Potential molecular targets of tea polyphenols in human tumor cells: Significance in cancer prevention

In Vivo

Volumn 16, Issue 6, 2002, Pages 397-403

  Kazi, Aslamuzzaman ^a,b   Smith, David M ^a,b   Daniel, Kenyon ^a,b   Zhong, Sherry ^a,b   Gupta, Puja ^a,b   Bosley, Marie E ^a,b   Dou, Q Ping ^a,b  

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

Cancer prevention; Polyphenols; Proteasome; Protein kinases; Tea

Indexed keywords

ANTINEOPLASTIC AGENT; ANTIOXIDANT; BLACK TEA EXTRACT; CATECHIN; DNA; EPICATECHIN; EPICATECHIN GALLATE; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIGALLOCATECHIN; EPIGALLOCATECHIN GALLATE; FLAVONOID; GREEN TEA EXTRACT; GROWTH FACTOR RECEPTOR; I KAPPA B; METALLOPROTEINASE; MITOGEN ACTIVATED PROTEIN KINASE; PLATELET DERIVED GROWTH FACTOR RECEPTOR; POLYPHENOL; PROTEASOME; PROTEIN KINASE; QUERCETIN; THEAFLAVIN; THEAFLAVIN 3,3' DIGALLATE; TRANSCRIPTION FACTOR; VASCULOTROPIN RECEPTOR; CYSTEINE PROTEINASE; DRUG DERIVATIVE; MULTIENZYME COMPLEX; PHENOL DERIVATIVE; PLANT EXTRACT; POLYMER;

ANGIOGENESIS; ANTIOXIDANT ACTIVITY; APOPTOSIS; BEVERAGE; CANCER; CANCER CELL; CANCER GROWTH; CANCER INHIBITION; CANCER PREVENTION; CANCER RISK; CANCER SURVIVAL; CELL PROLIFERATION; CELL TRANSFORMATION; DNA REPLICATION; DRUG EFFECT; ENZYME INHIBITION; GENOTOXICITY; HUMAN; HUMAN CELL; IN VIVO STUDY; MEDICAL RESEARCH; METASTASIS; MUTAGENESIS; NONHUMAN; REVIEW; TEA; ANIMAL; CHEMISTRY; CHEMOPROPHYLAXIS; DOSE RESPONSE; DRUG ANTAGONISM; ENZYMOLOGY; GENETICS; NEOPLASM;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; ANTIOXIDANTS; CATECHIN; CHEMOPREVENTION; CYSTEINE ENDOPEPTIDASES; DOSE-RESPONSE RELATIONSHIP, DRUG; FLAVONOIDS; HUMANS; METALLOENDOPEPTIDASES; MULTIENZYME COMPLEXES; NEOPLASMS; PHENOLS; PLANT EXTRACTS; POLYMERS; PROTEASOME ENDOPEPTIDASE COMPLEX; TEA;

EID: 0036861486     PISSN: 0258851X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (83)

