Synonymous codon bias is not caused by mutation bias in g+c-rich genes in humans

Molecular Biology and Evolution

Volumn 18, Issue 6, 2001, Pages 982-986

  Smith, Nick G C ^a   Eyre Walker, Adam ^a  

^a UNIVERSITY OF SUSSEX   (United Kingdom)

Author keywords

Human; Mutation bias; Synonymous codons

Indexed keywords

DNA;

ARTICLE; CODON; GENE CONVERSION; GENOME; HUMAN; MUTATION; NATURAL SELECTION; SINGLE NUCLEOTIDE POLYMORPHISM;

MAMMALIA;

EID: 0034993993     PISSN: 07374038     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.molbev.a003899     Document Type: Article

References (25)

1. The human genome: Organization and evolutionary history
2. The mosaic genome of warm blooded vertebrates
3. Neighbouring base effects on substitution rates in pseudogenes
4. The selection-mutation-drift theory of synonymous codon usage
5. Characterization of single-nucleotide polymorphisms in coding regions of human genes
6. Human coding and noncoding DNA: Compositional correlations
7. Expression pattern and, surprisingly, gene length shape codon usage in Caenorhabditis, Drosophila, and Arabidopsis
8. Differentiating selection and mutation bias
9. Problems with parsimony in sequences of biased base composition
10. Evidence of selection on silent site base composition in mammals: Potential implications for the evolution of isochores and junk DNA
11. High genomic deleterious mutation rates in hominids
12. Correlation between molecular clock ticking, codon usage, fidelity of DNA repair, chromosome banding and chromtin compactness in germline cells
13. Codon usage in bacteria: Correlation with gene expressivity
14. Determination of ancestral alleles for human single-nucleotide polymorphisms using high-density oligonucleotide arrays
15. Codon usage and tRNA content in unicellular and multicellular organisms
16. DNA methylation and chromatin structure
17. Low nucleotide diversity in man
18. An evaluation of the molecular clock hypothesis using mammalian DNA sequences
19. Evolution of a finite population under gene conversion
20. Population genetics of polymorphism and divergence
21. On the genetic basis of variation and heterogeneity of DNA base composition
22. Directional mutation pressure and neutral molecular evolution
23. The expected equilibrium of the CpG dinucleotide in vertebrate genomes under a mutation model
24. Mutation rates differ among regions of the mammalian genome