Insulin sensitivity and glucose effectiveness: Minimal model analysis of regular and insulin-modified FSIGT

American Journal of Physiology - Endocrinology and Metabolism

Volumn 274, Issue 4 37-4, 1998, Pages

  Pacini, Giovanni ^a,d   Tonolo, Giancarlo ^b   Sambataro, Maria ^c   Maioli, Mario ^b   Ciccarese, Milco ^b   Brocco, Enrico ^c   Avogaro, Angelo ^c   Nosadini, Romano ^b  

^a CNR   (Italy)

^b UNIVERSITY OF SASSARI   (Italy)

^c UNIVERSITY OF PADOVA   (Italy)

^d Istituto di Ingeneria Biomedica del CNR   (Italy)

Author keywords

Frequently sampled intravenous glucose tolerance test; Glucose tolerance; Insulin action; Minimal model protocols

Indexed keywords

GLUCOSE; INSULIN;

ADULT; ARTICLE; CONTROLLED STUDY; CORRELATION FUNCTION; FEMALE; GLUCOSE METABOLISM; HUMAN; HUMAN EXPERIMENT; INSULIN SENSITIVITY; INTRAVENOUS GLUCOSE TOLERANCE TEST; MALE; MODEL; NORMAL HUMAN; PRIORITY JOURNAL;

EID: 0031968971     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1998.274.4.e592     Document Type: Article

References (34)

