Histology of cystic tumors of the pancreas

Gastrointestinal Endoscopy Clinics of North America

Volumn 12, Issue 4, 2002, Pages 673-696

  Compton, Carolyn C ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CLINICAL FEATURE; CYSTADENOCARCINOMA; DIAGNOSTIC VALUE; HISTOLOGY; HUMAN; MICROSCOPY; PANCREAS CYST; PANCREAS TUMOR; PRIORITY JOURNAL; PSEUDOCYST; REVIEW;

CYST FLUID; CYSTADENOMA, MUCINOUS; CYSTADENOMA, SEROUS; DIAGNOSIS, DIFFERENTIAL; DNA, NEOPLASM; HISTOLOGICAL TECHNIQUES; HUMANS; IMMUNOHISTOCHEMISTRY; INCIDENCE; MOLECULAR DIAGNOSTIC TECHNIQUES; MUTATION; PANCREATIC CYST; PANCREATIC NEOPLASMS; PAPILLOMA, INTRADUCTAL;

EID: 0036817618     PISSN: 10525157     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1052-5157(02)00023-5     Document Type: Review

References (75)

1. Warshaw AL, Compton CC, Lewandrowski K, et al. Cystic tumors of the pancreas. Ann Surg 1990;212:432-44.
2. Yamaguchi K, Enjoli M. Cystic neoplasms of the pancreas. Gastroenterology 1987;92:1934-43.
3. Compagno J, Oertel JE. Microcystic adenomas of the pancreas (glycogen-rich cystadenomas); a clinicopathologic study of 34 cases. Am J Clin Pathol 1978;6:289-98.
4. Hodgkinson DJ, ReMine WH, Weiland LH, Pancreatic cystadenoma: A clinicopathologic study of 45 cases. Arch Surg 1978;113:512-7.
5. Morohoshi T, Held G, Klöppel G. Exocrine pancreatic tumours and their histological classification; a study based on 167 autopsy and 97 surgical cases. Histopathology 1983;7: 645-61.
6. Balthazar EJ, Chako AC. Computed tomography of pancreatic masses. Am J Gastroenterol 1990; 85:343-9.
7. Cubilla AL, Fitzgerald PJ. Classification of pancreatic cancer (non-endocrine). Mayo Clin Proc 1979;54:449-58.
8. Kimura W, Makuuchi M. Operative indications for cystic lesions of the pancreas with malignant potential - Our experience. Hepatogastroenterology 1999;46:483-91.
9. Carlson SK, Johnson CD, Brandt KR, et al. Pancreatic cystic neoplasms: The role and sensitivity of needle aspiration and biopsy. Abdom Imaging 1998;23:387-93.
10. Kamei K, Funabiki T, Ochiai M, et al. Some considerations on the biology of pancreatic serous cystadenoma. Int J Pancreatol 1992;11:97-104.
11. Zamora JL, Gunn LC, Manaligod JR. Microcystic adenoma of the pancreas: A newly recognized benign lesion. Curr Surg 1984;41:448-52.
12. Solcia E, Capella C, Klöppel G. Atlas of Tumor Pathology: Tumors of the Pancreas. Washington, DC: Armed Forces Institute of Pathology; 1997.
13. Shorten SD, Hart WR, Petras RE. Microcystic adenomas (serous cystadenomas) of pancreas: A clinicopathologic investigation of eight cases with immunohistochemical and ultrastructural studies. Am J Surg Pathol 1986;10:365-72.
14. Torres-Barrera G, Fernández-del Castillo C, Reyes E, et al. Microcystic adenoma of the pancreas. Dig Dis Sci 1987;32:454-8.
15. Alpert LC, Truong LD, Bossart MI, et al. Microcystic adenoma (serous cystadenoma) of the pancreas: A study of 14 cases with immunohistochemical and electron-microscopic correlation. Am J Surg Pathol 1988;12:251-63.
16. Pyke C, van Heerden J, Colby TV, et al. The spectrum of serous cystadenoma of the pancreas. Ann Surg 1992;215:132-9.
17. Corbally MT, McAnena OJ, Urmacher C, et al. Pancreatic cystadenoma: A clinicopathologic study. Arch Surg 1989;124:1271-4.
18. Martin I, Hammond P, Scott J, et al. Cystic tumours of the pancreas. Br J Surg 1998;85:1484-6.
