A model for PKC involvement in the pathogenesis of inborn errors of metabolism

Trends in Molecular Medicine

Volumn 8, Issue 11, 2002, Pages 524-531

  Boneh, Avihu ^a,b  

^a Genetic Health Services Victoria   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; FATTY ACID; HOMOCYSTEINE; PROTEIN KINASE C; TRANSCRIPTION FACTOR; SPHINGOLIPID;

AMINO ACID METABOLISM; CHOLESTEROL METABOLISM; DISORDERS OF PEROXISOMAL FUNCTIONS; ENZYME ACTIVITY; ENZYME SUBSTRATE; FATTY ACID METABOLISM; GENE EXPRESSION; GENOTYPE PHENOTYPE CORRELATION; INBORN ERROR OF METABOLISM; LYSOSOME STORAGE DISEASE; METABOLITE; MODEL; PATHOGENESIS; REVIEW; ANIMAL; BIOLOGICAL MODEL; DISORDERS OF LIPID AND LIPOPROTEIN METABOLISM; ENZYMOLOGY; HUMAN; LIPIDOSIS; METABOLISM; PATHOLOGY;

ANIMALS; HUMANS; LIPID METABOLISM, INBORN ERRORS; MODELS, BIOLOGICAL; PROTEIN KINASE C; SPHINGOLIPIDOSES; SPHINGOLIPIDS;

EID: 0036839948     PISSN: 14714914     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1471-4914(02)02418-8     Document Type: Review

References (58)

