KB-R7943, a Na+/Ca2+ exchange inhibitor, does not suppress ischemia/reperfusion arrhythmias nor digitalis arrhythmias in dogs

Japanese Journal of Pharmacology

Volumn 90, Issue 3, 2002, Pages 229-235

  Miyamoto, Shigeki ^a   Zhu, Bing Mei ^a   Kamiya, Kazunori ^a   Nagasawa, Yoshinobu ^a   Hashimoto, Keitaro ^a  

^a UNIVERSITY OF YAMANASHI   (Japan)

Author keywords

Arrhythmia; Digitalis; Dog; Ischemia reperfusion; KB R7943

Indexed keywords

2 [2 [4 (4 NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA METHANESULFONATE; ANTIARRHYTHMIC AGENT; CALCIUM ION; DIGITALIS; DIMETHYL SULFOXIDE; OUABAIN; PENTOBARBITAL; PROTEIN INHIBITOR; SODIUM CALCIUM EXCHANGE PROTEIN; SODIUM CALCIUM EXCHANGE PROTEIN INHIBITOR; UNCLASSIFIED DRUG; 2 (2 (4 (4 NITROBENZYLOXY)PHENYL)ETHYL)ISOTHIOUREA METHANESULFONATE; 2-(2-(4-(4-NITROBENZYLOXY)PHENYL)ETHYL)ISOTHIOUREA METHANESULFONATE; DRUG DERIVATIVE; THIOUREA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY OCCLUSION; ARTICLE; BLOOD PRESSURE MEASUREMENT; BOLUS INJECTION; CALCIUM TRANSPORT; CONTROLLED STUDY; DOG; DRUG EFFECT; DRUG EFFICACY; ELECTROCARDIOGRAM; FEMALE; HEART ARRHYTHMIA; HEART RATE; HEMODYNAMIC PARAMETERS; ISCHEMIA; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MALE; MORTALITY; NONHUMAN; REPERFUSION; ANIMAL; BLOOD PRESSURE; COMPARATIVE STUDY; DOSE RESPONSE; DRUG ANTAGONISM; ELECTROCARDIOGRAPHY; HEART MUSCLE ISCHEMIA; PATHOPHYSIOLOGY; REPERFUSION INJURY; TIME;

ANIMALS; ARRHYTHMIA; BLOOD PRESSURE; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROCARDIOGRAPHY; FEMALE; HEART RATE; MALE; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION INJURY; OUABAIN; SODIUM-CALCIUM EXCHANGER; THIOUREA; TIME FACTORS;

EID: 0036857089     PISSN: 00215198     EISSN: None     Source Type: Journal    
DOI: 10.1254/jjp.90.229     Document Type: Article

References (31)