1. Wang ZY, Huang MT, Ferraro T, Wong CQ, Lou YR, Reuhl K, Latropoulos M, Yang CS and Conney AH: Inhibitory effect of green tea in the drinking water on tumorigenesis by ultraviolet light and 12-O-tetradecanoylphorbol-13-acetate in the skin of SKH-1 mice. Cancer Res 52: 1162-1170, 1992.
2. Hara Y, Matsuzaki S and Nakamura K: Anti-tumor activity of tea catechins. J Japan Soc Nutr Food Sci 42: 39-45, 1989.
3. Liu JD, Chen SH, Lin CL, Tsai SH and Liang YC: Inhibition of melanoma growth and metastasis by combination with (-)-epigallocatechin-3-gallate and dacarbazine in mice. J Cell Biochem. 83: 631-42, 2001.
4. Kuroda Y and Hara Y: Antimutagenic and anticarcinogenic activity of tea polyphenols. Mutat Res 436: 69-97, 1999.
5. Jung YD and Ellis LM: Inhibition of tumour invasion and angiogenesis by epigallocatechin gallate (EGCG), a major component of green tea. Int J Exp Pathol 82: 309-16, 2001.
6. Cao Y and Cao R: Angiogenesis inhibited by drinking tea. Nature. 398; 381, 1999.
7. Goldbohm RA, Hertog MG, Brants HA Van Poppel G and Van Den Brandt PA: Consumption of black tea and cancer risk: A prospective cohot study. J Natl Cancer Inst 88: 93-100, 1996.
8. Blot WJ, Chow WH and McLaughlin JK: Tea and cancer: A review of the epidemiological evidence. Eur J Cancer Prev 5: 425-38, 1996.
9. Yang CS and Wang YZ: Tea and cancer. J Natl Cancer Inst 85: 1038-49, 1993.
10. Heilbrun LK, Nomura A and Stemmermann GN: Black tea consumption and cancer risk: A prospective study. Br J Cancer 54: 677-83, 1986.
11. Kinlen LJ, Willows AN, Goldblatt P and Yudkin J: Tea consumption and cancer. Br J Cancer 58: 397-401, 1988.
12. Inoue M, Tajima K, Mizutani M, Iwata H, Iwase T, Miura S, Hirose K, Hamajima N and Tominaga S: Regular consumption of green tea and the risk of breast cancer recurrence: Follow-up study from the Hospital-based Epidemiologic Research Program at Aichi Cancer Center (HERPACC), Japan. Cancer Lett 167: 175-82, 2001.
13. Muto S, Yokoi T, Gondo Y, Katsuki M, Shioyama Y, Fujita K and Kamataki T: Inhibition of benzo[a]pyrene-induced mutagenesis by (-)-epigallocatechin gallate in the lung of rpsL transgenic mice. Carcinogenesis 20: 421-4, 1999.
14. Okuda T, Mori K and Hayatsu H: Inhibitory effect of tannins on direct-acting mutagens. Chem Pharm Bull (Tokyo) 32: 3755-8, 1984.
15. Kuroda Y: Bio-antimutagenic activity of green tea catechins in cultured Chinese hamster V79 cells. Mutat Res 361: 179-8, 1996.
16. Sasaki YE, Yamada H, Shimoi K, Kator K and Kinae N: The clastogen-suppressing effects of green tea, Po-lei tea and Rooibos tea in CHO cells and mice. Mutat Res 286: 221-32, 1993.
17. Xu M, Bailey AC, Hernaez JF, Taoka CR, Schut HA and Dashwood RH: Protection by green tea, black tea, and indole-3-carbinol against 2-amino-3-methylimidazo[4,5-f]quinoline-induced DNA adducts and colonic aberrant crypts in the F344 rat. Carcinogenesis 17: 1429-34, 1996.
18. McCann J, Choi E, Yamasaki E and Ames BN: Detection of carcinogens as mutagens in the Salmonella/microsome test: Assay of 300 chemicals. Proc Natl Acad Sci USA 72: 5135-9, 1975.
19. Ames BN: Identifying environmental chemicals causing mutations and cancer. Science 204: 587-93, 1979.
20. Smith DM, Gao G, Zhang X, Wang G and Dou QP: Regulation of tumor cell apoptotic sensitivity during the cell cycle (Review). Int J Mol Med 6: 503-7, 2000.
21. Komatsu K, Tauchi H, Yano N, Endo S, Matsuura S and Shoki S: Inhibitory action of (-)-epigallocatechin gallate on radiation-induced mouse oncogenic transformation. Cancer Lett 112: 135-9, 1997.
22. Komatsu K, Kator K, Mitsuda Y, Mine M and Okumura Y: Inhibitory effects of Rooibos tea, Aspalathus linealis, on X-ray-induced C3H10T1/2 cell transformation. Cancer Lett 77: 33-8, 1994.
23. Terao J, Piskula M and Yao Q: Protective effect of epicatechin, epicatechin gallate, and quercetin on lipid peroxidation in phospholipid bilayers. Arch Biochem Biophys 308: 278-84, 1994.
