Cardioprotective effects of KB-R7943: A novel inhibitor of the reverse mode of Na+/Ca2+ exchanger

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 276, Issue 6 45-6, 1999, Pages

  Ladilov, Y ^a   Haffner, S ^a   Balser Schafer C ^a   Maxeiner, H ^a   Piper, H M ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

Calcium overload; Cardiomyocytes; Heart; Reoxygenation injury; Sodium overload

Indexed keywords

2 [2 [4 (4 NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA METHANESULFONATE; ADENOSINE TRIPHOSPHATASE INHIBITOR; SODIUM CALCIUM EXCHANGE PROTEIN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; DRUG EFFECT; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PROTECTION; MALE; MUSCLE CONTRACTILITY; NONHUMAN; PRIORITY JOURNAL; RAT; REOXYGENATION; REPERFUSION INJURY; SODIUM CALCIUM EXCHANGE; SODIUM CELL LEVEL;

EID: 0032997275     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1999.276.6.h1868     Document Type: Article

References (32)

1. 2+ in single rat heart cells during anoxia and reoxygenation. Biochem. J. 244: 381-385, 1987.
2. Bowers, K. C., A. P. Allshire, and P. H. Cobbold. Bioluminescent measurement in single cardiomyocytes of sudden cytosolic ATP depletion coincident with rigor. J. Mol. Cell. Cardiol. 24: 213-218, 1992.
3. Bowers, K. C., A. P. Allshire, and P. H. Cobbold. Continuous measurements of cytoplasmic ATP in single cardiomyocytes during simulation of the "oxygen paradox." Cardiovasc. Res. 27: 1836-1839, 1993.
4. Ganote, C. E. Contraction band necrosis and irreversible myocardial injury. J. Mol. Cell. Cardiol. 15: 67-73, 1983.
5. Haigney, M. C., E. G. Lakatta, M. D. Stern, and H. S. Silverman. Sodium channel blockade reduces hypoxic sodium loading and sodium-dependent calcium loading. Circulation 90: 391-399, 1994.
6. + in individual fibroblasts and lymphocytes. J. Biol. Chem. 264: 19458-19467, 1989.
7. + during acidosis in rat ventricular myocytes. Am. J. Physiol. 262 (Cell Physiol. 31): C348-C357, 1992.
8. 2+ exchanger via protein kinase C. J. Biol. Chem. 271: 13609-13615, 1996.
9. 2+ exchange in cells expressing NCX1. J. Biol. Chem. 271: 22391-22397, 1996.
10. Koop, A., and H. M. Piper. Protection of energy status of hypoxic cardiomyocytes by mild acidosis. J. Mol. Cell. Cardiol. 24: 55-65, 1992.
11. Ladilov, Y. V., C. Baiser, and H. P. Piper. Protection of rat cardiomyocytes against simulated ischemia and reoxygenation by treatment with protein kinase C activator. Circ. Res. 82: 451-457, 1998.
12. Ladilov, Y. V., B. Siegmund, C. Baiser, and H. M. Piper. Simulated ischemia increases the susceptibility of rat cardiomyocytes to hypercontracture. Circ. Res. 80: 69-75, 1997.
13. + exchange. Am. J. Physiol. 268 (Heart Circ. Physiol. 37): H1531-H1539, 1995.
14. Miyata, H., E. G. Lakatta, M. D. Stern, and H. S. Silverman. Relation of mitochondrial and cytosolic free calcium to cardiac myocyte recovery after exposure to anoxia. Circ. Res. 71: 605-613, 1992.
15. 2+ exchange in isolated guinea-pig cardiac myocytes. J. Mol. Cell. Cardiol. 29: 2979-2987, 1997.
16. Murphy, E., M. Perlman, R. E. London, and C. Steenbergen. Amiloride delays the ischemia-induced rise in cytosolic free calcium. Circ. Res. 68: 1250-1258, 1991.
17. 2+ exchange inhibitor, on myocardial ischemia/reperfusion injury. Folia Pharmacol. Jpn. 111: 105-115, 1998.
18. 23Na-nuclear magnetic resonance study of the isolated rat heart. Circulation 86: 302-310, 1992.
19. Nishida, M., S. Borzak, B. Kraemer, J. P. Navas, R. A. Kelly, T. W. Smith, and J. D. Marsh. Role of cation gradients in hypercontracture of myocytes during simulated ischemia and reperfusion. Am. J. Physiol. 264 (Heart Circ. Physiol. 33): H1896-H1906, 1993.
20. Piper, H. M., I. Probst, P. Schwartz, F. J. Hütter, and P. G. Spieckermann. Culturing of calcium stable adult cardiac myocytes. J. Mol. Cell. Cardiol. 14: 397-412, 1982.
21. Piper, H. M., B. Siegmund, Y. V. Ladilov, and K. D. Schluter. Calcium and sodium control in hypoxic-reoxygenated cardiomyocytes. Basic Res. Cardiol. 88: 471-482, 1993.
22. Poole-Wilson, P. A. Regulation of intracellular pH in the myocardium; relevance to pathology. Mol. Cell. Biochem. 89: 151-155, 1989.
23. Schlack, W., A. Uebing, M. Schafer, F. Bier, S. Schafer, H. M. Piper, and V. Thamer. Regional contractile blockade at the onset of reperfusion reduces infarct size in the dog heart. Pflügers Arch. 428: 134-141, 1994.
24. Schlüter, K. D., P. Schwartz, B. Siegmund, and H. M. Piper. Prevention of the oxygen paradox in hypoxic-reoxygenated hearts. Am. J. Physiol. 261 (Heart Circ. Physiol. 30): H416-H423, 1991.
25. 2+ and contraction in single adult mammalian cardiac myocytes. Am. J. Physiol. 266 (Cell Physiol. 35): C222-C233, 1994.
26. Steenbergen, C., E. Murphy, J. A. Watts, and R. E. London. Correlation between cytosolic free calcium, contracture, ATP, and irreversible ischemic injury in perfused rat heart. Circ. Res. 66: 135-146, 1990.
27. 2+ overload and impairs function in anoxic rat heart. J. Mol. Cell. Cardiol. 22: 57-72, 1990.
28. Tsukube, T., J. D. McCully, M. Federman, I. B. Krukenkamp, and S. Levitsky. Developmental differences in cytosolic calcium accumulation associated with surgically induced global ischemia: optimization of cardioplegic protection and mechanism of action. J. Thorac. Cardiovasc. Surg. 112: 175-184, 1996.
29. Vander Heide, R. S., J. P. Angelo, R. A. Altschuld, and C. E. Ganote. Energy dependence of contraction band formation in perfused hearts and isolated adult myocytes. Am. J. Pathol. 125: 55-68, 1986.
30. Ver-Donck, L., M. Borgers, and F. Verdonck. Inhibition of sodium and calcium overload pathology in the myocardium: a new cytoprotective principle. Cardiovasc. Res. 27: 349-357, 1993.
31. 2+ exchange current in guinea-pig cardiac ventricular cells. Br. J. Pharmacol. 119: 555-563, 1996.
32. 2+ exchange and not by its antioxidant effects. Circ. Res. 70: 804-811, 1992.