Paclitaxel Induces Prolonged Activation of the Ras/MEK/ERK Pathway Independently of Activating the Programmed Cell Death Machinery

Journal of Biological Chemistry

Volumn 276, Issue 22, 2001, Pages 19555-19564

  Okano, Jun Ichi ^a,b   Rustgi, Anil K ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; ENZYMES; IMMUNOLOGY; PHYSIOLOGY; PRECIPITATION (CHEMICAL); TUMORS;

PHOSPHORYLATION;

BIOCHEMISTRY;

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; PACLITAXEL; RAS PROTEIN; STRESS ACTIVATED PROTEIN KINASE; ANTINEOPLASTIC AGENT; BENZYLOXYCARBONYLVALYL ALANYL ASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLVALYL-ALANYL-ASPARTYL FLUOROMETHYL KETONE; CASP7 PROTEIN, HUMAN; CASPASE; CASPASE 7; EPIDERMAL GROWTH FACTOR; ISOPROTEIN; MAP2K1 PROTEIN, HUMAN; MAP2K2 PROTEIN, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE P38; PEPTIDE CHLOROMETHYL KETONE; PROTEIN SERINE THREONINE KINASE; PROTEIN TYROSINE KINASE;

APOPTOSIS; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION; SQUAMOUS CELL; WESTERN BLOTTING; BIOLOGICAL MODEL; CELL CULTURE; CELL NUCLEUS; CELL SURVIVAL; DOSE RESPONSE; FLOW CYTOMETRY; METABOLISM; PHOSPHORYLATION; SERODIAGNOSIS; TIME;

AMINO ACID CHLOROMETHYL KETONES; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BLOTTING, WESTERN; CASPASE 7; CASPASES; CELL NUCLEUS; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; EPIDERMAL GROWTH FACTOR; FLOW CYTOMETRY; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE KINASE 1; MAP KINASE KINASE 2; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, BIOLOGICAL; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PACLITAXEL; PHOSPHORYLATION; PRECIPITIN TESTS; PROTEIN ISOFORMS; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; RAS PROTEINS; SIGNAL TRANSDUCTION; TIME FACTORS; TUMOR CELLS, CULTURED;

EID: 0035377357     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M011164200     Document Type: Article

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