24. Paggi MG, Baldi A, Bonetto F and Giordano A: Retinoblastoma protein family in cell cycle and cancer: A review. J Cell Biochem 62: 418-30: 1996.
25. Collins K, Jacks T and Pavletich NP: The cell cycle and cancer. Proc Natl Acad Sci USA 94: 2776-8, 1997.
26. Sherr CJ: Cancer cell cycles. Science 274: 1672-7, 1996.
27. Ahmad N, Cheng P and Mukhtar H: Cell cycle dysregulation by green tea polyphenol epigallocatechin-3-gallate. Biochem Biophys Res Commun. 275: 328-34, 2000.
28. Liang YC, Lin-Shiau SY, Chen CF and Lin JK: Inhibition of cyclin-dependent kinases 2 and 4 activities as well as induction of Cdk inhibitors p21 and p27 during growth arrest of human breast carcinoma cells by (-)-epigallocatechin-3-gallate. J Cell Biochem 75: 1-12, 1999.
29. Liberto M and Cobrinik D: Growth factor-dependent induction of p21(CIP1) by the green tea polyphenol, epigallocatechin gallate. Cancer Lett 154: 151-61, 2000.
30. Smith DM and Dou, QP: Green tea polyphenol epigallocatechin inhibits DNA replication and consequently induces leukemia cell apoptosis. Int J Mol Med 7: 645-52, 2001.
31. Ahmad N, Feyes DK, Nieminen AL, Agarwal R and Mukhtar H: Green tea constituent epigallocatechin-3-gallate and induction of apoptosis and cell cycle arrest in human carcinoma cells. J Natl Cancer Inst 89: 1881-6, 1997.
32. Jankun J, Selman SH, Swiercz R and Skrzypczak-Jankun E: Why drinking green tea could prevent cancer. Nature 387: 561, 1997.
33. Liao S, Umekita Y, Guo J, Kokontis JM and Hiipakka RA: Growth inhibition and regression of human prostate and breast tumors in athymic mice by tea epigallocatechin gallate. Cancer Lett 96: 239-43, 1995.
34. Gupta S, Ahmad N, Nieminen AL and Mukhtar H: Growth inhibition, cell-cycle dysregulation, and induction of apoptosis by green tea constituent (-)-epigallocatechin-3-gallate in androgen-sensitive and androgen-insensitive human prostate carcinoma cells. Toxicol Appl Pharmacol 164: 82-90, 2000.
35. Islam S, Islam N, Kermode T, Johnstone B, Mukhtar H, Moskowitz RW, Goldberg VM, Malemud CJ and Haqqi TM: Involvement of caspase-3 in epigallocatechin-3-gallate-mediated apoptosis of human chondrosarcoma cells. Biochem Biophys Res Commun 270: 793-7, 2000.
36. Ahmad N, Adhami VM, Gupta S, Cheng P and Mukhtar H: Role of the retinoblastoma (pRb)-E2F/DP pathway in cancer chemopreventive effects of green tea polyphenol epigallocatechin-3-gallate. Arch Biochem Biophys 398: 125-31, 2002.
37. Folkman J: Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med 1: 27-31, 1995.
38. Hanahan D and Folkman J: Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 86: 353-64, 1996.
39. Larcher F, Robles AI, Duran H, Murillas R, Quintanilla M, Cano A, Conti CJ and Jorcano JL: Up-regulation of vascular endothelial growth factor/vascular permeability factor in mouse skin carcinoma genesis correlates with malignant progression state and activated H-ras expression levels. Cancer Res 56: 5391-6, 1996.
40. Huang MT, Ho CT, Wang ZY, Ferraro T, Finnegan-Olive T, Lou YR, Mitchell JM, Laskin JD, Newmark H and Yang CS et al.: Inhibitory effect of topical application of a green tea polyphenol fraction on tumor initiation and promotion in mouse skin. Carcinogenesis 13: 947-54, 1992.
41. Khan SD, Katiyar SK, Agarwal R and Mukhtar H: Enhancement of antioxidant and phase II enzymes by oral feeding of green tea polyphenols in drinking water to SKH-1 hairless mice: Possible role in cancer chemoprevention. Cancer Res 52: 4050-2, 1992.
42. Lin JK, Liang YC and Lin-Shiau SY: Cancer chemoprevention by tea polyphenols through mitotic signal transduction blockade. Biochem Pharmacol 58: 911-5, 1999.
43. Lee MJ, Wang ZY, Li H, Chen L, Sun Y, Gobbo S, Balentine DA, and Yang CS: Analysis of plasma and urinary tea polyphenols in human subjects. Cancer Epidemiol Biomarkers Prev 4: 393-9, 1995.
44. Unno T, Kondo K, Itakura H and Takeo T: Analysis of (-)-epigallo-catechin gallate in human serum obtained after ingesting green tea. Biosci Biotechnol Biochem 60: 2066-8, 1996.
