메뉴 건너뛰기




Volumn 8, Issue 10, 2002, Pages 476-482

Hepatitis C: Molecular virology and antiviral targets

Author keywords

[No Author keywords available]

Indexed keywords

STRUCTURAL PROTEIN; VIRUS ENVELOPE PROTEIN; VIRUS PROTEIN;

EID: 0036788397     PISSN: 14714914     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1471-4914(02)02395-X     Document Type: Review
Times cited : (53)

References (71)
  • 1
  • 2
    • 0032841846 scopus 로고    scopus 로고
    • Pathogenesis of chronic hepatitis C: Immunological features of hepatic injury and viral persistence
    • Cerny, A. and Chisari, F.V. (1999) Pathogenesis of chronic hepatitis C: immunological features of hepatic injury and viral persistence. Hepatology 30, 595-601
    • (1999) Hepatology , vol.30 , pp. 595-601
    • Cerny, A.1    Chisari, F.V.2
  • 3
    • 0035934568 scopus 로고    scopus 로고
    • Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: A randomised trial
    • Manns, M.P. et al. (2001) Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial. Lancet 358, 958-965
    • (2001) Lancet , vol.358 , pp. 958-965
    • Manns, M.P.1
  • 4
    • 0037133079 scopus 로고    scopus 로고
    • Surprisingly small effect of antiviral treatment in patients with hepatitis C
    • Falck-Ytter, Y. et al. (2002) Surprisingly small effect of antiviral treatment in patients with hepatitis C. Ann. Intern. Med. 136, 288-292
    • (2002) Ann. Intern. Med. , vol.136 , pp. 288-292
    • Falck-Ytter, Y.1
  • 5
    • 0036186459 scopus 로고    scopus 로고
    • Modeling the hepatitis C virus epidemic in France using the temporal pattern of hepatocellular carcinoma deaths
    • Griffiths, J. and Nix, B. (2002) Modeling the hepatitis C virus epidemic in France using the temporal pattern of hepatocellular carcinoma deaths. Hepatology 35, 709-715
    • (2002) Hepatology , vol.35 , pp. 709-715
    • Griffiths, J.1    Nix, B.2
  • 6
    • 0024509701 scopus 로고
    • Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome
    • Choo, Q-L. et al. (1989) Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science 244, 359-362
    • (1989) Science , vol.244 , pp. 359-362
    • Choo, Q.-L.1
  • 7
    • 0024511734 scopus 로고
    • An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis
    • Kuo, G. et al. (1989) An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis. Science 244, 362-364
    • (1989) Science , vol.244 , pp. 362-364
    • Kuo, G.1
  • 8
    • 0030864915 scopus 로고    scopus 로고
    • Transmission of hepatitis C by intrahepatic inoculation with transcribed RNA
    • Kolykhalov, A.A. et al. (1997) Transmission of hepatitis C by intrahepatic inoculation with transcribed RNA. Science 277, 570-574
    • (1997) Science , vol.277 , pp. 570-574
    • Kolykhalov, A.A.1
  • 9
    • 0345188811 scopus 로고    scopus 로고
    • Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line
    • Lohmann, V. et al. (1999) Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line. Science 285, 110-113
    • (1999) Science , vol.285 , pp. 110-113
    • Lohmann, V.1
  • 10
    • 0033920795 scopus 로고    scopus 로고
    • Replication of hepatitis C virus
    • Bartenschlager, R. and Lohmann, V. (2000) Replication of hepatitis C virus. J. Gen. Virol. 81, 1631-1648
    • (2000) J. Gen. Virol. , vol.81 , pp. 1631-1648
    • Bartenschlager, R.1    Lohmann, V.2
  • 11
    • 0000163169 scopus 로고    scopus 로고
    • Flaviviridae: The viruses and their replication
    • (Knipe, D.M. and Howley, P.M., eds), Lippincott-Raven Publishers
    • Lindenbach, B.D. and Rice, C.M. (2001) Flaviviridae: the viruses and their replication. In Fields Virology (Knipe, D.M. and Howley, P.M., eds), pp. 991-1041, Lippincott-Raven Publishers
    • (2001) Fields Virology , pp. 991-1041
    • Lindenbach, B.D.1    Rice, C.M.2
