Molecular epidemiology of malaria in Cameroon. XIII. Analysis of PFCRT mutations and in vitro chloroquine resistance

American Journal of Tropical Medicine and Hygiene

Volumn 67, Issue 4, 2002, Pages 388-391

  Basco, Leonardo K ^a  

^a Institut de Recherche pour le Developpement Cameroon   (Cameroon)

Author keywords

[No Author keywords available]

Indexed keywords

AMODIAQUINE; ASPARAGINE; CHLOROQUINE; CYSTEINE; GLUTAMIC ACID; ISOLEUCINE; LYSINE; METHIONINE; MOLECULAR MARKER; THREONINE;

ADOLESCENT; ALLELE; AMINO ACID SUBSTITUTION; ARTICLE; CAMEROON; CHILD; CODON; EXON; GENE; GENE MUTATION; GENE SEQUENCE; GENETIC MARKER; HUMAN; IC 50; MALARIA; NONHUMAN; PFCRT GENE; PHENOTYPE; WILD TYPE;

PLASMODIUM FALCIPARUM; PROTOZOA;

EID: 0036807027     PISSN: 00029637     EISSN: None     Source Type: Journal    
DOI: 10.4269/ajtmh.2002.67.388     Document Type: Article

References (24)

1. Foote SJ, Thompson JK, Cowman AF, Kemp DJ, 1989. Amplification of the multidrug resistance gene in some chloroquine-resistant isolates of P. falciparum. Cell 57: 921-930.
2. Foote SJ, Kyle DE, Martin RK, Oduola AMJ, Forsyth K, Kemp DJ, Cowman AF, 1990. Several alleles of the multidrug-resistance gene are closely linked to chloroquine resistance in Plasmodium falciparum. Nature 345: 255-258.
3. Wellems TE, Panton LJ, Gluzman IY, Rosario VE, Gwadz RW, Walker-Jonah A, Krogstad DJ, 1990. Chloroquine resistance not linked to mdr-like genes in Plasmodium falciparum cross. Nature 345: 253-255.
4. Wellems TE, Walker-Jonah A, Panton LJ, 1991. Genetic mapping of the chloroquine-resistance locus on Plasmodium falciparum chromosome 7. Proc Natl Acad Sci USA 88: 3382-3386.
5. Su XZ, Kirkman LA, Fujioka H, Wellems TE, 1997. Complex polymorphisms in an approximately 330 kDa protein are linked to chloroquine-resistant P. falciparum in Southeast Asia and Africa. Cell 91: 593-603.
6. Fidock DA, Nomura T, Cooper RA, Su XZ, Talley AK, Wellems TE, 2000. Allelic modifications of the cg2 and cg1 genes do not alter the chloroquine response of drug-resistant Plasmodium falciparum. Mol Biochem Parasitol 110: 1-10.
7. Fidock DA, Nomura T, Talley AK, Cooper RA, Dzekunov SM, Ferdig MT, Ursos LMB, Sidhu ABS, Naude B, Deitsch KW, Su XZ, Wootton JC, Roepe PD, Wellems TE, 2000. Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance. Mol Cell 6: 861-871.
8. Babiker HA, Pringle SJ, Abdel-Muhsin A, Mackinnon M, Hunt P, Walliker D, 2001. High-level chloroquine resistance in Sudanese isolates of Plasmodium falciparum is associated with mutations in the chloroquine resistance transporter gene pfcrt and the multidrug resistance gene pfmdr1. J Infect Dis 183: 1535-1538.
9. Basco LK, Ringwald P, 2001. Analysis of the key pfcrt point mutation and in vitro and in vivo response to chloroquine in Yaounde, Cameroon. J Infect Dis 183: 1828-1831.
10. Vieira PP, das Graças Alecrim M, da Silva LHP, Gonzalez-Jimenez I, Zalis MG, 2001. Analysis of the PfCRT K76T mutation in Plasmodium falciparum isolates from the Amazon region of Brazil. J Infect Dis 183: 1832-1833.
