Ceramide inhibition of NF-κB activation involves reverse translocation of classical protein kinase C (PKC) isoenzymes: Requirement for kinase activity and carboxyl-terminal phosphorylation of PKC for the ceramide response

FASEB Journal

Volumn 15, Issue 13, 2001, Pages 2401-2414

  Signorelli, Paola ^a   Luberto, Chiara ^a   Hannun, Yusuf A ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

C6 ceramide; Diacylglycerol; Glycerolipid; Sphingolipid

Indexed keywords

ALANINE; CERAMIDE; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; ISOENZYME; MUTANT PROTEIN; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN KINASE C;

ARTICLE; AUTOPHOSPHORYLATION; BREAST CANCER; CARBOXY TERMINAL SEQUENCE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME PHOSPHORYLATION; GENE MUTATION; GENE OVEREXPRESSION; GENE TRANSLOCATION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; IMMUNOREGULATION; INHIBITION KINETICS; LEUKEMIA CELL; LIPID METABOLISM; LIPID TRANSPORT; PRIORITY JOURNAL;

BIOLOGICAL TRANSPORT; CERAMIDES; GREEN FLUORESCENT PROTEINS; HUMANS; ISOENZYMES; JURKAT CELLS; LUMINESCENT PROTEINS; NF-KAPPA B; PHOSPHORYLATION; PROTEIN KINASE C; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; SPHINGOMYELIN PHOSPHODIESTERASE; TETRADECANOYLPHORBOL ACETATE; TUMOR CELLS, CULTURED;

EID: 0035163570     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.01-0244com     Document Type: Article

References (59)

1. Selective involvement of ceramide in cytokine- induced apoptosis. Ceramide inhibits phorbol ester activation of nuclear factor kappaB
2. Differential effects of sphingomyelin hydrolysis and resynthesis on the activation of NF-kappa B in normal and SV40-transformed human fibroblasts
3. Sphingolipid metabolism in the regulation of bioactive molecules
4. Does ceramide play a role in neural cell apoptosis?
5. Structure and functional properties of diacylglycerols in membranes
6. Protein kinase C: A paradigm for regulation of protein function by two membrane-targeting modules
7. Anchoring proteins for protein kinase C: A means for isozyrne selectivity
8. Ceramide in the eukaryotic stress response
9. Signalling sphingomyelinases: Which, where, how and why?
10. Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ
11. Compartmentalization of ceramide signaling: Physical foundations and biological effects
12. Atypical PKC zeta is activated by ceramide, resulting in coactivation of NF-kappaB/JNK kinase and cell survival
13. Protein kinase C zeta isoform is critical for kappa B-dependent promoter activation by sphingomyelinase
14. Protein phosphatase 2A is a critical regulator of protein kinase C zeta signaling targeted by SV40 small t to promote cell growth and NF-kappaB activation
15. Activation of IkappaB kinase beta by protein kinase C isoforms
16. Inactivation of the inhibitory kappaB protein kinase/nuclear factor kappaB pathway by Par-4 expression potentiates tumor necrosis factor alpha-induced apoptosis
17. Mapping of atypical protein kinase C within the nerve growth factor signaling cascade: Relationship to differentiation and survival of PC12 cells
18. Protein kinase C-alpha is an upstream activator of the IkappaB kinase complex in the TPA signal transduction pathway to NF-kappaB in U2OS cells
19. Antisense oligonucleotides targeting protein kinase C-alpha, -beta I, or -delta but not -eta inhibit lipopolysaccharide-induced nitric oxide synthase expression in RAW 264.7 macrophages: Involvement of a nuclear factor kappa B-dependent mechanism
20. Protein kinase C and calcineurin synergize to activate IkappaB kinase and NF-kappaB in T lymphocytes
21. Rottlerin, a PKC isozyme-selective inhibitor, affects signaling events and cytokine production in human monocytes
22. Protein kinase ctheta cooperates with calcineurin to induce Fas ligand expression during activation-induced T cell death
23. PKC-theta is required for TCR-induced NF-kappaB activation in mature but not immature T lymphocytes
24. Protein tyrosine kinase p561ck is required for ceramide-induced but not tumor necrosis factor-induced activation of NF-kappa B. AP-1, JNK, and apoptosis
25. TNF activates NF-kappa B by phosphatidylcholine-specific phospholipase C-induced 'acidic' sphingomyelin breakdown
26. Activation of NF kappa B and potentiation of TNF-induced NF kappa B activation by ceramide analogues in leukemic cell lines despite the absence of an observed sphingomyelinase signalling event
27. Regulation of receptor-mediated protein kinase C membrane trafficking by autophosphorylation
28. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
29. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
30. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications
31. Separation of oxidant-initiated and redox-regulated steps in the NF-kappa B signal transduction pathway
32. Wortmannin inhibits activation of nuclear transcription factors NF-kappaB and activated protein-1 induced by lipopolysaccharide and phorbol ester
33. The Rel/NF-kappa B family: Friend and foe
34. Identification of PKC-isoform-specific biological actions using pharmacological approaches
35. Ceramide inactivates cellular protein kinase Calpha
36. Functional dichotomy of protein kinase C (PKC) in tumor necrosis factor-alpha (TNF-alpha) signal transduction in L929 cells. Translocation and inactivation of PKC by TNF-alpha
37. An essential role for autophosphorylation in the dissociation of activated protein kinase C from the plasma membrane
38. Expression of neutral sphingomyelinase identifies a distinct pool of sphingomyelin involved in apoptosis
39. Multiple pathways control protein kinase C phosphorylation
40. 2+-activated and phospholipid-dependent protein kinase
41. 2+-dependent signal transduction pathways
42. A dominant negative protein kinase C zeta subspecies blocks NF-kappa B activation
43. Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets
44. Selective ceramide binding to protein kinase C-alpha and -delta isoenzymes in renal mesangial cells
45. PKC zeta is a molecular switch in signal transduction of TNF-alpha, bifunctionally regulated by ceramide and arachidonic acid
46. Ceramide-induced translocation of protein kinase C-delta and -epsilon to the cytosol. Implications in apoptosis
47. Differential effects of sphingomyelinase and cell-permeable ceramide analogs on proliferation of Swiss 3T3 fibroblasts
48. Ceramide induces Bc12 dephosphorylation via a mechanism involving mitochondrial PP2A
49. Regulation of protein kinase C
50. Cytokine response modifier A (CrmA) inhibits ceramide formation in response to tumor necrosis factor (TNF)-alpha: CrmA and Bcl-2 target distinct components in the apoptotic pathway
51. Phosphatidic acid is a potent and selective inhibitor of protein phosphatase 1 and an inhibitor of ceramide-mediated responses
52. BAD enables ceramide to signal apoptosis via Ras and Raf-1
53. Regulation of cyclin-dependent kinase 2 activity by ceramide
54. An accessory, role for ceramide in interleukin-1beta induced prostaglandin synthesis
55. Long chain ceramides activate protein phosphatase-1 and protein phosphatase-2A. Activation is stereospecific and regulated by phosphatidic acid
56. Ceramide activates heterotrimeric protein phosphatase 2A
57. Kinase suppressor of Ras is ceramide-activated protein kinase
58. Programmed cell death induced by ceramide
59. Phospholipase D in cellular senescence