A mouse strain defective for αβ versus γδ T cell lineage commitment

International Immunology

Volumn 14, Issue 9, 2002, Pages 1039-1053

  Mertsching, Elisabeth ^a   Wurster, Andrea L ^d   Katayama, Carol ^a   Esko, Jeffrey ^b   Ramsdell, Fred ^c   Marth, Jamey D ^a,b   Hedrick, Stephen M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Chiroscience R and D Inc   (United States)

^d HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Chromosomal deletion; Development; Immune response; Lineage commitment; T cells

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL LINEAGE; CELL POPULATION; CHROMOSOME 10; CHROMOSOME DELETION; CONTROLLED STUDY; GENE DELETION; GENE EXPRESSION; GENE INSERTION; GENE LOCUS; GENE MAPPING; GENE REARRANGEMENT; GENETIC ANALYSIS; IMMUNE RESPONSE; LYMPH NODE; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; SPLEEN; T LYMPHOCYTE; THYMOCYTE; THYMUS;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CARRIER PROTEINS; INTEGRASES; MICE; MICE, TRANSGENIC; PROMOTER REGIONS (GENETICS); RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; T-LYMPHOCYTES; THYMUS GLAND; VIRAL PROTEINS;

EID: 0036733441     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (74)

1. γδ Cells: A right time and a right place for a conserved third way of protection
2. - T lymphocytes. A CD3-associated disulfide-linked gamma chain heterodimer
3. Characterization of T cell receptor gamma chain expression in a subset of murine thymocytes
4. Direct presentation of nonpeptide prenyl pyrophosphate antigens to human gamma delta T cells
5. Recognition of a self major histocompatibility complex TL region product by gamma delta T-cell receptors
6. Gamma delta T cells can recognize nonclassical MHC in the absence of conventional antigenic peptides
7. The nature of major histocompatibility complex recognition by gamma delta T cells
8. HSV-1 glycoprotein I-reactive TCR gamma delta cells directly recognize the peptide backbone in a conformationally dependent manner
9. Diversification, expression, and gamma delta T cell recognition of evolutionarily distant members of the MIC family of major histocompatibility complex class I-related molecules
10. + dendritic epidermal cells express T3 antigen and the T-cell receptor gamma chain
11. + intraepithelial lymphocytes
12. + intraepithelial lymphocytes provided by serial analysis of gene expression (SAGE)
13. Development of natural killer cells, B lymphocytes, macrophages, and mast cells from single hematopoietic progenitors in culture of murine fetal liver cells
14. Direct evidence for the commitment of hematopoietic stem cells to T, B and myeloid lineages in murine fetal liver
15. Identification of a fetal hematopoietic precursor with B cell, T cell, and macrophage potential
16. Clonal characterization of a bipotent T cell and NK cell progenitor in the mouse fetal thymus
17. Separate lineages of T cells expressing the alpha beta and gamma delta receptors
18. Self-reactive gamma delta T cells are eliminated in the thymus
19. + stage in the absence of TCR-beta rearrangement
20. Alpha beta lineage-committed thymocytes can be rescued by the gamma delta T cell receptor (TCR) in the absence of TCR beta chain
21. T cell receptor alpha gene rearrangement and transcription in adult thymic gamma delta cells
22. Commitment to the T cell receptor-alpha beta or -gamma delta lineages can occur just prior to the onset of CD4 and CD8 expression among immature thymocytes
23. Alpha beta and gamma delta T cells can share a late common precursor
24. Inframe TCR delta gene rearrangements play a critical role in the alpha beta/gamma delta T cell lineage decision
25. Evidence that productive rearrangements of TCR gamma genes influence the commitment of progenitor cells to differentiate into alpha beta or gamma delta T cells
26. On the role of the pre-T cell receptor in alphabeta versus gammadelta T lineage commitment
27. Crucial role of the pre-T-cell receptor alpha gene in development of alpha beta but not gamma delta T cells
28. Notch activity influences the alphabeta versus gammadelta T cell lineage decision
29. Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice
30. E2A proteins: Essential regulators at multiple stages of B-cell development
31. Disruption of alpha beta but not of gamma delta T cell development by overexpression of the helix-loop-helix protein Id3 in committed T cell progenitors
32. Analysis of C-MYC function in normal cells via conditional gene-targeted mutation
33. Dissection of thymocyte signaling pathways by in vivo expression of pertussis toxin ADP-ribosyltransferase
34. + T cells in transgenic mice expressing a class II MHC-restricted antigen receptor
35. T cell receptor antagonist peptides induce positive selection
36. An improved PCR method for walking in uncloned genomic DNA
37. Kinetic PCR analysis: Real-time monitoring of DNA amplification reactions
38. High-resolution mapping of mammalian genes by in situ hybridization to free chromatin
39. Modes of DAPI banding and simultaneous in situ hybridization
40. Recent advances in gene mutagenesis by sitedirected recombination
41. Cre recombinase: The universal reagent for genome tailoring
42. Creation and use of a Cre recombinase transgenic database
43. Zp3-cre, a transgenic mouse line for the activation or inactivation of loxP-flanked target genes specifically in the female germ line
44. A pertussis toxinsensitive process controls thymocyte emigration
45. Developmental regulation of Ick gene expression in T lymphocytes
46. + T lymphocyte homeostasis by modulating O-glycan biosynthesis
47. A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival
48. Analysis of C-MYC function in normal cells via conditional gene-targeted mutation
49. Growth inhibition and DNA damage induced by Cre recombinase in mammalian cells
50. -/- mice by anti-CD3epsilon antibody treatment or with transgenes encoding activated Lck or tailless pT alpha
51. Regulation of TCR alpha and beta gene allelic exclusion during T-cell development
52. T-cell receptor alpha locus V(D)J recombination by-products are abundant in thymocytes and mature T cells
53. T-cell receptor delta-chain can substitute for alpha to form a beta delta heterodimer
54. Thymocyte development: An analysis of T cell receptor gene expression in 519 newborn thymocyte hybridomas
55. Mouse T-cell receptor variable gene segment families
56. + intraepithelial lymphocytes by apoptosis
57. + T cells
58. Lymphocyte development and function in T-cell receptor and RAG-1 mutant mice
59. Stepwise specification of lymphocyte developmental lineages
60. Transcriptional regulation of lymphocyte lineage commitment
61. Gamma delta T-cell receptor repertoire in human peripheral blood and thymus
62. + T cell clones expressing gamma delta T cell receptors
63. - T cell receptor-gamma delta clones from peripheral blood
64. The alpha beta T cell receptor can replace the gamma delta receptor in the development of gamma delta lineage cells
65. Activation and activation-driven death of human gamma/delta T cells
66. Gamma delta T cells differentiate into a functional but nonproliferative state during a normal immune response
67. T cell receptor beta chain gene rearrangement and selection during thymocyte development in adult mice
68. T cell receptor-gamma, delta-expressing fetal mouse thymocytes are generated without T cell receptor V beta selection
69. TCR gene recombination and alpha beta-gamma delta lineage divergence: Productive TCR-beta rearrangement is neither exclusive nor preclusive of gamma delta cell development
70. T cell receptor-mediated signs and signals governing T cell development
71. The role of membrane-associated adaptors in T cell receptor signalling
72. Signal transduction by the TCR for antigen
73. The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells
74. MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent