MAP kinases and vascular smooth muscle function

Acta Physiologica Scandinavica

Volumn 164, Issue 4, 1998, Pages 611-621

  Takahashi, E ^a   Berk, B C ^a,b  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b UNIVERSITY OF ROCHESTER   (United States)

Author keywords

Angiotensin II; BMK1; Cross talk; ERK; JNK; p38; Remodelling; Signal transduction

Indexed keywords

ANGIOTENSIN; MEMBRANE RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOTRANSFERASE; PROTEIN SERINE KINASE; PROTEIN SERINE THREONINE KINASE; TRANSCRIPTION FACTOR;

ANGIOPLASTY; APOPTOSIS; ATHEROSCLEROSIS; CARDIOVASCULAR DISEASE; CELL GROWTH; CONFERENCE PAPER; ENZYME ACTIVATION; ESSENTIAL HYPERTENSION; MOLECULAR INTERACTION; MUSCLE FUNCTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RESTENOSIS; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE;

EID: 0032413324     PISSN: 00016772     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-201X.1998.tb10705.x     Document Type: Conference Paper

References (107)

1. Abe, J., Kusuhara, M., Ulevitch, R.J., Berk, B.C. & Lee, J.D. 1996. Big mitogen-activated protein kinase 1 (BMK1) is a redox-sensitive kinase. J Biol Chem 271, 16586-16590.
2. Abe, J., Takahashi, M., Ishida, M., Lee, J.-D. & Berk, B.C. 1997. c-Src is required for oxidative stress-mediated activation of big mitogen-activated protein kinase (BMK1). J Biol Chem 272, 20389-20394.
3. Adam, L.P., Franklin, M.T., Raff, G.J. & Hathaway, D.R. 1995. Activation of mitogen-activated protein kinase in porcine carotid arteries. Circ Res 76, 183-190.
4. Adam, L.P., & Hathaway, D.R. 1993. Identification of mitogen-activated protein kinase phosphorylation sequences in mammalian h-Caldesmon. FEBS Lett 322, 56-60.
5. + exchanger in human platelets. J Biol Chem 271, 16494-16499.
6. Bennett, M.R., Evan, G.I. & Schwartz, S.M. 1995. Apoptosis of human vascular smooth muscle cells derived from normal vessels and coronary atherosclerotic plaques, J Clin Invest 95, 2266-2274.
7. + Exchanger, pp. 47-67. Landes Biosciences Publishers, Austin.
8. + exchange in cultured vascular smooth muscle cells. Evidence for protein kinase C-dependent and-independent pathways. J Biol Chem 262, 5057-5064.
9. Berk, B.C., Vekshtein, V., Gordon, H.M. & Tsuda, T. 1989. Angiotensin II-stimulated protein synthesis in cultured vascular smooth muscle cells. Hypertension 13, 305-314.
10. Bhat, G.J., Thekkumkara, T.J., Thomas, W.G., Conrad, K.M. & Baker, K.M. 1994. Angiotensin II stimulates sis-inducing factor-like DNA binding activity. J Biol Chem 269, 31443-31449.
11. Birukov, K.G., Lehoux, S., Birukova, A.A., Merval, R., Tkachuk, V.A. & Tedgui, A. 1997. Increased pressure induces sustained protein kinase C-independent herbimycin A-sensitive activation of extracellular signal-related kinase 1/2 in the rabbit aorta in organ culture. Circ Res 81, 895-903.
12. Blenis, J. 1993. Signal transduction via the MAP kinases: Proceed at your own RSK. Proc Natl Acad Sci USA 90, 5889-5892.
13. Blenis, J., Chung, J., Erikson, E., Alcorta, D.A. & Erikson, R.L. 1991. Distinct mechanisms for the activation of the RSK kinases/MAP2 kinase/pp. 90rsk and pp. 70-S6 kinase signaling systems are indicated by inhibition of protein synthesis. Cell Growth Differ 2, 279-285.
14. Bobik, A., Grooms, A., Little, P.J., Cragoe, E.J. & Grinpukel, S. 1991. Ethylisopropylamiloride-sensitive pH control mechanisms modulate vascular smooth muscle cell growth. Am J Physiol 260, C581-C588.