1. Ader, M., and R. N. Bergman. Peripheral effects of insulin dominate suppression of fasting hepatic glucose production. Am. J. Physiol. 258 (Endocrinol. Metab. 21): E1020-E1032, 1990.
2. Ader, M., T.-C. Ni, and R. N. Bergman. Glucose effectiveness assessed under dynamic and steady state conditions. Comparability of uptake versus production components. J. Clin. Invest. 99: 1187-1199, 1997.
3. Ader, M., G. Pacini, Y. Yang, and R. N. Bergman. Importance of glucose per se to intravenous glucose tolerance. Comparison of the minimal-model prediction with direct measurements. Diabetes 34: 1092-1103, 1985.
4. Ahrén, B., and G. Pacini. Impaired adaptation of first-phase insulin secretion in postmenopausal women with glucose intolerance. Am. J. Physiol. 273 (Endocrinol. Metab. 36): E701-E707, 1997.
5. Basu, A., A. Caumo, F. Bettini, A. Gelisio, A. Alzaid, C. Cobelli, and R. Rizza. Impaired basal glucose effectiveness in NIDDM. Diabetes 46: 421-432, 1997.
6. Beard, J. C., R. N. Bergman, W. K. Ward, and D. Porte, Jr. The insulin sensitivity index in nondiabetic man. Correlation between clamp-derived and IVGTT-derived values. Diabetes 35: 362-369, 1986.
7. Bergman, R. N. Toward physiological understanding of glucose tolerance. Minimal model approach. Diabetes 38: 1512-1527, 1989.
8. Bergman, R. N., Y. Z. Ider, C. R. Bowden, and C. Cobelli. Quantitative estimation of insulin sensitivity. Am. J. Physiol. 236 (Endocrinol. Metab. Gastrointest. Physiol. 5): E667-E677, 1979.
9. Bergman, R. N., L. S. Phillips, and C. Cobelli. Physiologic evaluation of factors controlling glucose tolerance in man. J. Clin. Invest. 68: 1456-1467, 1981.
10. Bergman, R. N., R. Prager, A. Vølund, and J. M. Olefsky. Equivalence of the insulin sensitivity index in man derived by the minimal model method and the euglycemic glucose clamp. J. Clin. Invest. 79: 790-800, 1987.
11. Best, J., S. E. Kahn, M. Ader, R. M. Watanabe, T.-C. Ni, and R. N. Bergman. Role of glucose effectiveness in the determination of glucose tolerance. Diabetes Care 19: 1018-1030, 1996.
12. Bland, J. M., and D. G. Altman. Statistical methods for assessing agreement between two methods of clinical measurements. Lancet i: 307-310, 1986.
13. Caumo, A., and C. Cobelli. Hepatic glucose production during the labeled IVGTT: estimation by deconvolution with a new minimal model. Am. J. Physiol. 264 (Endocrinol. Metab. 27): E829-E841, 1993.
14. Cobelli, C., G. Pacini, G. Toffolo, and L. Saccà. Estimation of insulin sensitivity and glucose clearance from minimal model: new insights from labeled IVGTT. Am. J. Physiol. 250 (Endocrinol. Metab. 13): E591-E598, 1986.
15. Cobelli, C., and K. Thomaseth. The minimal model of glucose disappearance: optimal input studies. Math. Biosci. 83: 127-155, 1987.
16. Finegood, D. T., I. M. Hramiak, and J. Dupre. A modified protocol for estimation of insulin sensitivity with the minimal model of glucose kinetics in patients with insulin-dependent diabetes. J. Clin. Endocrinol. Metab. 70: 1538-1549, 1990.
17. Finegood, D. T., G. Pacini, and R. N. Bergman. The insulin sensitivity index: correlation in dogs between values determined from the intravenous glucose tolerance test and the euglycemic glucose clamp. Diabetes 33: 362-368, 1984.
18. Finegood, D. T., and D. Tzur. Reduced glucose effectiveness associated with reduced insulin release: an artifact of the minimal-model method. Am. J. Physiol. 271 (Endocrinol. Metab. 34): E485-E495, 1996.
19. Kahn, S. E., L. J. Klaff, M. W. Schwartz, J. C. Beard, R. N. Bergman, and J. Taborsky, Jr. Treatment with a somatostatin analog decreases pancreatic B-cell and whole body sensitivity to glucose. J. Clin. Endocrinol. Metab. 71: 994-1002, 1990.
20. Kautzky-Willer, A., G. Pacini, U. Barnas, B. Ludvik, C. Streli, H. Graf, and R. Prager. Intravenous calcitriol normalizes insulin sensitivity in uremic patients. Kidney Int. 47: 200-206, 1995.
21. Mari, A. Assessment of insulin sensitivity with minimal model: role of model assumptions. Am. J. Physiol. 272 (Endocrinol. Metab. 35): E925-E934, 1997.
22. Ni, T.-C., M. Ader, and R. N. Bergman. Reassessment of glucose effectiveness and insulin sensitivity from minimal model analysis: a theoretical evaluation of the single-compartment glucose distribution assumption. Diabetes 46: 1813-1821, 1997.
23. Pacini, G., and R. N. Bergman. MINMOD: a computer program to calculate insulin sensitivity and pancreatic responsivity from the frequently sampled intravenous glucose tolerance test. Comput. Methods Programs Biomed. 23: 113-122, 1986.
24. Prigeon, R. L., M. E. Røder, D. Porte, Jr., and S. E. Kahn. The effect of insulin dose on the measurement of insulin sensitivity by the minimal model technique. Evidence for saturable insulin transport in humans. J. Clin. Invest. 97: 501-507, 1996.
25. Quon, M. J., C. Cochran, S. I. Taylor, and R. C. Eastman. Direct comparison of standard and insulin modified protocols for minimal model estimation of insulin sensitivity in normal subjects. Diabetes Res. 25: 139-149, 1994.
26. Saad, M. F., G. M. Steil, W. W. Kades, M. F. Ayad, W. A. Elsewafy, R. Boyadjian, S. D. Jinagouda, and R. N. Bergman. Differences between the tolbutamide-boosted and the insulin-modified minimal model protocols. Diabetes 46: 1167-1171, 1997.
27. Steil, G. M., A. Vølund, S. E. Kahn, and R. N. Bergman. Reduced sample number for calculation of insulin sensitivity and glucose effectiveness from the minimal model. Diabetes 42: 250-256, 1993.
28. Söderström, T., and P. Stoica. System Identification. New York: Prentice Hall, 1989.
29. Taniguchi, A., Y. Nakai, M. Fukushima, H. Imura, H. Kawamura, and I. Nagata. Insulin sensitivity, insulin secretion, and glucose effectiveness in subjects with impaired glucose tolerance: a minimal model analysis. Metab. Clin. Exp. 43: 714-718, 1994.
30. Thomaseth, K., and C. Cobelli. Parameter information content during model identification experiments. In: Modelling and Control in Biomedical Systems, edited by D. A. Linkens and E. R. Carson. Oxford: Pergamon, 1997, p. 107-112.
31. G. In: The Minimal Model Approach and Determinants of Glucose Tolerance, edited by R. N. Bergman and J. C. Lovejoy. Baton Rouge, LA: Louisiana State University Press, 1997, p. 187-201.
32. Tobin, B. L., and D. T. Finegood. Reduced insulin secretion by repeated low doses of STZ impairs glucose effectiveness but does not induce insulin resistance in dogs. Diabetes 42: 474-483, 1993.
33. Welch, S., S. S. P. Gebhart, R. N. Bergman, and L. S. Phillips. Minimal model analysis of intravenous glucose tolerance test-derived insulin sensitivity in diabetic subjects. J. Clin. Endocrinol. Metab. 71: 1508-1518, 1990.
34. Yang, Y. J., J. H. Youn, and R. N. Bergman. Modified protocols improve insulin sensitivity estimation using the minimal model. Am. J. Physiol. 253 (Endocrinol. Metab. 16): E595-E602, 1987.