(-)U50,488H [(trans)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)-cyclohexyl] benzeneacetamide] induces internalization and down-regulation of the human, but not the rat, κ-opioid receptor: Structural basis for the differential regulation

Journal of Pharmacology and Experimental Therapeutics

Volumn 302, Issue 3, 2002, Pages 1184-1192

  Zhang, Fengqin ^a   Li, Jin ^a   Li, Jian Guo ^a   Liu Chen, Lee Yuan ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE METHANESULFONATE; DIPRENORPHINE; EPITOPE; KAPPA OPIATE RECEPTOR; MONENSIN; NALOXONE; RECEPTOR; SERINE;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CHO CELL; CONTROLLED STUDY; DRUG EFFECT; DRUG EXPOSURE; HUMAN; HUMAN CELL; INTERNALIZATION; MUTANT; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN TRANSPORT; RAT; RECEPTOR DOWN REGULATION;

3,4-DICHLORO-N-METHYL-N-(2-(1-PYRROLIDINYL)-CYCLOHEXYL)-BENZENEACETAMIDE, (TRANS)-ISOMER; AMINO ACID SEQUENCE; ANALGESICS, NON-NARCOTIC; ANIMALS; CELL MEMBRANE; CHO CELLS; CRICETINAE; DIPRENORPHINE; DOWN-REGULATION; FLUORESCENT ANTIBODY TECHNIQUE, DIRECT; HUMANS; INTRACELLULAR MEMBRANES; IONOPHORES; MOLECULAR SEQUENCE DATA; MONENSIN; MUTATION; NARCOTIC ANTAGONISTS; RATS; RECEPTORS, OPIOID, KAPPA; RECOMBINANT FUSION PROTEINS; SPECIES SPECIFICITY;

EID: 0036721040     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.302.3.1184     Document Type: Article

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