45. Nakagawa K, Okuda S and Miyazawa T: Dose-dependent incorporation of tea catechins, (-)-epigallocatechin-3-gallate and (-)-epigallocatechin, into human plasma. Biosci Biotechnol Biochem 61; 1981-5, 1997.
46. Nam S, Smith DM and Dou QP: Ester bond-containing tea polyphenols potently inhibit proteasome activity in vitro and in vivo. J Biol Chem 276: 13322-30, 2001.
47. Nakagawa K, Ninomiya M, Okubo T, Aoi N, Juneja LR, Kim M, Yamanaka K and Miyazawa T: Tea catechin supplementation increases antioxidant capacity and prevents phospholipid hydroperoxidation in plasma of humans. J Agric Food Chem 47: 3967-73, 1999.
48. Freeman BA and Crapo JD: Biology of disease: Free radicals and tissue injury. Lab Invest 49: 523-44, 1993.
49. Guyton KZ and Kensler TW: Oxidative mechanisms in carcinogenesis. Br Med Bull 49: 523-44, 1993.
50. Thannickal VJ and Fanburg BL: Reactive oxygen species in cell signaling. Am J Physiol 279: L1005-28, 2000.
51. Birnboim HC and Sandhu JK: Levels of DNA strand breaks and superoxide in phorbol ester-treated human granulocytes. J Cell Biochem 66: 219-28, 1997.
52. Ruch RJ, Cheng SJ and Klaunig JE: Prevention of cytotoxicity and inhibition of intercellular communication by antioxidant catechins isolated from Chinese green tea. Carcinogenesis 10: 1003-8, 1989.
53. Wei H, Zhang X, Zhao JF, Wang ZY, Bickers D and Lebwohl M: Scavenging + of hydrogen peroxide and inhibition of ultraviolet light-induced oxidative DNA damage by aqueous extracts from green and black teas. Free Radic Biol Med 26: 1427-35, 1999.
54. Lee HL, Marie VC and Barry H: Artifacts in cell culture: Rapid generation of hydrogen peroxide on addition of (-)-epigallocatechin, (-)-epigallocatechin gallate, (+)-catechin, and quercetin on commonly used cell culture media. Biochem Biophys Res Commun 251: 50-53, 2000.
55. Yang GY, Liao J, Li C, Chung J, Yurkow EJ, Ho CT and Yang CS: Effect of black and green tea polyphenols on c-jun phosphorylation and H(2)O(2) production in transformed and non-transformed human bronchial cell lines: Possible mechanisms of cell growth inhibition and apoptosis induction. Carcinogenesis 21: 2035-9, 2000.
56. Dong Z, Ma W, Huang C and Yang CS: Inhibition of tumor promoter-induced activator protein 1 activation and cell transformation by tea polyphenols, (-)-epigalloctechin gallate, and theaflavins. Cancer Res 57: 4414-9, 1997.
57. Lopez-Ilasaca M: Signaling from G-protein-coupled receptors to mitogen-activated protein (MAP)-kinase cascades. Biochem Pharmacol 56: 269-77, 1998.
58. Liang YC, Lin-Shiau SY, Chen CF and Lin JK: Suppression of extracellular signals and cell proliferation through EGF receptor binding by (-)-epigallocatechin gallate in human A431 epidermoid carcinoma cells. J Cell Biochem 67: 55-65, 1997.
59. Levitzki A and Gazit A: Tyrosine kinase inhibition: An approach to drug development. Science 267; 1782-8, 1995.
60. Ahn HY, Hadizadeh KR, Seul C, Yun YP, Vetter H and Sachinidis A: Epigallocatechin-3 gallate selectively inhibits the PDGF-BB-induced intracellular signaling transduction pathway in vascular smooth muscle cells and inhibits transformation of sis-transfected NIH 3T3 fibroblasts and human glioblastoma cells (A172). Mol Biol Cell 10: 1093-104, 1999.
61. Chung JH, Park JO, Phyu H, Dong Z and Yang CS: Mechanisms of inhibition of the Ras-MAP kinase signaling pathway in 30.7b Ras 12 cells by tea polyphenols (-)-epigallocatechin-3-gallate and theaflavin-3,3′-digallate. FASEB J 15: 2022-4, 2001.
62. Masuda M, Suzui M and Weinstein IM: Effects of epigallocatechin-3-gallate on growth, epidermal growth factor receptor signaling pathway, gene expression, and chemosensitivity in human head and neck squamous cell carcinoma cell lines. Clin Cancer Res 7: 4220-9, 2001.