19. Albores-Saavedra J, Gould EW, Angeles-Angeles A, et al. Cystic tumors of the pancreas. Pathol Annu 1990;25:19-50.
20. Procacci C, Graziani R, Bicego E, et al. Serous cystadenoma of the pancreas: Report of 30 cases with emphasis on the imaging findings. J Comput Assist Tomogr 1997;21:373-82.
21. Egawa N, Maillot B, Schröder S, et al. Serous oligocystic and ill-demarcated adenoma of the pancreas: A variant of serous cystic adenoma. Virch Arch 1994;424:13-7.
22. Bogomoletz WV, Adnet JJ, Widgren S, Stavrou M, et al. Cystadenoma of the pancreas: A histological, histochemical and ultrastructural study of seven cases. Histopathology 1980;4: 309-20.
23. Tanno S, Obara T, Sohma M, et al. Multifocal serous cystadenoma of the pancreas. Int J Pancreatol 1998;24:129-32.
24. Kim YI, Wook J, Suh JS, et al. Microcystic adenomas of the pancreas: Report of three cases with two of multicentric origin. Am J Clin Pathol 1990;94:150-6.
25. Lewandrowski KB, Warshaw AL, Compton CC. Macrocystic serous cystadenoma of the pancreas: A morphologic variant differing from microcystic adenoma. Hum Pathol 1992;23:871-5.
26. Capella C, Solcia E, Klöppel G, Hruban RH. Serous cystic neoplasms of the pancreas. In: Hamilton SR, Aaltonen LA, editors. World Health Organization Classification of Tumours: Pathology and Genetics of Tumours of the Digestive System. Lyon, France: IARC Press; 2000. p. 231-3.
27. Inuoe S, Yamaguchi K, Shimizu S, et al. Serous cystadenoma of the pancreas with atypical imaging features: A new variant of serous cystadenoma of the pancreas? Pancreas 1998;16: 102-6.
28. Casadei R, Santini D, Greco VM, et al. Macrocystic serous cystadenoma of the pancreas: Diagnostic, therapeutic and pathological considerations of three cases. Ital J Gastroenterol Hepatol 1997;29:54-7.
29. Mori K, Takeyama S, Hirosawa H, et al. A case of macrocystic serous cystadenoma of the pancreas. Int J Pancreatol 1997;17:91-3.
30. George DH, Murphy F, Michalski R, et al. Serous cystadenocarcinoma of the pancreas: A new entity? Am J Surg Pathol 1989;13:61-6.
31. Yoshimi N, Sugie S, Tanaka T, et al. A rare case of serous cystadenocarcinoma of the pancreas. Cancer 1992;69:2449-53.
32. Montag AG, Fossati N, Michelassi F. Pancreatic microcystic adenoma coexistent with pancreatic ductal carcinoma. Am J Surg Pathol 1990;14:352-5.
33. Keel SB, Zukerberg L, Graeme-Cook F, et al. A pancreatic endocrine tumor arising within a serous cystadenoma of the pancreas. Am J Surg Pathol 1996;20:471-5.
34. Beerman MH, Fromkes JJ, Carey LC, et al. Pancreatic cystadenoma in von Hippel-Lindau disease: An unusual cause of pancreatic and common bile duct obstruction. Clin Gastroenterol 1982;4:537-40.
35. Bickler S, Wile AG, Melicharek M, et al. Pancreatic involvement in von Hippel-Lindau disease. West J Med 1984;140:280-2.
36. Neumann HPH, Dinkel E, Brambs H, et al. Pancreatic lesions in the von Hippel-Lindau syndrome. Gastroenterology 1991;101:465-71.
37. Girelli R, Bassi C, Falconi M, et al. Pancreatic cystic manifestations in von Hippel-Lindau disease. Int J Pancreatol 1997;22:101-9.
38. Cheng T-Y, Su C-H, Shyr Y-M, et al. Management of pancreatic lesions in von Hippel-Lindau disease. World J Surg 1997;21:307-12.
39. Binkovitz LA, Johnson CD, Stephens DH. Islet cell tumors in von Hippel-Lindau disease: Increased prevalence and relationship to multiple endocrine neoplasias. AJR Am J Roentgenol 1990;155:501-5.
