To DRiP or not to DRiP: Generating peptide ligands for MHC class I molecules from biosynthesized proteins

Molecular Immunology

Volumn 39, Issue 3-4, 2002, Pages 139-146

  Yewdell, Jonathan ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIGAND; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PEPTIDE; PROTEASOME; PROTEIN; UBIQUITIN;

CYTOSOL; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; REVIEW; RIBOSOME; VIRUS;

ANIMALS; CYSTEINE ENDOPEPTIDASES; CYTOSOL; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; LIGANDS; LYMPHOCYTE ACTIVATION; MULTIENZYME COMPLEXES; PEPTIDES; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BIOSYNTHESIS; RIBOSOMES; T-LYMPHOCYTES; UBIQUITIN;

EID: 0036777493     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0161-5890(02)00097-4     Document Type: Review

References (75)

1. Intracellular localization of proteasomal degradation of a viral antigen
2. Dissociation of proteasomal degradation of biosynthesized viral proteins from generation of MHC class I-associated antigenic peptides
3. Introduction of a glycosylation site into a secreted protein provides evidence for an alternative antigen processing pathway: Transport of precursors of major histocompatibility complex class I-restricted peptides from the endoplasmic reticulum to the cytosol
4. Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions
5. The unfolding of substrates and ubiquitin-independentprotein degradation by proteasomes
6. Allelic differences in the relationship between proteasome activity and MHC class I peptide loading
7. Proteasome inhibitors and antigen presentation
8. Gamma-interferon decreases the level of 26S proteasomes and changes the pattern of phosphorylation
9. ER protein quality control and proteasome-mediated protein degradation
10. Subcellular localization of proteasomes and their regulatory complexes in mammalian cells
11. Proteasome inhibition leads to a heat-shock response, induction of endoplasmic reticulum chaperones, and thermotolerance
12. The proteasome-specific inhibitor lactacystin blocks presentation of cytotoxic T lymphocyte epitopes in human and murine cells
13. A novel influenza A virus mitochondrial protein that induces cell death
14. Immunoproteasomes shape immunodominance hierarchies of antiviral CD8+ T cells at the levels of T cell repertoire and presentation of viral antigens
15. Regulation of cellular polyamines by antizyme
16. 1 ubiquitin-activating enzyme in temperature-sensitive cell lines
17. Expression of a membrane protease enhances presentation of endogenous antigens to MHC class I-restricted T lymphocytes
18. Transporter associated with antigen processing
19. Subcellular distribution of proteasomes implicates a major location of protein degradation in the nuclear envelope-ER network in yeast
20. Efficient MHC class I-independent amino-terminal trimming of epitope precursor peptides in the endoplasmic reticulum
21. Folding of newly translated proteins in vivo: The role of molecular chaperones
22. A proteolytic sysytem that compensates for loss of proteasome function
23. Functional analysis of the proteasome regulatory particle
24. Proteasomal degradation of Smad1 induced by bone morphogenetic proteins
25. The immunochemical detection and quantitation of intracellular ubiquitin-protein conjugates
26. Misfolded major histocompatibility complex class I heavy chains are translocated into the cytoplasm and degraded by the proteasome
27. CHIP is a U-box-dependent E3 ubiquitin ligase: Identification of Hsc70 as a target for ubiquitylation
28. Aggresomes: A cellular response to misfolded proteins
29. The transporter associated with antigen processing: Function and implications in human diseases
30. Proteasome inhibitors: Valuable new tools for cell biologists
31. Roles of heat-shock proteins in antigen presentation and cross-presentation
32. Protein-splicing intein: Genetic mobility, origin, and evolution
33. Proteasomes can either generate or destroy MHC class I epitopes: Evidence for non-proteasomal epitope generation in the cytosol
34. Review: Properties and assembly mechanisms of ND10, PML bodies, or PODs
35. Non-traditionally derived CTL epitopes: Exceptions that prove the rules?