  • 12
    • 0036346427 scopus 로고    scopus 로고
    • Advances in model systems for hepatitis C virus research
    • Lanford, R.E. and Bigger, C. (2002) Advances in model systems for hepatitis C virus research. Virology 293, 1-9
    • (2002) Virology , vol.293 , pp. 1-9
    • Lanford, R.E.1    Bigger, C.2
  • 13
    • 0033992656 scopus 로고    scopus 로고
    • Internal ribosome entry site-mediated translation in hepatitis C virus replication
    • Rijnbrand, R.C. and Lemon, S.M. (2000) Internal ribosome entry site-mediated translation in hepatitis C virus replication. Curr. Top. Microbiol. Immunol. 242, 85-116
    • (2000) Curr. Top. Microbiol. Immunol. , vol.242 , pp. 85-116
    • Rijnbrand, R.C.1    Lemon, S.M.2
  • 14
    • 0035831269 scopus 로고    scopus 로고
    • Hepatitis C virus IRES RNA-induced changes in the conformation of the 40S ribosomal subunit
    • Spahn, C.M. et al. (2001) Hepatitis C virus IRES RNA-induced changes in the conformation of the 40S ribosomal subunit. Science 291, 1959-1962
    • (2001) Science , vol.291 , pp. 1959-1962
    • Spahn, C.M.1
  • 15
    • 0036094885 scopus 로고    scopus 로고
    • Genetic analysis of sequences in the 3′ nontranslated region of hepatitis C virus that are important for RNA replication
    • Friebe, P. and Bartenschlager, R. (2002) Genetic analysis of sequences in the 3′ nontranslated region of hepatitis C virus that are important for RNA replication. J. Virol. 76, 5326-5338
    • (2002) J. Virol. , vol.76 , pp. 5326-5338
    • Friebe, P.1    Bartenschlager, R.2
  • 16
    • 0034053296 scopus 로고    scopus 로고
    • Properties of the hepatitis C virus core protein: A structural protein that modulates cellular processes
    • McLauchlan, J. (2000) Properties of the hepatitis C virus core protein: a structural protein that modulates cellular processes. J. Viral Hepatitis 7, 2-14
    • (2000) J. Viral Hepatitis , vol.7 , pp. 2-14
    • McLauchlan, J.1
  • 17
    • 0034775964 scopus 로고    scopus 로고
    • Biogenesis of hepatitis C virus envelope glycoproteins
    • Op De Beeck, A. et al. (2001) Biogenesis of hepatitis C virus envelope glycoproteins. J. Gen. Virol. 82, 2589-2595
    • (2001) J. Gen. Virol. , vol.82 , pp. 2589-2595
    • Op De Beeck, A.1
  • 18
    • 0034663695 scopus 로고    scopus 로고
    • A model for the hepatitis C virus envelope glycoprotein E2
    • Yagnik, A.T. et al. (2000) A model for the hepatitis C virus envelope glycoprotein E2. Proteins 40, 355-366
    • (2000) Proteins , vol.40 , pp. 355-366
    • Yagnik, A.T.1
  • 19
    • 0036199092 scopus 로고    scopus 로고
    • Subcellular localization and topology of the p7 polypeptide of hepatitis C virus
    • Carrère-Kremer, S. et al. (2002) Subcellular localization and topology of the p7 polypeptide of hepatitis C virus. J. Virol. 76, 3720-3730
    • (2002) J. Virol. , vol.76 , pp. 3720-3730
    • Carrère-Kremer, S.1
  • 20
    • 0033819541 scopus 로고    scopus 로고
    • E2-p7 region of the bovine viral diarrhea virus polyprotein: Processing and functional studies
    • Harada, T. et al. (2000) E2-p7 region of the bovine viral diarrhea virus polyprotein: processing and functional studies. J. Virol. 74, 9498-9506
    • (2000) J. Virol. , vol.74 , pp. 9498-9506
    • Harada, T.1
  • 21
    • 0035050164 scopus 로고    scopus 로고
    • Evidence for a new hepatitis C virus antigen encoded in an overlapping reading frame
    • Walewski, J.L. et al. (2001) Evidence for a new hepatitis C virus antigen encoded in an overlapping reading frame. RNA 7, 710-721
    • (2001) RNA , vol.7 , pp. 710-721
    • Walewski, J.L.1
  • 22
    • 0035898608 scopus 로고    scopus 로고
    • Synthesis of a novel hepatitis C virus protein by ribosomal frameshift
    • Xu, Z. et al. (2001) Synthesis of a novel hepatitis C virus protein by ribosomal frameshift. EMBO J. 20, 3840-3848