40. Cornish D, Pont A, Minor D, et al. Metastatic islet cell tumor in von Hippel-Lindau disease. Am J Med 1984;77:147-50.
41. Vortmeyer AO, Lubensky IA, Fogt F, et al. Allelic deletion and mutation of the von Hippel-Lindau (VHL) tumor suppressor gene in pancreatic microcystic adenomas. Am J Pathol 1997; 151:951-6.
42. Ishikawa T, Kakao A, Nomoto S, et al. Immunohistochemical and molecular biological studies of serous cystadenoma of the pancreas. Pancreas 1998;16:40-4.
43. Ebert MPA, Hoffman J, Schneider-Stock R, et al. Analysis of K-ras gene mutations in rare pancreatic and ampullary tumours. Eur J Gastroenterol Hepatol 1998;10:1025-9.
44. Bartsch D, Bastian D, Barth P, et al. K-ras oncogene mutations indicate malignancy in cystic tumors of the pancreas. Ann Surg 1998;228:79-86.
45. Jimenez RE, Warshaw AL, Z'Graggen K, Compton CC, Fernandez-del Castillo C. Sequential accumulation of K-ras mutations and p53 overexpression in the progression of pancreatic mucinous cystic neoplasms to malignancy. Ann Surg 1999;230:501-9.
46. Fléjou J-F, Boulange B, Bernades P, et al. p53 protein expression and DNA ploidy in cystic tumors of the pancreas. Pancreas 1996;13:247-52.
47. Hruban RH, Petersen GM, Ha PK, et al. Genetics of pancreatic cancer: From genes to families. Surg Oncol Clin N Am 1998;7:1-23.
48. Zamboni G, Longnecker DS, Klöppel G, Adler G, Hruban RH. Mucinous cystic neoplasms of the pancreas. In: Hamilton SR, Aaltonen LA, editors. World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Digestive System. Lyon, Frabce: IARC Press; 2000. p. 234-6.
49. Solcia E, Capella C, Klöppel G. Tumors of the exocrine pancreas. In: Rosai J, Sobin LH, editors. Atlas of Tumor Pathology: Tumors of the Pancreas. Washington, DC: Armed Forces Institute of Pathology; 1997. p. 31-129.
50. Thompson LDR, Becker RC, Przygodzki RM, Adair CF, Heffess CS. Mucinous cystic neoplasm (mucinous cystadenocarcinoma of low-grade malignant potential) of the pancreas: A clinicopathologic study of the pancreas. Am J Surg Pathol 1999;23:1-16.
51. Wilentz RE, Albores-Saavedra J, Zahurak M, et al. Pathologic examination accurately predicts prognosis in mucinous cystic neoplasms of the pancreas. Am J Surg Pathol 1999;23:1320-7.
52. Zamboni G, Scarpa A, Bogina G, et al. Mucinous cystic tumors of the pancreas: Clinicopathological features, prognosis, and relationship to other mucious cystic tumors. Am J Surg Pathol 1999;23:410-22.
53. Adsay NV, Klimstra DS, Compton CC. Cystic lesions of the pancreas. Semin Diagn Pathol 2000;17:1-6.
54. Lewandrowski KB, Southern JF, Pins MR, et al. Cyst fluid analysis in the differential diagnosis of pancreatic cysts: A comparison of pseudocysts, serous cystadenomas, mucinous cystic neoplasms, and mucinous cystadenocarcinomas. Ann Surg 1993;217:41-7.
55. Hammel P, Voitot H, Vilgrain V, et al. Diagnostic value of CA 72-4 and carcinoembryonic antigen determination in the fluid of pancreatic cystic lesions. Eur J Gastroenterol Hepatol 1998; 10:345-8.
56. Yang JM, Southern JF, Warshaw AL, et al. Proliferation tissue polypeptide antigen distinguishes malignant mucinous cystadenocarcinomas from benign cystic tumors and pseudocysts. Am J Surg 1996;171:126-30.
57. Sperti C, Pasquali C, Pedrazzoli S, et al. Expression of mucin-like carcinoma-associated antigen in the cyst fluid differentiates mucinous from nonmucinous pancreatic cysts. Am J Gastroenterol 1997;92:672-5.
