Reduction of hepatic glycogen synthesis and breakdown in patients with agenesis of the dorsal pancreas

Journal of Clinical Endocrinology and Metabolism

Volumn 87, Issue 10, 2002, Pages 4678-4685

  Stingl, Harald ^a   Schnedl, Wolfgang J ^b   Krssak, Martin ^c   Bernroider, Elisabeth ^b   Bischof, Martin G ^c   Lahousen, Theresa ^b   Pacini, Giovanni ^a   Roden, Michael ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY OF GRAZ   (Austria)

^c UNIVERSITY OF PADOVA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GLYCOGEN;

ADULT; AGENESIS; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CASE REPORT; CONTROLLED STUDY; FEMALE; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; GLYCOGEN LIVER LEVEL; GLYCOGEN METABOLISM; GLYCOGEN SYNTHESIS; HUMAN; INSULIN CLEARANCE; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; INSULIN SENSITIVITY; INTRAVENOUS GLUCOSE TOLERANCE TEST; MALE; PANCREAS AGENESIS; PRIORITY JOURNAL;

BLOOD GLUCOSE; C-PEPTIDE; DIABETES MELLITUS, TYPE 1; FATTY ACIDS, NONESTERIFIED; FEMALE; GLUCAGON; GLUCONEOGENESIS; GLUCOSE TOLERANCE TEST; GLYCOGEN; HUMAN GROWTH HORMONE; HUMANS; HYDROCORTISONE; INSULIN; INSULIN RESISTANCE; KINETICS; LEPTIN; LIVER; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MIDDLE AGED; NOREPINEPHRINE; PANCREAS;

EID: 0036775759     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2002-020036     Document Type: Article

References (50)