    • (2001) EMBO J. , vol.20 , pp. 3840-3848
    • Xu, Z.1
  • 23
    • 0037124073 scopus 로고    scopus 로고
    • Alternate translation occurs within the core coding region of the hepatitis C viral genome
    • Varaklioti, A. et al. (2002) Alternate translation occurs within the core coding region of the hepatitis C viral genome. J. Biol. Chem. 277, 17713-17721
    • (2002) J. Biol. Chem. , vol.277 , pp. 17713-17721
    • Varaklioti, A.1
  • 24
    • 0036199776 scopus 로고    scopus 로고
    • Hepatitis C virus-like particle morphogenesis
    • Blanchard, E. et al. (2002) Hepatitis C virus-like particle morphogenesis. J. Virol. 76, 4073-4079
    • (2002) J. Virol. , vol.76 , pp. 4073-4079
    • Blanchard, E.1
  • 25
    • 0036196022 scopus 로고    scopus 로고
    • Persistent and transient replication of full-length hepatitis C virus genomes in cell culture
    • Pietschmann, T. et al. (2002) Persistent and transient replication of full-length hepatitis C virus genomes in cell culture. J. Virol. 76, 4008-4021
    • (2002) J. Virol. , vol.76 , pp. 4008-4021
    • Pietschmann, T.1
  • 26
    • 18344387519 scopus 로고    scopus 로고
    • Structure of dengue virus: Implications for flavivirus organization, maturation, and fusion
    • Kuhn, R.J. et al. (2002) Structure of dengue virus: implications for flavivirus organization, maturation, and fusion. Cell 108, 717-725
    • (2002) Cell , vol.108 , pp. 717-725
    • Kuhn, R.J.1
  • 27
    • 0035862964 scopus 로고    scopus 로고
    • CD81 extracellular domain 3D structure: Insight into the tetraspanin superfamily structural motifs
    • Kitadokoro, K. et al. (2001) CD81 extracellular domain 3D structure: insight into the tetraspanin superfamily structural motifs. EMBO J. 20, 12-18
    • (2001) EMBO J. , vol.20 , pp. 12-18
    • Kitadokoro, K.1
  • 28
    • 0032582538 scopus 로고    scopus 로고
    • Binding of hepatitis C virus to CD81
    • Pileri, P. et al. (1998) Binding of hepatitis C virus to CD81. Science 282, 938-941
    • (1998) Science , vol.282 , pp. 938-941
    • Pileri, P.1
  • 29
    • 0033607281 scopus 로고    scopus 로고
    • Hepatitis C virus and other flaviviridae viruses enter cells via low density lipoprotein receptor
    • Agnello, V. et al. (1999) Hepatitis C virus and other flaviviridae viruses enter cells via low density lipoprotein receptor. Proc. Natl. Acad. Sci. U. S. A. 96, 12766-12771
    • (1999) Proc. Natl. Acad. Sci. U. S. A. , vol.96 , pp. 12766-12771
    • Agnello, V.1
  • 30
    • 0033781909 scopus 로고    scopus 로고
    • Characterization of hepatitis C virus (HCV) and HCV E2 interactions with CD81 and the low-density lipoprotein receptor
    • Wünschmann, S. et al. (2000) Characterization of hepatitis C virus (HCV) and HCV E2 interactions with CD81 and the low-density lipoprotein receptor. J. Virol. 74, 10055-10062
    • (2000) J. Virol. , vol.74 , pp. 10055-10062
    • Wünschmann, S.1
  • 31
    • 0034122661 scopus 로고    scopus 로고
    • Binding of hepatitis C virus E2 glycoprotein to CD81 does not correlate with species permissiveness to infection
    • Meola, A. et al. (2000) Binding of hepatitis C virus E2 glycoprotein to CD81 does not correlate with species permissiveness to infection. J. Virol. 74, 5933-5938
    • (2000) J. Virol. , vol.74 , pp. 5933-5938
    • Meola, A.1
  • 32
    • 0032768960 scopus 로고    scopus 로고
    • Characterization of hepatitis C virus E2 glycoprotein interaction with a putative cellular receptor, CD81
    • Flint, M. et al. (1999) Characterization of hepatitis C virus E2 glycoprotein interaction with a putative cellular receptor, CD81. J. Virol. 73, 6235-6244
    • (1999) J. Virol. , vol.73 , pp. 6235-6244
    • Flint, M.1
  • 33
    • 0037033363 scopus 로고    scopus 로고