15. Bornfeldt, K.E., Campbell, J.S. & Koyama, H. et al. 1997. The mitogen-activated protein kinase pathway can mediate growth inhibition and proliferation in smooth muscle cells. Dependence on the availability of downstream targets. J Clin Invest 100, 875-885.
16. Brinson, A.E., Harding, T. & Diliberto, P.A. et al. 1998. Regulation of a calcium-dependent tyrosine kinase in vascular smooth muscle cells by angiotensin 11 and platelet-derived growth factor. J Biol Chem 273, 1711-1718.
17. rsk) in somatic cells: phosphorylation and activation during initiation of cell proliferation. Mol Cell Biol 10, 3204-3215.
18. Chen, Y.R., Wang, X., Templeton, D., Davis, R.J. & Tan, T.H. 1996. The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C. and gamma radiation. Duration of JNK activation may determine cell death and proliferation. J Biol Chem 271, 31929-31936.
19. Clarkson, T.B., Prichard, R.W., Morgan, T.M., Petrick, G.S. & Klein, K.P. 1994. Remodeling of coronary arteries in human and nonhuman primates. JAMA 271, 289-294.
20. D'Erijard, B., Raingeaud, J. & Barrett, T. et al. 1995. Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms. Science 267, 682-685.
21. Dickens, M., Rogers, J.S. & Cavanagh, J. et al. 1997. A cytoplasmic inhibitor of the JNK signal transduction pathway. Science 277, 693-696.
22. Duff, J.L. & Berk, B.C. 1995. Angiotensin II-mediated signal transduction events in vascular smooth muscle cells: kinases and phosphatases. Blood Pressure 4, 55-60.
23. Duff, J.L., Berk, B.C. & Corson, M.A. 1992. Angiotensin II stimulates the pp44 and pp42 mitogen-activated protein kinases in cultured rat aortic smooth muscle cells. Biochem Biophys Res Commun 188, 257-264.
24. Duff, J.L., Monia, B.P. & Berk, B.C. 1995. Mitogen-activated protein (MAP) kinase is regulated by the MAP kinase phosphatase (MKP-1) in vascular smooth muscle cells. Effect of actinomycin D and antisense oligonucleotides. J Biol Chem 270, 7161-7166.
25. 2+/calmodulin-sensitive tyrosine kinase. J Biol Chem 271, 14169-14175.
26. Enslen, H., Raingeaud, J. & Davis, R.J. 1998. Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6. J Biol Chem 273, 1741-1748.
27. Erikson, E. & Maller, J.L. 1985. A protein kinase from Xenopus eggs specific for ribosomal protein S6. Proc Natl Acad Sci U S A 82, 742-746.
28. Fridell, Y.W., Jin, Y. & Quilliam, L.A. et al. 1996. Differential activation of the Ras/extracellular-signal-regulated protein kinase pathway is responsible for the biological consequences induced by the Axl receptor tyrosine kinase. Mol Cell Biol 16, 135-145.
29. Fukuda, M., Gotoh, I., Adachi, M., Gotoh, Y. & Nishida, E. 1997. A novel regulatory mechanism in the mitogen-activated protein (MAP) kinase cascade. Role of nuclear export signal of MAP kinase kinase. J Biol Chem 272, 32642-32648.
30. Galcheva, G.-Z., D'Erijard, B., Wu, I.H. & Davis, R.J. 1994. An osmosensing signal transduction pathway in mammalian cells. Science 265, 806-808.
31. Geisterfer, A.A.T., Peach, M.J. & Owens, G.K. 1988. Angiotensin II induces hypertrophy, not hyperplasia, of cultured rat aortic smooth muscle cells. Circ Res 62, 749-756.
32. Geng, Y.J. & Libby, P. 1995. Evidence for apoptosis in advanced human atheroma. Colocalization with interleukin-1 beta-converting enzyme. Am J Pathol 147, 251-266.
