메뉴 건너뛰기




Volumn 169, Issue 7, 2002, Pages 3819-3824

Bcl-2 rescues the germinal center response but does not alter the V gene somatic hypermutation spectrum in MSH2-deficient mice

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE; PROTEIN BCL 2; PROTEIN MSH2; PYRIMIDINE NUCLEOTIDE;

EID: 0036784624     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.169.7.3819     Document Type: Article
Times cited : (15)

References (33)
  • 1
    • 0023161405 scopus 로고
    • Evolution of antibody variable region structure during the immune response
    • Manser, T., L. J. Wysocki, M. N. Margolies, and M. L. Gefter. 1987. Evolution of antibody variable region structure during the immune response. Immunol. Rev. 96:141.
    • (1987) Immunol. Rev. , vol.96 , pp. 141
    • Manser, T.1    Wysocki, L.J.2    Margolies, M.N.3    Gefter, M.L.4
  • 2
    • 0023161406 scopus 로고
    • Mutation drift and repertoire shift in the maturation of the immune response
    • Berek, C., and C. Milstein. 1987. Mutation drift and repertoire shift in the maturation of the immune response. Immunol. Rev. 96:23.
    • (1987) Immunol. Rev. , vol.96 , pp. 23
    • Berek, C.1    Milstein, C.2
  • 4
    • 0035377541 scopus 로고    scopus 로고
    • DNA polymerases in immunity: Profiting from errors
    • Storb, U. 2001. DNA polymerases in immunity: profiting from errors. Nat. Immunol. 2:484.
    • (2001) Nat. Immunol. , vol.2 , pp. 484
    • Storb, U.1
  • 5
    • 0032100485 scopus 로고    scopus 로고
    • The role of DNA repair in somatic hypermutation of immunoglobulin genes
    • Kim, N., and U. Storb. 1998. The role of DNA repair in somatic hypermutation of immunoglobulin genes. J. Exp. Med. 187:1729.
    • (1998) J. Exp. Med. , vol.187 , pp. 1729
    • Kim, N.1    Storb, U.2
  • 6
    • 0032555715 scopus 로고    scopus 로고
    • Somatic hypermutation, transcription and DNA mismatch repair
    • Wiesendanger, M., M. D. Scharff, and W. Edelman. 1998. Somatic hypermutation, transcription and DNA mismatch repair. Cell 94:415.
    • (1998) Cell , vol.94 , pp. 415
    • Wiesendanger, M.1    Scharff, M.D.2    Edelman, W.3
  • 7
    • 0029784320 scopus 로고    scopus 로고
    • Biochemistry and genetics of eukaryotic mismatch repair
    • Kolodner, R. 1996. Biochemistry and genetics of eukaryotic mismatch repair. Genes Dev. 10:1433.
    • (1996) Genes Dev. , vol.10 , pp. 1433
    • Kolodner, R.1
  • 8
    • 0032527704 scopus 로고    scopus 로고
    • Mismatch repair, molecular switches and signal transduction
    • Fishel, R. 1998. Mismatch repair, molecular switches and signal transduction. Genes Dev. 12:2096.
    • (1998) Genes Dev. , vol.12 , pp. 2096
    • Fishel, R.1
  • 9
    • 0032101611 scopus 로고    scopus 로고
    • Increased hypermutation at G and C nucleotides in immunoglobulin genes from mice deficient in the MSH2 mismatch repair protein
    • Phung, Q. H., D. B. Winter, A. Cranston, R. E. Tarone, V. A. Bohr, R. Fishel, and P. J. Gearhart. 1998. Increased hypermutation at G and C nucleotides in immunoglobulin genes from mice deficient in the MSH2 mismatch repair protein. J. Exp. Med. 187:1745.
    • (1998) J. Exp. Med. , vol.187 , pp. 1745
    • Phung, Q.H.1    Winter, D.B.2    Cranston, A.3    Tarone, R.E.4    Bohr, V.A.5    Fishel, R.6    Gearhart, P.J.7
  • 11
    • 0032127804 scopus 로고    scopus 로고
    • Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting
    • Rada, C., M. R. Ehrenstein, M. S. Neuberger, and C. Milstein. 1998. Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting. Immunity 9:135.
    • (1998) Immunity , vol.9 , pp. 135
    • Rada, C.1    Ehrenstein, M.R.2    Neuberger, M.S.3    Milstein, C.4
  • 12