    • Binding of the hepatitis C virus envelope protein E2 to CD81 inhibits natural killer cell functions
    • Tseng, C.T. and Klimpel, G.R. (2002) Binding of the hepatitis C virus envelope protein E2 to CD81 inhibits natural killer cell functions. J. Exp. Med. 195, 43-49
    • (2002) J. Exp. Med. , vol.195 , pp. 43-49
    • Tseng, C.T.1    Klimpel, G.R.2
  • 34
    • 0037033359 scopus 로고    scopus 로고
    • Inhibition of natural killer cells through engagement of CD81 by the major hepatitis C virus envelope protein
    • Crotta, S. et al. (2002) Inhibition of natural killer cells through engagement of CD81 by the major hepatitis C virus envelope protein. J. Exp. Med. 195, 35-41
    • (2002) J. Exp. Med. , vol.195 , pp. 35-41
    • Crotta, S.1
  • 35
    • 19044396066 scopus 로고    scopus 로고
    • Characterization of low-and very-low-density hepatitis C virus RNA-containing particles
    • Andre, P. et al. (2002) Characterization of low-and very-low-density hepatitis C virus RNA-containing particles. J. Virol. 76, 6919-6928
    • (2002) J. Virol. , vol.76 , pp. 6919-6928
    • Andre, P.1
  • 36
    • 0033920304 scopus 로고    scopus 로고
    • Hepatitis C virus-encoded enzymatic activities and conserved RNA elements in the 3′ nontranslated region are essential for virus replication in vivo
    • Kolykhalov, A.A. et al. (2000) Hepatitis C virus-encoded enzymatic activities and conserved RNA elements in the 3′ nontranslated region are essential for virus replication in vivo. J. Virol. 74, 2046-2051
    • (2000) J. Virol. , vol.74 , pp. 2046-2051
    • Kolykhalov, A.A.1
  • 37
    • 0034812856 scopus 로고    scopus 로고
    • Characterization of the hepatitis C virus NS2/3 processing reaction by using a purified precursor protein
    • Pallaoro, M. et al. (2001) Characterization of the hepatitis C virus NS2/3 processing reaction by using a purified precursor protein. J. Virol. 75, 9939-9946
    • (2001) J. Virol. , vol.75 , pp. 9939-9946
    • Pallaoro, M.1
  • 38
    • 0033992657 scopus 로고    scopus 로고
    • Structure and function of the hepatitis C virus NS3-NS4A serine protease
    • De Francesco, R. and Steinkühler, C. (2000) Structure and function of the hepatitis C virus NS3-NS4A serine protease. Curr. Top. Microbiol. Immunol. 242, 149-169
    • (2000) Curr. Top. Microbiol. Immunol. , vol.242 , pp. 149-169
    • De Francesco, R.1    Steinkühler, C.2
  • 39
    • 0033992576 scopus 로고    scopus 로고
    • Structure and function of hepatitis C virus NS3 helicase
    • Kwong, A.D. et al. (2000) Structure and function of hepatitis C virus NS3 helicase. Curr. Top. Microbiol. Immunol. 242, 171-196
    • (2000) Curr. Top. Microbiol. Immunol. , vol.242 , pp. 171-196
    • Kwong, A.D.1
  • 40
    • 0033571623 scopus 로고    scopus 로고
    • Molecular views of viral polyprotein processing revealed by the crystal structure of the hepatitis C virus bifunctional protease-helicase
    • Yao, N. et al. (1999) Molecular views of viral polyprotein processing revealed by the crystal structure of the hepatitis C virus bifunctional protease-helicase. Structure Fold Des. 7, 1353-1363
    • (1999) Structure Fold Des. , vol.7 , pp. 1353-1363
    • Yao, N.1
  • 41
    • 0036100578 scopus 로고    scopus 로고
    • Expression of hepatitis C virus proteins induces distinct membrane alterations including a candidate viral replication complex
    • Egger, D. et al. (2002) Expression of hepatitis C virus proteins induces distinct membrane alterations including a candidate viral replication complex. J. Virol. 76, 5974-5984
    • (2002) J. Virol. , vol.76 , pp. 5974-5984
    • Egger, D.1
  • 42
    • 0031780867 scopus 로고    scopus 로고
    • The NS5A/NS5 proteins of viruses from three genera of the family flaviviridae are phosphorylated by associated serine/threonine kinases
