Effects of acute ethanol exposure on cellular immune responses in a murine model of thermal injury

Journal of Leukocyte Biology

Volumn 62, Issue 6, 1997, Pages 733-740

  Faunce, Douglas E ^a,b   Gregory, Meredith S ^a,b   Kovacs, Elizabeth J ^a,b,c  

^a Dept Cell Biol Neurbio Anat   (United States)

^b Burn and Shock Trauma Institute   (United States)

^c LOYOLA UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Ethanol; Immune dysfunction

Indexed keywords

ALCOHOL; CONCANAVALIN A; MONOCLONAL ANTIBODY CD3;

ALCOHOL BLOOD LEVEL; ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL INFECTION; CELL PROLIFERATION; CELLULAR IMMUNITY; CONTROLLED STUDY; DELAYED HYPERSENSITIVITY; MACROPHAGE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; THERMAL INJURY;

EID: 0031458718     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1002/jlb.62.6.733     Document Type: Article

References (39)

1. Smith, G. S., Kraus, J. F. (1988) Alcohol and residential, recreational, and occupational injuries. Annu. Rev. Pub. Health 9, 99-121.
2. Thal, E. R., Bost, R. O., Anderson, R. J. (1985) Effects of alcohol and other drugs on traumatized patients. Arch. Surg. 120, 708-712.
3. Howland, J., Hingson, R. (1987) Alcohol as a risk factor for injuries or death due to fires and burns. Public Health Rep. 102, 475-483.
4. McGill, V., Kowal-Vern, A., Fisher, S. G., Kahn, S., Gamelli, R. L. (1995) The impact of substance use on mortality and morbidity from thermal injury. J. Trauma 38, 931-934.
5. Brezel, B. S., Kassenbrock, J. M., Stein, J. M. (1988) Burns in substance abusers and in neurologically and mentally impaired patients. J. Burn Care Rehab. 9, 169-171.
6. Jerrels, T. R., Saad, A. J., Domiati-Saad, R. (1992) Effects of ethanol on parameters of cellular immunity and host defense mechanisms to infectious agents. Alcohol 9, 445-463.
7. Winkelstein, A. (1984) What are the immunological alterations induced by burn injury? J. Trauma 72 (Suppl.), 72-83.
8. Alexander, J. W. (1990) Mechanisms of immunologic suppression in burn injury. J. Trauma 30 (Suppl.). S70-S75.
9. Miller, C. L., Baker, C. C. (1979) Changes in lymphocyte activity after thermal injury. J. Clin. Invest. 63, 202-210.
10. Napolitano, L. M., Koruda, M. J., Zimmerman, K., McCowan, K., Chang, J., Meyer, A. A. (1995) Chronic ethanol intake and burn injury: Evidence for synergistic alteration in gut and immune integrity. J. Trauma 38, 198-207.
11. Chadha, K. C., Stadler, I., Albini, B., Nakeeb, S. M., Thacore, H. R. (1991) Effect of alcohol on spleen cells and their functions in C57BL/6 mice. Alcohol 8, 481-485.
12. Kawakami, M., Switzer, B. R., Herzog, S. R., Meyer, A. A. (1991) Immune suppression after acute ethanol ingestion and thermal injury. J. Surg. Res. 51, 210-215.
13. Walker, H. L., Mason, A. D. (1968) A standard animal burn. J. Trauma 8, 1049-1051.
14. Spector, W. S. (1956) Handbook of Biological Data. Philadelphia, PA: Saunders, 157.
15. Gamelli, R. L., He, L. K., Liu, H. (1995) Recombinant human granulocyte colony-stimulating factor treatment improves macrophage suppression of granulocyte and morphage growth after burn and burn wound infection. J. Trauma 39, 1141-1146.
16. Gaspari, A. A., Katz, S. I. (1994) Contact hypersensitivity. In Current Protocols in Immunology Vol. I, New York: Wiley, 4.2.1-4.2.5.
17. Hansbrough, J., Peterson, V., Zapata-Sirvent, R., Claman, H. N. (1984) Postburn immunosuppression in an animal model. II. Restoration of cell mediated immunity by immunomodulating drugs. Surgery 95, 290-296.
18. Gamelli, R. L., Hebert, J. C., Foster, R. S. (1985) Effect of burn injury on granulocyte and macrophage production. J. Trauma 24, 615-619.
19. Nelson, S., Bagby, G., Andersen, J., Nakamura, C., Shellito, J., Summer, W. (1991) The effects of ethanol, tumor necrosis factor, and granulocyte colony-stimulating factor on lung antibacterial defenses. Adv. Exp. Med. Biol. 228, 245-253.
