6-Substituted 3,4-dihyro-naphthalene-2-carboxylic acids: Synthesis and structure - Activity studies in a novel class of human 5α reductase inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 17, Issue 5, 2002, Pages 303-320

  Baston, Eckhard ^a   Salem, Ola I A ^a   Hartmann, Rolf W ^a  

^a SAARLAND UNIVERSITY   (Germany)

Author keywords

5 reductase inhibitors; 6 substituted 3,4 dihydro naphthalene 2 carboxylic acids; Benign prostatic hyperplasia; Dual non steroidal inhibitors; Rat and human steroid 5 reductase isozymes 1 and 2

Indexed keywords

17BETA (N,N DIETHYLCARBAMOYL) 4 METHYL 4 AZA 5ALPHA ANDROSTAN 3 ONE; 4,7BETA DIMETHYL 4 AZACHOLESTAN 3 ONE; 6 (3 METHOXYPHENYL) 3,4 DIHYDRONAPHTHALENE 2 CARBOXYLIC ACID; 6 (4 BENZOYLPHENYL) 3,4 DIHYDRONAPHTHALENE 2 CARBOXYLIC ACID; 6 (4 METHOXYPHENYL) 3,4 DIHYDRONAPHTHALENE 2 CARBOXYLIC ACID; 6 [3 (N TRIPHENYLMETHYLAMINOCARBONYL)PHENYL] 3,4 DIHYDRONAPHTHALENE 2 CARBOXYLIC ACID; 6 [3 (N,N DICYCLOHEXYLAMINOCARBONYL)PHENYL] 3,4 DIHYDRONAPHTHALENE 2 CARBOXYLIC ACID; 6 [3 (N,N DIISOPROPYLAMINOCARBONYL)PHENYL] 3,4 DIHYDRONAPHTHALENE 2 CARBOXYLIC ACID; 6 [4 (3 METHYLBUTYRYL)PHENYL] 3,4 DIHYDRONAPHTHALENE 2 CARBOXYLIC ACID; 6 [4 (N PHENYLAMINOCARBONYL)PHENYL] 3,4 DIHYDRONAPHTHALENE 2 CARBOXYLIC ACID; 6 [4 (N TERT BUTYLAMINOCARBONYL)PHENYL] 3,4 DIHYDRONAPHTHALENE 2 CARBOXYLIC ACID; 6 [4 (N,N DICYCLOHEXYLAMINOCARBONYL)PHENYL] 3,4 DIHYDRONAPHTHALENE 2 CARBOXYLIC ACID; 6 [4 (N,N DICYCLOHEXYLAMINOCARBONYL)PHENYL]NAPHTHALENE 2 CARBOXYLIC ACID; 6 [4 (N,N DIISOPROPYLAMINOCARBONYL)PHENYL] 3,4 DIHYDRONAPHTHALENE 2 CARBOXYLIC ACID; 6 [4 (N,N DIISOPROPYLAMINOCARBONYL)PHENYL]NAPHTHALENE 2 CARBOXYLIC ACID; 6 [4 [N (1 ADAMANTYL)AMINOCARBONYL]PHENYL] 3,4 DIHYDRONAPHTHALENE 2 CARBOXYLIC ACID; 6 PHENYL 3,4 DIHYDRONAPHTHALENE 2 CARBOXYLIC ACID; ANDROSTANOLONE; BENZAMIDE DERIVATIVE; CARBOXYLIC ACID DERIVATIVE; DUTASTERIDE; EPRISTERIDE; FINASTERIDE; ISOENZYME; N,N DICYCLOHEXYL 4 (6 OXO 5,6,7,8 TETRAHYDRONAPHTHALEN 2 YL)BENZAMIDE; N,N DIISOPROPYL 4 (6 OXO 5,6,7,8 TETRAHYDRONAPHTHALEN 2 YL)BENZAMIDE; STEROID 5ALPHA REDUCTASE; STEROID 5ALPHA REDUCTASE INHIBITOR; TESTOSTERONE; UNCLASSIFIED DRUG; CARBOXYLIC ACID; ENZYME INHIBITOR;

ANIMAL TISSUE; ARTICLE; CARBOXYLATION; CELL LINE; CHEMICAL REACTION; CONTROLLED STUDY; DRUG STRUCTURE; DRUG TARGETING; ENZYME INACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; MALE; NONHUMAN; ORCHIECTOMY; PRIORITY JOURNAL; PROSTATE; RAT; STRUCTURE ACTIVITY RELATION; SYNTHESIS; ANIMAL; CELL CULTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG SCREENING; ENZYMOLOGY; IC 50; PROSTATE TUMOR; SPRAGUE DAWLEY RAT;

ANIMALS; CARBOXYLIC ACIDS; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; ISOENZYMES; MALE; ORCHIECTOMY; PROSTATE; PROSTATIC NEOPLASMS; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP; TESTOSTERONE 5-ALPHA-REDUCTASE; TUMOR CELLS, CULTURED;

EID: 0036817350     PISSN: 14756366     EISSN: None     Source Type: Journal    
DOI: 10.1080/1475636021000059092     Document Type: Article

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