1. Nishizuka, Y. (1995) Protein kinase C and lipid signaling for sustained cellular responses. FASEB J. 9, 484-496
2. Mellor, H. and Parker, P.J. (1998) The extended protein kinase C superfamily. Biochem. J. 332, 281-292
3. Hannun, Y.A. and Bell, R.M. (1987) Lysosphingolipids inhibit protein kinase C: Implications for the sphingolipidoses. Science 235, 670-674
4. Boneh, A. (1995) Possible role for protein kinase C in the pathogenesis of inborn errors of metabolism. J. Cell. Biochem. 59, 27-32
5. Signorelli, P. et al. (2001) Ceramide inhibition of NF-kappaB activation involves reverse translocation of classical protein kinase C (PKC) isoenzymes: Requirement for kinase activity and carboxyl-terminal phosphorylation of PKC for the ceramide response. FASEB J. 15, 2401-2414
6. Pyne, S. and Pyne, N.J. (2000) Sphingosine 1-phosphate signalling in mammalian cells. Biochem. J. 349, 385-402
7. Wang, Y.M. et al. (1999) Atypical PKC zeta is activated by ceramide, resulting in coactivation of NF-kappaB/JNK kinase and cell survival. J. Neurosci. Res. 55, 293-302
8. Siehler, S. et al. (2001) Sphingosine 1-phosphate activates nuclear factor-kappa B through Edg receptors. Activation through Edg-3 and Edg-5, but not Edg-1, in human embryonic kidney 293 cells. J. Biol. Chem. 276, 48733-48739
9. Pebay, A. et al. (2001) Sphingosine-1-phosphate induces proliferation of astrocytes: Regulation by intracellular signalling cascades. Eur. J. Neurosci. 13, 2067-2076
10. Yamada, H. and Suzuki, K. (1999) Responses to cyclic AMP is impaired in the twitcher Schwann cells in vitro. Brain Res. 816, 390-395
11. Giri, S. et al. (2002) Galactosylsphingosine (psychosine)-induced expression of cytokine-mediated inducible nitric oxide synthases via AP-1 and C/EBP: Implications for Krabbe disease. FASEB J. 16, 661-672
12. Rodriguez-Lafrasse, C. et al. (1997) Modulation of protein kinase C by endogenous sphingosine: Inhibition of phorbol dibutyrate binding in Niemann-Pick C fibroblasts. Biochem. J. 325, 787-791
13. Garver, W.S. et al. (1999) The Npc1 mutation causes an altered expression of caveolin-1, annexin II and protein kinases and phosphorylation of caveolin-1 and annexin II in murine livers. Biochim. Biophys. Acta 1453, 193-206
14. Oka, N. et al. (1997) Caveolin interaction with protein kinase C. J. Biol. Chem. 272, 33416-33421
15. Littman, E.D. et al. (2000) Role of protein kinase C isoenzymes in fatty acid stimulation of insulin secretion. Pancreas 20, 256-263
16. Yaney, G.C. et al. (2000) Long-chain acyl CoA regulation of protein kinase C and fatty acid potentiation of glucose-stimulated insulin secretion in clonal beta-cells. Endocrinology 141, 1989-1998
17. Laybutt, D.R. et al. (1999) Muscle lipid accumulation and protein kinase C activation in the insulin-resistant chronically glucose-infused rat. Am. J. Physiol. 277, E1070-1076
18. Rickard, K.L. et al. (2000) Short-chain fatty acids reduce expression of specific protein kinase C isoforms in human colonic epithelial cells. J. Cell. Physiol. 182, 222-231
19. Clayton, P.T. et al. (2001) Hyperinsulinism in short-chain L-3-hydroxyacyl-CoA dehydrogenase deficiency reveals the importance of beta-oxidation in insulin secretion. J. Clin. Invest. 108, 457-465
20. Bowman, J.C. et al. (1997) Expression of protein kinase C β in the heart causes hypertrophy in adult mice and sudden death in neonates. J. Clin. Invest. 100, 2189-2195
21. Muth, J.N. et al. (2001) A Ca(2+)-dependent transgenic model of cardiac hypertrophy: A role for protein kinase C alpha. Circulation 103, 140-147
22. Wu, G. et al. (2000) Epsilon protein kinase C in pathological myocardial hypertrophy. Analysis by combined transgenic expression of translocation modifiers and G alpha. J. Biol. Chem. 275, 29927-29930
23. Ben-Yaacov, A. et al. (2000) Perturbation of protein kinase C subtype activation in X-ALD fibroblasts: Possible involvement of protein kinase C in the pathogenesis of adrenoleukodystrophy. J. Inherit. Metab. Dis. 23, 416-420
24. Denys, A. et al. (2001) Docosahexaenoic acid modulates phorbol ester-induced activation of extracellular signal-regulated kinases 1 and 2 in NIH/3T3 cells. Lipids 36, 813-818
25. Pahan, K. et al. (1998) Therapy for X-adrenoleukodystrophy: Normalization of very long chain fatty acids and inhibition of induction of cytokines by cAMP. J. Lipid Res. 39, 1091-1100
26. Stravitz, R.T. et al. (1996) Hepatocellular protein kinase C activation by bile acids: Implications for regulation of cholesterol 7α-hydroxylase. Am. J. Physiol. 271, G293-G303
27. Jones, B.A. et al. (1997) Bile salt-induced apoptosis of hepatocytes involves activation of protein kinase C. Am. J. Physiol. 272, G1109-G1115
28. Rao, Y.P. et al. (2002) Activation of the Raf-1/MEK/ERK cascade by bile acids occurs via the epidermal growth factor receptor in primary rat hepatocytes. Hepatology 35, 307-314
29. Beuers, U. et al. (1999) Modulation of protein kinase C by taurolithocholic acid in isolated rat hepatocytes. Hepatology 29, 477-482
30. Alpini, G. et al. (2002) Ursodeoxycholate and tauroursodeoxycholate inhibit cholangiocyte growth and secretion of BDL rats through activation of PKC alpha. Hepatology 35, 1041-1052
31. Han, C.Y. et al. (2000) Role of endocytosis in the transactivation of nuclear factor-kappaB by oxidized low-density lipoprotein. Biochem. J. 350, 829-837
