Resistance to ocular herpes simplex virus type 1 infection in IL-12 transgenic mice

Journal of Neuroimmunology

Volumn 132, Issue 1-2, 2002, Pages 41-48

  Al Khatib, Khaldun ^a   Campbell, Iain L ^b   Carr, Daniel J J ^a  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

HSV 1; Interferon ; Interleukin 12; Transgenic mice

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 12; MESSENGER RNA; PROTEIN P35; PROTEIN P40;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN STEM; CONTROLLED STUDY; DECISION THEORY; EYE; EYE DISEASE; GENE; GENE EXPRESSION; HERPES SIMPLEX VIRUS 1; MOUSE; NONHUMAN; P35 GENE; P40 GENE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SURVIVAL; TISSUE LEVEL; TRANSGENIC MOUSE; TRIGEMINUS GANGLION; VIRUS RESISTANCE;

ANIMALS; CERCOPITHECUS AETHIOPS; GLIAL FIBRILLARY ACIDIC PROTEIN; HERPESVIRUS 1, HUMAN; INTERFERON TYPE II; INTERLEUKIN-12; KERATITIS, HERPETIC; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PROMOTER REGIONS (GENETICS); VERO CELLS; VIRUS REPLICATION;

EID: 0036849266     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(02)00305-3     Document Type: Article

References (40)