    • 0032127811 scopus 로고    scopus 로고
    • Mismatch repair deficiency interferes with the accumulation of mutations in chronically stimulated B cells and not with the hypermutation process
    • Frey, S., B. Bertocci, L. Delbos, F. Quint, J.-C. Weill, and C.-A. Reynaud. 1998. Mismatch repair deficiency interferes with the accumulation of mutations in chronically stimulated B cells and not with the hypermutation process. Immunity 9:127.
    • (1998) Immunity , vol.9 , pp. 127
    • Frey, S.1    Bertocci, B.2    Delbos, L.3    Quint, F.4    Weill, J.-C.5    Reynaud, C.-A.6
  • 13
    • 0028811073 scopus 로고
    • Somatic mutations during an immune response in Xenopus tadpoles
    • Wilson, M., A. Marcuz, and L. D. Pasquier. 1995. Somatic mutations during an immune response in Xenopus tadpoles. Dev. Immunol. 4:227.
    • (1995) Dev. Immunol. , vol.4 , pp. 227
    • Wilson, M.1    Marcuz, A.2    Pasquier, L.D.3
  • 14
    • 0031894290 scopus 로고    scopus 로고
    • Evolution of somatic hypermutation and gene conversion in adaptive immunity
    • Diaz, M., and M. F. Flajnik. 1998. Evolution of somatic hypermutation and gene conversion in adaptive immunity. Immunol. Rev. 162:13.
    • (1998) Immunol. Rev. , vol.162 , pp. 13
    • Diaz, M.1    Flajnik, M.F.2
  • 15
    • 0031942085 scopus 로고    scopus 로고
    • Immunoglobulin hypermutation in cultured cells
    • Green, N. S., M. M. Lin, and M. D. Scharff. 1998. Immunoglobulin hypermutation in cultured cells. Immunol. Rev. 162:67.
    • (1998) Immunol. Rev. , vol.162 , pp. 67
    • Green, N.S.1    Lin, M.M.2    Scharff, M.D.3
  • 16
    • 0030071749 scopus 로고    scopus 로고
    • An immunoglobulin mutator that targets G:C base pairs
    • Bachl, J., and M. Wabl. 1996. An immunoglobulin mutator that targets G:C base pairs. Proc. Natl. Acad. Sci. USA 93:851.
    • (1996) Proc. Natl. Acad. Sci. USA 93: , vol.851
    • Bachl, J.1    Wabl, M.2
  • 19
    • 0024521441 scopus 로고
    • bcl-2 immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation
    • McDonnell, T., N. Deane, F. M. Platt, G. Nunez, U. Jaeger, J. P. McKearn, and S. J. Korsmeyer. 1989. bcl-2 immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation. Cell 57:79.
    • (1989) Cell , vol.57 , pp. 79
    • McDonnell, T.1    Deane, N.2    Platt, F.M.3    Nunez, G.4    Jaeger, U.5    McKearn, J.P.6    Korsmeyer, S.J.7
  • 21
    • 0032006177 scopus 로고    scopus 로고
    • Bcl-2 obstructs negative selection of autoreactive, hypermutated antibody V regions during memory B cell development
    • Hande, S., E. Notidis, and T. Manser. 1998. Bcl-2 obstructs negative selection of autoreactive, hypermutated antibody V regions during memory B cell development. Immunity 8:189.
    • (1998) Immunity , vol.8 , pp. 189
    • Hande, S.1    Notidis, E.2    Manser, T.3
  • 22
    • 0027305024 scopus 로고
    • In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl) acetyl. III. The kinetics of V-region mutation and selection in germinal center B-cells
    • Jacob, J., J. Przylepa, C. Miller, and G. Kelsoe. 1993. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl) acetyl. III. The kinetics of V-region mutation and selection in germinal center B-cells. J. Exp. Med. 178: 1293.
    • (1993) J. Exp. Med. , vol.178 , pp. 1293
    • Jacob, J.1    Przylepa, J.2    Miller, C.3    Kelsoe, G.4
  • 23
    • 0035660720 scopus 로고    scopus 로고
    • Enforced expression of Bcl-2 selectively perturbs negative selection of dual reactive antibodies
    • Notidis, E., S. Hande, and T. Manser. 2001. Enforced expression of Bcl-2 selectively perturbs negative selection of dual reactive antibodies. Dev. Immunol. 8:223.
    • (2001) Dev. Immunol. , vol.8 , pp. 223