33. Geng, Y.J., Wu, Q., Muszynski, M., Hansson, G.K. & Libby, P. 1996. Apoptosis of vascular smooth muscle cells induced by in vitro stimulation with interferon-gamma, tumor necrosis factor-alpha, and interleukin-1 beta. Arterioscler Thromb Vasc Biol 16, 19-27.
34. Gerthoffer, W.T. & Pohl, J. 1994. Caldesmon and calponin phosphorylation in regulation of smooth muscle contraction, Can J Physiol Pharmacol 72, 1410-1414.
35. Gerthoffer, W.T., Yamboliev, I.A., Pohl, J., Haynes, R., Dang, S. & McHugh, J. 1997. Activation of MAP kinases in airway smooth muscle. Am J Physiol 272, L244-L252.
36. Gerthoffer, W.T., Yamboliev, I.A. & Shearer, M. et al. 1996. Activation of MAP kinases and phosphorylation of caldesmon in canine colonie smooth muscle. J Physiol Lond 495, 597-609.
37. Gerwins, P., Blank, J.L. & Johnson, G.L. 1997. Cloning of a novel mitogen-activated protein kinase kinase kinase, MEKK4, that selectively regulates the c-Jun amino terminal kinase pathway. J Biol Chem 272, 8288-8295.
38. Glagov, S., Weisenberg, E., Zarins, C.K., Stankunavicius, R. & Kolettis, G.J. 1987. Compensatory enlargement of human atherosclerotic coronary arteries. N Engl J Med 316, 1371-1375.
39. + antiporter during cell volume regulation. Evidence for a phosphorylation-independent mechanism. J Biol Chem 267, 23823-23828.
40. Guzman, R.J., Lemarchand, P., Crystal, R.G., Epstein, S.E. & Finkel, T. 1993. Efficient and selective adenovirus-mediated gene transfer into vascular neointima. Circulation 88, 2838-3848.
41. Guzman, L.A., Mick, M.J., Arnold, A.M., Forudi, F. & Whitlow, P.L. 1996. Role of intimal hyperplasia and arterial remodeling after balloon angioplasty: an experimental study in the atherosclerotic rabbit model. Arterioscler Thromb Vasc Biol 16, 479-487.
42. Man, D.K., Haudenschild, C.C., Hong, M.K., Tinkle, B.T., Leon, M.B. & Liau, G. 1995. Evidence for apoptosis in human atherogenesis and in a rat vascular injury model. Am J Pathol 147, 267-277.
43. Han, J., Lee, J.D., Bibbs, L. & Ulevitch, R.J. 1994. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science 265, 808-811.
44. Han, J., Lee, J.-D., Jiang, Y., Li, Z., Feng, L. & Ulevitch, R.J. 1996. Characterization of the structure and function of a novel MAP kinase kinase (MKK6). J Biol Chem 221, 2886-2891.
45. Higashita, R., Li, L., Van, P.-V. et al. 1997. Galpha16 mimics vasoconstrictor action to induce smooth muscle alpha-actin in vascular smooth muscle cells through a Jun-NH2-terminal kinase-dependent pathway. J Biol Chem 272, 25845-25850.
46. Hu, M.C., Qiu, W.R. & Wang, Y.P. 1997. JNK1, JNK2 and JNK3 are p53 N-terminal serine 34 kinases. Oncogene 15, 2277-2287.
47. Huang, S., Jiang, Y. & Li, Z., et al. 1997. Apoptosis signaling pathway in T cells is composed of ICE/Ced-3 family proteases and MAP kinase kinase 6b. Immunity 6, 739-749.
48. Ichijo, H., Nishida, E. Irie, K. et al. 1997. Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways. Science 275, 90-94.
49. Ihle, J.N., Witthuhn, B.A., Quelle, F.W. et al. 1994. Signaling by the cytokine receptor superfamily: JAKs and STATs. Trends Biochem Sci 19, 222-227.
50. Ishida, M., Ishida, T., Thomas, S. & Berk, B.C. 1998. Activation of extracellular signal-regulated kinases (ERK1/ 2) by angiotensin II is dependent on c-Src in vascular smooth muscle cells. Circ Res 82, 7-12.
51. c-src in vascular smooth muscle cells. Circ Res 77, 1053-1059.
52. Johnson, N.L., Gardner, A.M. & Diener, K.M., et al. 1996. Signal transduction pathways regulated by mitogen-activated/extracellular response kinase kinase kinase induce cell death. J Biol Chem 271, 3229-3237.
53. Kakuta, T., Currier, J.W., Haudenschild, C.C., Ryan, T.J. & Faxon, D.P. 1994. Differences in compensatory vessel enlargement, not intimai formation, account for restenosis after angioplasty in the hypercholesterolemic rabbit model. Circulation 89, 2809-2815.
54. Kamei, Y., Xu, L., Heinzel, T. et al. 1996. A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors, Cell 85, 403-414.
55. Kato, Y., Kravchenko, V.V., Tapping, R.I., Han, J., Ulevitch, R.J. & Lee, J.D. 1997. BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C. Embo J 16, 7054-7066.
56. Katoch, S.S. & Moreland, R.S. 1995. Agonist and membrane depolarization induced activation of MAP kinase in the swine carotid artery. Am J Physiol 269, H222-H229.
57. Khalil, R.A. & Morgan, K.G. 1993. PKC-mediated redistribution of mitogen-activated protein kinase during smooth muscle cell activation. Am J Physiol 265, C406-C411.
58. Koyama, H., Olson, N.E., Dastvan, F.F. & Reidy, M.A. 1998. Cell replication in the arterial wall activation of signaling pathway following in vivo injury. Circ Res 82, 713-721.
59. Koyama, H., Raines, R.W., Bornfeldt, K.E., Roberts, J.M. & Ross, R. 1996. Fibrillar collagen inhibits arterial smooth muscle proliferation through regulation of Cdk2 inhibitors. Cell 87, 1069-1078.
60. + exchange and ERK1/2. Circ Res 83, in press.
61. Kyriakis, J.M. & Avruch, J. 1996. Sounding the alarm: protein kinase cascades activated by stress and inflammation. J Biol Chem 271, 24313-24316.
62. Kyriakis, J.M., Banerjee, P., Nikolakaki, E. et al. 1994. The stress-activated protein kinase subfamily of c-Jun kinases. Nature 369, 156-160.
63. L'Opez, C.-A., Holmes, D.K., Liao, S. et al. 1997. Decreased vascular smooth muscle cell density in medial degeneration of human abdominal aortic aneurysms. Am J Pathol 150, 993-1007.
64. Lai, K., Wang, H., Lee, W.S., Jain, M.K., Lee, M.E. & Haber, E. 1996. Mitogen-activated protein kinase phosphatase-1 in rat arterial smooth muscle cell proliferation. J Clin Invest 98, 1560-1567.
65. mapkk) in fibroblasts. J Cell Biol 122, 1079-1088.
66. Liao, D.F., Monia, B, Dean, N. & Berk, B.C. 1997. Protein kinase C-mediates angiotensin II activation of ERK1/2 in vascular smooth muscle cells. J Biol Chem 272, 6146-6150.
67. Linseman, D.A., Benjamin, C.W. & Jones, D.A. 1995. Convergence of angiotensin II and platelet-derived growth factor receptor signaling cascades in vascular smooth muscle cells. J Biol Chem 270, 12563-12568.
68. 2+-dependent mitogen-activated protein kinase activation in spontaneously hypertensive rat vascular smooth muscle defines a hypertensive signal transduction phenotype. Circ Res 78, 962-970.
69. Lucchesi, P.A., DeRoux, N. & Berk, B.C. 1994. Na+-H+ exchanger expression in vascular smooth muscle of spontaneously hypertensive and Wistar-Kvoto rats. Hypertesion 24, 734-738.
70. Marrero, M.B., Schieffer, B., Li, B., Sun, J., Harp, J.B. & Ling, B.N. 1997. Role of Janus kinase/signal transducer and activator of transcription and mitogen-activated protein kinase cascades in angiotensin II-and platelet-derived growth factor-induced vascular smooth muscle cell proliferation. J Biol Chem 272, 24684-24690.
