Lysophosphatidic acid stimulates proliferation of human retinal pigment epithelial cells

Current Eye Research

Volumn 16, Issue 7, 1997, Pages 698-702

  Thoreson, Wallace B ^a   Khandalavala, Birgit N ^a   Manahan, Robert G ^a   Polyak, Inga A ^a   Liu, Janette L ^a   Chacko, David M ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Cell culture; Cell migration; Cell proliferation; Human; Lysophosphatidic acid; Proliferative vitreoretinopathy; Retinal pigment epithelium (RPE)

Indexed keywords

CELL RECEPTOR; CHOLERA TOXIN; COLLAGEN GEL; GUANINE NUCLEOTIDE BINDING PROTEIN; LYSOPHOSPHATIDIC ACID; LYSOPHOSPHATIDYLCHOLINE; PERTUSSIS TOXIN;

ADULT; AGED; ARTICLE; CELL COUNT; CELL CULTURE; CELL MIGRATION; CELL PROLIFERATION; CHEMOTAXIS; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; HUMAN; HUMAN CELL; MALE; PATHOGENESIS; PIGMENT EPITHELIUM; PRIORITY JOURNAL; THROMBOCYTE ACTIVATION; VITREORETINOPATHY;

ADULT; AGED; CELL DIVISION; CELL MOVEMENT; CELLS, CULTURED; CHOLERA TOXIN; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; LYSOPHOSPHATIDYLCHOLINES; LYSOPHOSPHOLIPIDS; MALE; MIDDLE AGED; PIGMENT EPITHELIUM OF EYE; VIRULENCE FACTORS, BORDETELLA;

EID: 0030797918     PISSN: 02713683     EISSN: None     Source Type: Journal    
DOI: 10.1076/ceyr.16.7.698.5056     Document Type: Article

References (17)

1. Glaser, B. M. and Lemor, M. (1994) Pathobiology of proliferative vitreoretinopathy. In Retina, vol. 3, Surgical Retina (Ed. Glaser, B. M.). Pp. 2249-2263. Mosby, St. Louis, Mo.
2. Moolenaar, W. H. (1995) Lysophosphatidic acid signalling. Curr. Opin. Cell Biol. 7, 203-210.
3. Fukami, K. and Takenawa, T. (1992) Phosphatidic acid that accumulates in platelet-derived growth factor-stimulated Balb/c 3T3 cells is a potential mitogenic signal. J. Biol. Chem. 267, 10988-10993.
4. Thoreson, W. B., Liu, J. L., Manahan, R. G. and Chacko, D. M. (1995) Lysophosphatidic acid stimulates cell proliferation and cation currents in cultured human retinal pigment epithelial cells. (Abstract). Invest. Ophthalmol. Vis. Sci. 36 (Suppl.), 275.
5. Chacko, D. M., Khandalavala, B., Manahan, R. G., Polyak, I. A. and Thoreson, W. B. (1996) A comparison of effects of lysophosphatidic acid on cell proliferation, chemotaxis, and cation currents in cultured human RPE cells. (Abstract). Invest. Ophthalmol. Vis. Sci. 37(Suppl.), 388.
6. Campochiaro, P. A., Jerdan, J. A. and Glaser, B. M. (1984) Serum contains chemoattractants for human retinal pigment epithelial cells. Arch. Ophthalmol. 102, 1830-1833.
7. Durieux, M. E. and Lynch, K. R. (1993) Signalling properties of lysophosphatidic acid. Trends Pharm. Sci. 14, 249-253.
8. Thoreson, W. B. and Chacko, D. M. (1997) Lysophosphatidic acid stimulates two ion currents in cultured human retinal pigment epithelial cells. Exp. Eye Res. In Press.
9. Van Corven, E. J., Van Rijswijk, A., Jalink, K., Van der Bend, R. L, Van Blitterswijk, W. J. and Moolenaar, W. H. (1992) Mitogenic action of lysophosphatidic acid and phosphatidic acid on fibroblasts: dependence on acyl-chain length and inhibition by suramin. Biochem. J. 281, 163-169.
10. Defoe, D. M. and Uebersax, E. (1996) A serum phospholipid is a potent rat RPE cell survival factor in vitro. (Abstract). Invest. Ophthalmol. Vis. Sci. 37 (Suppl.), 389.
11. Eichholtz, T., Jalink, K., Fahrenfort, I. and Moolenaar, W. H. (1993) The bioactive phospholipid lysophosphatidic acid is released from activated platelets. Biochem. J. 291, 677-680.
12. Tokumura, A., Iimori, M., Nishioka, Y., Kitahara, M., Sakashita, M. and Tanaka, S. (1994) Lysophosphatidic acids induce proliferation of cultured vascular smooth muscle cells from rat aorta. Am. J. Physiol. 264, C204-C210.
13. Wiedemann, P. (1992) Growth factors in retinal diseases: proliferative vitreoretinopathy, proliferative diabetic retinopathy, and retinal degeneration. Surv. Ophthalmol. 36, 373-384.
14. Leschey, K. H., Hackett, S. F., Singer, J. H. and Campochiaro, P. A. (1990) Growth factor responsiveness of human retinal pigment epithelial cells. Invest. Ophthalmol. Vis. Sci. 31, 839-846.
15. Campochiaro, P. A. (1993) Cytokine production by retinal pigmented epithelial cells. Int. Rev. Cytol. 146, 75-82.
16. Gierschik, P. (1992) ADP-ribosylation of signal-transducing guanine nucleotide-binding proteins by pertussis toxin. Curr. Topics Microbiol. Immunol. 175, 69-96.
17. Hepler, J. R. and Gilman, A. G. (1992) G proteins. Trends Biochem. Sci. 17, 383-387.