1. Adler H., Beland J.L., Del-Pan N.C., Kobzik L., Sobel R.A., Rimm I.J. In the absence of T cells, natural killer cells protect from mortality due to HSV-1 encephalitis. J. Neuroimmunol. 93:1999;208-213.
2. Biron C.A. Activation and function of natural killer cell responses during viral infection. Curr. Opin. Immunol. 9:1997;24-34.
3. Bouley D.M., Kanangat S., Wire W., Rouse B.T. Characterization of herpes simplex virus type-1 infection and herpetic stromal keratitis development in IFN-γ knockout mice. J. Immunol. 155:1995;3964-3971.
4. Cantin E., Tanamachi B., Openshaw H., Mann J., Clarke K. Gamma interferon (IFN-γ) receptor null-mutant mice are more susceptible to herpes simplex virus type 1 infection than IFN-γ ligand null-mutant mice. J. Virol. 73:1999;5196-5200.
5. Carr D.J.J., Veress L.A., Noisakran S., Campbell I.L. Astrocyte-targeted expression of IFN-α1 protects mice from acute ocular herpes simplex virus type 1 infection. J. Immunol. 161:1998;4859-4865.
6. Carr D.J.J., Härle P., Gebhardt B.M. The immune response to ocular herpes simplex virus type 1 infection. Exp. Biol. Med. 226:2001;353-366.
7. Carr D.J.J., Ash J., Al-khatib K., Campbell I.L. Unforeseen consequences of IL-12 expression in the eye of GFAP-IL12 transgenic mice following herpes simplex virus type 1 infection. DNA Cell Biol. 21:2002;467-473.
8. Daheshia M., Kanangat S., Rouse B.T. Production of key molecules by ocular neutrophils early after herpetic infection of the cornea. Exp. Eye Res. 67:1998;619-624.
9. Edelmann K.H., Wilson C.B. Role of CD28/CD80-86 and CD40/CD154 costimulatory interactions in host defense to primary herpes simplex virus infection. J. Virol. 75:2001;612-621.
10. + T cells from human immunodeficiency virus-infected persons. J. Exp. Med. 182:1995;1759-1767.
11. Feinstein D.L., Akira S., Narazaki M., Taga T. Isolation of cDNA clones encoding rat glial fibrillary acidic protein: expression in astrocytes and Schwann cells. J. Neurosci. Res. 32:1992;1-14.
12. Gately M.K., Renzetti L.M., Magram J., Stern A.S., Adorini L., Gubler U., Presky D.H. The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses. Annu. Rev. Immunol. 16:1998;495-521.
13. Geiger K.D., Nash T.C., Sawyer S., Krahl T., Patstone G., Reed J.C., Krajewski S., Dalton D., Buchmeier M.J., Sarvetnick N. Interferon-γ protects against herpes simplex virus type 1-mediated neuronal death. Virology. 238:1997;189-197.
14. Germann T., Gately M.K., Schoenhaut D.S., Lohoff M., Mattner F., Fischer S., Jin S.-C., Schmitt E., Rude E. Interleukin-12/T cell stimulating factor, a cytokine with multiple effects on T helper type 1 (Th1) but not on Th2 cells. Eur. J. Immunol. 23:1993;1762-1770.
15. Halford W.P., Gehbardt B.M., Carr D.J.J. Persistent cytokine expression in trigeminal ganglion latently infected with herpes simplex virus type 1. J. Immunol. 157:1996;3542-3549.
16. Härle P., Cull V., Agbag P.-M., Silverman R., Williams B.R.G., James C., Carr D.J.J. Differential effect of murine alpha/beta interferon transgenes on antagonization of herpes simplex virus type 1 replication. J. Virol. 76:2002;6558-6567.
17. Ikemoto K., Pollard R.B., Fukumoto T., Morimatsu M., Suzuki F. Small amounts of exogenous IL-4 increase the severity of encephalitis induced in mice by the intranasal infection of herpes simplex virus type 1. J. Immunol. 155:1995;1326-1333.
18. Ito M., Watanabe M., Kamiya H., Sakurai M. Herpes simplex virus type 1 induces apoptosis in peripheral blood T lymphocytes. J. Infect. Dis. 175:1997;1220-1224.
19. Jayaraman S., Neiligenhaus A., Rodriguez A., Soukiasian S., Dorf M.E., Foster C.S. Exacerbation of murine herpes simplex virus-mediated stromal keratitis by Th2 type T cells. J. Immunol. 151:1993;5777-5789.
20. Kanangat S., Thomas J., Gangappa S., Babu J.S., Rouse B.T. Herpes simplex virus type 1-mediated up-regulation of IL-12 (p40) mRNA expression. J. Immunol. 156:1996;1110-1116.
21. Kobayashi M., Fitz L., Ryan M., Hewick R.M., Clark S.C., Chan S., Loudon R., Sherman F., Perussia B., Trinchieri G. Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biological effects on human lymphocytes. J. Exp. Med. 170:1989;827-845.
22. Lassmann S., Kincaid C., Asensio V.C., Campbell I.L. Induction of type 1 immune pathology in the brain following immunization without central nervous system autoantigen in transgenic mice with astrocyte-targeted expression of IL-12. J. Immunol. 167:2001;5485-5493.
23. Liesagang T.J. Herpes simplex virus epidemiology and ocular importance. Cornea. 20:2001;1-13.
24. Manickan E., Rouse B.T. Roles of different T-cell subsets in control of herpes simplex virus infection determined by using T-cell-deficient mouse models. J. Virol. 69:1995;8178-8179.
25. Mercadal C.M., Bouley D.M., DeStephano D., Rouse B.T. Herpetic stromal keratitis in the reconstituted scid mouse model. J. Virol. 67:1993;3404-3408.
26. Murphy E.E., Terres G., Macatonia S.E., Hsieh C.-S., Mattson J., Lanier L., Wysocka M., Trinchieri G., Murphy K., O'Garra A. B7 and interleukin 12 cooperate for proliferation and interferon γ production by mouse T helper clones that are unresponsive to B7 costimulation. J. Exp. Med. 180:1994;223-231.
27. + T cell subsets in the control of an acute herpes simplex virus infection of the skin and nervous system. J. Gen. Virol. 68:1987;825-833.
28. + T lymphocytes. J. Immunol. 164:2000;6435-6443.
29. Noisakran S., Härle P., Carr D.J.J. ICAM-1 is required for resistance to herpes simplex virus type 1 but not interferon-α1 transgene efficacy. Virology. 283:2001;69-77.
30. Orange J.S., Biron C.A. An absolute and restricted requirement for IL-12 in natural killer cell IFN γ production and antiviral defense. Studies of natural killer and T cell responses in contrasting viral infections. J. Immunol. 156:1996;1138-1142.
31. Orange J.S., Wolf S.F., Biron C.A. Effects of IL-12 in the response and susceptibility to experimental virus infections. J. Immunol. 152:1994;1253-1264.
32. Ozmen L., Aguet M., Trinchieri G., Garotta G. The in vivo antiviral activity of interleukin-12 is mediated by gamma interferon. J. Virol. 69:1995;8147-8150.
33. Pagenstecher A., Lassmann S., Carson M.J., Kincaid C.L., Stadler A.K., Campbell I.L. Astrocyte-targeted expression of IL-12 induces active cellular immune responses in the central nervous system and modulates experimental allergic encephalomyelitis. J. Immunol. 164:2000;4481-4492.
34. Palmer E.M., Farrakh-Siar L., van Seventer J.M., van Seventer G.A. IL-12 decreases activation-induced cell death in human naive Th cells costimulated by intercellular adhesion molecule-1: I. IL-12 alters caspase processing and inhibits enzyme function. J. Immunol. 167:2001;749-758.
35. Raftery M.J., Behrens C.K., Muller A., Krammer P.H., Walczak H., Schonrich G. Herpes simplex virus type 1 infection of activated cytotoxic T cells: induction of fratricide as a mechanism of viral immune evasion. J. Exp. Med. 190:1999;1103-1114.
36. Shimeld C., Whiteland J.L., Nicholls S.M., Grinfeld E., Easty D.L., Gao H., Hill T.J. Immune cell infiltration and persistence in the mouse trigeminal ganglion after infection of the cornea with herpes simplex virus type 1. J. Neuroimmunol. 61:1995;7-16.
37. Simmons A., Tscharke D.C. Anti-CD8 impairs clearance of herpes simplex virus from the nervous system: implications for the fate of virally infected neurons. J. Exp. Med. 175:1992;1337-1344.
38. Thomas J., Gangappa S., Kanangat S., Rouse B.T. On the essential involvement of neutrophils in the immunopathogenic disease. Herpetic stromal keratitis. J. Immunol. 158:1997;1383-1391.
39. Trinchieri G. Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes. Blood. 84:1994;4008-4027.
40. Tumpey T.M., Chen S.-H., Oakes J.E., Lausch R.N. Neutrophil-mediated suppression of virus replication after herpes simplex virus type 1 infection of the murine cornea. J. Virol. 70:1996;898-904.