71. Marrero, M.B., Schieffer, B., Paxton, W.G. et al. 1995. Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor. Nature 375, 247-250.
72. Matsuo, H., Li, H., McGuire, A.M. et al. 1997. Structure of translation factor eIF4E, bound to m7GDP and interaction with 4E-binding protein. Nat Struct Biol 4, 717-724.
73. Melaragno, M.G., Wuthrich, D.A. & Poppa, V. et al. 1998. Increased expression of AxI tyrosine kinase after vascular injury and regulation by G protein-coupled receptor agonists in rats, Cir Res 83, in press.
74. Mischak, H., Seitz, T., Janosch, P. et al. 1996. Negative regulation of Raf-1 by phosphorylation of serine 621. Mol Cell Biol 16, 5409-5418.
75. + exchange inhibitors decrease neointimal formation after rat carotid injury, Circ Res 73, 269-275.
76. Modur, V., Zimmerman, G.A., Prescott, S.M. & McIntyre, T.M. 1996. Endothelial cell inflammatory responses to tumor necrosis factor alpha, Ceramide-dependent and-independent mitogen-activatcd protein kinase cascades. J Biol Chem 271, 13094-13102.
77. 2+-mobilizing growth factors. J Biol Chem 270, 5702-5705.
78. Nohara, A., Ohmichi, M., Koike, K. et al. 1996. The role of mitogen-activated protein kinase in oxytocin-induced contraction of uterine smooth muscle in pregnant rat. Biochem Biophys Res Commun 229, 938-944.
79. 2-production in the pig coronary artery. Circulation 96, 3593-3601.
80. O'Bryan, J.P., Frye, R.A., Cogswell, P.C. et al. 1991. axl, a transforming gene isolated from primary human mycloid leukemia cells, encodes a novel receptor tyrosine kinase. Mol Cell Biol 11, 5016-5031.
81. Pollman, M.J., Yamada, T., Horiuchi, M. & Gibbons, G.H. 1996. Vasoactive substances regulate vascular smooth muscle cell apoptosis. Countervailing influences of nitric oxide and angiotensin II. Circ Res 79, 748-756.
82. Pyles, J.M., March, K.L., Franklin, M., Mehdi, K., Wilensky, R.L. & Adam, L.P. 1997. Activation of MAP kinase in vivo follows balloon overstretch injury of porcine coronary and carotid arteries. Circ Res 81, 904-910.
83. Rao, G.N. & Berk, B.C. 1992. Active oxygen species stimulate vascular smooth muscle cell growth and proto-oncogene expression. Circ Res 70, 593-599.
84. Rao, G.N., Lassegue, B., Alexander, R.W. & Griendling, K.K. 1994. Angiotensin II stimulates phosphorylation of high-molecular-mass cytosolic phospholipase A2 in vascular smooth muscle cells. Biochem J 299, 197-201.
85. Reusch, H.P., Chan, G., Ives, H.E. & Nemenoff, R.A. 1997. Activation of JNK SAPK and ERK by mechanical strain in vascular smooth muscle cells depends on extracellular matrix composition. Biochem Biophys Res Commun 237, 239-244.
86. Rosskopf, D., Fromter, E. & Siffert, W. 1993. Hypertensive sodium-proton exchanger phenotype persists in immortalized lymphoblasts from essential hypertensive patients. A cell culture model for human hypertension. J Clin Invest 92, 2553-2559.
87. Schieffer, B., Paxton, W.G., Chai, Q., Marrero, M.B. & Bernstein, K.E. 1996. Angiotensm II controls p21ras activity via pp. 60c-src. J Biol Chem 271, 10329-10333.
88. Schmitz, U. & Berk, B.C. 1997. Angiotensin II signal transduction. Stimulation of multiple mitogen-activated protein kinase pathways. Trends Endocrinol Metab 8, 261-266.
89. Schmitz, U., Ishida, M., Ishida, T. & Berk, B.C. 1997. Angiotensin II stimulates tyrosinc phosphorylation of PLC-γ associated proteins: Characterization of a c-Src-dependent 97 kD protein in vascular smooth muscle cells. Cire Res 81, 550-557.
