Unforeseen consequences of IL-12 expression in the eye of GFAP-IL12 transgenic mice following herpes simplex virus type 1 infection

DNA and Cell Biology

Volumn 21, Issue 5-6, 2002, Pages 467-473

  Carr, Daniel J J ^a   Ash, John ^a   Al Khatib, Khaldun ^a   Campbell, Iain L ^b  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CRYSTALLIN; GLIAL FIBRILLARY ACIDIC PROTEIN; INTERLEUKIN 12; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CATARACT; CELL INFILTRATION; CONTROLLED STUDY; CORNEA STROMA; HERPES SIMPLEX KERATITIS; HERPES SIMPLEX VIRUS 1; IMMUNOHISTOCHEMISTRY; INFECTION RESISTANCE; INFECTION SENSITIVITY; MONONUCLEAR CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; TRANSGENIC MOUSE;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; EYE; GLIAL FIBRILLARY ACIDIC PROTEIN; HERPESVIRUS 1, HUMAN; INTERLEUKIN-12; KERATITIS, HERPETIC; LYMPHOCYTE COUNT; MICE; MICE, TRANSGENIC; PROMOTER REGIONS (GENETICS); TRANSFORMING GROWTH FACTOR BETA;

ANIMALIA; DNA VIRUSES; HUMAN HERPESVIRUS 1; MUS MUSCULUS; SIMPLEXVIRUS;

EID: 0036376647     PISSN: 10445498     EISSN: None     Source Type: Journal    
DOI: 10.1089/10445490260099764     Document Type: Article

References (54)

1. In the absence of T cells, natural killer cells protect from mortality due to HSV-1 encephalitis
2. Herpes simplex virus infections: The genital tract and the newborn
3. Transforming growth factor-beta in leishmanial infeciton: A parasite escape mechanism
4. Incidence and severity of herpetic stromal keratitis: Impaired by the depletion of lymph node macrophages
5. B cell-deficient mice have increased susceptibility to HSV-1 encephalomyelitis and mortality
6. Contrasting mechanisms for suppression of macrophage cytokine release by transforming growth factor-β and interleukin-10
7. Studies on the problem of corneal homografts
8. Characterization of herpes simplex virus type-1 infection and herpetic stromal keratitis development in IFN-γ knockout mice
9. Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6
10. Transgenic models to assess the pathogenic actions of cytokines in the central nervous system
11. Gamma interferon (IFN-γ) receptor null-mutant mice are more susceptible to herpes simplex virus type 1 infection than IFN-γ ligand null-mutant mice
12. Regulation of the proinflammatory effects of Fas ligand (CD95L)
13. Pathogenesis of herpetic neuritis and ganglionitis in mice: Evidence for intra-axonal transport of infection
14. Humoral response to herpes simplex virus is complement-dependent
15. The biological complexity of transforming growth factor β
16. Dual role of B cells in mediating innate and acquired immunity to herpes simplex virus infections
17. Virus-induced immunoinflammatory lesions in the absence of viral antigen recognition
18. Interferon-γ protects against herpes simplex virus type 1-mediated neuronal death
19. Fas ligand-induced apoptosis as a mechanism of immune privilege
20. Innate and adaptive immunity to herpes simplex virus type 1
21. Kinetics of cytokine production in the cornea and trigeminal ganglion of C57BL/6 mice after corneal HSV-1 infection
22. Critical role of corneal Langerhans cells in the CD4- but not CD8-mediated immunopathology in herpes simplex virus-1-infected mouse corneas
23. IFN-γ and IL-2 are protective in the skin but pathologic in the corneas of HSV-1-infected mice
24. Maintenance of clonotype specificity in CD95/Apo-1/Fas-mediated apoptosis of mature T lymphocytes
25. Herpes simplex virus type 1-mediated up-regulation of IL-12 (p40) mRNA expression
26. Macrophage control of herpes simplex virus type 1 replication in the peripheral nervous system
27. Herpes simplex virus glycoprotein D can bind to poliovirus receptor-related protein 1 or herpes entry mediator, two structurally unrelated mediators of virus entry
28. Induction of type 1 immune pathology in the brain following immunization without central nervous system autoantigen in transgenic mice with astrocyte-targeted expression of IL-12
29. Lack of interleukin-6 (IL-6) enhances susceptibility to infection but does not alter latency or reactivation of herpes simplex virus type 1 in IL-6 knockout mice
30. Specific phenotypic resotration of an attenuated virus by knockout of a host resistance gene
31. Regulation of immune responses by TGF-β
32. Immunotolerance induced by intratesticular antigen priming: Expression of TGF-β, Fas and Fas ligand
33. Roles of different T-cell subsets in control of herpes simplex virus infection determined by using T-cell-deficient mouse models
34. Embryonic gene expression patterns of TGF-β1, TGF-β2, and TGF-β3 suggest different developmental functions in vivo
35. Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor beta
36. Transforming growth factor β stimulates collagen-matrix contraction by fibroblasts: Implications for wound healing
37. Phenotypic and functional studies on ocular T cells during herpetic infections of the eye
38. + T lymphocytes
39. Astrocyte-targeted expression of IL-12 induces active cellular immune responses in the central nervous system and modulates experimental allergic encephalomyelitis
40. Genital herpes: Epidemiology and pathophysiology. Update and new perspectives
41. Herpes simplex viruses and their replication
42. Characterization of the activation of latent TGF-β by co-cultures of endothelial cells and pericytes or smooth muscle cells: A self-regulating system
43. Cytokine production in the nervous system of mice during acute and latent infection with herpes simplex virus type 1
44. Lens-specific expression of transforming growth factor β1 in transgenic mice causes anterior subcapsular cataracts
45. Immunobiology and immunopathology of corneal transplantation
46. Reciprocal IFN-gamma and TGF-β responses regulate the occurrence of mucosal inflammation
47. The role of natural killer cells in the development of herpes simplex virus type 1 induced stromal keratitis in mice
48. Interferon γ regulates platelet endothelial cell adhesion molecule 1 expression and neutrophil infiltration into herpes simplex virus-infected mouse corneas
49. Proinflammatory functions of IL-2 in herpes simplex virus corneal infection
50. On the essential involvement of neutrophils in the immunopathologic disease. Herpetic stromal keratitis
51. Deactivation of macrophages by transforming growth factor-β
52. Absence of macrophage inflammatory protein-1α prevents the development of blinding herpes stromal keratitis
53. Neutrophil-mediated suppression of virus replication after herpes simplex virus type 1 infection of the murine cornea
54. Chemokine synthesis in the HSV-1-infected cornea and its suppression by interleukin-10