    • Reed, K.E. et al. (1998) The NS5A/NS5 proteins of viruses from three genera of the family flaviviridae are phosphorylated by associated serine/threonine kinases. J. Virol. 72, 6199-6206
    • (1998) J. Virol. , vol.72 , pp. 6199-6206
    • Reed, K.E.1
  • 43
    • 9144257569 scopus 로고    scopus 로고
    • Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infection
    • Enomoto, N. et al. (1996) Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infection. New Engl. J. Med. 334, 77-81
    • (1996) New Engl. J. Med. , vol.334 , pp. 77-81
    • Enomoto, N.1
  • 44
    • 0037007105 scopus 로고    scopus 로고
    • Regulation of PKR and IRF-1 during hepatitis C virus RNA replication
    • Pflugheber, J. et al. (2002) Regulation of PKR and IRF-1 during hepatitis C virus RNA replication. Proc. Natl. Acad. Sci. U. S. A. 99, 4650-4655
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 4650-4655
    • Pflugheber, J.1
  • 45
    • 0035947270 scopus 로고    scopus 로고
    • How hepatitis C virus counteracts the interferon response: The jury is still out on NS5A
    • Tan, S-L. and Katze, M.G. (2001) How hepatitis C virus counteracts the interferon response: the jury is still out on NS5A. Virology 284, 1-12
    • (2001) Virology , vol.284 , pp. 1-12
    • Tan, S.-L.1    Katze, M.G.2
  • 46
    • 0032876683 scopus 로고    scopus 로고
    • Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site
    • Lesburg, C.A. et al. (1999) Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site. Nat. Struct. Biol. 6, 937-943
    • (1999) Nat. Struct. Biol. , vol.6 , pp. 937-943
    • Lesburg, C.A.1
  • 47
    • 0036120573 scopus 로고    scopus 로고
    • Structural analysis of the hepatitis C virus RNA polymerase in complex with ribonucleotides
    • Bressanelli, S. et al. (2002) Structural analysis of the hepatitis C virus RNA polymerase in complex with ribonucleotides. J. Virol. 76, 3482-3492
    • (2002) J. Virol. , vol.76 , pp. 3482-3492
    • Bressanelli, S.1
  • 48
    • 0037192863 scopus 로고    scopus 로고
    • Hepatitis C virus NS5A binds RNA-dependent RNA polymerase NS5B and modulates RNA-dependent RNA polymerase activity
    • Shirota, Y et al. (2002) Hepatitis C virus NS5A binds RNA-dependent RNA polymerase NS5B and modulates RNA-dependent RNA polymerase activity. J. Biol. Chem. 277, 11149-11155
    • (2002) J. Biol. Chem. , vol.277 , pp. 11149-11155
    • Shirota, Y.1
  • 49
    • 0242456017 scopus 로고    scopus 로고
    • Subcellular localization, stability and trans-cleavage competence of the hepatitis C virus NS3-NS4A complex expressed in tetracycline-regulated cell lines
    • Wölk, B. et al. (2000) Subcellular localization, stability and trans-cleavage competence of the hepatitis C virus NS3-NS4A complex expressed in tetracycline-regulated cell lines. J. Virol. 74, 2293-2304
    • (2000) J. Virol. , vol.74 , pp. 2293-2304
    • Wölk, B.1
  • 50
    • 0035941344 scopus 로고    scopus 로고
    • Determinants for membrane association of the hepatitis C virus RNA-dependent RNA polymerase
    • Schmidt-Mende, J. et al. (2001) Determinants for membrane association of the hepatitis C virus RNA-dependent RNA polymerase. J. Biol. Chem. 276, 44052-44063
    • (2001) J. Biol. Chem. , vol.276 , pp. 44052-44063
    • Schmidt-Mende, J.1
  • 51
    • 0037040923 scopus 로고    scopus 로고
    • An aminoterminal amphipathic alpha-helix mediates membrane association of the hepatitis C virus nonstructural protein 5A
    • Brass, V. et al. (2002) An aminoterminal amphipathic alpha-helix mediates membrane association of the hepatitis C virus nonstructural protein 5A. J. Biol. Chem. 277, 8130-8139
    • (2002) J. Biol. Chem. , vol.277 , pp. 8130-8139
    • Brass, V.1
  • 52
    • 0032475822 scopus 로고    scopus 로고
    • Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-alpha therapy
    • Neumann, A.U. et al. (1998) Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-alpha therapy. Science 282, 103-107
    • (1998) Science , vol.282 , pp. 103-107
    • Neumann, A.U.1
  • 53
    • 0010589395 scopus 로고    scopus 로고
    • Cell lines that allow regulated expression of HCV proteins: Principles and applications
    • (Schinazi, R.F. et al., eds), Elsevier Science (in press)
    • Moradpour, D. et al. Cell lines that allow regulated expression of HCV proteins: principles and applications. In Frontiers in Viral Hepatitis (Schinazi, R.F. et al., eds), Elsevier Science (in press)
    • Frontiers in Viral Hepatitis
    • Moradpour, D.1
  • 54
    • 0005042486 scopus 로고    scopus 로고
    • Poliovirus/hepatitis C virus (internal ribosomal entry site-core) chimeric viruses: Improved growth properties through modification of proteolytic cleavage site and requirement for core RNA sequences but not for core-related polypeptides
    • Zhao, W.D. et al. (1999) Poliovirus/hepatitis C virus (internal ribosomal entry site-core) chimeric viruses: improved growth properties through modification of proteolytic cleavage site and requirement for core RNA sequences but not for core-related polypeptides. J. Virol. 73, 1546-1554
    • (1999) J. Virol. , vol.73 , pp. 1546-1554
    • Zhao, W.D.1
  • 55
    • 0032889528 scopus 로고    scopus 로고
    • Selection of functional variants of the NS3-NS4A protease of hepatitis C virus by using chimeric Sindbis viruses
    • Filocamo, G. et al. (1999) Selection of functional variants of the NS3-NS4A protease of hepatitis C virus by using chimeric Sindbis viruses. J. Virol. 73, 561-575
    • (1999) J. Virol. , vol.73 , pp. 561-575
    • Filocamo, G.1
  • 56
    • 0034623816 scopus 로고    scopus 로고
    • Efficient initiation of HCV RNA replication in cell culture
    • Blight, K.J. et al. (2000) Efficient initiation of HCV RNA replication in cell culture. Science 290, 1972-1974
    • (2000) Science , vol.290 , pp. 1972-1974
    • Blight, K.J.1
  • 57
    • 0035157218 scopus 로고    scopus 로고
    • Mutations in hepatitis C virus RNAs conferring cell culture adaptation
    • Lohmann, V. et al. (2001) Mutations in hepatitis C virus RNAs conferring cell culture adaptation. J. Virol. 75, 1437-1449
    • (2001) J. Virol. , vol.75 , pp. 1437-1449
    • Lohmann, V.1
  • 58
    • 0035065277 scopus 로고    scopus 로고
    • Interferon-α inhibits hepatitis C virus subgenomic RNA replication by an MxA-independent pathway
    • Frese, M. et al. (2001) Interferon-α inhibits hepatitis C virus subgenomic RNA replication by an MxA-independent pathway. J. Gen. Virol. 82, 723-733
    • (2001) J. Gen. Virol. , vol.82 , pp. 723-733
    • Frese, M.1
  • 59
    • 0036190918 scopus 로고    scopus 로고
    • Selectable subgenomic and genome-length dicistronic RNAs derived from an infectious molecular clone of the HCV-N strain of hepatitis C virus replicate efficiently in cultured Huh7 cells
    • Ikeda, M. et al. (2002) Selectable subgenomic and genome-length dicistronic RNAs derived from an infectious molecular clone of the HCV-N strain of hepatitis C virus replicate efficiently in cultured Huh7 cells. J. Virol. 76, 2997-3006
    • (2002) J. Virol. , vol.76 , pp. 2997-3006
    • Ikeda, M.1
  • 60
    • 0032503247 scopus 로고    scopus 로고
    • Transmission of hepatitis C virus infection to tree shrews
    • Xie, Z.C. et al. (1998) Transmission of hepatitis C virus infection to tree shrews. Virology 244, 513-520
    • (1998) Virology , vol.244 , pp. 513-520
    • Xie, Z.C.1
  • 61
    • 0036158719 scopus 로고    scopus 로고
    • Steatosis and liver cancer in transgenic mice expressing the structural and nonstructural proteins of hepatitis C virus