1. Leblanc N and Hume JR: Sodium current-induced release of calcium from cardiac sarcoplasmic reticulum. Science 248, 372-376 (1990)
2. 2+ exchange. Science 255, 850-853 (1992)
3. Philipson KD and Nicoll DA: Sodium-calcium exchange: A molecular perspective. Annu Rev Physiol 62, 111-133 (2000)
4. 23Na-NMR measurements of intracellular sodium in intact perfused ferret hearts during ischemia and reperfusion. Am J Physiol (Heart Circ Physiol) 259, H1767-H1773 (1990)
5. Imahashi K, Kusuoka H, Hashimoto K, Yoshioka J, Yamaguchi H and Nishimura T: Intracellular sodium accumulation during ischemia as the substrate for reperfusion injury. Circ Res 84, 1401-1406 (1999)
6. Noble D, LeGuennec JY and Winslow R: Functional roles of sodium-calcium exchange in normal and abnormal cardiac rhythm. Ann NY Acad Sci 779, 480-488 (1996)
7. 2+ exchanger. Am J Physiol (Heart Circ Physiol) 276, H1868-H1876 (1999)
8. 2+ exchange, KB-R7943, on reoxygenation-induced injuries in guinea pig papillary muscles. J Cardiovasc Pharmacol 35, 121-128 (2000)
9. 2+ overload in rat ventricular myocytes. Circulation 101, 1441-1446 (2000)
10. 2+ exchange by KB-R7943: Transport mode selectivity and anti-arrhythmic consequences. Am J Physiol (Heart Circ Physiol) 281, H1334-H1345 (2001)
11. 2+ exchanger, attenuates reperfusion injury in the in vitro and in vivo cerebral ischemic models. J Pharmacol Exp Ther 298, 249-256 (2001)
12. 2+ exchange inhibitor, on myocardial ischemia/reperfusion injury. Folia Pharmacol Jpn (Nippon Yakurigaku Zasshi) 111, 105-115 (1998) (text in Japanese with English abstract)
13. 2+ influx. Eur J Pharmacol 365, 233-239 (1999)
14. 2+ exchange current in guinea-pig cardiac ventricular cells. Br J Pharmacol 119, 555-563 (1996)
15. Tanaka H, Nishimaru K, Aikawa T, Hirayama W, Tanaka Y and Shigenobu K: Effect of SEA0400, a novel inhibitor of sodium-calcium exchanger, on myocardial ionic currents. Br J Pharmacol 135, 1096-1100 (2002)
16. 2+ exchange current by KB-R7943 in guinea-pig cardiac myocytes. Br J Pharmacol 128, 969-974 (1999)
17. Awaji T, Wu ZJ and Hashimoto K: Acute antiarrhythmic effects of intravenously administered amiodarone on canine ventricular arrhythmia. J Cardiovasc Pharmacol 26, 869-878 (1995)
18. Hashimoto K, Ishii M, Komori S and Mitshuhashi H: Canine digitalis arrhythmia as a model for detecting Na-channel blocking antiarrhythmic drugs: A comparative study using other canine arrhythmia models and the new antiarrhythmic drugs, propafenone, tocainide, and SUN 1165. Heart Vessels 1, 29-35 (1985)
19. 2+ exchange inhibitor, KB-R7943 on ouabain-induced arrhythmias in guinea-pigs. Br J Pharmacol 127, 1846-1850 (1999)
20. Hashimoto K, Haruno A, Matsuzaki T, Sugiyama A and Akiyama K. Effects of antiarrhythmic drugs on canine ventricular arrhythmia models: Which electrophysiological characteristics of drugs are related to their effectiveness? Cardiovasc Drugs Ther 5, 805-817 (1991)
21. Xue YX, Arita J, Aye NN and Hashimoto K: Effects of an antiarrhythmic drug A-2545 on canine ventricular arrhythmia models; Comparison with mexiletine and flecainide. Naunyn Schmiedebergs Arch Pharmacol 358, 649-656 (1998)
22. Ch'en FF, Vaughan-Jones RD, Clarke K and Noble D: Modeling myocardial ischaemia and reperfusion. Prog Biophys Mol Biol 69, 515-538 (1998)
23. Bers DM, Bassani JW and Bassani RA: Na-Ca exchange and Ca fluxes during contraction and relaxation in mammalian ventricular muscle. Ann NY Acad Sci 779, 430-442 (1996)
24. Menick DR, Barnes KV, Thacker UF, Dawson MM, McDermott DE, Rozich JD, Kent R.L and Cooper G IV: The exchange and cardiac hypertrophy. Ann NY Acad Sci 779, 489-501 (1996)
25. 2+ exchange in the infracted heart; Implications for excitation-contraction coupling. Circ Res 81, 1083-1093 (1997)
26. Bersohn MM, Philipson KD and Fukushima JY: Sodium-calcium exchange and sarcolemmal enzymes in ischemic rabbit hearts. Am J Physiol (Cell Physiol) 242, C288-C295 (1982)
27. 2+ exchange; Molecular and pharmacological aspects. Circ Res 88, 864-876 (2001)
28. 2+ transient induced by angiotensin II in isolated adult rabbit ventricular myocytes. Naunyn Schmiedebergs Arch Pharmacol 360, 575-584 (1999)
29. 2+ transient and contractility in rabbit ventricular myocytes: Pharmacological analysis with KB-R7943. Br J Pharmacol 126, 1785-1795 (1999)
30. 2+ exchanger inhibitor, KB-R7943, caused negative inotropic responses and negative followed by positive chronotropic responses in isolated, blood-perfused dog heart preparations. Jpn J Pharmacol 82, 155-163 (2000)
31. Schweda F, Seebauer H, Kramer BK and Kurtz A: Functional role of sodium-calcium exchange in the regulation of renal vascular resistance. Am J Physiol (Renal Physiol) 280, F155-F161 (2001)