Evidence for purifying selection acting on silent sites in BRCA1

Trends in Genetics

Volumn 17, Issue 2, 2001, Pages 62-65

  Hurst, Laurence D ^a   Pál, Csaba ^a  

^a University of Bath   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CODING; DOG; EVOLUTION; GENE MUTATION; GENETIC SELECTION; HUMAN; MOUSE; NONHUMAN; PHYLOGENY; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; SHORT SURVEY; SILENT GENE; SPECIES DIFFERENCE; STATISTICAL ANALYSIS; TECHNIQUE; TUMOR SUPPRESSOR GENE;

ANIMALS; EVOLUTION, MOLECULAR; GENE SILENCING; GENES, BRCA1; HUMANS; SELECTION (GENETICS);

MAMMALIA;

EID: 0035252561     PISSN: 01689525     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-9525(00)02173-9     Document Type: Short Survey

References (23)

1. Circumsporozoite protein genes of malaria parasites (Plasmodium spp.): evidence for positive selection on immunogenic regions
2. Positive Darwinian selection promotes charge profile diversity in the antigen binding cleft of class I MHC molecules
3. Adaptive evolution of the tumour suppressor BRCA1 in humans and chimpanzees
4. Likelihood ratio tests for detecting positive selection and application to primate lysozyme evolution
5. Molecular evidence for natural-selection
6. DNA-sequence evolution: the sounds of silence
7. An analysis of codon usage in mammals: selection or mutation bias?
8. The causes of synonymous rate variation in the rodent genome: can substitution rates be used to estimate the sex bias in mutation rate?
9. Evidence of selection on silent site base composition in mammals: Potential implications for the evolution of isochores and junk DNA
10. Selection on silent sites in the rodent H3 histone gene family
11. Nonrandom spatial distribution of synonymous substitutions in the GP63 gene from Leishmania
12. Genealogical evidence for positive selection in the nef gene of HIV-1
13. HOVERGEN - a database of homologous vertebrate genes
14. The CLUSTAL
15. Unbiased estimation of the rates of synonymous and nonsynonymous substitution
16. Evolution of the Zfx and Zfy genes: rates and interdependence between the genes
17. Codon-substitution models for heterogeneous selection pressure at amino acid sites
18. Codon-based model of nucleotide substitution for protein-coding DNA sequences
19. The evolution of functionally novel proteins after gene duplication
20. Isochores and the evolutionary genomics of vertebrates
21. Synonymous and nonsynonymous substitutions in mammalian genes: Intragenic correlations
22. The effective number of codons used in a gene
23. Silent sites in Drosophila genes are not neutral - evidence of selection among synonymous codons