11. Chen N, Russell B, Staley J, Kotecka B, Nasveld P, Cheng Q, 2001. Sequence polymorphisms in pfcrt are strongly associated with chloroquine resistance in Plasmodium falciparum. J Infect Dis 183: 1543-1545.
12. Wellems TE, Plowe CV, 2001. Chloroquine-resistant malaria. J Infect Dis 184: 770-776.
13. Mount DL, Nahlen BL, Patchen LC, Churchill FC, 1989. Adaptations of the Saker-Solomons test: Simple reliable colorimetric field assays for chloroquine and its metabolites in urine. Bull World Health Organ 67: 295-300.
14. Basco LK, Ringwald P, 1999. Molecular epidemiology of malaria in Yaounde, Cameroon. V. Analysis of the omega repetitive region of the Plasmodium falciparum cg2 gene and chloroquine resistance. Am J Trop Med Hyg 61: 807-813.
15. Djimde A, Doumbo OK, Cortese JF, Kayentao K, Doumbo S, Diourte Y, Dicko A, Su XZ, Nomura T, Fidock DA, Wellems TE, Plowe CV, Coulibaly D, 2001. A molecular marker for chloroquine-resistant falciparum malaria. N Engl J Med 344: 257-263.
16. Basco LK, Ndounga M, Keundjian A, Ringwald P, 2002. Molecular epidemiology of malaria in Cameroon. IX. Characteristics of recrudescent and persistent Plasmodium falciparum infections after chloroquine or amodiaquine treatment in children. Am J Trop Med Hyg 66: 117-123.
17. Basco LK, Ringwald P, 2002. Molecular epidemiology of malaria in Yaounde, Cameroon. VIII. Multiple Plasmodium falciparum infections in symptomatic patients. Am J Trop Med Hyg 65: 798-803.
18. Basco LK, Ndounga M, Foumane Ngane V, Soula G, 2002. XIV. Molecular epidemiology of malaria in Cameroon. Pfcrt gene sequences of isolates before and after chloroquine treatment. Am J Trop Med Hyg 67: 392-395.
19. Durand R, Jafari S, Vauzelle J, Delabre J, Jesic Z, Le Bras J, 2001. Analysis of pfcrt point mutations and chloroquine susceptibility in isolates of Plasmodium falciparum. Mol Biochem Parasitol 114: 95-102.
20. Wernsdorfer WH, Payne D, 1988. Drug sensitivity tests in malaria parasites. In: Wernsdorfer WH, McGregor I (eds), Malaria: Principles and Practice of Malariology, London: Churchill Livingstone, 1765-1800.
21. Mayor AG. Gomez-Olive X, Aponte JJ, Casimiro S, Mabunda S, Dgedge M, Barreto A, Alonso PL, 2001. Prevalence of the K76T mutation in the putative Plasmodium falciparum chloroquine resistance transporter (pfcrt) gene and its relation to chloroquine resistance in Mozambique. J Infect Dis 183: 1413-1416.
22. Mockenhaupt FP, Eggelte TA, Till H, Bienzle U, 2001. Plasmodium falciparum pfcrt and pfmdr1 polymorphisms are associated with the pfdhfr N108 pyrimethamine-resistance mutation in isolates from Ghana. Trop Med Int Health 6: 749-755.
23. Nomura T, Carlton JMR, Baird JK, del Portillo HA, Fryauff DJ, Rathore D, Fidock DA, Su XZ, Collins WE, McCutchan TF, Wootton JC, Wellems TE, 2001. Evidence for different mechanisms of chloroquine resistance in 2 Plasmodium species that cause human malaria. J Infect Dis 183: 1653-1661.
24. Carlton JM, Fidock DA, Djinide A, Plowe CV, Wellems TE, 2001. Conservation of a novel vacuolar transporter in Plasmodium species and its central role in chloroquine resistance of P. falciparum. Curr Opin Microbiol 4: 415-420.