1. Stoffers DA, Zinkin NT, Stanojevic V, Clarke WL, Habener JF 1997 Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence. Nat Genet 15:106-110
2. Stoffers DA, Stanojevic V, Habener JF 1998 Insulin promoter factor-1 gene mutation linked to early-onset type 2 diabetes mellitus directs expression of a dominant negative isoprotein. J Clin Invest 102:232-241
3. Harrison KA, Thaler J, Pfaff SL, Gu H, Kehrl JH 1999 Pancreas dorsal lobe agenesis and abnormal islets of Langerhans in Hlxb9-deficient mice. Nat Genet 23:71-75
4. Li H, Arber S, Jessell TM, Edlund H 1999 Selective agenesis of the dorsal pancreas in mice lacking homeobox gene Hlxb9. Nat Genet. 23:67-70
5. Scharfmann R 2000 Control of early development of the pancreas in rodents and humans: Implications of signals from the mesenchyme. Diabetologia 43:1083-1092
6. McKinnon CM, Docherty K 2001 Pancreatic duodenal homeobox-1, PDX-1, a major regulator of β cell identity and function, Diabetologia 44:1203-1214
7. Adda G, Hannoun L, Loygue J 1984 Development of the human pancreas: Variations and pathology. A tentative classification. Anat Clin 5:275-283
8. Wildling R, Schnedl WJ, Reisinger EC, Schreiber F, Lipp RW, Lederer A, Krejs GJ 1993 Agenesis of the dorsal pancreas in a woman with diabetes mellitus and in both of her sons. Gastroenterology 104:1182-1186
9. Wang JT, Lin JT, Chuang CN, Wang SM, Chuang LM, Chen JC, Huang SH, Chen DS, Wang TH 1990 Complete agenesis of the dorsal pancreas - A case report and review of the literature. Pancreas 5:493-497
10. Klein WA, Dabezies MA, Friedman AC, Caroline DF, Boden GH, Cohen S 1994 Agenesis of dorsal pancreas in a patient with weight loss and diabetes mellitus. Dig Dis Sci 39:1708-1713
11. Oldenburg B, van Leeuwen MS, van Berge Henegouwen GP, Koningsberger JC 1998 Pancreatitis and agenesis of the dorsal pancreas. Eur J Gastroenterol Hepatol 10:887-889
12. Schnedl WJ, Reisinger EC, Schreiber F, Pieber TR, Lipp RW, Krejs GJ 1995 Complete and partial agenesis of the dorsal pancreas within one family. Gastrointest Endosc 42:485-487
13. Wittingen J, Frey CF 1974 Islet concentration in the head, body, tail and uncinate process of the pancreas. Ann Surg 179:412-414
14. Trimble ER, Halban PA, Wollheim CB, Renold AE 1982 Functional differences between rat islets of ventral and dorsal pancreatic origin. J Clin Invest 69:405-413
15. Leclercq-Meyer V, Marchand J, Malaisse WJ 1985 Insulin and glucagon release from the ventral and dorsal parts of the perfused pancreas of the rat. Effects of glucose, arginine, glucagon and carbamylcholine. Horm Res 21:19-32
16. Roden M, Perseghin G, Petersen KF, Hwang JH, Cline GW, Gerow K, Rothman DL, Shulman GI 1996 The roles of insulin and glucagon in the regulation of hepatic glycogen synthesis and turnover in humans. J Clin Invest 97:642-648
17. Petersen KF, Laurent D, Rothman DL, Cline GW, Shulman GI 1998 Mechanism by which glucose and insulin inhibit net hepatic glycogenolysis in humans. J Clin Invest 101:1203-1209
18. 13C NMR. Science 254:573-576
19. Stingl H, Krssak M, Krebs M, Bischof MG, Nowotny P, Furnsinn C, Shulman GI, Waldhausl W, Roden M 2001 Lipid-dependent control of hepatic glycogen stores in healthy humans. Diabetologia 44:48-54
20. Roden M, Petersen KF, Shulman GI 2001 Nuclear magnetic resonance studies of hepatic glucose metabolism in humans. Recent Prog Horm Res 56:219-237
21. Pacini G, Bergman RN 1986 MINMOD: A computer program to calculate insulin sensitivity and pancreatic responsivity from the frequently sampled intravenous glucose tolerance test. Comput Methods Programs Biomed 23:113-122
22. Bergman RN 1989 Lilly lecture 1989. Toward physiological understanding of glucose tolerance. Minimal-model approach. Diabetes 38:1512-1527
23. Bischof MG, Krssak M, Krebs M, Bernroider E, Stingl H, Waldhausl W, Roden M 2001 Effects of short-term improvement of insulin treatment and glycemia on hepatic glycogen metabolism in type 1 diabetes. Diabetes 50:392-398
24. Roden M, Stingl H, Chandramouli V, Schumann WC, Hofer A, Landau BR, Nowotny P, Waldhausl W, Shulman GI 2000 Effects of free fatty acid elevation on postabsorptive endogenous glucose production and gluconeogenesis in humans. Diabetes 49:701-707
25. Petersen KF, Price T, Cline GW, Rothman DL, Shulman GI 1996 Contribution of net hepatic glycogenolysis to glucose production during the early postprandial period. Am J Physiol 270:E186-E191
26. Pacini G, Tonolo G, Sambataro M, Maioli M, Ciccarese M, Brocco E, Avogaro A, Nosadini R 1998 Insulin sensitivity and glucose effectiveness: Minimal model analysis of regular and insulin-modified FSIGT. Am J Physiol 274:E592-E529
