vascular smooth muscle cell migration mediated by thrombin and urokinase receptor. Amer. J. Physiol. Cell Physiol., 37:C1195-C1201.
35. Parpura, V., Basarsky, T.A., Liu, F., Jeftinija, K., Jeftinija, S., and Haydon, P.G. (1994) Glutamate-mediated astrocyte-neuron signaling. Nature, 369:744-747.
36. Paterson, H.F., Self, A.J., Garrett, M.D., Just, I., Aktories, K., and Hall, A. (1990) Microinjection of recombinant p21rho induces rapid changes in cell morphology. J. Cell Biol., 111:1001-1007.
37. Perraud, F., Besnard, F., Sensenbrenner, M., and Labourdette, G. (1987) Thrombin is a potent mitogen for rat astroblasts but not for oligodendroblasts and neuroblasts in primary culture. Int. J. Dev. Neurosci., 5:181-188.
38. Raff, M.C. (1989) Glial cell diversification in the rat optic nerve. Science, 243:1450-1455.
39. Raff, M.C., Abney, E.R., Cohen, J., Lindsay, R., and Noble, M. (1983) Two types of astrocytes in cultures of developing rat white matter: Differences in morphology, surface gangliosides, and growth characteristics. J. Neurosci., 3:1289-1300.
40. Ransom, B.R. and Orkand, R.K. (1996) Glial-neuronal interactions in non-synaptic areas of the brain: Studies in the optic nerve. Trends Neurosci., 19:352-358.
41. Ridley, A.J. and Hall, A. (1992) The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell, 70:389-399.
42. Ridley, A.J., Paterson, H.F., Johnston, C.L., Diekmann, D., and Hall, A. (1992) The small GTP-binding protein rac regulates growth factorinduced membrane ruffling. Cell, 70:401-410.
43. Salm, A.K., Smithson, K.G., and Hatton, G.I. (1985) Lactationassociated redistribution of the glial fibrillary acidic protein within the supraoptic nucleus. An immunocytochemical study. Cell Tissue Res., 242:9-15.
44. Sekine, A., Fujiwara, M., and Narumiya, S. (1989) Asparagine residue in the rho gene product is the modification site for botulinum ADP-ribosyltransferase. J. Biol. Chem., 264:8602-8605.
45. Shapiro, D.L. (1973) Morphological and biochemical alterations in foetal rat brain cells cultured in the presence of monobutyryl cyclic AMP. Nature, 241:203-204.
46. Suidan, H.S. and Monard, D. (1993) How does thrombin cause neurite retraction? In: Biology and Pathology of Astrocyte-Neuron Interactions. S. Fedoroff, B.H.J. Juurlink, and R. Doucette, eds. Plenum Press, New York, pp. 181-191.
47. Suidan, H.S., Stone, S.R., Hemmings, B.A., and Monrad, D. (1992) Thrombin causes neurite retraction in neuronal cells through activation of cell surface receptors. Neuron, 8:363-375.
48. Suidan, H.S., Bouvier, J., Schaerer, E., Stone, S.R., Monard, D., and Tschopp, J. (1994) Granzyme A released upon stimulation of cytotoxic T lymphocytes activates the thrombin receptor on neuronal cells and astrocytes. Proc. Natl. Acad. Sci. USA, 91:8112-8116.
49. Suidan, H.S., Niclou, S., and Monard, D. (1996) The thrombin receptor in the nervous system. Sem. Thromb. Hemost., 22:125-134.
50. Tas, P.W. and Koschel, K. (1990) Thrombin reverts the β-adrenergic agonist-induced morphological response in rat glioma C6 cells. Exp. Cell Res., 189:22-27.
51. Theodosis, D.T. and MacVicar, B. (1996) Neurone-glia interactions in the hypothalamus and pituitary. Trends Neurosci., 19:363-367.
52. Thomson, F.J., Perkins, L., Ahern, D., and Clark, M. (1994) Identification and characterization of a lysophosphatidic acid receptor. Mol. Pharmacol., 45:718-723.
53. Tigyi, G., Fischer, D.J., Sebok, A., Yang, C., Dyer, D.L., and Miledi, R. (1996) Lysophosphatidic acid-induced neurite retraction in PC 12 cells: Control by phosphoinositide-Ca2+ signaling and Rho. J. Neurochem., 66:537-548.
54. Vaughan, P.J., Pike, C.J., Cotman, C.W., and Cunningham, D.D. (1995) Thrombin receptor activation protects neurons and astrocytes from cell death produced by environmental insults. J. Neurosci., 15:5389-5401.
55. Weinstein, J.R., Gold, S.J., Cunningham, D.D., and Gall, C.M. (1995) Cellular localization of thrombin receptor mRNA in rat brain: Expression by mesencephalic dopaminergic neurons and codistribution with prothrombin mRNA. J. Neurosci., 15:2906-2919.