    • Notidis, E.1    Hande, S.2    Manser, T.3
  • 24
    • 0019442186 scopus 로고
    • Heavy chain variable region contribution to the NPb family of antibodies: Somatic mutation evident in a γ2a variable region
    • Bothwell, A. L., M. Paskind, M. Reth, T. Imanishi-Kari, K. Rajewsky, and D. Baltimore. 1981. Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a γ2a variable region. Cell 24:625.
    • (1981) Cell , vol.24 , pp. 625
    • Bothwell, A.L.1    Paskind, M.2    Reth, M.3    Imanishi-Kari, T.4    Rajewsky, K.5    Baltimore, D.6
  • 25
    • 0026443954 scopus 로고
    • Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighboring base sequence on mutagenesis
    • Rogozin, I. B., and N. A. Kolchanov. 1992. Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighboring base sequence on mutagenesis. Biochim. Biophys. Acta 1171:11.
    • (1992) Biochim. Biophys. Acta , vol.1171 , pp. 11
    • Rogozin, I.B.1    Kolchanov, N.A.2
  • 26
  • 27
    • 0024044570 scopus 로고
    • Antibody engineering for the analysis of affinity maturation of an anti-hapten response
    • Allen, D., T. Simon, F. Sablitsky, K. Rajewsky, and A. Cumano. 1988. Antibody engineering for the analysis of affinity maturation of an anti-hapten response. EMBO J. 7:1995.
    • (1988) EMBO J. , vol.7 , pp. 1995
    • Allen, D.1    Simon, T.2    Sablitsky, F.3    Rajewsky, K.4    Cumano, A.5
  • 28
    • 0023692791 scopus 로고
    • Is rapid proliferation in B centroblasts linked to somatic mutation in memory B cell clones?
    • Shang, J., I. C. M. MacLennan, J. J. Liu, and P. J. L. Lane. 1988. Is rapid proliferation in B centroblasts linked to somatic mutation in memory B cell clones? Immunol. Lett. 18:297.
    • (1988) Immunol. Lett. , vol.18 , pp. 297
    • Shang, J.1    MacLennan, I.C.M.2    Liu, J.J.3    Lane, P.J.L.4
  • 29
    • 0033526760 scopus 로고    scopus 로고
    • Different mismatch repair deficiencies all have the same effects on somatic hypermutation: Intact primary mechanism accompanied by secondary modifications
    • Kim, N., G. Bozek, J. C. Lo, and U. Storb. 1999. Different mismatch repair deficiencies all have the same effects on somatic hypermutation: intact primary mechanism accompanied by secondary modifications. J. Exp. Med. 190:21.
    • (1999) J. Exp. Med. , vol.190 , pp. 21
    • Kim, N.1    Bozek, G.2    Lo, J.C.3    Storb, U.4
  • 30
    • 0034614916 scopus 로고    scopus 로고
    • Somatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution pattern
    • Wiesendanger, M., B. Kneitz, W. Edelmann, and M. D. Scharff. 2000. Somatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution pattern. J. Exp. Med. 191:579.
    • (2000) J. Exp. Med. , vol.191 , pp. 579
    • Wiesendanger, M.1    Kneitz, B.2    Edelmann, W.3    Scharff, M.D.4
  • 31
  • 32
    • 0034268780 scopus 로고    scopus 로고
    • Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme
    • Masamichi, M., K. Kinoshita, S. Fagarasan, S. Yamada, Y. Shinkai, and T. Honjo. 2000. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 102:553.
    • (2000) Cell , vol.102 , pp. 553
    • Masamichi, M.1    Kinoshita, K.2    Fagarasan, S.3    Yamada, S.4    Shinkai, Y.5    Honjo, T.6
  • 33
    • 0037083364 scopus 로고    scopus 로고
    • Requirement of the activation-induced deaminase (AID) gene for immunoglobulin gene conversion
    • Arakawa, H., J. Hauschild, and J. M. Buerstedde. 2002. Requirement of the activation-induced deaminase (AID) gene for immunoglobulin gene conversion. Science 295:1301.
    • (2002) Science , vol.295 , pp. 1301
    • Arakawa, H.1    Hauschild, J.2    Buerstedde, J.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.