36. A role for the ubiquitin-dependent proteolytic pathway in MHC class I-restricted antigen presentation
37. c-erbB-2 receptor protein-tryrosine kinase induced by geldanamycin
38. Distinct proteolytic processes generate the C and N termini of MHC class I-binding peptides
39. Generation and TAP/mediated transport of peptides for major histocompatibility complex class I molecules
40. Identification of a fourth class of proteins linked to the murine major histocompatibility complex
41. Processing of some antigens by the standard proteasome but not by the immunoproteasome results in poor presentation by dendritic cells
42. The class I antigen-processing pathway for the membrane protein tyrosinase involves translation in the endoplasmic reticulum and processing in the cytosol
43. Immunoproteasome assembly and antigen presentation in mice lacking both PA28alpha and PA28beta
44. Protein splicing and related forms of protein autoprocessing
45. Impaired immunoproteasome assembly and immune responses in PA28-/- mice
46. Cells adapted to the proteasome inhibitor 4-hydroxy-5-iodo-3-nitrophenylacetyl-Leu-Leu-leucinal-vinyl sulfone require enzymatically active proteasomes for continued survival
47. The proteasome activator 11S REG (PA28) and class I antigen presentation
48. The major substrates for TAP in vivo are derived from newly synthesized proteins
49. Dynamics of proteasome distribution in living cells
50. Class I MHC-restricted ctytoxic T lymphocyte recognition of cells infected with human cytomegalovirus does not require endogenous viral gene expression
51. Regulation of proteasome complexes by gamma-interferon and phosphorylation
52. Degradation of cell proteins and the generation of MHC class I-presented peptides
53. MHC class I-presented peptides are degraded in cytosolic extracts primarily by thimet oligopeptidase
54. Rapid degradation of a large fraction of newly synthesized proteins by proteasomes
55. The selective proteasome inhibitors lactacystin and epoxomicin can be used to either up- or down-regulate antigen presentation at nontoxic doses
56. Heat shock proteins transfer peptides during antigen processing and CTL priming
57. Nuclear dots: Actors on many stages
58. The MHC class I ligand-generating system: Roles of immunoproteasomes and the interferon-gamma-inducible proteasome activator PA28
59. Recognition of the polyubiquitin proteolytic signal
60. T cell-recognized antigenic peptides derived from the cellular genome are not protein degradation products but can be generated directly by transcription and translation of short subgenic regions: A hypothesis
61. Efficiency of MHC class I antigen processing: A quantitative analysis
62. Listeriolysin is processed efficiently into an MHC class I-associated epitope in listeria monocytogenes-infected cells
63. The generation of MHC class I-associated peptides is only partially inhibited by proteasome inhibitors: Involvement of non-proteasomal cyosolic proteases in antigen processing?
64. The 26S proteasome: A molecular machine designed for controlled proteolysis
65. Integration of the ubiquitin-proteasome pathway with a cytosolic oligopeptidase activity
66. Costimulation in antiviral immunity: Differential requirements for CD4+ and CD8+ T cell responses
67. Localization of the 26S proteasome during mitosis and meiosis in fission yeast
68. Ubiquitination and deubiquitination: Targeting of proteins for degradation by the proteasome
69. Ubiquitin-mediated proteolysis centers in HeLa cells: Indication from studies of an inhibitor of the chymotrypsin-like activity of the proteasome
70. Not such a dismal science: The economics of protein synthesis, folding, degradation and antigen processing
71. Defective ribosomal products (DRiPs). A major source of antigenic peptides for MHC class I molecules?
72. Mechanisms of exogenous antigen presentation by MHC class I molecules in vitro and in vivo: Implications for generating CD8+ T cell responses to infectious agents, tumors, transplants, and vaccines
73. Cytotoxic T cells to type A influenza virus: Viral hemagglutinin induces A-strain specificity while infected cells confer cross-reactive cytotoxicity