20. Guyre, P. M., Goulding, N. (1993) Glucocorticoids, lipocortins and the immune response. Curr. Op. Immunol. 5, 108-113.
21. Waage, A., Lupphaug, G., Shalaby, R. (1990) Glucocorticoids inhibit the production of IL-6 from monocytes, endothelial cells and fibroblasts. Eur. J. Immunol. 20, 2439-2443.
22. Guyre, P. M., Girard, M. T., Morganelli, P. M., Manganiello, P. C. (1988) Glucocortcoid effects on the production and actions of immune cytokines. J. Steroid Biochem. 30, 89-93.
23. Jonat, C., Rahmsdorff, H. J., Park, K. K., Cato, A. C., Gebel, S., Ponta, H., Herrlich, P. (1990) Anti-tumor promotion and antiinflammation: down regulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone. Cell 62, 1189-1204.
24. Heinrich, P., Ponta, H. (1994) Mutual cross-modulation of steroid/retinoic acid receptor and AP-1 transcription factor activities. Trends Endocrinol. Metab. 5, 341-345.
25. Karin, M., Yang-Yen, H. E., Chambard, J. C., Deng, T., Saatcioglu, E. (1993) Various modes of gene regulation by nuclear receptor for steroid and thyroid hormones. Eur. J. Pharmacol. 45, S9-S15.
26. Mandrup-Poulsen, T., Wogensen, L. D., Jensen, M., Svensson, P., Nilsson, P., Emdal, T., Molvig, J., Dinarello, C. A., Nerup, J. (1995) Circulating interleukin-1 receptor antagonist concentrations are increased in adult patients with thermal injury. Crit. Care Med. 23, 26-33.
27. Vicente-Gutierrez, M. M., Ruiz, D., Extremera, B. G., Bermudez, J. M., Gutierrez Gea, F. (1991) Low serum levels of α-interferon, γ-interferon, and interleukin-2 in alcoholic cirrhosis. Digest. Dis. Sci. 36, 1209-1212.
28. 2 and cAMP. J. Immunol. 141, 587-591.
29. Wood, J. J., Rodrick, M. L., O'Mahoney, B. J., Palder, S. B., Sarporoschetz, I., D'Eon, P., Mannick, J. A. (1984) Inadequate interleukin-2 production: a fundamental immunological deficiency in patients with major burns. Ann. Surg. 200, 311-320.
30. Wood, J. J., Grbic, J. T., Rodrick, M. L., Jordan, A., Mannick, J. A. (1987) Suppression of interleukin-2 production in an animal model of thermal injury is related to prostaglandin synthesis. Arch. Surg. 122, 179-184.
31. Faist, E., Mewes, A., Stradder, T., Alkan, S., Baker, C., Erterl, W., Heberrer, G. (1988) Alterations of monocyte function following major trauma. Arch. Surg. 123, 287-292.
32. Martinez, F., Abril, E. R., Earnest, D. L., Watson, R. R. (1992) Ethanol and cytokine secretion. Alcohol 9, 445-458.
33. Bermudez, L. E., Wu, M., Martinelli, J., Young, L. S. (1991) Ethanol affects release of TNF and GM-CSF and membrane expression of TNF receptors by human macrophages. Lymphokine Cytokine Res. 10, 413-419.
34. Szabo, G., Mandrekar, P., Verma, B., Isaac, A., Catalano, D. (1994) Acute ethanol consumption synergizes with trauma to increase monocytes tumor necrosis factor alpha production late post injury. J. Clin. Immunol. 14, 340-352.
35. 2 production by ethanol in human monocytes. J. Leukoc. Biol. 52, 602-610.
36. Glenn, K. C., Ross, R. (1981) Human monocyte-derived growth factor(s) for mesenchymal cells. Cell 25, 603-615.
37. O'Sullivan, S. T., Lederer, J. A., Horgan, A. F., Chin, D. H., Mannick, J. A., Rodrick, M. L. (1995) Major injury leads to predominance of the T helper-2 lymphocyte phenotype and diminished interleukin-12 production associated with decreased resistance to infection. Ann. Surg. 222, 482-490.
38. 2 by isolated enterocytes and gut macrophages: Effect of lipopolysaccharide and thermal injury. J. Burn Care Rehab. 15, 470-477.
39. Wu, J. Z., Ogle, C. K., Mao, J. X., Szczur, K., Fischer, J. E., Ogle, J. D. (1995) The increased potential for the production of inflammatory cytokines by Kupffer cells and splenic macrophages eight days after thermal injury. Inflammation 19, 529-541.