Evidence for the role of p38 MAP kinase in hypoxia-induced pulmonary vasoconstriction

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 283, Issue 4 27-4, 2002, Pages

  Karamsetty, M R ^a,c   Klinger, J R ^a,b   Hill, N S ^a  

^a BROWN UNIVERSITY   (United States)

^b PROVIDENCE VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c TUFTS MEDICAL CENTER   (United States)

Author keywords

Extracellular signal regulated kinase 1 2; Mitogen activated protein kinase kinase; Phospho p38; Rat pulmonary artery

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANISOMYCIN; ENZYME ACTIVATOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PHENYLEPHRINE; POTASSIUM CHLORIDE; SYNAPTOPHYSIN; UO 126;

ANIMAL TISSUE; ARTERY DILATATION; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HYPOXIA; LUNG VASOCONSTRICTION; MALE; NONHUMAN; PRIORITY JOURNAL; PULMONARY ARTERY; RAT; SIGNAL TRANSDUCTION; SMOOTH MUSCLE CONTRACTION;

EID: 0036783661     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.00475.2001     Document Type: Article

References (40)

1. Growth regulation via p38 mitogen-activated protein kinase in developing liver
2. Direct inhibition of cyclooxygenase-1 and -2 by the kinase inhibitors SB 203580 and PD 98059. SB 203580 also inhibits thromboxane synthase
3. 2+/CaM in the activation of MAPK and p38 gamma
4. Selective activation of p38alpha and p38gamma by hypoxia. Role in regulation of cyclin D1 by hypoxia in PC12 cells
5. Hypoxia-induced proliferative response of vascular adventitial fibroblasts is dependent on g protein-mediated activation of mitogen-activated protein kinases
6. Specificity and mechanism of action of some commonly used protein kinase inhibitors
7. Inhibition of p42 and p44 MAP kinase does not alter smooth muscle contraction in swine carotid artery
8. The activation of distinct mitogen-activated protein kinase cascades is required for the stimulation of 2-deoxyglucose uptake by interleukin-1 and insulin-like growth factor-1 in KB cells
9. Effects of NADPH oxidase inhibitors on hypoxic vasoconstriction in buffer-perfused rabbit lungs
10. Regulation of actin filament dynamics by p38 map kinase-mediated phosphorylation of heat shock protein 27
11. Excitation-contraction coupling in pulmonary vascular smooth muscle involves tyrosine kinase and Rho kinase
12. Vasoconstrictor actions of isoprostanes via tyrosine kinase and Rho kinase in human and canine pulmonary vascular smooth muscles
13. Hypoxia activates jun-N-terminal kinase, extracellular signal-regulated protein kinase, and p38 kinase in pulmonary arteries
14. Pulmonary arterial hypoxic contraction: Signal transduction
15. The NADPH oxidase inhibitors iodonium diphenyl and cadmium sulphate inhibit hypoxic pulmonary vasoconstriction in isolated rat pulmonary arteries
16. + channel blocking drugs and nitric oxide synthase inhibition on the response to hypoxia in rat pulmonary artery rings
17. Extracellular signal-regulated kinase 1/2 control Ca(2+)-independent force development in histamine-stimulated bovine tracheal smooth muscle
18. Hypoxic vasoconstriction in rat pulmonary and mesenteric arteries
19. The stress-responsive MAP kinase p38 is activated by low-flow ischemia in the in situ porcine heart
20. Pulmonary artery NADPH-oxidase is activated in hypoxic pulmonary vasoconstriction
21. p38 MAP kinase pathway regulates angiotensin II-induced contraction of rat vascular smooth muscle
22. ERK activation upon hypoxia: Involvement in HIF-1 activation
23. 2+ sensitization
24. Inhibition of sustained hypoxic vasoconstriction by Y-27632 in isolated intrapulmonary arteries and perfused lung of the rat
25. Differences in acute hypoxic pulmonary vasoresponsiveness between rat strains: Role of endothelium
26. Hypoxic stimulation of the stress-activated protein kinases in pulmonary artery fibroblasts
27. Hypoxia and hypoxia/reoxygenation activate p65PAK, p38 mitogen-activated protein kinase (MAPK), and stress-activated protein kinase (SAPK) in cultured rat cardiac myocytes
28. Osteopontin mediates hypoxia-induced proliferation of cultured mesangial cells: Role of PKC and p38 MAPK
29. MAP kinases and vascular smooth muscle function
30. Mitogen-activated protein/extracellular signal-regulated kinase inhibition attenuates angiotensin II-mediated signaling and contraction in spontaneously hypertensive rat vascular smooth muscle cells
31. The role of tyrosine kinase in hypoxic constriction of sheep pulmonary artery rings
32. Vasoconstrictor and vasodilator effects of hypoxia
33. Rho-kinase activation is involved in hypoxia-induced pulmonary vasoconstriction
34. Mechanisms of hypoxic pulmonary vasoconstriction: Can anyone be right?
35. Evidence for a role of protein kinase C in hypoxic pulmonary vasoconstriction
36. Effect of a calcium sensitization modulator, Y-27632, on isolated human bronchus and pulmonary artery
37. Evidence for modulation of smooth muscle force by the p38 MAP kinase/HSP 27 pathway
38. Endothelin-1 activates MAP kinases and c-Jun in pulmonary artery smooth muscle
39. Mitogen-activated protein kinase inhibitors suppress prostaglandin F(2alpha)-induced myosin-light chain phosphorylation and contraction in iris sphincter smooth muscle
40. i and contraction: Responses to diphenyleneiodonium and hypoxia