32. Thurberg, B.L. and Collins, T. (1998) The nuclear factor-kappa B/inhibitor of kappa B autoregulatory system and atherosclerosis. Curr. Opin. Lipidology 9, 387-396
33. Biwa, T. et al. (2000) Granulocyte/macrophage colony-stimulating factor plays an essential role in oxidized low density lipoprotein-induced macrophage proliferation. J. Atheroscler. Thromb. 7, 14-20
34. Rosenblat, M. and Aviram, M. (2002) Oxysterol-induced activation of macrophage NADPH-oxidase enhances cell-mediated oxidation of LDL in the atherosclerotic apolipoprotein E deficient mouse: Inhibitory role for vitamin E. Atherosclerosis 160, 69-80
35. Paragh, G. et al. (1999) Altered signal pathway in granulocytes from patients with hyper-cholesterolemia. J. Lipid Res. 40, 1728-1733
36. Yasunari, K. et al. (2001) HMG-CoA reductase inhibitors prevent migration of human coronary smooth muscle cells through suppression of increase in oxidative stress. Arterioscler. Thromb. Vasc. Biol. 21, 937-942
37. Carr, A.C. et al. (2000) Potential antiatherogenic mechanisms of ascorbate (vitamin C) and α-tocopherol (vitamin E). Circ. Res. 87, 349-354
38. Feng, J. et al. (2000) Induction of CD36 expression by oxidized LDL and IL-4 by a common signaling pathway dependent on protein kinase C and PPAR-gamma. J. Lipid Res. 41, 688-696
39. Natarajan, R. et al. (2001) Signaling mechanisms of nuclear factor-kappa B-mediated activation of inflammatory genes by 13-hydroperoxyoctadecadienoic acid in cultured vascular smooth muscle cells. Arterioscler. Thromb. Vasc. Biol. 21, 1408-1413
40. Zhu, Y. et al. (1998) LDL induces transcription factor activator protein-1 in human endothelial cells. Arterioscler. Thromb. Vasc. Biol. 18, 473-480
41. Takahashi, M. et al. (2002) Lysophosphatidylcholine induces apoptosis in human endothelial cells through a p38-mitogen-activated protein kinase-dependent mechanism. Atherosclerosis 161, 387-394
42. Bochkov, V.N. et al. (2002) Oxidized phospholipids stimulate tissue factor expression in human endothelial cells via activation of ERK/EGR-1 and Ca(++)/NFAT. Blood 99, 199-206
43. Giardina, J.B. et al. (2001) Oxidized-LDL enhances coronary vasoconstriction by increasing the activity of protein kinase C isoforms alpha and epsilon. Hypertension 37, 561-568
44. Haidar, B. et al. (2001) Cellular cholesterol efflux is modulated by phospholipid-derived signaling molecules in familial HDL deficiency/Tangier disease fibroblasts. J. Lipid Res. 42, 249-257
45. Lynn, E.G. et al. (2001) Lipoprotein-X stimulates monocyte chemoattractant protein-1 expression in mesangial cells via nuclear factor-kappa B. Kidney Int. 60, 520-532
46. Sung, F.L. et al. (2001) Homocysteine stimulates the expression of monocyte chemoattractant protein-1 in endothelial cells leading to enhanced monocyte chemotaxis. Mol. Cell. Biochem. 216, 121-128
47. Wang, G. et al. (2000) Homocysteine stimulates nuclear factor kappaB activity and monocyte chemoattractant protein-1 expression in vascular smooth-muscle cells: A possible role for protein kinase C. Biochem. J. 352, 817-826
48. Wang, G. et al. (2001) Homocysteine induces monocyte chemoattractant protein-1 expression by activating NF-kappaB in THP-1 macrophages. Am. J. Physiol. Heart Circ. Physiol. 280, H2840-2847
49. Chu, F. et al. (2001) Potent inactivation of representative members of each PKC isozyme subfamily and PKD via S-thiolation by the tumor-promotion/progression antagonist glutathione but not by its precursor cysteine. Carcinogenesis 22, 1221-1229
50. Amuthan, G. et al. (2001) Mitochondria-to-nucleus stress signaling induces phenotypic changes, tumor progression and cell invasion. EMBO J. 20, 1910-1920
51. Cui, S.H. et al. (2001) A thiol proteinase inhibitor, E-64-d, corrects the abnormalities in concanavalin A cap formation and the lysosomal enzyme activity in leucocytes from patients with Chediak-Higashi syndrome by reversing the down-regulated protein kinase C activity. Clin. Exp. Immunol. 125, 283-290
52. Ryu, J. et al. (2000) Thrombin induces NO release from cultured rat microglia via protein kinase C, mitogen-activated protein kinase, and NF-kappa B. J. Biol. Chem. 275, 29955-29959
53. Hesslinger, C. et al. (1998) Phosphorylation of GTP cyclohydrolase I and modulation of its activity in rodent mast cells. GTP cyclohydrolase I hyperphosphorylation is coupled to high affinity IgE receptor signaling and involves protein kinase C. J. Biol. Chem. 273, 21616-21622
54. Pahan, K. et al. (1998) Sphingomyelinase and ceramide stimulate the expression of inducible nitric-oxide synthase in rat primary astrocytes. J. Biol. Chem. 273, 2591-2600
55. Vann, L.R. et al. (2002) Involvement of sphingosine kinase in TNF-alpha-stimulated tetrahydrobiopterin biosynthesis in C6 glioma cells. J. Biol. Chem. 277, 12649-12656
56. Faergeman, N.J. and Knidsen, J. (2002) Role of long-chain fatty acyl-CoA esters in the regulation of metabolism and cell signalling. Biochem. J. 323, 1-12
57. Boneh, A. (1996) Protein kinase C activity, phosphate uptake and endogenous substrate phosphorylation are altered in Zellweger syndrome. J. Inherit. Metab. Dis. 19, 661-666
58. Rust, C. et al. (2000) The bile acid taurochenodeoxycholate activates a phosphatidylinositol 3-kinase-dependent survival signaling cascade. J. Biol. Chem. 275, 20210-20216