27. Waldhausl W, Herkner K, Nowotny P, Bratusch-Marrain P 1978 Combined 17α- and 18-hydroxylase deficiency associated with complete male pseudohermaphroditism and hypoaldosteronism. J Clin Endocrinol Metab 46:236-246
28. Musso NR, Vergassola C, Pende A, Lotti G 1989 Reversed-phase HPLC separation of plasma norepinephrine, epinephrine, and dopamine, with three-electrode colorometric detection. Clin Chem 35:1975-1977
29. Raber W, Raffesberg W, Bischof M, Scheuba C, Niederle B, Gasic S, Waldhausl W, Roden M 2000 Diagnostic efficacy of unconjugated plasma metanephrines for the detection of pheochromocytoma. Arch Intern Med 160:2957-2963
30. Krebs M, Krssak M, Nowotny P, Weghuber D, Gruber S, Mlynarik V, Bischof M, Stingl H, Furnsinn C, Waldhausl W, Roden M 2001 Free fatty acids inhibit the glucose-stimulated increase of intramuscular glucose-6-phosphate concentration in humans. J Clin Endocrinol Metab 86:2153-2160
31. Bier DM, Leake RD, Haymond MW, Arnold KJ, Gruenke LD, Sperling MA, Kipnis DM 1977 Measurement of "true" glucose production rates in infancy and childhood with 6, 6-dideuteroglucose. Diabetes 26:1016-1023
32. Gibaldi M, Perrier D 1982 Pharmacokinetics, 2nd Ed. New York: Marcel Dekker
33. Ader M, Pacini G, Yang YJ, Bergman RN 1985 Importance of glucose per se to intravenous glucose tolerance. Comparison of the minimal-model prediction with direct measurements. Diabetes 34:1092-1103
34. Kahn SE, Prigeon RL, McCulloch DK, Boyko EJ, Bergman RN, Schwartz MW, Neifing JL, Ward WK, Beard JC, Palmer JP 1993 Quantification of the relationship between insulin sensitivity and β-cell function in human subjects. Evidence for a hyperbolic function. Diabetes 42:1663-1672
35. Ahren B, Pacini G 1997 Impaired adaptation of first-phase insulin secretion in postmenopausal women with glucose intolerance. Am J Physiol 273:E701-E707
36. Fukuoka K, Ajiki T, Yamamoto M, Fujiwara H, Onoyama H, Fujita T, Katayama N, Mizuguchi K, Ikuta H, Kuroda Y, Hanioka K 1999 Complete agenesis of the dorsal pancreas. J Hepatobiliary Pancreat Surg 6:94-97
37. Terruzzi V, Radaelli F, Spinzi GC, Imperiali G, Minoli G 1998 Congenital short pancreas. Report of a new case observed during the course of a recurrent acute pancreatitis. Ital J Gastroenterol Hepatol 30:199-201
38. Hwang JH, Perseghin G, Rothman DL, Cline GW, Magnusson I, Petersen KF, Shulman GI 1995 Impaired net hepatic glycogen synthesis in insulin-dependent diabetic subjects during mixed meal ingestion. A 13C nuclear magnetic resonance spectroscopy study. J Clin Invest 95:783-787
39. Waldhausl W, Bratusch-Marrain P, Gasic S, Korn A, Nowotny P 1982 Insulin production rate, hepatic insulin retention and splanchnic carbohydrate metabolism after oral glucose ingestion in hyperinsulinaemic type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 23:6-15
40. 13C nuclear magnetic resonance study. J Clin Invest 90:1323-1327
41. Chen YD, Jeng CY, Hollenbeck CB, Wu MS, Reaven GM 1988 Relationship between plasma glucose and insulin concentration, glucose production, and glucose disposal in normal subjects and patients with non-insulin-dependent diabetes. J Clin Invest 82;21-25
42. Hundal RS, Krssak M, Dufour S, Laurent D, Lebon V, Chandramouli V, Inzucchi SE, Schumann WC, Petersen KF, Landau BR, Shulman GI 2000 Mechanism by which metformin reduces glucose production in type 2 diabetes. Diabetes 49:2063-2069
43. Stoffers DA, Heller RS, Miller CP, Habener JF 1999 Developmental expression of the homeodomain protein IDX-1 in mice transgenic for an IDX-1 promoter/lacZ transcriptional reporter. Endocrinology 140:5374-5381
44. Habener JF, Stoffers DA 1998 A newly discovered role of transcription factors involved in pancreas development and the pathogenesis of diabetes mellitus. Proc Assoc Am Physicians 110:12-21
45. Moede T, Leibiger B, Pour HG, Berggren P, Leibiger IB 1999 Identification of a nuclear localization signal, RRMKWKK, in the homeodomain transcription factor PDX-1. FEBS Lett 461:229-234
46. Macfarlane WM, Frayling TM, Ellard S, Evans JC, Allen LI, Bulman MP, Ayres S, Shepherd M, Clark P, Millward A, Demaine A, Wilkin T, Docherty K, Hattersley AT 1999 Missense mutations in the insulin promoter factor-1 gene predispose to type 2 diabetes. J Clin Invest 104:R33-R39
47. Hems DA, Whitton PD 1980 Control of hepatic glycogenolysis. Physiol Rev 60:1-50
48. Landau BR 1999 Quantifying the contribution of gluconeogenesis to glucose production in fasted human subjects using stable isotopes. Proc Nutr Soc 58:963-972
49. Polonsky KS, Rubenstein AH 1984 C-peptide as a measure of the secretion and hepatic extraction of insulin. Pitfalls and limitations. Diabetes 33:486-494
50. Tura A, Ludvik B, Nolan JJ, Pacini G, Thomaseth K 2001 Insulin and C-peptide secretion and kinetics in humans: Direct and model-based measurements during OGTT. Am J Physiol 281:E966-E974