Alternative splicing of β4 subunit proline-rich motif regulates voltage-dependent gating and toxin block of Cav2.1 Ca2+ channels

Journal of Neuroscience

Volumn 22, Issue 21, 2002, Pages 9331-9339

  Helton, Thomas D ^a,b   Kojetin, Douglas J ^a,b   Cavanagh, John ^a,b   Horne, William A ^a,b  

^a Department of Molecular Biomedical Sciences ^*  (United States)

^b NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

Alternative splicing; Calcium channel; Gating; N terminus; PSD 95; 4subunit; CTx MVIIC

Indexed keywords

CALCIUM CHANNEL; OMEGA CONOTOXIN MVIIC; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL N TYPE; MESSENGER RNA; NERVE PROTEIN; OMEGA CONOTOXIN; OMEGA-CONOTOXIN-MVIIC; POSTSYNAPTIC DENSITY PROTEINS; PROTEIN SUBUNIT; VOLTAGE DEPENDENT CALCIUM CHANNEL (P Q TYPE); VOLTAGE-DEPENDENT CALCIUM CHANNEL (P-Q TYPE);

ALTERNATIVE RNA SPLICING; AMINO TERMINAL SEQUENCE; ARTICLE; BETA CHAIN; CHANNEL GATING; CONTROLLED STUDY; ELECTRIC POTENTIAL; ELECTROPHYSIOLOGY; MOLECULAR EVOLUTION; MOLECULAR INTERACTION; MOLECULAR MODEL; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN STRUCTURE; REGULATORY MECHANISM; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; STRUCTURE ANALYSIS; ANIMAL; ANTIBODY SPECIFICITY; BRAIN; CELL MEMBRANE POTENTIAL; CHEMICAL STRUCTURE; DRUG EFFECT; GENE DELETION; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; OOCYTE; PATCH CLAMP; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; SPINAL CORD; STRUCTURE ACTIVITY RELATION; XENOPUS LAEVIS;

ALTERNATIVE SPLICING; AMINO ACID MOTIFS; ANIMALS; BRAIN; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, N-TYPE; HUMANS; ION CHANNEL GATING; MEMBRANE POTENTIALS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NERVE TISSUE PROTEINS; OMEGA-CONOTOXINS; OOCYTES; ORGAN SPECIFICITY; PATCH-CLAMP TECHNIQUES; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; RNA, MESSENGER; SEQUENCE DELETION; SEQUENCE HOMOLOGY, AMINO ACID; SPINAL CORD; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS LAEVIS;

EID: 0036827034     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.22-21-09331.2002     Document Type: Article

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