63. Pianetti S, Arsura M, Romieu-Mourez R, Coffey RJ and Sonenshein GH: Her-2/neu overexpression induces NF-kappaB via a PI3-kinase/Akt pathway involving calpain-mediated degradation of IkappaB-alpha that can be inhibited by the tumor suppressor PTEN. Oncogene 20: 1287-99, 2001.
64. Pianetti S, Guo S, Kavanagh KT and Sonenshein GE: Green tea polyphenol epigallocatechin-3 gallate inhibits Her-2/neu signaling, proliferation, and transformed phenotype of breast cancer cells. Cancer Res 62: 652-5, 2002.
65. Ferrara N: Role of vascular endothelial growth factor in the regulation of angiogenesis. Kidney Int 56: 794-814, 1999.
66. Benjamin LE, Golijanin D, Itin A, Pode D and Keshet E: Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal. J Clin Invest 103: 159-65, 1999.
67. Jung YD, Nakano K, Liu W, Gallick GE and Ellis LM: Extracellular signal-regulated kinase activation is required for up-regulation of vascular endothelial growth factor by serum starvation in human colon carcinoma cells. Cancer Res 59: 4804-7, 1999.
68. Jung YD, Kim MS, Shin BA, Chay KO, Ahn BW, Bucana CD, Gallick GE and Ellis LM: EGCG, a major component of green tea, inhibits tumour growth by inhibiting VEGF induction in human colon carcinoma cells. Br J Cancer 84: 844-50, 2001.
69. Lamy S, Gingras D and Beliveau R: Green tea catechins inhibit vascular endothelial growth factor receptor phosphorylation. Cancer Res 62: 381-5, 2002.
70. Kazi A, Smith D, Zhong Q and Dou QP: Down regulation of Bcl-xL protein expression by green tea polyphenols is associated with prostate cancer cell apoptosis.(Abstract No. 788: The AACR-NCI-EORTC. Molecular Targets and Cancer Therapeutics, Miami Beach, FL. October 29-November 2, 2001).
71. Hochstrasser M: Ubiquitin, proteasomes, and the regulation of intracellular protien degradation. Curr Opin Cell Biol 2: 215-223, 1995.
72. Dou QP and Li B: Proteasome inhibitors as potential novel anticancer agents. Drug Resist Updat 2: 215-223, 1999.
73. Cohen L, Henzel WJ and Baeuerle PA: IKAp is a scaffold protein of the IkappaB kinase complex. Nature 395: 292-6. 1998.
74. Fujihara SM and Nadler SG: Modulation of nuclear protein import: A novel means of regulating gene expression. Biochem Pharmacol 56: 157-61, 1998.
75. Pan MH, Lin-Shiau SY, Ho CT, Lin JH and Lin JK: Suppression of lipopolysaccharide-induced nuclear factor-kappaB activity by theaflavin-3,3′-digallate from black tea and other polyphenols through down-regulation of IkappaB kinase activity in macrophages. Biochem Pharmacol 59: 357-67, 2000.
76. Yang F, Oz HS, Barve S, De Villiers WJ, McClain CJ and Varilek GW: The green tea polyphenol (-)-epigallocatechin-3-gallate blocks nuclear factor-kappa B activation by inhibiting I kappa B kinase activity in the intestinal epithelial cell line IEC-6. Mol Pharmacol 60: 528-533, 2001.
77. Tao P: The inhibitory effects of catechin derivatives on the activities of human immunodeficiency virus reverse transcriptase and DNA polymerase. Zhongguo, Yi, Xue, Ke Xue, Yuan, Xue Bao 14: 334-8, 1992.
78. Nakane H and Ono K: Differential inhibition of HIV-reverse transcriptase and various DNA and RNA polymerase by some catechin derivatives. Nucleic Acids Symp Ser 115-6, 1989.
79. Takimoto CH, Wright J and Arbuck SG: Clinical applications of the camptothecins. Biochim Biophys Acta 1400: 107-19, 1998.
80. Berger SJ, Gupta S, Belfi CA, Gosky DM and Mukhtar H: Green tea constituent (--)-epigallocatechin-3-gallate inhibits topoisomerase I activity in human colon carcinoma cells. Biochem Biophys Res Commun 288: 101-5, 2001.
81. Suzuki K, Yahara S, Hashimoto F and Uyeda M: Inhibitory activities of (-)-epigallocatechin-3-O-gallate against topoisomerases I and II. Biol Pharm Bull 24: 1088-90, 2001.
82. Healy KC: Telomere dynamics and telomerase activation in tumor progression: Prospects for prognosis and therapy. Oncol Res 7: 121-30, 1995.
83. Naasani I, Seimiya H and Tsuruo T: Telomerase inhibition, telomere shortening, and senescence of cancer cells by tea catechins. Biochem Biophys Res Commun 249: 391-6, 1998.