90. Schmitz, U., Ishida, T., Ishida, M., Surapisitchat, J., Hasham, M.I. & Pelech, S. 1998. Angiotensin II stimulates p21-activated kinase in vascular smooth muscle cells: Role in activation of JNK. Circ Res 82, 1272-1278.
91. Schramek, H., Feifel, E., Healy, E. & Pollack, V. 1997. Constitutively active mutant of the mitogen-activated protein kinase kinase MEK1 induces epithelial dedifferentiation and growth inhibition in madin-darby canine kidney-C7 cells, J Biol Chem 272, 11426-11433.
92. Schramm, K., Niehof, M., Radziwill, G., Rommel, C. & Moelling, K. 1994. Phosphorylation of c-Raf-1 by protein kinase A interferes with activation. Riochem Biophys Res Commun 201, 740-747.
93. Stitt, T.N., Conn, G., Gore, M. et al. 1995. The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases. Cell 80, 661-670.
94. Suero, J.A., Duff, J.L. & Berk, B.C. 1998. Angiotensin II prevents serum deprivation-induced apoptosis of vascular smooth muscle cells by inhibiting c-Jun N-terminal kinase. Circ Res, submitted.
95. Sun, H., Charles, C.H., Lau, L.F. & Tonks, N.K. 1993. MKP-1 (3CU134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo. Cell 75, 487-493.
96. + exchanger kinase. Circ Res 81, 268-273.
97. Takahashi, T., Kawahara, Y., Okuda, M., Ueno, H., Takeshita, A. & Yokoyama, M. 1997. Angiotensin II stimulates mitogen-activated protein kinases and protein synthesis by a Ras-independent pathway in vascular smooth muscle cells. J Biol Chem 272, 16018-16022.
98. Tournier, C., Whitmarsh, AJ., Cavanagh, J., Barrett, T. & Davis, R.J. 1997. Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase. Proc Natl Acad Sci USA 94, 7337-7342.
99. Verheij, M., Bose, R., Lin, X.H. et al. 1996. Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. Nature 380, 75-79.
100. Wang, Y., Su, B., Sah, V.P., Brown, J.H., Han, J. & Chien, K.R. 1998. Cardiac hypertrophy induced by mitogen-activated protein kinase kinase 7, a specific activator for c-Jun NH2-terminal kinase in ventricular muscle cells. J Biol Chem 273, 5423-5426.
101. Whalen, A.M., Galasinski, S.C., Shapiro, P.S., Nahreini, T.S. & Ahn, N.G. 1997. Megakaryocytic differentiation induced by constitutive activation of mitogen-activated protein kinase kinase. Mol Cell Biol 17, 1947-1958.
102. Wilson, D.J., Fortner, K.A., Lynch, D.H. et al. 1996. JNK, but not MAPK, activation is associated with Fas-mediated apoptosis in human T cells. Eur J Immunol 26, 989-994.
103. Xia, Z., Dickens, M., Raingeaud, J., Davis, R.J. & Greenberg, ME. 1995. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270, 1326-1331.
104. Xu, Q., Fawcett, T.W., Gorospe, M., Guyton, K. Z., Liu, Y. & Holbrook, N.J. 1997. Induction of mitogen-activated protein kinase phosphatase-1 during acute hypertension. Hypertension 30, 106-111.
105. Xu, Q., Liu, Y., Gorospe, M., Udelsman, R. & Holbrook, N.J. 1996. Acute hypertension activates mitogen-activated protein kinases in arterial wall. J Clin Invest 97, 508-514.
106. Yu, H., Li, X., Marchetto, G.S. et al. 1996. Activation of a novel calcium-dependent protein-tyrosine kinase. J Biol Chem 271, 29993-29998.
107. Zhang, Y., Moreland, S. & Moreland, R.S. 1994. Regulation of vascular smooth muscle contraction: myosin light chain phosphorylation dependent and independent pathways. Can J Physiol Pharmacol 72, 1386-1391.