58. Alles AJ, Warshaw AL, Southern JF, et al. Expression of CA72-4 (TAG-72) in the fluid contents of pancreatic cysts. Ann Surg 1994;219:131-4.
59. Sand JA, Hyötym MK, Mattila J, et al. Clinical assessment compared with cyst fluid analysis in the differential diagnosis of cystic lesions of the pancreas. Surgery 1996;199:275-80.
60. Alles AJ, Lee J, Southern JF, et al. Measurement of pS2 protein in pancreatic cyst fluids. Int J Pancreatol 1998;24:181-6.
61. Lewandrowski KB, Lee J, Southern JF, et al. Cyst fluid analysis in the differential diagnosis of pancreatic cysts: A new approach to the preoperative assessment of pancreatic cystic lesions. AJR Am J Roentgenol 1995;164:815-9.
62. Hammel P, Levy P, Voitot H, et al. Preoperative cyst fluid analysis is useful for the differential diagnosis of cystic lesions of the pancreas. Gastroenterology 1995;108:1230-5.
63. Yong WH, Southern JF, Warshaw AL, et al. Cyst fluid NB/70K concentration and leukocyte esterase: Two new markers for differentiating pancreatic serous tumors from pseudocysts. Pancreas 1995;10:342-6.
64. Yang JM, Lee J, Southern JF, et al. Measurement of pS2 protein in pancreatic cyst fluids. Int J Pancreatol 1998;24:181-6.
65. Rubin D, Warshaw AL, Southern JF, et al. Cyst fluid CA15-3 concentration differentiates pancreatic mucinous cystadenocarcinomas from benign pancreatic cysts. Surgery 1994;115: 52-5.
66. Lewandrowski KB, Warshaw AL, Compton CC, et al. Variability in cyst fluid carcinoembryonic antigen level, fluid viscosity, amylase content, and cytologic findings among multiple loculi of a pancreatic mucinous cystic neoplasm. Am J Clin Pathol 1993;100:425-7.
67. Jones EC, Suen CS, Grant DR, Chan NH. Fine-needle aspiration cytology of neoplastic cysts of the pancreas. Diagn Cytopathol 1987;3:238-43.
68. Centano BA, Lewandrowski KB, Warshaw AL, Compton CC, Southern JF. Cyst fluid analysis in the differential diagnosis of pancreatic cystic lesions. Am J Clin Pathol 1994;101:483-7.
69. Flejou JF, Boulange B, Bernandes P, et al. p53 protein expression and DNA ploidy in cystic tumors of the pancreas. Pancreas 1996;13:247-52.
70. Iacobuzio-Donahue CA, Wilentz RE, Argani P, et al. DPC4 protein in mucinous cystic neoplasms of the pancreas. Am J Surg Pathol 2000;24:1544-8.
71. Longnecker DS, Hruban RH, Adler G, Klöppel G. Intraductal Papillary-Mucinous Neoplasms of the pancreas. In: Hamilton SR, Aaltonen LA, editors. World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Digestive System. Lyon, France: IARC Press; 2000. p. 237-40.
72. Adsay V, Longnecker DS, Klimstra DS. Cystic tumors of the pancreas: Intraductal papillarymucinous tumors and intraductal oncocytic papillary neoplasms. Semin Diagn Pathol 2000; 17:16-30.
73. Longnecker DS. Observations on the etiology and pathogenesis of intraductal papillary-mucinous neoplasms of the pancreas. Hepatogastroenterology 1998;45:1973-80.
74. Hruban RH, Adsay NV, Albores-Saavedra J, et al. Pancreatic intraepithelial neoplasia: A new nomenclature and classification system for pancreatic duct lesions. Am J Surg Pathol 2001; 25:579-86.
75. Cuillerier E, Cellier C, Palazzo L, et al. Outcome after surgical resection of intraductal papillary mucinous tumors of the pancreas. Am J Gastroenterol 2000;95:441-5.