    • Lerat, H. et al. (2002) Steatosis and liver cancer in transgenic mice expressing the structural and nonstructural proteins of hepatitis C virus. Gastroenterology 122, 352-365
    • (2002) Gastroenterology , vol.122 , pp. 352-365
    • Lerat, H.1
  • 62
    • 0033619115 scopus 로고    scopus 로고
    • Toward a surrogate model for hepatitis C virus: An infectious molecular clone of the GB virus-B hepatitis agent
    • Bukh, J. et al. (1999) Toward a surrogate model for hepatitis C virus: an infectious molecular clone of the GB virus-B hepatitis agent. Virology 262, 470-478
    • (1999) Virology , vol.262 , pp. 470-478
    • Bukh, J.1
  • 63
    • 0034864550 scopus 로고    scopus 로고
    • Ribavirin induces error-prone replication of GB virus B in primary tamarin hepatocytes
    • Lanford, R.E. et al. (2001) Ribavirin induces error-prone replication of GB virus B in primary tamarin hepatocytes. J. Virol. 75, 8074-8081
    • (2001) J. Virol. , vol.75 , pp. 8074-8081
    • Lanford, R.E.1
  • 64
    • 17944379233 scopus 로고    scopus 로고
    • Hepatitis C virus replication in mice with chimeric human livers
    • Mercer, D.F. et al. (2001) Hepatitis C virus replication in mice with chimeric human livers. Nat. Med. 7, 927-933.
    • (2001) Nat. Med. , vol.7 , pp. 927-933
    • Mercer, D.F.1
  • 65
    • 0032975077 scopus 로고    scopus 로고
    • Molecular biology and gene therapy in gastroenterology and hepatology
    • Blum, H.E. (1999) Molecular biology and gene therapy in gastroenterology and hepatology. Eur. J. Gastroenterol. Hepatology. 11, 1-7
    • (1999) Eur. J. Gastroenterol. Hepatology , vol.11 , pp. 1-7
    • Blum, H.E.1
  • 66
    • 0028147612 scopus 로고
    • Vaccination of chimpanzees against infection by the hepatitis C virus
    • Choo, Q-L. et al. (1994) Vaccination of chimpanzees against infection by the hepatitis C virus. Proc. Natl. Acad. Sci. U. S. A. 91, 1294-1298
    • (1994) Proc. Natl. Acad. Sci. U. S. A. , vol.91 , pp. 1294-1298
    • Choo, Q.-L.1
  • 67
    • 0035657650 scopus 로고    scopus 로고
    • Perspectives: Towards a peptide-based vaccine against hepatitis C virus
    • Hunziker, I.P. et al. (2001) Perspectives: towards a peptide-based vaccine against hepatitis C virus. Mol. Immunol. 38, 475-484
    • (2001) Mol. Immunol. , vol.38 , pp. 475-484
    • Hunziker, I.P.1
  • 68
    • 0037181727 scopus 로고    scopus 로고
    • Protection against persistence of hepatitis C
    • Mehta, S.H. et al. (2002) Protection against persistence of hepatitis C. Lancet 359, 1478-1483
    • (2002) Lancet , vol.359 , pp. 1478-1483
    • Mehta, S.H.1
  • 69
    • 0026767691 scopus 로고
    • Lack of protective immunity against reinfection with hepatitis C virus
    • Farci, P. et al. (1992) Lack of protective immunity against reinfection with hepatitis C virus. Science 258, 135-140
    • (1992) Science , vol.258 , pp. 135-140
    • Farci, P.1
  • 70
    • 0034985916 scopus 로고    scopus 로고
    • Protective immune response to hepatitis C virus in chimpanzees rechallenged following clearance of primary infection
    • Bassett, S.E. et al. (2001) Protective immune response to hepatitis C virus in chimpanzees rechallenged following clearance of primary infection. Hepatology 33, 1479-1487
    • (2001) Hepatology , vol.33 , pp. 1479-1487
    • Bassett, S.E.1
  • 71
    • 0036284899 scopus 로고    scopus 로고
    • Previously infected and recovered chimpanzees exhibit rapid responses that control hepatitis C virus replication upon rechallenge
    • Major, M.E. et al. (2002) Previously infected and recovered chimpanzees exhibit rapid responses that control hepatitis C virus replication upon rechallenge. J. Virol. 76, 6586-6595
    • (2002) J. Virol. , vol.76 , pp. 6586-6595
    • Major, M.E.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.